Clinical trials: Autoimmune Disorder
Neuropathic Pain, Multiple Sclerosis
Efficacy and Safety Evaluation of Nabilone as Adjunctive Therapy to Gabapentin for the Management of Neuropathic Pain in Multiple Sclerosis
The purpose of this study is to determine whether nabilone (Cesamet) when used as an adjunctive agent with gabapentin (Neurontin) provides significantly improved pain relief over gabapentin alone for the management of neuropathic…
- Trial name
- NCT00480181
- Testing
- nabilone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Antiphospholipid Antibody Syndrome
Rivaroxaban for Antiphospholipid Antibody Syndrome
The antiphospholipid antibody syndrome (APS) is a syndrome associated with excessive blood clotting (thrombosis). APS is among the most common cause of heart attack and stroke in patients under the age of 50 and is particularly…
- Trial name
- RAPS (NCT02116036)
- Testing
- Rivaroxaban
- Where
- 6 sites in Canada
- Volunteers
- 81 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Stroke, Multiple Sclerosis
Improving Social Cognition and Social Behaviour in Various Brain Disorders
Impairments in aspects of social cognition are disorder-transcending: these have been demonstrated in various neurological disorders, such as traumatic brain injury (TBI), stroke, brain tumours (both low grade glioma's and…
- Conditions
- Stroke, Multiple Sclerosis, Brain Tumor
- Trial name
- T-ScEmo4ALL (NCT06330298)
- Testing
- Treatment social cognition and emotion regulation (T-ScEmo)
- Where
- 2 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- University Medical Center Groningen
Systemic Lupus Erythematosus (SLE), Lupus Nephritis (LN)
The Efficacy and Safety of Biologics (Belimumab/ Telitacicept) Induction Therapy in Proliferative Lupus Nephritis Patients for 6 Months Compared With Mycophenolate Mofetil Treatment
1. Study Design This is a single-center, prospective, randomized, controlled, exploratory clinical trial. The study is designed to evaluate and compare the efficacy and safety of two biologic-based induction regimens against…
- Trial name
- NCT07340463
- Testing
- Glucocorticoids, belimumab, Telitacicept
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Nanjing University School of Medicine
Primary Adrenal Insufficiency, Secondary Adrenal Insufficiency
Dual RElease Hydrocortisone Versus conventionAl Glucocorticoid replaceMent Therapy in Hypocortisolism (DREAM)
This is a randomized, controlled, open, three-armed, multi-centre study designed to compare the effects of dual-release hydrocortisone preparations versus conventional glucocorticoid therapy on anthropometric parameters…
- Trial name
- DREAM (NCT02277587)
- Testing
- Plenadren, Conventional glucocorticoid therapy
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Type 1 Diabetes
Insulin-based Strategies to Prevent Hypoglycemia During Exercise
It has been reported that insulin basal rate reduction initiated at exercise onset can reduce the hypoglycemic risk during exercise.
- Trial name
- NCT02631265
- Testing
- Exercise 1, Exercise 2, Exercise 3
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- Institut de Recherches Cliniques de Montreal
Relapsing Remitting Multiple Sclerosis
Impact of Vitamin A on Gene Expression, in Multiple Sclerosis Patient
The aim of this study is the comparison between the effects of supplementation with vitamin A (retinyl palmitate) or placebo for 6 months on gene expression of T CD4+ lymphocyte in multiple sclerotic patient.
- Trial name
- MS (NCT01407211)
- Testing
- vitamin A
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Tehran University of Medical Sciences
Dry Eye, Sjogren's Syndrome
Pilot Study for Testing Safety of Repetitive Magnetic Stimulation for Treatment of Dry Eye
The study aims to test the safety of Repetitive Magnetic Stimulation (RMS) treatment for dry eye disease. Patients are asked to undergo a one-time treatment with Epitech Ocular Magnetic Stimulation Device on one eye in the first…
- Conditions
- Dry Eye, Sjogren's Syndrome, Aqueous Tear Deficiency, Meibomian Gland Dysfunction
- Trial name
- NCT03012698
- Testing
- Ocular Repetitive Magnetic Stimulation (RMS) treatment
- Where
- 3 sites in Israel
- Volunteers
- 29 people
- Sponsor
- Epitech Mag Ltd.
Rheumatoid Arthritis, Crystal-induced Arthritides
Cryotherapy and Doppler in Inflammatory Rheumatic Diseases
The primary aim of the study is to evaluate the effects of two local cryotherapy (ice or cold gas) applications on arthritic knees.
- Conditions
- Rheumatoid Arthritis, Crystal-induced Arthritides, Spondyloarthritis
- Trial name
- CDRI (NCT02573298)
- Testing
- ice, cold gas
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Autoimmune Hepatitis, Liver Disorder
Development of a Autoimmune Hepatitis Patient's Database Linked to a Biological Sample Storage
Autoimmune Hepatitis (AIH) is chronic fibroinflammatory disease of the liver characterized by chronic, relapsing liver inflammation, and a risk for progression to liver failure and need for liver transplantation.
