Clinical trials: Atrophy, Muscle
Polycystic Kidney Diseases, Polycystic Liver Disease
The Association Between Skeletal Muscle Mass and Severity of Polycystic Liver Disease and Polycystic Kidney Disease
Primary sarcopenia is used to describe aging and progressed with the physiologic decline. Secondary sarcopenia is associated many chronic disease, including acquired immune deficiency syndrome, cancer, chronic heart failure…
- Conditions
- Polycystic Kidney Diseases, Polycystic Liver Disease, Muscle Loss
- Trial name
- NCT05215964
- Testing
- Renal artery embolization
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Sarcopenia, Sarcopenic Obesity
Effects of Sarcopenia and Sarcopenic Obesity in Complex Abdominal Wall Surgery
The objective of our study is to evaluate the prevalence of sarcopenia and sarcopenic obesity in our surgical population and their relationship in postoperative complications after complex abdominal wall surgery and its influence…
- Conditions
- Sarcopenia, Sarcopenic Obesity, Incisional Hernia
- Trial name
- NCT04690179
- Volunteers
- 150 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Sarcopenia
Frailty and Assocciated Factors in Sarcopenia
Primary sarcopenia is a condition that occurs with the aging process and is characterized by symptoms such as decreased muscle mass, impaired muscle function and decreased physical strength.
- Trial name
- NCT06931964
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Liver Cirrhosis, Fibrosis
Growth Hormone in Decompensated Liver Cirrhosis
Globally, cirrhosis and liver cancer carries a huge burden and accounts for about 3.5% (2 million) of all deaths every year. Once decompensated, i.e.
- Conditions
- Liver Cirrhosis, Fibrosis, End Stage Liver Disease, Digestive System Disease
- Trial name
- NCT05253287
- Testing
- Growth Hormone
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Myopathy
Maintenance of Muscle Mass in Older People: the Negative Impact of Statin Therapy
A major contributor to frailty and immobility in the elderly is the age related loss of muscle mass (sarcopenia). Cardiovascular disease (CVD) is the leading cause of mortality in the elderly, with high blood cholesterol and…
- Trial name
- NCT01047163
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Muscular Dystrophy, Duchenne
A Study of Tadalafil for Duchenne Muscular Dystrophy
The main purpose of this study is to determine if tadalafil can slow the decline in walking ability of boys who have Duchenne muscular dystrophy (DMD).
- Trial name
- NCT01865084
- Testing
- Tadalafil
- Where
- 62 sites in United States, Argentina and 14 more
- Volunteers
- 331 people
- Sponsor
- Eli Lilly and Company
Colorectal Cancer, Sarcopenia
Predictive Effect of Abdominal Fat and Muscle Area Calculated Based on Abdominal CT on Colorectal Cancer Patients
This study aims to create a clinical prediction model. Abdominal fat and muscle area also play an important role in the prediction of surgical outcomes in colorectal cancer.
- Conditions
- Colorectal Cancer, Sarcopenia, Obesity and Overweight
- Trial name
- NCT06614699
- Testing
- abdominal fat and muscle area
- Where
- 3 sites in China
- Volunteers
- 8,000 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Sarcopenia
Low Versus High-intensity Exercises in Sarcopenia
this study aims to compare the effect of high-intensity resistance exercises measured using the 10-repetition maximum versus low-intensity aerobic exercises on muscle performance, physical function and quality of life in chronic…
- Trial name
- NCT05593471
- Testing
- high intensity exercises, low intensity aerobic exercises
- Where
- Saudi Arabia
- Volunteers
- 82 people
- Sponsor
- University of Hail
Sarcopenia, Aging
Sarcopenia, Obesity, and Resistance Training
The purpose of this study was to examine the effects of resistance training on sarcopenic obesity in older women.
