Clinical trials: Autoimmune Disorder
Multiple Sclerosis
A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, and Pharmacodynamics of P-CD19CD20-ALLO1 in Participants With Multiple Sclerosis
This study aims to explore the safety, tolerability, cellular kinetics, and pharmacodynamics of P-CD19CD20-ALLO1 in participants with progressive multiple sclerosis (PMS) and relapsing multiple sclerosis (RMS).
- Trial name
- NCT07008378
- Testing
- P-CD19CD20-ALLO1 Cells, Cyclophosphamide, Fludarabine
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Genentech, Inc.
Type 1 Diabetes (T1D)
Feasibility Study of a Continuous Glucose-Ketone Monitoring Device in People With Type 1 Diabetes
The goal of this study is to evaluate a CGM-CKM device during insulin suspension in patients with type 1 diabetes. 10 patients with T1D will be recruited for a pilot study. The patients will visit CTRU at Stanford Medical School.
- Trial name
- NCT06977633
- Testing
- Temporary Insulin Suspension, Glucose and ketone sensor
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Mahla Poudineh
IgA Nephropathy
Managed Access Programs for EXV811, Atrasentan
The purpose of this registration is to list Managed Access Programs (MAPs) related to EXV811, Atrasentan
- Trial name
- NCT07319585
- Testing
- Atrasentan
- Sponsor
- Novartis Pharmaceuticals
Myasthenia Gravis, Generalized
Open-Label Extension of Tocilizumab in Subjects With Generalized Myasthenia Gravis
To evaluate the safety and efficacy of tocilizumab in the treatment of generalized myasthenia gravis (gMG) as an extension study for the participants who previously completed Study tMG(NCT05067348).
- Trial name
- tMG-E (NCT05716035)
- Testing
- Tocilizumab Injection
- Where
- 6 sites in China
- Volunteers
- 64 people
- Sponsor
- Tang-Du Hospital
Type 1 Diabetes, Celiac Disease
Gluten Immunity and Islet Autoimmunity in Type-1 Diabetes
The purpose of this study is to determine whether the immune response causing celiac disease is related to the autoimmune response causing type-1 diabetes.
- Trial name
- NCT01932476
- Testing
- Gluten Challenge
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Joslin Diabetes Center
Multiple Sclerosis, Fatigue
Confirmatory Trial for Alleviating Fatigue in Multiple Sclerosis
CAFE-MS will assess the effectiveness of two online programs for fatigue in multiple sclerosis (MS). Although they differ, both of these online programs contain information about MS and fatigue intended to help people with MS…
- Trial name
- CAFE-MS (NCT06441617)
- Testing
- Online Program for Fatigue
- Where
- 6 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Accelerated Cure Project for Multiple Sclerosis
Rheumatoid Arthritis, Ankylosing Spondylitis
T Cells and TNF (Tumor Necrosis Factor): The Impact of TNF Blockade
We aim to translate these findings into patients with rheumatoid arthritis and other conditions treated with anti-TNF (anti-tumor necrosis factor) therapy, such as psoriatic arthritis and ankylosing spondylitis.
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT01060098
- Testing
- anti-TNF therapy (etanercept or adalimumab)
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- Imperial College London
Arthritis, Traumatic Arthritis
The Medacta International GMK Sphere Cementless Post-Marketing Surveillance Study
This is a Post-Marketing Surveillance study of GMK Sphere cementless knee prosthesis.
- Conditions
- Arthritis, Traumatic Arthritis, Rheumatoid Arthritis, Poly-arthritis
- Trial name
- NCT05003414
- Testing
- GMK Sphere cementless Knee Replacement
- Where
- 5 sites in France, Switzerland
- Volunteers
- 200 people
- Sponsor
- Medacta International SA
Inflammatory Diseases
Study of Efavaleukin Alfa in Healthy Chinese, Japanese, and Caucasian Participants
The primary objective of this study is to evaluate the pharmacokinetics (PK) of efavaleukin alfa after single subcutaneous (SC) administration in healthy Chinese, Japanese, and Caucasian participants.
- Trial name
- NCT04987333
- Testing
- Efavaleukin alfa
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Amgen
Type 1 Diabetes
Pilot Study of Closed-Loop Glucose Control in People With Type 1 Diabetes (BPK004)
This study plans to link two existing technologies, the insulin pump and the continuous glucose monitor (CGM), to essentially develop an artificial pancreas, i.e., closed-loop.
