Clinical trials: Autofluorescence
Breast Cancer Invasive
Intra-operative Detection of Positive Margins and Lymph Nodes in Breast Surgery
In this project, the investigators will develop novel optical coherence tomography (OCT)-Raman spectroscopy and autofluorescence (AF)-Raman spectroscopy systems based on a selective sampling approach optimised for high-resolution…
- Trial name
- NCT06977698
- Testing
- OCT-Raman, AF-Raman
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Nottingham
Diabetes Mellitus, Impaired Glucose Tolerance
Skin Autofluorescence (AF) Decision Tree in Detecting Impaired Glucose Tolerance (IGT) or Diabetes Mellitus (DM)
Early detection of (pre)diabetes, including impaired glucose tolerance is currently deficient because the best accepted standard, an oral glucose tolerance test (oGTT), is not feasible in a setting of screening or broad…
- Trial name
- NCT01406665
- Where
- 2 sites in Netherlands
- Volunteers
- 218 people
- Sponsor
- University Medical Center Groningen
Childhood Thyroid Gland Carcinoma, Thyroid Diseases
Fluorescence Imaging of the Parathyroid Glands of Children
The aim of this study is to develop a standardized and user-independent imaging workflow model for autofluorescence and quantified fluorescence angiography with Indocyanine Green (ICG) of the parathyroid glands of children.
- Trial name
- FLUOPATCH (NCT05917067)
- Testing
- Fluorescence imaging of the parathyroid glands of children
- Where
- 3 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)
Thyroid Cancer
Surgery for Thyroid Cancer With or Without Autofluorescence to Prevent Hypoparathyroidism
The study aims to test if use of autofluorescence imaging (AF) reduces the risk of developing hypoparathyroidism (hypoPT) following surgery for thyroid cancer, either total thyroidectomy (TT) or completion hemithyroidectomy (cHT).
- Trial name
- NCT06222606
- Testing
- Surgery with autofluorescence
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Aarhus University Hospital
Thyroid Cancer, Thyroidectomy With Central Lymph Node Dissection
Does Parathyroid Autofluorescence Reduces Unintensional Parathyroidectomy During Total Thyroidectomy With Central Lymph Node Compartment Dissection
The aim of the study is to evaluate the effectiveness of autofluorescence in the intraoperative preservation of parathyroids during total thyroidectomy with central lymph node compartment dissection.
- Trial name
- FLUOBCC (NCT04339478)
- Where
- 2 sites in Greece, Jordan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Autofluorescence Imaging, Neuroimaging
Measurement of Retinal Auto Fluorescence With a Fluorescence Lifetime Imaging Ophthalmoscope
Fluorescent lifetime microscopy has emerged as a useful tool to study fluorescent lifetimes in vitro. Fluorescence lifetime represents the average amount of time a fluorophore remains in the excited state following excitation and…
- Trial name
- FLIO-Group (NCT01981148)
- Testing
- Fluorescence lifetime ophthalmoscope
- Where
- Switzerland
- Volunteers
- 892 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Thyroid Neoplasms, Thyroid Diseases
Assessing Benefits of Near Infrared Autofluorescence (NIRAF) Detection for Identifying Parathyroid Glands During Total Thyroidectomy
This study will see if the use of near infrared autofluorescence (NIRAF) detection with a 'Parathyroid Eye (PTeye)' for identifying parathyroid glands (PGs) during total thyroidectomy (TTx) is better than surgeon's detection…
- Conditions
- Thyroid Neoplasms, Thyroid Diseases, Hypoparathyroidism, Endocrine System Diseases
- Trial name
- NCT05022667
- Testing
- PTeye
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- University of Michigan
Thyroid Cancer, Hypoparathyroidism
Near-Infrared Autofluorescence With PTH Test Strip as an SOP of Parathyroid in Thyroid Surgery
This is a prospective study aiming to establish near-infrared autofluorescence technology and PTH test strip as a standardized process for finding and identifying parathyroid glands in thyroid surgery.
- Conditions
- Thyroid Cancer, Hypoparathyroidism, Optical Imaging
- Trial name
- PTFINDER (NCT05684029)
- Testing
- Near-infrared devices, PTH test strip
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Fujian Medical University
Age-Related Macular Changes, Age-Related Macular Degeneration
Effects of Sun Filters on Age-related Macular Degeneration in People With Lens Implants
This study will test a new method for preventing worsening of age-related macular degeneration (AMD) and for developing imaging methods to follow the very earliest microscopic changes in the disease.
- Conditions
- Age-Related Macular Changes, Age-Related Macular Degeneration, Cataract and IOL Surgery, Retinal Photochemistry
- Trial name
- NCT00487838
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Thyroid Surgery, Parathyroid Dysfunction
PTeye vs Surgeons Eyes in Intraoperative Identification and Functional Preservation of Parathyroid Glands During Thyroid Surgery: A Parallel Randomized Controlled Clinical Trial.
