Clinical trials: Auricular Vagus Nerve Stimulation
Chronic Constipation
Effect of Transcutaneous Auricular Vagal Nerve Stimulation on Chronic Constipation
The worldwide prevalence of chronic constipation (CC) is 15%, and women are more likely to develop the disease than men. CC have a significant impact on quality of life and increase the burden of national health insurance.
- Trial name
- NCT05723731
- Testing
- taVNS, Laxative Agent
- Where
- 5 sites in China
- Volunteers
- 106 people
- Sponsor
- Air Force Military Medical University, China
Sleep Disorder (Disorder)
Effects of Ultrasound-Guided Stellate Ganglion Block and Transcutaneous Auricular Vagus Nerve Stimulation on Sleep Quality After Radical Mastectomy for Breast Cancer
This study aims to design a prospective, randomized, controlled, dual-center, non-inferiority trial to compare the effects of ultrasound-guided sympathetic ganglion block (SGB) and transcutaneous auricular vagus nerve stimulation…
- Trial name
- NCT07272954
- Testing
- SGB, taVNS
- Volunteers
- 136 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Diabetes Mellitus, Diabetic Neuropathies
Use of taVNS for Painful Diabetic Neuropathy: 12-Week Randomized, Sham-Controlled Trial
This 12-week, randomized, double-blind, sham-controlled, parallel-group trial will evaluate the analgesic and mechanistic effects of home-based transcutaneous auricular vagus nerve stimulation (taVNS) in adults with painful…
- Conditions
- Diabetes Mellitus, Diabetic Neuropathies, Type2diabetes, Neuropathic Pain
- Trial name
- PAK-VAGUS (NCT06292962)
- Testing
- non-invasive transcutaneous vagal nerve stimulation (tVNS)
- Where
- Pakistan
- Volunteers
- 185 people
- Sponsor
- Saima Abass Tahammal
Knee Osteoarthritis, Central Pain Syndrome
Effects of Vagus Nerve Stimulation on Central Pain Sensitivity & Parasympathetic Function in Knee Osteoarthritis
The goal of this clinical trial is to test the feasibility and effectiveness of transcutaneous vagus nerve stimulation (tVNS) to the ear on pain and autonomic function in people with knee osteoarthritis (OA).
- Trial name
- NCT05625178
- Testing
- Transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Texas, El Paso
Pupillary Response
taVNS on Pupillary Response and Perceptual Learning
This study has two parts. The study team will evaluate transcutaneous auricular vagal nerve stimulation (taVNS) and two sham settings during a passive task while measuring pupillary response.
- Trial name
- NCT05386563
- Testing
- Transcutaneous Auricular Vagal Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Spinal Fusion, Hyperglycemia
Trans-Auricular Stimulation for Postoperative Inflammation in Spine Surgery
This study is a randomized controlled trial that will evaluate the effect of non-invasive auricular vagal nerve stimulation on inflammatory markers, glycemic control, postoperative pain, and inflammation-related clinical outcomes…
- Conditions
- Spinal Fusion, Hyperglycemia, Postoperative Pain Management, Postoperative Care
- Trial name
- TAPIS (NCT07218133)
- Testing
- Auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alexander T. Yahanda
Postoperative Delirium
The Effect of Transcutaneous Electrical Acupoint Stimulation Combined With Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium in Elderly Patients Undergoing Gastrointestinal Surgery
The aim of this clinical trial is to study the effect of transcutaneous electrical acupoint stimulation combined with auricular vagus nerve stimulation on postoperative delirium in elderly patients undergoing gastrointestinal…
- Trial name
- NCT07045090
- Testing
- Transcutaneous electrical acupoint stimulation, Transcutaneous electrical acupoint stimulation combined with auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Affiliated Hospital of Nantong University
Irritable Bowel Syndrome (IBS)
NEUROMODULATION WITH TRANSCUTANEOUS AURICULAR VAGUS NERVE STIMULATION IN ADULTS WITH IRRITABLE BOWEL SYNDROME: A RANDOMIZED, SINGLE-BLIND, SHAM-CONTROLLED CROSSOVER STUDY
Randomized, single-blind, sham-controlled crossover study evaluating the efficacy and safety of transcutaneous auricular vagus nerve stimulation (taVNS) in adult patients with IBS.
- Trial name
- NCT07890948
- Testing
- Nurosym Device
- Volunteers
- 40 people
- Sponsor
- Hoag Memorial Hospital Presbyterian
Healthy Adult Participants
Exploring the Role of taVNS in Nausea Management
This single-center randomized controlled trial aims to investigate the efficacy of transcutaneous auricular vagus nerve stimulation in alleviating nausea in healthy adults.
