Clinical trials: Atrophy, active
Lung Cancer, Sarcopenia
Impact of Fat-free Mass in the Carboplatin Calculated Dose and Chemotherapeutic Toxicity in Patients With Advanced NSCLC
This study evaluate the association of body composition (mainly free-fat mass), clinical and biochemical parameters with development of toxicity in patients under treatment with Carboplatin/Paclitaxel in advanced NSCLC.
- Conditions
- Lung Cancer, Sarcopenia, Toxicity
- Trial name
- NCT02734069
- Testing
- Carboplatin
- Where
- Mexico
- Volunteers
- 132 people
- Sponsor
- Instituto Nacional de Cancerologia de Mexico
Neurodegenerative Diseases, Parkinson Disease
Neurodegenerative Diseases Registry
With the increase in life expectancy of our population due to advancement of medical diagnosis and treatments, the incidence of age dependent neurodegenerative diseases increased, including Alzheimer's disease (AD), parkinsonian…
- Conditions
- Neurodegenerative Diseases, Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NDD Registry (NCT04472130)
- Where
- Hong Kong
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Vincent Mok
Parkinson's Disease, Parkinsonian Disorders
Gait Analysis in Neurological Disease
The purpose of this study is to investigate whether speed-dependent measures of gait (so called gait signatures) can be identified in patients with neurological conditions that affect gait, particularly in subjects with…
- Conditions
- Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy
- Trial name
- NCT02994719
- Testing
- Anti-Parkinson medication, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Gingival Recession
Effect Of Microneedling With Coronally Advanced Flap For Management of RT1 Gingival Recession In Thin Gingival Phenotype
The goal of this clinical trial is to explore the effect of microneedling to increase the gingival tissue thickness which could improve the outcome of root coverage in coronally advanced flap procedure in thin gingival phenotype.
- Trial name
- RT1 (NCT06988839)
- Testing
- Microneedling followed by coronally advanced flap, Coronally advanced flap with connective tissue graft
- Where
- India
- Volunteers
- 36 people
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Muscle Loss, Extracellular Fluid Alteration
Ultrasound Detection of Body Composition in Critical Care
Objective assessment of the Changes in body composition of critically ill patients is very valuable. Ultrasound stands as a solution due to its portability, bedside availability, and radiation-free technology.
- Conditions
- Muscle Loss, Extracellular Fluid Alteration, Critical Illness, Pregnancy Complications
- Trial name
- NCT06728722
- Testing
- ultrasound detection of body composition
- Where
- Egypt
- Volunteers
- 121 people
- Sponsor
- Ain Shams University
Sarcopenia, Obesity
Investigating the Link Between Advanced Glycation End Products (AGEs) and Muscle Wasting in Sarcobesity
The study aims to explore whether a high level of AGEs (Advanced Glycation end products) derived from the diet may mediate diet-related muscle loss in Western-type diet, influencing the onset and progression of sarcopenia…
- Trial name
- Westernage (NCT06438900)
- Where
- Italy
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Primary Sjögren Syndrome, Sarcopenia
Possible Sarcopenia, Sarcopenia, and Functional Status in Patients With Primary Sjögren's Syndrome
The aim of this study is to evaluate the frequency of probable sarcopenia and sarcopenia in patients with primary Sjögren syndrome and to investigate the effects of sarcopenia on functional status, muscle strength, and quality of…
- Trial name
- NCT07804719
- Testing
- dexa, hand grip strength, myostatin, follistatin
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Geographic Atrophy Secondary to Age-related Macular Degeneration
A Non-Interventional Study Observing Short-Term Progression in Geographic Atrophy (GA)
This is a non-interventional, observational study to provide insights into the short-term progression of GA secondary to AMD in participants aged ≥55 years.
- Trial name
- Pre-GAIN (NCT07144137)
- Where
- 19 sites in United States, United Kingdom
- Volunteers
- 75 people
- Sponsor
- Complement Therapeutics
Liver Cirrhosis, Hepatocellular Carcinoma
Relevance of Sarcopenia in Advanced Liver Disease
Patients with established liver cirrhosis, or end-stage liver disease (ESLD), are at high risk of developing liver cancer (hepatic carcinoma; HCC), portal hypertension, and sarcopenia, all which lead to significant morbidity and…
- Conditions
- Liver Cirrhosis, Hepatocellular Carcinoma, Sarcopenia, Portal Hypertension
- Trial name
- ACCESS-ESLD (NCT05502198)
- Where
- 3 sites in Sweden
- Volunteers
- 150 people
- Sponsor
- Linkoeping University
Muscle Fatigue (C23.888.592.612.612), Muscle Weakness or Atrophy
A Biomechanical Study of Collaborative FES on Lower Limb Motor Function in the Elderly
This study will first conduct a precise assessment of the differences in muscle coordination among the elderly through muscle synergy analysis; then, based on this, it will extract abnormal synergy patterns and muscle activation…
- Trial name
- NCT07245602
- Testing
- Collaborative Functional Electrical Stimulation, Traditional functional electrical stimulation
- Volunteers
- 30 people
- Sponsor
- Chen Xuan
Age-Related Macular Degeneration, Geographic Atrophy
Personalized Monitoring of Non-foveal, Non-vision Compromising Atrophic Age-related Macular Degeneration With Artificial Intelligence and Identification of Disease Progression
The goal of this prospective, multinational, multicenter observational study is to assess and predict progression in non-foveal, non-vision compromising atrophic AMD on an individual-based level over two years.