The goal of this randomized clinical trial is to learn if there are any added benefits of using near-infrared autofluorescence (NIRAF) probe-based imaging system (the PTeye) for intraoperative identification of parathyroid glands…
- Conditions
- Thyroid Surgery, Parathyroid Dysfunction, Hypoparathyroidism Post-surgical
- Trial name
- PTSURGEYE (NCT06765941)
- Testing
- Probe-based near-infrared parathyroid autofluorescence detection system, Surgeons naked eyes for parathyroid glands identification
- Where
- Poland
- Volunteers
- 154 people
- Sponsor
- Marcin Barczynski
Retinal Disease, Retinal Degeneration
Performance of Long-wavelength Autofluorescence Imaging
Fundus autofluorescence imaging has become an important diagnostic tool in ophthalmology, guiding diagnosis and assessment of progression of retinal diseases.
- Conditions
- Retinal Disease, Retinal Degeneration, Retinal Dystrophies
- Trial name
- NCT03592017
- Testing
- Long-wavelength autofluorescence imaging
- Where
- United Kingdom
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Gastric Cancer
A Randomized Study Comparing Autofluorescence Imaging(AFI) Followed by Narrow Band Imaging(NBI) With Videoendoscopy for the Detection of High Risk Lesions of Stomach
Videoendoscopy is the standard tool for examination of gastrointestinal tract. However, precancerous lesions and early gastric cancer can be easily missed by routine videoendoscopy.
- Trial name
- CAFBI (NCT01132534)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
End Stage Renal Disease
Effect of Hemodialysis on Toe Pressure- and Finger Pressure and Skin Autofluorescence in Hemodialysis Patients
The aim of this study is to determine the vascular condition of hemodialysis patients with toe pressure measurement, finger pressure measurement and measuring glycated and oxidated proteins by skin autofluorescence.
- Trial name
- NCT00431314
- Volunteers
- 82 people
- Sponsor
- Isala
Preeclampsia, Superimposed Preeclampsia
Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome
Evaluation of practicability in survey and test procedures and of successful implementation of complex interventions - feasibility analysis based on a pilot study: Influence of conditional workout postpartum on arterial stiffness…
- Conditions
- Preeclampsia, Superimposed Preeclampsia, HELLP Syndrome
- Trial name
- RedCarRisk (NCT02754778)
- Testing
- conditional workout
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Medical Need for Fluorescein Angiography Imaging
Triton Fundus Autofluorescence and Fluorescein Angiography
Compare the image quality of the fundus autofluorescence and fluorescein angiography
- Trial name
- NCT03107104
- Testing
- Topcon DRI OCT Triton (plus), TRC-50DX retinal camera
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Topcon Medical Systems, Inc.
Precancerous Conditions, Thoracic Neoplasms
Follow-up Modalities of Low Grade Precancerous Bronchial Lesions
The goal of this multicentric French randomized trial is to determine the best auto fluorescence bronchial endoscopic follow-up strategy in high risk patients bearing low grade bronchial precancerous lesions.
- Trial name
- NCT00213603
- Where
- France
- Volunteers
- 365 people
- Sponsor
- University Hospital, Rouen
Healthy Volunteers
Validation of a Medical Device, a Mobile Spectrofluorimeter, Measuring Skin Autofluorescence in Healthy Volunteers.
The Institut has developed a spectrofluorimeter for the registration and monitoring of skin autofluorescence. This Spectrofluorometer must be initially validated in healthy volunteers.
- Trial name
- PHOTOFLUO (NCT02904616)
- Testing
- mobile spectrofluorimeter
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Institut de Cancérologie de Lorraine
Infection, Surgical Site
Use of Real-time Fluorescence Imaging in Diabetic Foot Ulcers: the Impact of Colonization
The study evaluates the efficacy of fluorescence-guided de-colonization in patients with non-infected diabetic foot ulcers. The efficacy will also be compared between those who used artificial dermis and split-thickness skin…
- Trial name
- NCT05873049
- Testing
- MolecuLight
- Where
- Taiwan
- Volunteers
- 210 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Renal Transplant
Kidney Transplant Low-AGE Diet Study
The purpose of the present study is to test the feasibility of conducting a larger randomised controlled trial (RCT) which will investigate whether a diet low in toxins called advanced glycation end-products (AGEs) decreases skin…
- Trial name
- Transplant LAD (NCT05104242)
- Testing
- Diet low in Advanced Glycation End-Products (AGE)
- Where
- United Kingdom
- Volunteers
- 38 people
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Cervical Cancer
Significance of Fluorescence Colposcopy With Autofluorescence Imaging for Cervical Cancer
Clinical Trial to access Significance of fluorescence colposcopy with autofluorescence imaging for the screening of cervical cancer
- Trial name
- NCT01854983
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center