Clinical trials: Autoimmune Diabetes
CTLA4 Haploinsufficiency
Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency
CTLA4 and LRBA deficiencies are rare genetic disorders, recently described, and associated with multiple clinical features. It ranges from recurrent infections, auto-immunity, and organ infiltration with lymphocytes.
- Trial name
- NCT05040256
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus, Type 1, Diabetes Mellitus
Investigating Genetic Risk for Type 1 Diabetes
The objective of this study is to determine the percentage of children with genetic markers putting them at increased risk of developing type 1 diabetes, and to offer the opportunity for these children to be enrolled into a phase…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Glucose Metabolism Disorders, Metabolic Disease
- Trial name
- INGR1D (NCT03503747)
- Where
- United Kingdom
- Volunteers
- 15,640 people
- Sponsor
- University of Oxford
Type1 Diabetes
Multiple Ascending Dose (MAD) Study of IMT-002 in HLA-DQ8-positive Type 1 Diabetes
This study is designed to characterize the safety, steady-state pharmacokinetics (PK) of IMT-002, and will serve as a dose range identification for the pharmacodynamic effect of blocking self-antigen presentation in adults with…
- Trial name
- NCT04625595
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Immunomolecular Therapeutics, Inc.
Type 1 Diabetes, Diabetes, Autoimmune
Characteristics of Young-onset Diabetes in Sub-Saharan Africa (YODA) Study
Type 1 diabetes has been poorly characterised, with very sparse information available in the literature about the characteristics of the disease in Africa.
- Trial name
- YODA (NCT05013346)
- Testing
- No intervention needed
- Where
- 4 sites in Cameroon, South Africa and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Yaounde Central Hospital
Type 1 Diabetes Mellitus
Anti-CD3 mAb Treatment of Recent Onset Type 1 Diabetes
This is a randomized placebo controlled study to test whether a single 14 course of treatment with the anti-CD3 monoclonal antibody, hOKT3gamma1(Ala-Ala),Teplizumab will prevent the loss of insulin secretory capacity in…
- Trial name
- NCT00378508
- Testing
- mAb hOKT3gamma1(Ala-Ala), Teplizumab
- Where
- 4 sites in United States
- Volunteers
- 63 people
- Sponsor
- Yale University
Type 1 Diabetes Mellitus
The Effect of Probiotics on Type 1 Diabetes Mellitus in Children
In this study, investigators try to administer probiotics (Lactobacillus salivarius + Lactobacillus johnsonii + Bifidobacterium lactis from glac biotech Co., Ltd.) to children T1DM patients for 6 months to observe if the…
- Trial name
- NCT03880760
- Testing
- L. johnsonii MH-68, B. animalis subsp. lactis CP-9 and L. salivarius AP-32
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- China Medical University Hospital
Type 1 Diabetes, Autoimmune Diabetes
Is the Artificial Pancreas, Without Carbohydrate Counting, Efficient and Safe in an Outpatient Setting
This is a pilot, interventional clinical trial to assess the effectiveness and safety of artificial pancreas (AP) using the ARG algorithm closed-loop system in a monitored 3-day period outpatient study.
- Trial name
- NCT04793165
- Testing
- Non-hybrid closed-loop system with ARG algorithm
- Where
- Argentina
- Volunteers
- 5 people
- Sponsor
- Hospital Italiano de Buenos Aires
Type 1 Diabetes, Autoimmune Diseases
Additional Autoimmune Diseases With Type 1 Diabetes in Pediatrics at Diabetes Diagnosis and During Follow-up
This study aims to describe the prevalence of additional autoimmune diseases and their specific antibodies at type 1 diabetes (T1D) diagnosis, and their incidence rate during follow-up, for children and adolescents.
- Conditions
- Type 1 Diabetes, Autoimmune Diseases, Hashimoto Disease, Graves Disease
- Trial name
- AADT1D (NCT04789993)
- Testing
- No intervention.
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Central Hospital, Nancy, France
SCAD, Addison Disease
Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity
This case control study aims to determine whether spontaneous coronary artery dissection (SCAD) is associated with autoimmune diseases and to update the incidence of SCAD in a population-based cohort.
- Conditions
- SCAD, Addison Disease, Ankylosing Spondylitis, Antiphospholipid Antibody Syndrome
- Trial name
- NCT03941184
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Natural History of Autoimmune Diabetes and Its Complications
Background: Diabetes is a disease defined by abnormally high blood sugar (glucose) levels. Glucose is an essential source of energy for the body s cells, but insulin is required to move the glucose into the cells.
