Clinical trials: Autoimmune Diseases
Multiple Sclerosis, Gait Disorders, Neurologic
"Balance, Gait, and Motion Analysis in Multiple Sclerosis"
The goal of this observational cross-sectional study is to investigate the relationship between functional measures of balance and gait and objective kinetic and kinematic parameters in people with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Gait Disorders, Neurologic, Postural Balance, Motion Analysis
- Trial name
- MS-BALGAIT (NCT07630311)
- Where
- 2 sites in Greece
- Volunteers
- 40 people
- Sponsor
- University of Patras
NMOSD, Neuromyelitis Optica Spectrum Disorders
Efficacy, Safety, PK, PD, and ADA of Eculizumab in Chinese Adults With NMOSD
The primary objective of this study is to evaluate the efficacy, safety, pharmacokinetics, pharmacodynamics, and immunogenicity of Eculizumab in Chinese Adults with Neuromyelitis Optica Spectrum Disorders (NMOSD).
- Trial name
- ECU-NMO-304 (NCT06724809)
- Testing
- eculizumab
- Where
- 7 sites in China
- Volunteers
- 21 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Lupus Erythematosus, Systemic
Safety and Efficacy Study of LymphoStat-B (Belimumab) in Subjects With Systemic Lupus Erythematosus (SLE)
The purpose of this study is to evaluate the safety and efficacy of 3 different doses of belimumab, administered in addition to standard therapy, in patients with active SLE disease.
- Trial name
- NCT00071487
- Testing
- Belimumab 1 mg/kg, Belimumab 4 mg/kg, Belimumab 10 mg/kg
- Where
- 62 sites in United States, Canada
- Volunteers
- 449 people
- Sponsor
- Human Genome Sciences Inc.
Juvenile Idiopathic Arthritis
Methotrexate Alone vs Methotrexate + Etanercept for Minimal/Low Disease Activity in Juvenile Idiopathic Arthritis
This open labelled randomized controlled trial will be carried out at the University of Child Health and the Children's Hospital, Lahore consisting of 6 months .
- Trial name
- NCT07386587
- Testing
- Injection, Etanercept, 25 Mg (Code May Be Used for Medicare When Drug Administered Under the Direct Supervision of A Physician, Not for Use When Drug is Self Administered)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Child Health Sciences and Children's Hospital, Lahore
Refractory Myasthenia Gravis, Rituximab
Efficacy and Safety of Low-dose Rituximab in the Treatment of Refractory Myasthenia Gravis
This study is designed to evaluate the effectiveness and safety of low-dose rituximab in patients with refractory myasthenia gravis.
- Trial name
- NCT05332587
- Testing
- Rituximab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Type 1 Diabetes Mellitus, Glycemic Control
Effect of Immediate Hemoglobin A1c on Glycemic Control in Children With Type I Diabetes Mellitus
Immediate feedback of hemoglobin A1c (A1c) results to adults with type 1 and 2 diabetes allows more appropriate care decisions at the clinic visit and may improve glycemic control.
- Trial name
- NCT00898534
- Testing
- Bayer DCA2000+ Hemoglobin A1c analyzer
- Where
- United States
- Volunteers
- 234 people
- Sponsor
- Boston Children's Hospital
Maturity-onset Diabetes of the Young
The Effects of GLP-1 in Maturity-Onset Diabetes of The Young (MODY)
The purpose of this study is to evaluate the treatment potential of GLP-1-analogues in patients with Maturity Onset Diabetes of the Young (MODY) compared to common treatment.
- Trial name
- NCT01610934
- Testing
- liraglutide, Glimepiride
- Where
- Denmark
- Volunteers
- 15 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Primary IgA Nephropathy
A Study of SHR-2173 in Participants With Primary IgA Nephropathy
This study is a randomized, double-blind, placebo-controlled Phase II clinical trial to evaluate the efficacy and safety of SHR-2173 in patients with Primary IgA Nephropathy(IgAN).
- Trial name
- NCT07354932
- Testing
- SHR-2173 injection
- Where
- 2 sites in China
- Volunteers
- 84 people
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Diabetes Mellitus, Type 1
Effects of Structured Group Education on Quality of Life and Glycemic Control in Type 1 Diabetes
Patients with type 1 diabetes aged 15-65 years without major complications will be randomized either to usual care or to a structured group education program, with 6 four-hour weekly interactive sessions devoted to diabetes…
- Trial name
- NCT02443532
- Testing
- Structured group education, Individual education
- Volunteers
- 72 people
- Sponsor
- Azienda Ospedaliero-Universitaria Careggi
Lupus Erythematosus, Systemic
A Study to Assess the Safety, Tolerability, and Pharmacokinetics of E6742 in Systemic Lupus Erythematosus Participants
The primary purpose of the study is to evaluate the safety and tolerability of multiple oral doses of E6742 in participants with systemic lupus erythematosus (SLE).
