Clinical trials: Autoimmune Disorder
Immune Thrombocytopenia, Warm Autoimmune Hemolytic Anemia
Efficacy and Safety of Ixazomib and Dexamethasone Refractory Autoimmune Cytopenia
Some patients with antibody-mediated autoimmune hematological diseases (warm autoimmune hemolytic anemia (wAIHA), cold agglutinin disease (cAIHA) and immune thrombocytopenia (ITP)) shows no or only minor and transient response to…
- Trial name
- Ixa-Cyto (NCT03965624)
- Testing
- Ninlaro
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease
Maternal-Fetal Heart Sound/Electrocardiogram Monitoring and Cardiac Risk Early Warning
This is a prospective observational cohort study conducted at Beijing Anzhen Hospital. The study aims to establish reference ranges of heart sound and electrocardiogram (ECG) parameters for both mothers and fetuses.
- Conditions
- Pregnancy-Associated Heart Disease, Fetal Congenital Heart Disease, Autoimmune-Related Fetal Heart Block, Perinatal Adverse Events
- Trial name
- NCT07526662
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Yihua He,MD
Rheumatoid Arthritis
Phase Ⅰ Clinical Trial of Gerilimzumab Injection in Healthy Subjects
The primary objectives of this study are to evaluate the safety, tolerability and pharmacokinetic (PK) profiles of single-dose, dose-escalated, abdominal subcutaneous injection of GB224 in Chinese healthy adult subjects.
- Trial name
- NCT04178070
- Testing
- GB224 2mg, GB224 5mg, GB224 10mg
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Genor Biopharma Co., Ltd.
Type 1 Diabetes
iHERO Study: Insurance, Health and Economic Resources Online for Emerging Adults With Type 1 Diabetes
This research study aims to test a financial and health insurance iHERO Toolkit for young adults with type1 diabetes. The iHERO Toolkit was developed over one year with the type 1 diabetes community, The Diabetes Link…
- Trial name
- NCT06348160
- Testing
- iHERO Toolkit Resource
- Where
- 4 sites in United States
- Volunteers
- 195 people
- Sponsor
- University Hospitals Cleveland Medical Center
Multiple Sclerosis
Blood Flow Restriction And Veterans With MS
There currently is a lack of evidence to support exercise interventions in people with advanced disability due to MS (i.e., need assistance to walk or use a wheelchair).
- Trial name
- BRAVe-MS (NCT05433103)
- Testing
- Low-Load Exercise with Blood Flow Restriction, Low-Load Exercise Control Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Multiple Sclerosis
TENS in Persons With MS
Persons with multiple sclerosis (pwMS) often have an increased sense of fatigue. Furthermore, they present walking difficulties which negatively affects their mobility and results in an additional increase of fatigue.
- Trial name
- NCT05321927
- Testing
- Trancutaneous Electrical Nerve Stimulation, Strength training
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
Multiple Sclerosis (MS), Neurogenic Bladder Disorder
Essential Oils for Urinary Symptoms in Multiple Sclerosis Patients
The goal of this clinical trial is to learn if essential oil aromatherapy works to improve urinary symptoms in adults with multiple sclerosis. It will also learn about the safety of essential oil use in this population.
- Conditions
- Multiple Sclerosis (MS), Neurogenic Bladder Disorder, Urinary Incontinence (UI), Urinary Urgency
- Trial name
- AROMA-MS (NCT07599189)
- Testing
- Essential Oil Blend (Lavender, Rosemary), Neutral Carrier Oil (Apricot Kernel Oil)
- Where
- 2 sites in Algeria
- Volunteers
- 60 people
- Sponsor
- University of Oran 1
Type 1 Diabetes
Atorvastatin in New Onset Type 1 Diabetes Mellitus (T1DM)
The goal of this application is to evaluate the safety and efficacy of atorvastatin as a potential treatment to preserve beta cell function in children and young adults with newly diagnosed type 1 diabetes (T1DM).
- Trial name
- TIDM (NCT00529191)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Philadelphia
Type 1 Diabetes, Pregnancy
Pilot Study of Between Visit Interaction to Improve Glycemic Control in Pregnancy With Pre-existing Diabetes
Hypothesis: Increased contact with the diabetes care team throughout pregnancy will lead to improved glucose control during pregnancy.
- Trial name
- NCT02315274
- Testing
- Frequent remote contact between clinic visits.
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Stem Cells, Type 1 Diabetes
Insulin Producing Stem Cell Transplantation Clinical Trial in Type 1 Diabetes
Type 1 Diabetes is a chronic autoimmune disease. It results from autoimmune destruction of pancreatic Beta cells leading to absolute insulin insufficiency.