- Trial name
- AIH Database (NCT06078098)
- Testing
- Clinical Information
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- University of Milano Bicocca
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
Continuous Glucose Monitoring in Dialysis Patients With Diabetes
The primary objective of this multicenter, randomized controlled trial is to assess whether the intermittent or continuous use of continous glucose monitoring can enhance glycaemic control among dialysis patients with type 1 or…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1, Continuous Glucose Monitoring, Haemodialysis
- Trial name
- NCT06641765
- Testing
- Continous Glucose Monitoring
- Where
- 5 sites in Denmark
- Volunteers
- 96 people
- Sponsor
- Bo Feldt-Rasmussen
Type 1 Diabetes
Use of Diazoxide in Acute Hypoglycaemia
The investigators know that intensive insulin therapy and tight glucose control is associated with reduction of diabetic complications.
- Trial name
- NCT01488136
- Testing
- Diazoxide
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Dundee
Rheumatoid Arthritis
Quality of Life Study With Adalimumab in Rheumatoid Arthritis
The purpose of the study is to evaluate the ability of adalimumab combined with methotrexate to improve the quality of life in patients with active RA.
- Trial name
- NCT00234936
- Testing
- Adalimumab, Methotrexate
- Volunteers
- 200 people
- Sponsor
- Abbott
Thyroid Eye Disease
Treatment of Graves' Orbitopathy to Reduce Proptosis With Teprotumumab Infusions in an Open-Label Clinical Extension Study
The overall objective is to evaluate the safety and efficacy of teprotumumab in the treatment of thyroid eye disease (TED) in participants who participated in the lead-in study HZNP-TEP-301 (NCT03298867; OPTIC) and who were…
- Trial name
- OPTIC-X (NCT03461211)
- Testing
- Teprotumumab
- Where
- 13 sites in United States, Germany and 1 more
- Volunteers
- 51 people
- Sponsor
- Amgen
SLE, Lupus Erythematosus, Systemic
Validation of a Mobile Phone Based on EPRO Tool in Subjects With Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) may involve a variety of organ systems expressed differently from patient to patient, and so can be difficult to characterize clinically.
- Conditions
- SLE, Lupus Erythematosus, Systemic, Systemic Lupus Erythematosus
- Trial name
- VALUE (NCT03142711)
- Testing
- No Medical Intervention
- Where
- 10 sites in United States, Canada
- Volunteers
- 80 people
- Sponsor
- Lupus Research Alliance
Relapsing Remitting Multiple Sclerosis
Rituximab and Ocrelizumab in Serum With Multiple Sclerosis
ROS-MS is a clinical pharmacological substudy to the OVERLORD-MS study (NCT04578639), designed to examine the possibilities of personalized treatment with rituximab and ocrelizumab in patients with relapsing-remitting multiple…
- Trial name
- ROS-MS (NCT06663111)
- Testing
- Blood samples for PK
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Haukeland University Hospital
Systemic Lupus Erythematosus, Sleep Disorders
Aerobic Exercise on Improving Sleep in Systemic Lupus Erythematosus.
The purpose of this study is to determine the effectiveness of exercise training on improving sleep in patients with systemic lupus erythematosus.
- Trial name
- EFEXO (NCT02037971)
- Testing
- Aerobic Exercise, Control Group
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Federal University of São Paulo
Dysphonia, Connective Tissue Disease
Characterization of "Bamboo" and Other Vocal Cord Lesions Responsible for Dysphonia in Patients With Systemic Autoimmune Diseases (BAMBOO)
The goal of this multicenter retrospective observational study is to provide an inventory of the specific and non specific cord vocal lesions that can cause dysphonia in patients with systemic autoimmune diseases.
- Conditions
- Dysphonia, Connective Tissue Disease, Vasculitis
- Trial name
- BAMBOO (NCT06779799)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Brest
Multiple Sclerosis, Covid19
MS Relapses During COVID-19 Pandemic
Throughout the COVID-19 pandemic, and to our knowledge there have been no studies looking systematically at the occurrence of MS relapses and their subsequent management, during the peak of the first wave of the pandemic.
- Conditions
- Multiple Sclerosis, Covid19, Relapsing Remitting Multiple Sclerosis
- Trial name
- NCT04858763
- Testing
- No Intervention
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Diabetes Mellitus, Type 1, Diabetic Retinopathy
Choroidal Blood Flow Changes During Dark/Light Transitions in Patients With Insulin-dependent Diabetes Mellitus (IDDM)
There is evidence from a variety of animal studies that choroidal blood flow is under neural control. Recent results in humans indicate that a light/dark transition is associated with a short lasting reduction in choroidal blood…
- Trial name
- NCT00718614
- Testing
- Light will be switched from 0.5µW/cm2/sr to 115µW/cm2/sr.
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
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