- Conditions
- Sarcopenia, Aging, Obesity
- Trial name
- NCT02681744
- Testing
- Resistance Training
- Where
- Brazil
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Muscular Atrophy, Spinal
A Pilot Therapeutic Trial Using Hydroxyurea in Type I Spinal Muscular Atrophy Patients
The objectives of this trial are: to establish a safety profile for use of Hydroxyurea in children with Type I Spinal Muscular Atrophy; to identify reliable outcome measures for HU treatment in Type I SMA; and to detect the…
- Trial name
- NCT00568698
- Testing
- Hydroxyurea
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Stanford University
Sarcopenia, Osteopenia
Exercise Effects on Sarco-Osteopenia in Older Men
The study determined the effects of predominately resistance type exercise in combination with protein supplements on parameters of sarcopenia and osteopenia (sarco-osteopenia) in older, community dwelling men with sarcopenia and…
- Trial name
- NCT03453463
- Testing
- exercise
- Where
- Germany
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Duchenne Muscular Dystrophy, Becker Muscular Dystrophy
CRD007 for the Treatment of Duchenne Muscular Dystrophy, Becker Muscular Dystrophy and Symptomatic Carriers
This is an investigation of the efficacy and safety of CRD007 in Duchenne Muscular Dystrophy (DMD), Becker Muscular Dystrophy (BMD) and symptomatic carriers.
- Trial name
- NCT01540604
- Testing
- CRD007
- Where
- Sweden
- Sponsor
- RSPR Pharma AB
Heart Failure, Sarcopenia
Mechanism of Sarcopenia in Heart Failure
The aim of the study is to provide information on the interaction between socioeconomic factors, daily physical activity, nutrition and lifestyle on loss of muscle mass and muscle function in patients with heart failure.
- Conditions
- Heart Failure, Sarcopenia, Cachexia
- Trial name
- MUSCLE-CHF (NCT05063955)
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Sarcopenia
VR-based Rehabilitation in the Treatment and Prevention of Sarcopenia of Older Residents
Background: Sarcopenia is the progressive loss of skeletal muscle mass and decline of muscle function associated with aging. The prevalence of sarcopenia among people older than 65 years old in Taiwan is over 20%.
- Trial name
- NCT03809104
- Testing
- Virtual reality-based rehabilitation programs
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- Cishan Hospital, Ministry of Health and Welfare
Becker Muscular Dystrophy, Limb-Girdle Muscular Dystrophy Type 2I
Muscle MRI in Becker Muscular Dystrophy and in Limb-girdle Muscular Dystrophy Type 2I
The purpose of this study is to investigate the paradoxical muscle enlargement in the calves and tongue seen in patients affected by Becker muscular dystrophy and Limb-girdle muscular dystrophy type 2I.
- Trial name
- NCT02165358
- Where
- Denmark
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Duchenne Muscular Dystrophy
Relationship Between PFTs and Pdi in DMD
A cross-sectional study to explore the relationship between clinically assessed pulmonary function test (PFT) measures and transdiaphragmatic (Pdi) measures in Duchenne muscular dystrophy (DMD) as well as to explore the…
- Trial name
- NCT03335384
- Testing
- Esophageal Balloon, Gastric Balloon, Nasal Pressure Transducer
- Sponsor
- University of Minnesota
Duchenne Muscular Dystrophy
Safety Study of Mini-dystrophin Gene to Treat Duchenne Muscular Dystrophy
The purpose of this study is to determine the safety of a miniature dystrophin gene in the treatment of progressive muscle weakness due to Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT00428935
- Testing
- rAAV2.5-CMV-minidystrophin (d3990)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Nationwide Children's Hospital
Muscle Atrophy, Insulin Resistance
Role of Metformin on Muscle Health of Older Adults
Muscle atrophy and insulin resistance are common after bed rest in healthy older adults. Metformin treatment has been shown to improve insulin sensitivity and attenuate muscle loss in insulin resistance adults though the…
- Trial name
- NCT03107884
- Testing
- Metformin (Bed Rest), Metformin (2 week run-in only)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sarcopenia
Sarcopenia Studies for the Elderly Population in Taiwan
Health promotion in the elderly has been a major recent public health concern. Sarcopenia is a term utilized to define the loss of muscle mass and strength that occurs with aging.
- Trial name
- NCT00174135
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Cancer, Sarcopenia
JUMP Prevalence of Sarcopenia and Chemobrain in Post-cancer Patients
Therapeutic advances in oncology have transformed the prognosis of cancer patients, placing a significant number of them either in a context of recovery or in prolonged remission close to a chronic disease.
- Trial name
- JUMP (NCT05800535)
- Testing
- Study of the adverse effects of long-term oncological treatments, Study of the long-term side effects of oncological treatments on the anxiety-depressive and cognitive state of patients
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon