Clinical trials: Autoimmune Disorder
Lupus Erythematosus, Lupus Nephritis
Study of EQ001 (Itolizumab) in Systemic Lupus Erythematosus With or Without Active Proliferative Nephritis
This is a multi-center study to evaluate the safety, tolerability, PK, PD, and clinical activity of itolizumab (EQ001) in subjects with Systemic Lupus Erythematosus with or without Active Proliferative Lupus Nephritis
- Trial name
- EQUALISE (NCT04128579)
- Testing
- Itolizumab [Bmab 600]
- Where
- 25 sites in United States, India and 1 more
- Volunteers
- 52 people
- Sponsor
- Biocon Limited
Type1 Diabetes Mellitus, Type2 Diabetes
Circulating Extracellular Vesicles Released by Human Islets of Langerhans
Beta-cells release extracellular vesicles (EV) and exosomes under normal and pathophysiologic conditions. These EV contain beta-cell specific autoantigens which may trigger the immune response at the initiation of type 1…
- Conditions
- Type1 Diabetes Mellitus, Type2 Diabetes, Islet Cell Transplantation
- Trial name
- NCT03106246
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Celiac Disease, Celiac
A Study of the Safety, Efficacy and Tolerability of Nexvax-2 in Patients With Celiac Disease (CeD)
A randomized, double-blind, placebo-controlled clinical study in human leukocyte antigen (HLA)-DQ 2.5+ adults with celiac disease (CeD).
- Conditions
- Celiac Disease, Celiac, Intestinal Disease, Malabsorption Syndromes
- Trial name
- NCT03644069
- Testing
- Nexvax2
- Where
- 41 sites in United States, Australia and 1 more
- Volunteers
- 146 people
- Sponsor
- ImmusanT, Inc.
Inflammation, Vasculitis
Analysis of Bronchial Tissue and Fluid in Patients With Wegener's Granulomatosis
This study will collect fluid and tissue samples from the bronchi (air passages to the lungs) of patients with Wegener's granulomatosis for laboratory examination.
- Conditions
- Inflammation, Vasculitis, Wegener's Granulomatosis
- Trial name
- NCT00001541
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis
Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis
The primary purpose of this study is to detect changes in the brain that may be associated with multiple sclerosis. Results will be compared to age matched controls.
- Trial name
- NCT01226654
- Testing
- Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Lupus Nephritis
Long-term Follow-up for Evaluating the Safety of CS20AT04 in Subject with Lupus Nephritis
This observation study is planned to evaluate the safety and efficacy of the subjects who received CS20AT04 in the phase 1 clinical trial.
- Trial name
- NCT04522505
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Corestemchemon, Inc.
Vitamin B12 Deficiency
Autoantibodies to Gastric Parietal Cells in Rheumatoid Arthritis Patients
A review of the literature reveals that very few studies have assessed the potential co-existence of vitamin B12 deficiency due to gastric parietal cell autoantibodies. While Segal et al.
- Trial name
- NCT01876329
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Keesler Air Force Base Medical Center
IGA Glomerulonephritis
Pilot Study of Enalapril and Renal Function in Patients With IgA Nephropathy
OBJECTIVES: I. Determine the most sensitive outcome measures (functional or morphological) of a progressive renal injury in patients with IgA nephropathy. II.
- Trial name
- NCT00006137
- Testing
- enalapril
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Purpura, Thrombocytopenic, Idiopathic, Autoimmune Thrombocytopenia
The ITP-RITUX Cohort: Rituximab in Immune ThrombocytoPenia.
The primary purpose of the study is to describe by a prospective observational study the serious adverse events occurring in patients treated off-label by rituximab for Immune Thrombocytopenia.
- Trial name
- ITP-RITUX (NCT01101295)
- Where
- 2 sites in France
- Volunteers
- 250 people
- Sponsor
- Henri Mondor University Hospital
Diabetes Mellitus, Type 1
Children's Hospital Academic Medical Organization (CHAMO) MyChart Study
Evolving technology and clinical innovation have led to dramatic changes in the management of type 1 diabetes (T1D). These changes have led to a need to collect a growing number of details from families during their visits.
- Trial name
- NCT05979077
- Testing
- MyChart Questionnaire
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Eastern Ontario
Multiple Sclerosis
Effect of Teriflunomide Treatment on Microglial Activation in an MS Patient Cohort at Risk of Progression
To evaluate the effect of teriflunomide treatment on microglial activation in late stage multiple sclerosis.
