Clinical trials: Autoimmune Disorder
Multiple Sclerosis
Smoldering Inflammation in MS
The goal of this observational study is to learn about inflammation in those with relapsing remitting Multiple Sclerosis (MS). The main questions it aims to answer are: How does abnormal neural inflammation compare to cellular…
- Trial name
- NCT06591429
- Testing
- Radiotracer [11C]-CS1P1, Radiotracer [11C]-DPA-713, anti-CD20 MS treatment
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Washington University School of Medicine
Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis
MUSCLE - Nordic Walking in MUltiple SCLErosis
The aim of the study is to analyze the effects of Nordic Walking and free walking in the clinical-functional, postural balance, motor control, muscular echographic quality, and gait analysis (pendulum gait mechanism), in people…
- Conditions
- Multiple Sclerosis, Chronic Progressive, Multiple Sclerosis, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- MUSCLE (NCT05385731)
- Testing
- Nordic Walking (NWG), Free Walking (FWG), Health Education (HEG)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Leonardo A. Peyré-Tartaruga
Systemic Lupus Erythematosus (SLE), Repository Corticotropin Injection
Acthar SLE (Systemic Lupus Erythematosus)
This is a randomized study exploring the efficacy, safety and steroid sparing ability of two doses (40 U and 80 U) of Acthar in SLE patients with immune mediated hematologic manifestations requiring steroid use for a minimum of 2…
- Trial name
- Acthar SLE (NCT02779153)
- Testing
- Acthar low dose (40 U), Acthar high dose (80 U)
- Sponsor
- NYU Langone Health
Rheumatoid Arthritis
A Phase 2 Dose-finding Study of Atacicept in Subjects With Rheumatoid Arthritis (AUGUST I)
This was a double-blind, placebo-controlled, parallel-arm, multicentre, prospective dose-finding trial of the safety and efficacy of atacicept in subjects with active rheumatoid arthritis who had failed a three month therapeutic…
- Trial name
- AUGUST I (NCT00430495)
- Testing
- Atacicept
- Where
- 2 sites in United States, Canada
- Volunteers
- 256 people
- Sponsor
- EMD Serono
Type 1 Diabetes
Prevalence of Post Traumatic Stress Disorder Related to Diabetes Diagnosis or Severe Hypoglycaemia in Adult With Type 1 Diabetes
In France, the adult population living with diabetes in 2016 is estimated at more than 3.3 million patients treated. Type 1 diabetes (T1DM) represents 5.6% of diabetic patients (approximately 185,000 patients).
- Trial name
- NCT05662657
- Testing
- Diagnostic Test: PCL-S Questionnaire
- Where
- 2 sites in France
- Volunteers
- 297 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Systemic Lupus Erythematosus (SLE)
LUMIER² Study : LUpus Molecular Immunomonitoring to Evaluate the Risk of Relapse
We aim to determine the accuracy or blood transcriptomic signatures to predict the occurrence of flares in patients with SLE that are clinically quiescent at inclusion Systemic Lupus Erythematosus (SLE) is a chronic auto-immune…
- Trial name
- LUMIER² (NCT02811094)
- Testing
- polymerase chain reaction (PCR) technique of blood transcriptome analysis
- Where
- France
- Volunteers
- 210 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Multiple Sclerosis
The Effects of Pilates-Based Core Stabilization Training in Multiple Sclerosis
Multiple Sclerosis (MS) is a chronic, autoimmune and neurodegenerative disease characterized by inflammation and progressive demyelination of the central nervous system.
- Trial name
- NCT04252053
- Testing
- Pilates Based Core Stabilization Training, Home based exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul University - Cerrahpasa
Multiple Sclerosis
CSF Free Kappa Light Chain for The Diagnosis of Demyelinating Disorders
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) which commonly leads to disability. The current preferred clinical laboratory test for the diagnosis is the detection of oligoclonal bands…
- Trial name
- NCT05347277
- Testing
- Kappa Free Light Chain (K-FLC)
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Aga Khan University
Type 1 AIP
Inebilizumab for the Treatment of Patients With Type 1 Autoimmune Pancreatitis
Autoimmune pancreatitis (AIP) is an immune-related inflammatory disease of the pancreas. Relapse can occur after treatment, and long-term treatment with glucocorticoids and conventional immunosuppressants can cause significant…
- Trial name
- NCT07862075
- Testing
- Inebilizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Ruijin Hospital
Rheumatoid Arthritis
Phase 2 AMG 714 in Rheumatoid Arthritis
Twelve week treatment of AMG 714 in RA patients who failed at least one DMARD, followed by a 3 month observational period.