- Trial name
- NCT05278663
- Testing
- E6742
- Where
- 12 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Eisai Co., Ltd.
Giant Cell Arteritis, Neurovascular Disorder
Efficacy of Tocilizumab in Association to Steroids in Giant Cell Arteritis With Cerebro-vascular Involvement
A French multicenter randomised and placebo-controlled study recruiting patients who present neurovascular involvement related to GCA (> 60 years) with symptomatic (stroke) or asymptomatic forms.
- Trial name
- TOGIAC (NCT04888221)
- Testing
- Tocilizumab
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis, Juvenile Idiopathic Arthritis
Anti-Biopharmaceutical Immunization: Prediction and Analysis of Clinical Relevance to Minimize the Risk of Immunization in Rheumatoid Arthritis Patients or Juvenile Idiopathic Arthritis Patients
One of the main potential causes of these failures of BP therapy response is the development of Anti-drug Anti-body (ADAb) in some patients.
- Trial name
- ABI-RA (NCT02116504)
- Testing
- Sampling of blood
- Where
- France
- Volunteers
- 156 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes Mellitus
Rezpegaldesleukin (NKTR-358) in New Onset Type 1 Diabetes Mellitus
This Phase 2 study is a 2-arm, multi-center, double-masked (masking of the participant, care provider and investigator), placebo-controlled, 2:1 randomized trial design in new onset T1D participants (within 100 days of…
- Trial name
- NCT07142252
- Testing
- Rezpegaldesleukin
- Where
- 15 sites in United States, Canada
- Volunteers
- 66 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes
M1no-Study - Early Identification of Infants With High Type 1 Diabetes Risk for Participation in Primary Prevention Trials
The goal of this observational study is to identify newborns at increased genetic risk of developing type 1 diabetes-specific beta-cell autoantibodies in order to determine eligibility for participation in primary prevention…
- Trial name
- M1N0 (NCT07670143)
- Where
- 5 sites in Italy
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
IgG4-related Disease, Orbital Infections, Inflammations and Irritations
Infraorbital Nerve Involvement on Magnetic Resonance Imaging in IgG4-related Ophthalmic Disease
Infraorbital nerve enlargement (IONE) on magnetic resonance imaging is known to be a possible consequence of IgG4-related ophthalmic disease.
- Trial name
- RetroG4 (NCT03690908)
- Testing
- no intervention (descriptive study)
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Arthritis, Juvenile Rheumatoid
A Study to Evaluate the Efficacy and Safety of Celecoxib Suspension Compared to Naproxen Suspension in Patients With JRA
To study Celebrex versus naproxen to see if it decreases symptoms of juvenile arthritis such as pain and swelling.
- Trial name
- NCT00652925
- Testing
- Celecoxib, Naproxen
- Where
- 58 sites in United States, Belgium and 13 more
- Volunteers
- 225 people
- Sponsor
- Pfizer
Type 1 Diabetes
Impact of a Diabetes Camp on Glycemic Control Among Children and Adolescents Living With Type 1 Diabetes in Cameroon
Therapeutic education is central to the management of diabetes, especially in children and adolescents. Camps represent an ideal environment for education.
- Trial name
- NCT02632032
- Testing
- Insulin
- Volunteers
- 46 people
- Sponsor
- Yaounde Central Hospital
Multiple Sclerosis, Foot Drop
Walking With FES or AFO in People With MS With Foot Drop
This investigation consists of two parallel groups of participants who will follow the same protocol. The aim of the study is to investigate the effects of using Functional Electrical Stimulation/Ankle Foot Orthosis (AFO) or…
- Trial name
- NCT01977287
- Testing
- Functional Electrical Stimulation, Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Queen Margaret University
Arthritis, Rheumatoid
Comparison Of 5 CP-690,550 Doses Vs. Placebo, For The Treatment Of Rheumatoid Arthritis In Japan
To evaluate the dose-response relationship of 5 dose of CP-690,550, compared to placebo for the treatment of signs and symptoms in patients with active RA who failed an adequate trial of therapy with at least 1 DMARD in a 12-week…
- Trial name
- NCT00687193
- Testing
- CP-690,550
- Where
- 40 sites in Japan
- Volunteers
- 318 people
- Sponsor
- Pfizer
Rheumatoid Arthritis
Real-World Study on Long-term Treatment With YISAIPU for Fujian RA Patients
Through real-world observation, understanding clinical efficacy and safety of treatment with YISAIPU (etanercept biosimilar) for RA patients of Fujian Province for three years
- Trial name
- LORMYF (NCT05424393)
- Testing
- YISAIPU® ( An etanercept biosimilar), csDMARDs
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Xiamen University