- Trial name
- NCT07632456
- Testing
- Vagal Nerve Stimulation
- Where
- Netherlands
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Daniel Keszthelyi
Depression
Investigation to Understand and Optimize Psilocybin
This study will examine the effects of a single dose of psilocybin, administered with psychological support, on symptoms of depression.
- Trial name
- OPTIMIZE (NCT06512194)
- Testing
- Psilocybin, Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- United States
- Volunteers
- 141 people
- Sponsor
- Charles Raison
Heavy Menstrual Bleeding
Delivering tAN to Reduce HMB: The LUNA Study
The LUNA study is a prospective, randomized, double-blind, sham-controlled, decentralized clinical trial in participants with heavy menstrual bleeding of no known structural cause.
- Trial name
- LUNA (NCT07326722)
- Testing
- Sparrow Link
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Spark Biomedical, Inc.
Pain Management
Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Opioid Consumption in Patients Undergoing Major Abdominal Surgery
This study aims to design a prospective, double-blind, randomized controlled trial to compare the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative visceral pain in patients undergoing major…
- Trial name
- NCT07260266
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 108 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Post-Treatment Lyme Disease
taVNS for Persistent Symptoms From Lyme Disease
This study is one of the first studies to investigate a non-antibiotic approach to the treatment of symptoms that persist after antibiotic treatment for Lyme disease (PTLS).
- Trial name
- NCT05776251
- Testing
- taVNS
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Columbia University
Rectal Surgery, Pain (Visceral, Somatic, or Neuropathic)
Post Operative Pain and Vagal Stimulation
Anorectal surgery is a type of surgery that can cause anal pain, particularly in the context of hemorrhoid surgery or anal fissure surgery. Generally, the period of discomfort related to the pain lasts about two weeks.
- Conditions
- Rectal Surgery, Pain (Visceral, Somatic, or Neuropathic), Vagal Nerve Stimulation
- Trial name
- VAGANAL (NCT07659314)
- Testing
- Experimental arm, Control arm
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Experimental Pain in Healthy Human Subjects
Tonic Pain and Transauricular Vagal Nerve Stimulation
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception.
- Trial name
- NCT07325058
- Testing
- taVNS, Earlobe Stimulation
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Vagus Nerve Stimulation, Heart Rate Variability
Auricular Vagus Stimulation and Heart Rate Variability
Transcutaneous electrical stimulation of the auricular vagus nerve (TENS) is a promising method of neuromodulation of the autonomic nervous system in patients with various pathologies.
- Trial name
- NCT05680337
- Testing
- TENS
- Where
- 3 sites in Russia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Bakulev Scientific Center of Cardiovascular Surgery
Dyspepsia
High Resolution Gastric Mapping and Gastroduodenal Manometry
Dyspepsia is a common problem attributed to gastric sensorimotor dysfunctions ie, delayed, or less frequently rapid gastric emptying (GE), impaired gastric accommodation, and increased gastric sensation.
- Trial name
- NCT06941545
- Testing
- Alimetry, tVNS, Gastroduodenal Manometry
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
PARKINSON DISEASE (Disorder)
Auricular Vagus Nerve Stimulation Combined With Rehabilitation in Parkinson's Disease
Parkinson's disease (PD) is a progressive, neurodegenerative movement disorder characterized by a combination of motor and non-motor symptoms.
- Trial name
- NCT07440563
- Testing
- Neurological Physiotherapy and Rehabilitation Combined with Active Vagus Nerve Stimua
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Gazi University
Tinnitus
FR-taVNS Tinnitus Tria
Tinnitus is a common neurosensory symptom affecting 12-30% of adults and is closely associated with anxiety, sleep disturbance, and autonomic dysregulation.
- Trial name
- NCT07711639
- Testing
- True Foot Reflexology, True ta-VNS, True Auricular Acupressure
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Tzu Chi University
Cerebral Palsy (CP), Musculoskeletal Pain
Transcutaneous Auricular Vagus Nerve Stimulation as a Treatment for Musculoskeletal Pain in Cerebral Palsy
This randomized, double-blind, sham-controlled clinical trial will evaluate the safety and efficacy of a 30-day home-based transcutaneous auricular vagus nerve stimulation (taVNS) intervention in adults with cerebral palsy (CP)…
- Trial name
- NCT07585292
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's