Clinical trials: Autoimmune Disorder
Chronic Immune Thrombocytopenia, Primary Immune Thrombocytopenia
Cognitive Status, Fatigue and Inflammation in Patients With Immune Thrombocytopenia (ITP)
This is a multi-center, hospital based, cross-sectional study based on data from patient medical records, including laboratory results.
- Conditions
- Chronic Immune Thrombocytopenia, Primary Immune Thrombocytopenia, Adult Immune Thrombocytopenia
- Trial name
- NCT06665308
- Testing
- No intervention
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 97 people
- Sponsor
- Sanofi
Lupus Nephritis (LN)
Urinary Congophilia as an Indicator of Activity of Lupus Nephritis
Evaluation of the impact of SLE on urinary levels of congophilia and their relationship to renal histopathology and activity of lupus nephritis (LN)
- Trial name
- lupus nephriti (NCT06654024)
- Where
- Egypt
- Volunteers
- 74 people
- Sponsor
- Assiut University
Rheumatoid Arthritis
A Study to Assess Efficacy With Respect to Clinical Improvement in Disease Activity and Safety of Tocilizumab in Patients Wtih Active Rheumatoid Arthritis.
This single arm study will assess the effectiveness of tocilizumab in combination with traditional DMARDs with regard to the clinical improvement in disease activity (achievement of LDAS) after 24 weeks' treatment in patients…
- Trial name
- NCT00754559
- Testing
- Tocilizumab
- Where
- 81 sites in Germany
- Volunteers
- 286 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis, Stroke
Short Arm Human Centrifuge Therapeutic Training and Rehabilitation (GRACER1)
The study is a single blind randomized controlled trial (RCT) designed to examine the benefit of a short arm human centrifuge intervention program (SAHC) combined with exercise, compared to a standard of care (SOC) rehabilitation…
- Conditions
- Multiple Sclerosis, Stroke, Pulmonary Disease, Chronic Obstructive, Aged
- Trial name
- GRACER1 (NCT04369976)
- Testing
- ARTIFICIAL GRAVITY COMBINED WITH EXERCISE
- Where
- Greece
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Greek Aerospace Medical Association and Space Research
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia).
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT04614168
- Testing
- Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Giant Cell Arteritis, Vasculitis
Giant Cell Arteritis and Differential Diagnoses Associated With Positive Temporal Artery Biopsy
Temporal artery biopsy is a useful tool helping to the diagnosis of giant cell arteritis. However, other diagnoses might be associated with abnormal temporal artery biopsy.
- Trial name
- NCT04554290
- Testing
- temporal artery biopsy
- Where
- France
- Volunteers
- 114 people
- Sponsor
- Central Hospital, Nancy, France
Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis, Primary Progressive
Efficacy and Safety of Masitinib in the Treatment of Progressive Multiple Sclerosis
The purpose of this study is to compare the safety and efficacy of masitinib 6 mg/kg/day versus placebo in the treatment of patients with primary progressive multiple sclerosis or relapse-free secondary progressive multiple…
- Conditions
- Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Relapse Free
- Trial name
- NCT01433497
- Testing
- Masitinib
- Where
- 8 sites in Bulgaria, France and 5 more
- Volunteers
- 656 people
- Sponsor
- AB Science
Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus
Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes
The purpose of this study is to see if the study drug CIR-0602K will improve glucose time-in-range and/or lower total daily insulin dose in people with type 1 diabetes who are using closed-loop automated insulin delivery.
- Conditions
- Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus, Insulin, Ketones
- Trial name
- WBH003 (NCT07186660)
- Testing
- CIR-0602K
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Pregnancy Complicated by Hyperthyroidism, Hypothyroidism in Pregnancy
Fetal Thyroid Ultrasound And Fetal Thyroid Hormones
Non invasive methods: maternal antithyroid antibodies and ultrasound measurement of the fetal thyroid gland could be an important tool for detecting fetal thyroid dysfunction in mothers with autoimmune thyroid disease.
- Trial name
- NCT02017080
- Where
- Serbia
- Volunteers
- 300 people
- Sponsor
- University of Belgrade
Giant Cell Arteritis, Optic Ischaemic Neuropathy
Efficacy of Tocilizumab for the Treatment of Acute AION Related to GCA
AION is the main cause of blindness in patients with GCA. High dose steroid is the reference treatment of this condition, but medical unmet need remains.