- Trial name
- NCT00977808
- Testing
- Closed-Loop, Model Predictive Control (MPC), Open-Loop
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Virginia
Rheumatoid Arthritis
Consortium for the Longitudinal Evaluation of African Americans With Early Rheumatoid Arthritis (The CLEAR Registry)
Rheumatoid arthritis (RA) is a long-term autoimmune disease that is characterized by pain, stiffness, inflammation, swelling, and sometimes destruction of joints.
- Trial name
- CLEAR (NCT00815425)
- Where
- United States
- Volunteers
- 1,613 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Myasthenia Gravis
Myasthenia Gravis and Psyche
The purpose of the study is to systematically capture and characterize mental comorbidities for patients with myasthenia gravis.
- Trial name
- NCT03205306
- Where
- Germany
- Volunteers
- 1,399 people
- Sponsor
- Charite University, Berlin, Germany
Lupus Nephritis
A Study of CellCept (Mycophenolate Mofetil) in Patients With Lupus Nephritis.
This 2 arm study will compare the efficacy and safety of CellCept plus corticosteroids, versus cyclophosphamide plus corticosteroids in the induction phase followed by azathioprine in the maintenance phase, in maintaining…
- Trial name
- NCT00425438
- Testing
- Mycophenolate Mofetil, Corticosteroids, Azathioprine
- Where
- 11 sites in China
- Volunteers
- 52 people
- Sponsor
- Hoffmann-La Roche
Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy
A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)
The purpose of this study is to establish the tolerability, preliminary efficacy, and pharmacokinetics of CC-97540 in participants with severe, refractory autoimmune diseases (Breakfree-1).
- Conditions
- Systemic Lupus Erythematosus, Idiopathic Inflammatory Myopathy, Systemic Sclerosis, Rheumatoid Arthritis
- Trial name
- NCT05869955
- Testing
- CC-97540, Fludarabine, Cyclophosphamide
- Where
- 46 sites in United States, Belgium and 4 more
- Volunteers
- 270 people
- Sponsor
- Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Rheumatoid Arthritis, Osteoarthritis
Rheumatology Informatics System for Effectiveness
The RISE Registry is an enhanced version of the ACR's Rheumatology Clinical Registry (RCR) and allows for a simplified entry process, while establishing a best-in-class resource to manage your patient population and improve…
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Gout
- Trial name
- RISE (NCT02230943)
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- American College of Rheumatology
Graves' Ophthalmopathy
Study of RVT-1401 for the Treatment of Patients With Moderate to Severe Active Graves' Ophthalmopathy (GO)
The purpose of this study was to evaluate safety, tolerability, and pharmacodynamic parameters of RVT-1401 in graves' ophthalmopathy (GO) patients.
- Trial name
- NCT03922321
- Testing
- RVT-1401
- Where
- 4 sites in Canada
- Volunteers
- 7 people
- Sponsor
- Immunovant Sciences GmbH
Immune Thrombocytopenia
An Observational Study to Evaluate the Efficacy of Biweekly Romiplostim in Adult Patients With ITP
The aim of this study is to evaluate the efficacy of romiplostim administered at every other week in ITP patients who attained stable platelet counts ≥ 50 x 109/L for 4 consecutive weeks after weekly doses of romiplostim.
- Trial name
- NCT02338414
- Testing
- Romiplostim
- Volunteers
- 20 people
- Sponsor
- Samsung Medical Center
Type 1 Diabetes
Making Diabetes Care Fit for Young Adults Living With Type 1 Diabetes: Observations, Reflections and Expert Opinions
The goal of this clinical study is to assess differences in collaborative efforts to make care fit between clinical encounters in usual care and those using the Making Care Fit tool among young adults with type 1 diabetes and…
- Trial name
- NCT07498738
- Testing
- Making Care Fit tool, Care as usual
- Where
- 2 sites in Netherlands
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Rheumatoid Arthritis
Autologous Tolerogenic Dendritic Cells for Rheumatoid Arthritis (AutoDECRA)
This is a study which will look at safety, feasibility and acceptability of a new therapy called tolerogenic dendritic cells (TolDC), derived from the patient's own white blood cells, which will be injected into the knee joints…
- Trial name
- AutoDECRA (NCT01352858)
- Testing
- TolDC, Arthroscopy & saline irrigation alone
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Newcastle University
Type 1 Diabetes, Hypoglycemia Associated Autonomic Failure
Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)
Exercise is a cornerstone of diabetes management. It helps reduce blood pressure, promote weight loss, lower insulin resistance and improve glucose and lipid (triglyceride and HDL-cholesterol) profiles.
- Trial name
- NCT01672255
- Testing
- Fluoxetine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
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