- Trial name
- NCT06951074
- Testing
- Insulin producing stem cells infusion
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Diabetes, Diabetes Mellitus, Type 1
Investigation of Pharmacodynamic Characteristics of Explorative Formulation of Insulin Degludec in Male Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of this trial is to investigate the pharmacodynamic (the effect of the investigated drug on the body) of insulin degludec (insulin 454), an explorative formulation, not similar to the…
- Trial name
- NCT01865318
- Testing
- insulin degludec
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Novo Nordisk A/S
Multiple Sclerosis
Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis
OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced T1 lesion volume, and the magnetization…
- Trial name
- NCT00006060
- Testing
- standard gadolinium contrast
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Multiple Sclerosis
Effects of Dalfampridine on Cognition in Multiple Sclerosis
Cognitive impairment is common in multiple sclerosis (MS) and has devastating impact on functional activities. There is great demand for medications that will enhance cognitive capacity in MS patients.
- Trial name
- NCT02006160
- Testing
- dalfampridine
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- State University of New York at Buffalo
Rheumatoid Arthritis
An Open-Label Extension Study Assessing the Long-Term Efficacy and Safety of ALX-0061 in Subjects With Rheumatoid Arthritis
This was a multicenter, open-label extension (OLE) Phase II study designed to evaluate the long-term efficacy and safety of ALX-0061 (i.e., vobarilizumab) administered subcutaneously (s.c.) in subjects with active rheumatoid…
- Trial name
- NCT02518620
- Testing
- ALX-0061
- Where
- 57 sites in Belgium, Bulgaria and 10 more
- Volunteers
- 406 people
- Sponsor
- Ablynx, a Sanofi company
Lupus Nephritis
Efficacy of Lower Dose Prednisolone in the Induction of Remission of Lupus Nephritis
The LN is a common cause of mortality and morbidity in SLE. The use of high-dose glucocorticoids (GC) with an immunosuppressive agent is usual practice for treating this condition.
- Trial name
- LN (NCT04146220)
- Testing
- Prednisolone
- Where
- Bangladesh
- Volunteers
- 32 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Type 1 Diabetes
Evaluation of Glycemic Control and Quality of Life in Adults With Type 1 Diabetes During Continuous Glucose Monitoring When Switching to Insulin Glargine 300 U/mL
Retrospective multicenter study analyzing data gathered during the FUTURE study (S59342) to assess the effect of using Insulin Glargine 300 U/mL (Gla-300) on measures of diabetes control and quality of life.
- Trial name
- FUTURE-GLARE (NCT05109520)
- Testing
- Insulin Glargine 300 UNT/ML [Toujeo]
- Where
- 3 sites in Belgium
- Volunteers
- 867 people
- Sponsor
- prof dr Pieter Gillard
Type 1 Diabetes
Evaluation of Functional Insulin Therapy in Type 1 Diabetic Patients
Functional Insulin Therapy (FIT) is an heath care method proposed to type 1 diabetic patients which focuses on patient autonomy, carbs counting and insulin dose adaptation.
- Trial name
- IFOPI (NCT01512680)
- Testing
- Education to Functional Insulin Therapy
- Where
- France
- Volunteers
- 52 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
A Study to Observe Characteristics of Rheumatoid Arthritis in Patients Using Infliximab (Study P04250)
This 14-week non-interventional study will observe patients with rheumatoid arthritis (RA) who are being treated with infliximab for the first time, in order to learn about their disease characteristics.
- Trial name
- REMARK (NCT00705289)
- Testing
- Infliximab
- Volunteers
- 728 people
- Sponsor
- Merck Sharp & Dohme LLC
Rheumatoid Arthritis
A Study of Japanese Rheumatoid Arthritis Participants
The objective of this study is to evaluate the safety and tolerability of 48 weeks subcutaneous (SC) dosing with LY2127399 for participants who have participated in a prior LY2127399 clinical study.
- Trial name
- NCT01253291
- Testing
- LY2127399
- Where
- 9 sites in Japan
- Volunteers
- 26 people
- Sponsor
- Eli Lilly and Company
Immune Thrombocytopenia
The Combination of Terbutaline and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
Single-arm, open-label, single center study to assess the efficacy and safety of terbutaline plus danazol in patients with corticosteroid resistant/relapsed ITP.
- Trial name
- NCT04481282
- Testing
- Terbutaline, Danazol
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Peking University People's Hospital
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