Clinical trials: Autoimmune Disorder
Multiple Sclerosis, Vestibular
The Effects of Vestibular Exercise and Cervical Stabilization Exercise Training on Balance and Gait in MS Patients
The population of this research consists of individuals between the ages of 18-65 with MS disease. MS patients to be included in the study will be directed by the Neurology outpatient clinic of Sanko University Hospital.
- Conditions
- Multiple Sclerosis, Vestibular, Exercises
- Trial name
- NCT05409599
- Testing
- Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Sanko University
Multiple Sclerosis, Relapse
Pharmacokinetic, Immunological and Biochemical Sample Collection and Analysis of a Tysabri Patient Cohort
This is an open-label study of patients with relapsing forms of Multiple Sclerosis designed to assess the biochemical, immunological and pharmacokinetic profiles of a large, actively infusing natalizumab patient population.
- Trial name
- NCT01070719
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- John F. Foley, MD
Multiple Sclerosis
Evaluation of a Spasticity Management Program for People With Multiple Sclerosis
This study will examine the impacts of two different methods of managing MS-related spasticity of the lower limbs. Both interventions will be presented via video teleconference in group classes consisting of exercises to reduce…
- Trial name
- STC (NCT03166930)
- Testing
- Spasticity Take Control, Stretching for People with MS: An Illustrated Manual
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- VA Office of Research and Development
Type 1 Diabetes Mellitus
Study of Safety and Efficacy of CFZ533 in Type 1 Diabetes Pediatric and Young Adult Subjects
The study was a Phase 2, multicounty, multicenter, non-confirmatory, investigator- and subject masked, randomized, placebo-controlled study to evaluate the safety, tolerability, pharmacokinetics, and efficacy of CFZ533 on…
- Trial name
- CCFZ533X2207 (NCT04129528)
- Testing
- CFZ533
- Where
- 12 sites in Belgium, Germany and 4 more
- Volunteers
- 44 people
- Sponsor
- Novartis Pharmaceuticals
Autoimmune Liver Disease, Autoimmune Hepatitis
MRI Biomarkers in as Predictor of Clinical Endpoints in Pediatric Autoimmune Liver Disease
Autoimmune liver diseases (AILD), which include Primary Sclerosing Cholangitis (PSC) and Autoimmune Hepatitis (AIH) are a common etiological factor for chronic liver disease among adolescents.
- Conditions
- Autoimmune Liver Disease, Autoimmune Hepatitis, Primary Sclerosing Cholangitis
- Trial name
- NCT03178630
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Multiple Sclerosis, Cognitive Impairment
Non-invasive Transcranial Electrical Stimulation in MS
The goal is to investigate the effects of non-invasive transcranial electrical stimulation on cognition in MS.
- Trial name
- NCT04466228
- Testing
- non-invasive transcranial electrical stimulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Lupus Erythematosus, Systemic
Efficacy and Safety of Telitacicept in Early SLE
The purpose of this study is to evaluate the safety and efficacy of Telitacicept in adult patients with early stage of SLE .
- Trial name
- NCT05899907
- Testing
- Telitacicept, Standard of Care
- Where
- 20 sites in China
- Volunteers
- 180 people
- Sponsor
- Peking Union Medical College Hospital
Autoimmune Diseases, Inflammatory Disorder
Immunological Response to COVID-19 Vaccine in Patients With Autoimmune and Inflammatory Diseases Treated With Immunosuppressants and/or Biologics
Vaccination against the new coronavirus (SARS-CoV-2) was extended to patients at risk of severe forms of Covid-19, including in particular patients with autoimmune and inflammatory diseases treated by immunosuppressants and/or…
- Trial name
- COVADIS (NCT04870411)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 78 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Knee Osteoarthritis, Rheumatoid Arthritis
Computer Navigation vs Conventional Technique in Knee Arthroplasty
Project summary: Background: Computer navigation in knee replacement surgery is increasingly being used around the world, but the documentation of its usefulness is lacking.