- Trial name
- NCT00896610
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus, Autoimmune Diabetes
Liraglutide as Additional Treatment to Insulin in Patients With Autoimmune Diabetes Mellitus
The purpose of this study is to investigate the therapeutic effect of Liraglutide on autoimmune diabetes.
- Trial name
- NCT03011008
- Testing
- Liraglutide, Insulin
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes Mellitus, Autoimmune Diabetes
Metformin Plus Insulin on Non-obese Autoimmune Diabetes
The objective of this study is to evaluate the therapeutic effect of metformin as additional treatment with insulin on non-obese autoimmune diabetes.
- Trial name
- NCT03513874
- Testing
- Metformin, Insulin
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Second Xiangya Hospital of Central South University
Type 1 Diabetes Mellitus, Autoimmune Diabetes
Medtronic Minimed Overnight Closed-Loop System
To test the function and safety of the Medtronic Overnight Closed Loop (OCL) System in a closely monitored 12 hour overnight inpatient study.
- Conditions
- Type 1 Diabetes Mellitus, Autoimmune Diabetes, Juvenile-Onset Diabetes, Diabetes, Mellitus, Type 1
- Trial name
- NCT01881009
- Testing
- Hybrid Closed-loop System, Sensor-augmented pump
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Bruce A. Buckingham
Type 1 Diabetes Mellitus
Study of IMCY-0098 in Patients With Recent Onset Type 1 Diabetes
This clinical study will evaluate the safety of an innovative approach expected to be disease-modifying by stopping the auto-immune-mediated destruction of islet β-cells in the pancreas.
- Trial name
- NCT03272269
- Testing
- IMCY-0098
- Where
- 17 sites in Belgium, Denmark and 5 more
- Volunteers
- 41 people
- Sponsor
- Imcyse SA
Type 1 Diabetes Mellitus, Nocturnal Hypoglycemia
Insulin Degludec and Symptomatic Nocturnal Hypoglycaemia
The purpose of this study is to determine whether insulin degludec compared to insulin glargine can reduce the risk of symptomatic nocturnal hypoglycaemia in subjects with the greatest potential benefit from optimised insulin…
- Conditions
- Type 1 Diabetes Mellitus, Nocturnal Hypoglycemia, Recurrent Severe Hypoglycaemia
- Trial name
- HypoDeg (NCT02192450)
- Testing
- Insulin aspart/glargine, Insulin aspart/degludec
- Where
- Denmark
- Volunteers
- 149 people
- Sponsor
- Nordsjaellands Hospital
Diabetes Mellitus, Type 1
Islet Cell Transplants for Diabetes
The purpose of this study is to test the safety and efficacy of islet cell transplants for the treatment of type 1 diabetes mellitus.
- Trial name
- NCT00303134
- Testing
- Islet Cell Transplantation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Weill Medical College of Cornell University
Type 1 Diabetes
Stem Cell Educator Therapy in Type 1 Diabetes
The translational potential to the clinical applications of cord blood stem cells has increased enormously in recent years, mainly because of its unique advantages including no risk to the donor, no ethical issues, low risk of…
- Trial name
- NCT01350219
- Testing
- Stem Cell Educator
- Where
- 4 sites in China, Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Throne Biotechnologies Inc.
Diabetes Mellitus Type 1, Autoimmune Diseases
Transplantation of Autologous Stem Cells for the Treatment of Type 1 Diabetes Mellitus
Type 1 diabetes mellitus (T1DM) is a chronic, autoimmune condition that involves the progressive destruction of pancreatic β-cells, eventually resulting in the loss of insulin production and secretion.
- Conditions
- Diabetes Mellitus Type 1, Autoimmune Diseases, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT02644759
- Testing
- Stem Cell Transplantation
- Where
- Jordan
- Volunteers
- 100 people
- Sponsor
- Stem Cells Arabia
Diabetes, Type I, Enterovirus Infections
Diabetes Virus Detection Project, Intervention With GAD-alum
The purposes of this study are to test whether GAD vaccination can stop the progression of newly diagnosed type 1 diabetes, to describe the related immunological processes (insulitis) in pancreas and small intestines evolving the…
- Conditions
- Diabetes, Type I, Enterovirus Infections, Autoimmunity
- Trial name
- DiViD (NCT01129232)
- Testing
- GAD-alum
- Where
- Norway
- Volunteers
- 6 people
- Sponsor
- Oslo University Hospital
Type 1 Diabetes, Autoimmunity
Prospective Assessment in Newborns for Diabetes Autoimmunity
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
- Trial name
- PANDA (NCT00649246)
- Where
- 3 sites in United States
- Volunteers
- 25,055 people, healthy volunteers welcome
- Sponsor
- Augusta University