- Trial name
- APENNINES (NCT06351657)
- Where
- 7 sites in Austria, France and 4 more
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Atrophy
Influence of β-hydroxy β-methyl Butyrate (HMB)Supplementation on Post-operative Muscle Mass and Function in Female Athletes
The proposed project will evaluate the musculoskeletal outcomes of quadriceps and hamstring muscle size and function following orthopedic knee surgery involving anterior cruciate ligament (ACL) repair or reconstruction.
- Trial name
- FAKS-HMB (NCT05869812)
- Testing
- CaHMB (Dietary supplement, not Drug), CaLa
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Obesity and Obesity-related Medical Conditions, Diabetes
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)
The purpose of this research study is to validate (check the accuracy of) laboratory assays, intravenous catheter insertion, and equipment or devices and their reproducibility, which is necessary to perform high quality research…
- Conditions
- Obesity and Obesity-related Medical Conditions, Diabetes, Atherosclerotic Disease, Heart Failure
- Trial name
- VALD (NCT07083557)
- Testing
- Endothelial cell collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Bettina Mittendorfer
Vulvar Atrophy, Vaginal Atrophy
Clinical and Molecular Study to Evaluate the Effect of the Pixel CO2 Laser (FemiLiftTM) for the Treatment of Vulvo-Vaginal Atrophy
Vulvo Vaginal Atrophy (VVA) refers to the changes in the vaginal and vulvar surfaces that occurs during menopause due to the progressive loss of estrogen.
- Trial name
- VVA PAP POPQ (NCT07024667)
- Testing
- Pixel CO2 Laser for the Treatment of Vulvo-Vaginal Atrophy (VVA)
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Hillel Yaffe Medical Center
Sarcopenia, Gastrointestinal Neoplasms
Preoperative Sarcopenia and Postoperative Outcomes in Older Patients With Gastrointestinal Cancer
This prospective cohort study aims to evaluate the association between preoperative sarcopenia and postoperative outcomes in patients aged 60 years or older undergoing elective surgery for gastrointestinal cancer.
- Trial name
- NCT07817758
- Testing
- Preoperative Sarcopenia Status
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Van Training and Research Hospital
Facioscapulohumeral Muscular Dystrophy
The United Kingdom Facioscapulohumeral Muscular Dystrophy Patient Registry
Facioscapulohumeral Dystrophy (FSHD) is the third most common form of neuromuscular dystrophy worldwide with an estimated prevalence of one in 20,000.
- Trial name
- NCT04001582
- Testing
- Patient Registry
- Where
- United Kingdom
- Volunteers
- 1,018 people
- Sponsor
- Newcastle University
Lung Cancer (Non-Small Cell), Sarcopenia
Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery
This prospective observational cohort study aims to evaluate the prognostic value of multimodal nutritional status and sarcopenia assessment in patients undergoing lung cancer surgery.
- Conditions
- Lung Cancer (Non-Small Cell), Sarcopenia, Malnutrition Severe
- Trial name
- NCT07500376
- Testing
- Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Ondokuz Mayıs University
Ridge Augmentation
Autogenous Sticky Bone Plus Platelet-rich Fibrin Membrane Versus Xenograft With Collagen Membrane for Posterior Atrophic Mandible
Background: Teeth loss in the posterior mandible initiates residual ridge resorption, this causes difficulty in implant placement so ridge augmentation must be done either simultaneous with implant placement or in a staged…
- Trial name
- NCT07825896
- Testing
- autogenous sticky bone + PRF membrane, Xenograft + collagen membrane
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Alexandria University
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Muscular Dystrophy, Facioscapulohumeral
Study of SRP-1001 in Adult and Adolescent Participants With Facioscapulohumeral Muscular Dystrophy Type 1
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics of SRP-1001 in participants with facioscapulohumeral muscular dystrophy Type 1 (FSHD1).
- Trial name
- NCT06131983
- Testing
- SRP-1001 for Injection
- Where
- 16 sites in Australia, Canada and 5 more
- Volunteers
- 60 people
- Sponsor
- Sarepta Therapeutics, Inc.
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