- Trial name
- NCT00433875
- Testing
- AMG 714
- Volunteers
- 180 people
- Sponsor
- Amgen
Type 1 Diabetes
Impact of the Menstrual Cycle in Reproductive Aged Women With Type 1 Diabetes Using a Closed Loop System (DIABETEXX/1).
The aim of this observational study is to assess the effectiveness of automatic insulin infusion in responding to changes in insulin sensitivity throughout various phases of the menstrual cycle in a cohort of reproductive-aged…
- Trial name
- DIABETEXX/1 (NCT06338072)
- Where
- Spain
- Volunteers
- 119 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Multiple Sclerosis
The Effect of a Probiotic Administration as an add-on Treatment in Multiple Sclerosis
It is a randomized, double-blind, placebo-controlled clinical trial whose general objective of this study is to determine the effects of probiotic administration in multiple sclerosis patients.
- Trial name
- PROBiMS (NCT07168772)
- Testing
- Lactibane Iki
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Multiple Sclerosis
Learning Strategies for Improving Dual Task Performance in Multiple Sclerosis
This study is a randomized controlled study in which we aim to include 60 persons with Multiple Sclerosis and 30 healthy controls.
- Trial name
- StraDiMS (NCT04538872)
- Testing
- StraDiMS implicit, StraDiMs explicit
- Where
- 2 sites in Belgium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
A Pilot Study to Assess microRNA Biomarkers in Early and Later Stage Multiple Sclerosis
This study will look at the blood and cerebrospinal fluid of consented participants who either have early stage multiple sclerosis (clinically isolated syndrome) or who have later stage (secondary progressive multiple sclerosis)…
- Conditions
- Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Clinically Isolated Syndrome
- Trial name
- NCT01737372
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- John F. Foley, MD
Multiple Sclerosis
Safety of Bryostatin in Patients With MS
This is a single-site, single-arm, single-dose, Phase 1 study of the safety of bryostatin in participants with multiple sclerosis (MS) receiving any disease modifying therapy (DMT).
- Trial name
- NCT06190912
- Testing
- Bryostatin 1
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Robert Fox
Diabetes, Type 1 Diabetes
Predictive and Protective Factors in the Cause of Diabetes - A Study in Twins
This study, conducted at St. Bartholomew's Hospital, London, England, will determine whether cells passed from mother to offspring during pregnancy increase or decrease the child's risk of developing type 1 diabetes.
- Trial name
- NCT00339781
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Multiple Sclerosis
Study on Cognitive Disorders of Multiple Sclerosis
The purpose of this study is to determine if memantine is effective in the treatment on cognitive disorders of Relapsing - Remitting multiple sclerosis. m
- Trial name
- NCT01074619
- Testing
- Memantine
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Caen
Type 1 Diabetes Mellitus, Adolescent Behavior
Using an mHealth App to Transition Care of Type-1 Diabetes From Parents to Teens
Type 1 diabetes (T1D) afflicts approximately 154,000 people under the age of 20. Most people with T1D are diagnosed at a young age; their parents have to manage their child's condition.
- Conditions
- Type 1 Diabetes Mellitus, Adolescent Behavior, Parent-Child Relations, Communication
- Trial name
- NCT03436628
- Testing
- MyT1DHero
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Type 1 Diabetes
Effect of Low-intensity Aerobic Regular Activity on Heart Rate Variability in Type 1 Diabetes
A monocentric prospective randomized trial included 35 patients with Type 1 diabetes. Participants were randomized into two groups: Group A with the patients who engaged in low-intensity physical activity matching aerobic…
- Trial name
- ELARA-T1D (NCT07382856)
- Testing
- low-intensity physical activity, Intensive insulin therapy
- Where
- Bosnia and Herzegovina
- Volunteers
- 35 people
- Sponsor
- University of Banja Luka
Multiple Sclerosis
Assessing the Induction of Long-term Immune Regulation Following Treatment With Lemtrada® (Alemtuzumab).
In this study the investigators wish to test the hypothesis that treatment with Lemtrada is associated with alterations in immune homeostasis in favor of multiple regulatory leukocyte populations which persist long after…
- Trial name
- NCT03647722
- Testing
- Assessment of leukocyte function.
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- University of Southern California
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