- Trial name
- TERIPET (NCT03368677)
- Where
- Finland
- Volunteers
- 26 people
- Sponsor
- Turku University Hospital
Multiple Sclerosis
A Reeducation Program to Effort to Improve the Walking of Multiple Sclerosis Patients
Multiple sclerosis (MS) is a disease affecting the white matter of the central nervous system. In France, it concerns approximately 80 000 patients and represents one of the most frequent neurological affections in young adults.
- Trial name
- AEROSEP (NCT02874677)
- Testing
- Effort reeducation program
- Where
- 4 sites in France
- Volunteers
- 46 people
- Sponsor
- Lille Catholic University
Diabetes
Automated Insulin Delivery Amongst Pregnant Women With Type 1 Diabetes
Evaluation of the biomedical and psychosocial impact of automated Closed-Loop (Artificial Pancreas) insulin delivery in women with type 1 diabetes during pregnancy
- Trial name
- AiDAPT (NCT04938557)
- Testing
- Automated closed-loop insulin delivery (AiD), A standard insulin delivery system
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Multiple Sclerosis
Multiple Sclerosis Self Monitoring Study
This study is a multicenter, prospective, randomized controlled trial (RCT) to compare the effectiveness of a smartphone-based self-monitoring and self-management tool on control self-efficacy with respect to standard clinical…
- Trial name
- MSSM (NCT06125301)
- Testing
- MS Sherpa
- Where
- Netherlands
- Volunteers
- 225 people
- Sponsor
- Amsterdam UMC, location VUmc
Rheumatoid Arthritis
Tofacitinib Versus Methotrexate as the First Line DMARD in the Treatment of Rheumatoid Arthritis
It is a randomized controlled study
- Trial name
- NCT04464642
- Testing
- Methotrexate, Tofacitinib
- Where
- Bangladesh
- Volunteers
- 110 people
- Sponsor
- Dr. Mohammad Mamun Khan
Multiple Sclerosis
Effects of a Multiple Sclerosis Relapse Therapy on Offspring Neurocognitive Development and Behaviour
Introduction: Fetal exposure to glucocorticoids (GCs) used to induce fetal lung maturation in women threatened by premature labour is known to induce aberrations in brain development and stress sensitivity, cognitive dysfunction…
- Trial name
- MS-Children (NCT04832269)
- Testing
- Exposure to methylprednisolone during pregnancy
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Jena University Hospital
Multiple Sclerosis, Relapsing-Remitting
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
This study will evaluate the efficacy and safety of ocrelizumab in participants with RRMS who have had a suboptimal response to an adequate course of DMT.
- Trial name
- NCT02637856
- Testing
- Ocrelizumab
- Where
- 82 sites in United States, Canada
- Volunteers
- 608 people
- Sponsor
- Genentech, Inc.
Multiple Sclerosis, Relapsing-Remitting
Photobiomodulation Therapy in Persons With Multiple Sclerosis
This study will test whether photobiomodulation therapy improves muscle endurance and decreases inflammation in persons with relapsing-remitting multiple sclerosis. We will also investigate mechanisms for any improvements.
- Trial name
- NCT03691766
- Testing
- Photobiomodulation Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Marquette University
Multiple Sclerosis
Efficacy of Cholecalciferol (Vitamin D3) for Delaying the Diagnosis of MS After a Clinically Isolated Syndrome
The main objective of this study is to evaluate the efficacy and tolerance of 2 years of treatment with cholecalciferol (vitamin D3) in patients with a clinically isolated syndrome at high risk for MS (CIS).
- Trial name
- D-Lay-MS (NCT01817166)
- Testing
- Vitamin D, Imaging, Lumbar puncture
- Where
- 33 sites in France, Martinique
- Volunteers
- 316 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Systemic Lupus Erythematosus, High LDL Cholesterol Level
Efficacy and Adverse Effect of Simvastatin Compare to Rosuvastatin in Systemic Lupus Erythematosus (SLE) Patients With Corticosteroid Therapy and High Low-Density Lipoprotein (LDL) Cholesterol Level
Early statin therapy in SLE patients that have high cholesterol level and other atherosclerosis risk should reduce atherosclerosis and coronary artery events in later course of disease.
- Trial name
- NCT00866229
- Testing
- Rosuvastatin, Simvastatin
- Where
- Thailand
- Volunteers
- 140 people
- Sponsor
- Ramathibodi Hospital
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