Clinical trials: Attention Disorder
Traumatic Brain Injury, Cognitive Dysfunction
Combined Transcranial Magnetic Stimulation and Cognitive Treatment in Blast Traumatic Brain Injury
This study investigates the efficacy of a novel neurorehabilitation program combining noninvasive brain stimulation (transcranial magnetic stimulation or TMS) and cognitive therapy, on cognitive function and quality of life in…
- Conditions
- Traumatic Brain Injury, Cognitive Dysfunction, Blast Injury
- Trial name
- COST-TBI (NCT01596569)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS), Cognitive Intervention
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Boston Medical Center
Alzheimer's Disease, Mild Cognitive Impairment
Study of Nasal Insulin to Fight Forgetfulness - Long-acting Insulin Detemir - 21 Days
The study will examine the effects of intranasally administered long-acting insulin detemir on cognition in persons with Alzheimer's disease (AD) or amnestic mild cognitive impairment (aMCI).
- Trial name
- SNIFF-LONG 21 (NCT01547169)
- Testing
- insulin detemir
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Osteoarthritis, Knee, Obesity
Influence of Weight Loss or Exercise on Cartilage in Obese Knee Osteoarthritis Patients
Obesity and osteoarthritis (OA) co-exist in an increasing part of the population. The two diseases intertwine in several ways. The evolution in the population shows a tendency towards deterioration of both by increasing general…
- Trial name
- CAROT (NCT00655941)
- Testing
- Dietary instruction, Exercise
- Where
- Denmark
- Volunteers
- 192 people
- Sponsor
- Henning Bliddal
Risk Behavior, Cognitive Decline
Intervention on Modifiable Lifestyle Risk Factors for Dementia Prevention
The overarching aim is to develop and deploy a multidomain intervention delivered on a mobile application to help older adults reduce their risk for dementia by improving a set of modifiable lifestyle risk factors associated with…
- Trial name
- NCT04616794
- Testing
- Cognitive Engagement Group, Physical Activity Group, Diet Group
- Where
- Canada
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- LuciLab
Frailty, Cognitive Dysfunction
Trajectory of Frailty and Cognitive Dysfunction in Older Adults
To explore the heterogeneity of the development trend of frailty and cognitive function of older adults.
- Conditions
- Frailty, Cognitive Dysfunction, Community-dwelling Older Adults
- Trial name
- NCT06276166
- Testing
- No intervention
- Volunteers
- 934 people, healthy volunteers welcome
- Sponsor
- Zheng Li
ADHD
Encouraging Positive Parenting Habits
This study evaluates the feasibility and preliminary impacts of a new parenting program consisting of a series of educational videos, automatically delivered via a popular texting platform.
- Trial name
- HABITE (NCT06305429)
- Testing
- HabitE (effective parenting habit) program (in Brazilian Portuguese)
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- D'Or Institute for Research and Education
Mild Cognitive Impairment
iTBS rTMS in Mild Cognitive Impairment
The purposes of this research are to test whether it is feasible to administer a treatment protocol called intermittent theta burst stimulation (iTBS) repetitive transcranial magnetic stimulation (rTMS) in adults with mild…
- Trial name
- NCT05327257
- Testing
- iTBS rTMS
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maria I. Lapid, M.D.
Schizophrenia, Bipolar Affective Disorder
A Study on the Preference of Risperidone Dosage Forms
This study aimed to understand patients' needs and preferences for antipsychotic dosage forms.
- Conditions
- Schizophrenia, Bipolar Affective Disorder, Autism Spectrum Disorder, Conduct Disorder
- Trial name
- NCT06657430
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Mental Health Center
RSV Infection
The EMBRACE Study: Enflonsia Monoclonal in Babies - RSV Antibody Concentration Evaluation
Clesrovimab is an FDA-approved antibody drug recommended for infants younger than 8 months who are entering their first respiratory syncytial virus (RSV) season and whose mothers did not receive an RSV vaccine during pregnancy.