- Trial name
- TOCIAION (NCT04239196)
- Testing
- tocilizumab and IV steroids combination, IV steroids combination alone
- Where
- 10 sites in France
- Volunteers
- 58 people
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Rheumatoid Arthritis
Targeted Remotely-delivered Anti-inflammatory Interventions With Exercise for Rheumatoid Arthritis
The primary objective of this study is to assess the feasibility of an intensive, remotely-delivered, combined aerobic and resistance training exercise program for patients with Rheumatoid Arthritis (RA) and to collect data to…
- Trial name
- TRAINERa (NCT06841562)
- Testing
- TRAINERa intensive exercise training
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Multiple Sclerosis
Herbal Therapy for Subcutaneous Injection Site Reactions in Multiple Sclerosis
The purpose of this study is to determine if an herbal over-the-counter cream can decrease skin site reactions in multiple sclerosis patients who currently take either Betaseron, Copaxone or Rebif as their subcutaneous medication…
- Trial name
- MSSkin (NCT00972062)
- Testing
- Bach's Rescue Remedy Cream
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of North Carolina, Charlotte
Type 1 Diabetes, Type 1 Diabetes Mellitus
Alleviating Carbohydrate Counting for Patients With Type 1 Diabetes Using a Novel Insulin-plus-pramlintide Artificial Pancreas
One of the main challenges in maintaining tight glucose control in a closed-loop system occurs at meal times. Amylin is a gluco-regulatory beta-cell hormone that is co-secreted with insulin in response to nutrient stimuli, and is…
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus, Hyperglycemia, Postprandial
- Trial name
- NCT04163874
- Testing
- Fiasp, Pramlintide Acetate, Artificial Pancreas
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- McGill University
Rheumatoid Arthritis
Comparative Analysis of Outcomes Among Patients Initiating Xeljanz in Combination With Oral MTX Who Withdraw MTX Versus Continue MTX
To address the objectives, a retrospective cohort design will be employed to evaluate patient characteristics, treatment patterns, medication effectiveness, and health care cost and utilization in RA patients newly initiating…
- Trial name
- NCT03975790
- Where
- United States
- Volunteers
- 479 people
- Sponsor
- Pfizer
Multiple Sclerosis
An Open-Label, Single-Arm Clinical Study to Evaluate the Safety and Preliminary Efficacy of CD20 Monoclonal Antibody Combined With NK042 Cell Injection in the Treatment of Multiple Sclerosis (MS).
This is an Open-Label, Single-Arm Clinical Study to Evaluate the Safety and Preliminary Efficacy of CD20 Monoclonal Antibody Combined with NK042 Cell Injection in the Treatment of Multiple Sclerosis (MS).
- Trial name
- NCT07546110
- Testing
- NK042, ofatumumab
- Volunteers
- 20 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Systemic Lupus Erythematosus, Systemic Scleroderma
Characterization of Autoreactive b Lymphocytes in Autoimmune Diseases and Immune Deficiencies
Autoimmune diseases (AID), whether systemic or organ-specific, affect approximately one in ten people, and their prevalence continues to increase.
- Conditions
- Systemic Lupus Erythematosus, Systemic Scleroderma, ANCA-associated Vasculitis, Antiphospholipid Syndrome
- Trial name
- AutoB-Tetramer (NCT07251179)
- Testing
- blood draw
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Strasbourg, France
Clinical Isolation Syndrome of Spinal Cord, Multiple Sclerosis
Clinical Isolation Syndrome of Spinal Cord and Multiple Sclerosis
The purpose of this study was to investigate the factors that influence the progression of patients with clinically isolated spinal cord syndrome to multiple sclerosis.
- Trial name
- NCT04952246
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Osteoarthritis, Knee, Osteoarthritis, Hip
Role of Topical Vancomycin in Reducing Infections in Hip and Knee Arthroplasty
The study is designed to assess the efficacy of vancomycin powder and dilute povidone-iodine lavage (VIP protocol) in reducing the PJI after primary Total Hip Arthroplasty (THA) and Total Knee Arthroplasty (TKA).
- Conditions
- Osteoarthritis, Knee, Osteoarthritis, Hip, Rheumatoid Arthritis, Avascular Necrosis of Hip
- Trial name
- NCT05972603
- Testing
- 1.0 g Vancomycin powder into the wound, 0,35% povidone-iodine solution lavage
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- Independent Public Healthcare Center in Rypin
Crohn Disease, Ulcerative Colitis
Autoimmune Protocol Diet and Inflammatory Bowel Disease
There is limited data to guide the use of dietary change in the management of IBD, and it can prove challenging to implement in the setting of altered anatomy, comorbid conditions, and patient compliance.
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT03512327
- Testing
- Autoimmune protocol (AIP) diet
- Volunteers
- 15 people
- Sponsor
- Scripps Health
Diabetes Mellitus, Type 1
Flexible, Intensive Insulin Therapy in Patients With Type 1 Diabetes
To prospectively evaluate the long term metabolic and psychological effects of flexible intensive insulin therapy (FIT) courses in an unselected population of type 1 diabetic patients at the University of Basel Hospital.
- Trial name
- NCT00595569
- Testing
- Flexible insulin therapy (FIT)
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Lausanne Hospitals
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