- Trial name
- CAOS (NCT00782444)
- Testing
- Computer navigated knee replacement, Conventional knee replacement
- Where
- 4 sites in Norway
- Volunteers
- 192 people
- Sponsor
- Haukeland University Hospital
Rheumatoid Arthritis, Systemic Lupus Erythematosus
The Effect of Deep Breathing and Transcutaneus Electrical Nerve Stimulation on Heart Rate Variability
This interventional study aims to investigate the effect of deep breathing (DB) and transcutaneous electrical vagus nerve stimulation (tVNS) on heart rate variability (HRV) in healthy participants and patients with rheumatoid…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Healthy Participants
- Trial name
- NCT05157334
- Testing
- Non-invasive auricular electrical transcutaneous vagus nerve stimulation, Deep breathing
- Where
- Denmark
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Multiple Sclerosis, Fatigue
Quantitative Fatigue and Muscle Performance in Multiple Sclerosis
Fatigue is consistently rated as the top symptomatic complaint for individuals with multiple sclerosis (MS). Currently, the MS Fatigue Impact Scale (MFIS), a subsection of the Multiple Sclerosis Quality of Life (MSQoL), is the…
- Trial name
- NCT02913209
- Volunteers
- 30 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Rheumatoid Arthritis, Palindromic Arthritis
Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity
Social determinants of health (SDoH), defined by the World Health Organization as "the conditions in which people are born, grow, work, live and age and the wider set of forces and systems shaping the conditions of daily life"…
- Conditions
- Rheumatoid Arthritis, Palindromic Arthritis, Juvenile Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- RAISE (NCT05715463)
- Testing
- Resource sheets, Community Resource Specialist, Nurse Navigator
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Brigham and Women's Hospital
Cerebral Palsy, Spina Bifida
A Peer E-mentoring Intervention to Improve Employment
Despite the strong business case of hiring people with disabilities, a significant proportion of youth with disabilities leave high school and neither work nor continue their education and are unprepared to meet the demands of a…
- Conditions
- Cerebral Palsy, Spina Bifida, Juvenile Arthritis, Spinal Cord Injury
- Trial name
- NCT02522507
- Testing
- Empowering youth towards employment
- Where
- Canada
- Volunteers
- 44 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Primary Immune Thrombocytopenia
Safety and Efficacy Study of PF-06835375 in Primary Immune Thrombocytopenia
This is a Phase 2, open-label, multicenter, multiple subcutaneous injection, safety and efficacy study of PF-06835375 in adult participants with primary immune thrombocytopenia (ITP).
- Trial name
- NCT05070845
- Testing
- PF-06835375
- Where
- 24 sites in United States, Australia and 5 more
- Volunteers
- 61 people
- Sponsor
- Pfizer
HLA Antibodies, Systemic Lupus Erythematosus
HLA Antibodies in Systemic Lupus Erythematosus
Patients suffering from autoimmune diseases show false-positive results when anti-HLA antibodies are identified. This false positivity makes it difficult to obtain an organ transplant based on immunological compatibility (absence…
- Trial name
- LEDHLA (NCT06921239)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Degenerative Joint Disease of Knee, Rheumatoid Arthritis
Intra-Articular Adelmidrol 2%/Hyaluronic Acid 1% With or Without m/umPEA, in Knee Pain Due to Joint Degeneration.
Degenerative knee joint diseases are characterized by chronic pain, inflammation, and functional impairment. In these conditions, mast cell density in the synovial membrane is increased, resulting in an excessive release of…
- Trial name
- NCT07680101
- Testing
- Adelmidrol 2% / Hyaluronic Acid 1%, micronized Palmitoylethanolamide (mPEA) 300mg + ultramicronized Palmitoylethanolamide (umPEA) 600mg
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Universita di Verona
Rheumatoid Arthritis
Changes of Depression After First-year of Tofacitinib in RA Patients
12-month, single arm, prospective, non-interventional, multi-center study according to Czech legal definitions (Law 378/2007 Sb.).The primary objective of this study is to describe and evaluate the changes of depression level…
- Trial name
- NCT03992781
- Where
- 6 sites in Czechia
- Volunteers
- 73 people
- Sponsor
- Pfizer
Systemic Lupus Erythematosus (SLE)
Omega-3 Replacement With Krill Oil in Disease Management of SLE
A randomized, double-blind controlled, multicenter study in SLE patients given AKBM-3031or placebo for 24 weeks (randomized period) and followed by an open label extension (OLE) treatment with AKBM-3031 for the next 24 weeks.
- Trial name
- ORKIDS (NCT03626311)
- Testing
- AKBM-3031
- Where
- 19 sites in United States, Canada
- Volunteers
- 76 people
- Sponsor
- Aker BioMarine Human Ingredients AS
Multiple Sclerosis
Muscle Vibration and Fatigue in Patients With MS
Multiple Sclerosis is the most common cause of neurologic chronic disability in young adults. Fatigue is one of the principal symptom in this disease.
- Trial name
- NCT05783999
- Testing
- vibra plus
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Bullous Pemphigoid
Impact of Neurological Diseases on the Prognosis of Bullous Pemphigoid: A Retrospective Study of 178 Patients
Bullous pemphigoid affects mainly elderly patients. It is often associated with neurologic disorders, which represent a major risk factor of the disease
- Trial name
- NCT03320798
- Testing
- Data record
- Where
- France
- Volunteers
- 178 people
- Sponsor
- CHU de Reims
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