- Trial name
- NCT07824167
- Testing
- Clesrovimab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Emory University
ADHD, Attention Deficit Disorder With Hyperactivity
RCT, Proof of Concept Study of TEAMS (Training Executive, Attention and Motor Skills) Intervention Program
Background: TEAMS (Training Executive Attention and Motor Skills) is a non-pharmacological, neurocognitive intervention program targeted preschool children with ADHD developed by Professor Jeffrey Halperin, and his team from New…
- Trial name
- TEAMS (NCT01918436)
- Testing
- TEAMS intervention, Control group
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Holbaek Sygehus
Mild Cognitive Impairment
Improving Performance in Drivers With Mild Cognitive Impairment
The objective of this study is to assess the effectiveness of an intervention to address both executive function and processing speed changes that contribute to poor driving performance in adults with Mild Cognitive Impairment…
- Trial name
- NCT01935219
- Testing
- Goal Management Training, Processing Speed Training, Brain Health Workshop
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Baycrest
PND, POCD - Postoperative Cognitive Dysfunction
Effects of Ciprofol on Perioperative Neurocognitive Function in Elderly Patients Undergoing Daytime Surgery
As life expectancy increases, the rate of disability among elderly individuals is also rising. Elderly patients undergoing home-based rehabilitation after surgery without medical supervision may experience complications and…
- Trial name
- NCT07895407
- Testing
- Ciprofol, propofol
- Where
- China
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Bipolar Disorder
AMIloride for the Treatment of Nephrogenic Diabetes Insipidus for Patients With Bipolar Disorder Treated With Lithium
Lithium (Li) is the leading treatment for BD, protecting against both maniac and depressive relapse, and reducing the risk of suicide and mortality.
- Trial name
- AMIND (NCT05044611)
- Testing
- Anhydrous Amiloride Hydrochloride
- Where
- 2 sites in France
- Volunteers
- 148 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild Cognitive Impairment, Dementia
Implications for Management of PET Amyloid Classification Technology in the Imaging Dementia(IDEAS) Trial
The main purpose of this study is to build upon the evidence captured in the Imaging Dementia - Evidence for Amyloid Scanning (IDEAS; NCT02420756) trial to include valuable information regarding patient-reported outcomes and…
- Conditions
- Mild Cognitive Impairment, Dementia, Alzheimer's Disease
- Trial name
- IMPACT2 (NCT02781220)
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Utah
Alzheimer Disease, Cognitive Impairment
Multi-Center Study of Sensory Stimulation to Improve Brain Function
The Overture Study is a randomized, controlled, single-blind multi-center clinical trial using the GammaSense Stimulation system to study safety, tolerability, and efficacy in people with mild to moderate cognitive impairment.
- Conditions
- Alzheimer Disease, Cognitive Impairment, Mild Cognitive Impairment, Dementia Alzheimers
- Trial name
- Overture (NCT03556280)
- Testing
- GammaSense Stimulation System (Active Settings)
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Cognito Therapeutics, Inc.
Aging, Cognitive Aging
Impact of Music Improvisation Training on Cognitive Function in Older Adults
This project will develop and test the effects and mechanisms of a music improvisation training intervention on self-regulation of older adults with and without MCI.
- Conditions
- Aging, Cognitive Aging, Cognitive Impairment, Cognitive Training
- Trial name
- NCT05980286
- Testing
- Piano Improvisation, Music Listening
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Attention Deficit Hyperactivity Disorder (ADHD)
Safety, Tolerability, Pharmacokinetic, and Efficacy Study of SPD489 in Preschool Children With Attention-deficit/Hyperactivity Disorder
The purpose of this study is to gain initial safety, tolerability, pharmacokinetic, and efficacy information on SPD489 in preschool children 4-5 years old who are diagnosed with ADHD.
- Trial name
- NCT02402166
- Testing
- SPD489
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- Shire
Mild Cognitive Impairment
Computerized Memory Enhancing Treatment in MCI
The investigators propose to apply neuroplasticity-based computerized cognitive remediation (nCCR) to improve memory function in patients with Mild Cognitive Impairment (MCI).
- Trial name
- COMET (NCT05332522)
- Testing
- Neuroplasticity-based Computerized Cognitive Remediation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Vanderbilt University Medical Center
Mild Cognitive Impairment, Mild Dementia
A Study to Evaluate the Effects of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)
The primary purpose of this study is to evaluate the effect of SAGE-718 on cognitive performance in participants with Alzheimer's Disease.
- Conditions
- Mild Cognitive Impairment, Mild Dementia, Alzheimer's Disease
- Trial name
- NCT05619692
- Testing
- SAGE-718
- Where
- 39 sites in United States, Puerto Rico
- Volunteers
- 174 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Alzheimer Disease
Whole Egg Intake and Choline Concentration in the Aging Brain
By doing this study, researchers hope to learn to see if there is relationship between whole egg consumption and brain choline status.
- Trial name
- NCT05021211
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center