Clinical trials: Autoimmune Disorder
Lupus Erythematosus, Systemic, Lupus
A Study to Evaluate Safety and Tolerability of Subcutaneous Doses of MEDI-545 in Subjects With Lupus
The primary objective of this study is to evaluate the safety and tolerability of multiple doses of MEDI-545 in subjects with moderately to severely active Lupus.
- Trial name
- NCT00657189
- Testing
- MEDI-545
- Where
- 22 sites in United States
- Volunteers
- 87 people
- Sponsor
- MedImmune LLC
Rheumatoid Arthritis (RA)
Clinical Study Comparing Diosmin vs Rebamipide as Adjuvant Therapies vs Conventional Therapy in Patients With Rheumatoid Arthritis
This study will be a randomized controlled parallel study that will be conducted on 66 patients with active rheumatoid arthritis who will be diagnosed with RA according to American College of Rheumatology (ACR)/European League…
- Trial name
- NCT07745426
- Testing
- Diosmin, Rebamipide 100mg, Convential medical treatment
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Rheumatoid Arthritis
Effectiveness Intraarticular Corticosteroid
The purpose of this study is to compare the small and large dose of corticosteroid used in intraarticular injection of wrist.
- Trial name
- NCT01851278
- Testing
- Triamcinolone hexacetonide
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Federal University of São Paulo
Rheumatoid Arthritis
Long Term Extension Study to Assess the Safety and Efficacy of Filgotinib in Adults With Rheumatoid Arthritis
The primary objective of this study is to evaluate the long-term safety and tolerability of filgotinib in participants who have completed one of the parent studies of filgotinib in rheumatoid arthritis (RA).
- Trial name
- FINCH 4 (NCT03025308)
- Testing
- Filgotinib
- Where
- 345 sites in United States, Argentina and 30 more
- Volunteers
- 2,731 people
- Sponsor
- Alfasigma S.p.A.
Rheumatoid Arthritis, Chronic Periodontitis
Impact of Photodynamic Therapy as an Adjunct to Non-surgical Periodontal Treatment on Clinical and Biochemical Parameters Among Patients Having Mild Rheumatoid Arthritis With Periodontitis
Purpose: To evaluate the efficacy of photodynamic therapy (PDT) as an adjunct to non-surgical periodontal therapy on the clinical periodontal and biochemical parameters among patients with rheumatoid arthritis (RA) having…
- Trial name
- NCT05122117
- Testing
- Methylene blue mediated Photodynamic therapy, Non-surgical periodontal therapy
- Where
- Saudi Arabia
- Volunteers
- 50 people
- Sponsor
- Zohaib Akram
Birdshot Chorioretinopathy, Cystoid Macular Edema
Evaluation of Birdshot Retine Choroidopathy Treatment by Either Steroid or Interferon alpha2a
Birdshot Retine choroidopathy (BRC) is a sight threatening posterior uveitis. The long term visual outcome has recently be studied showing a legal blindness to 14% at 5 years.
- Conditions
- Birdshot Chorioretinopathy, Cystoid Macular Edema, Transient Partial Visual Loss
- Trial name
- BIRDFERON (NCT00508040)
- Testing
- interferon alpha 2a, prednisone
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ITP, Immune Thrombocytopenia
The Combination of Iguratimod and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia
Randomized, open-label, multicenter study to compare the efficacy and safety of combination of iguratimod and danazol versus danazol for the treatment of adults with steroid-resistant/ relapse immune thrombocytopenia (ITP).
- Trial name
- NCT05281068
- Testing
- Iguratimod, Danazol
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Multiple Sclerosis, Balance
Monitoring Intensity During Balance Training in Persons With Multiple Sclerosis
Balance training is recommended to improve gait stability and mobility. However, there are currently no clearly defined methods for controlling the intensity (challenge) of balance training.
- Trial name
- BALANCE-MS (NCT07805850)
- Testing
- Balance training, Sporttherapy
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Klinik Valens
Refractory Systemic Lupus Erythematosus
Mesenchymal Stem Cells Transplantation for Refractory Systemic Lupus Erythematosus (SLE)
This study will explore a new approach to treat patients with a medical condition known as systemic lupus erythematosus (SLE) who have been resistant to previous treatments using a new population of cells with capability to…
- Trial name
- NCT00698191
- Testing
- Allogeneic MSC (AlloMSC)
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Nanjing Medical University
Type 1 Diabetes
Insulin Pump to Multiple Daily Injection Transition Clinical Trial
This randomized controlled, two arms, investigator initiated, intervention study is aimed to examine an investigational approach in contrast to the clinical standard of 1:1 dose basal insulin conversion in an attempt to lower the…
- Trial name
- TRANSITION (NCT03987191)
- Testing
- Multiple daily ijnection using Insulin Degludec and Insulin Aspart
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- University of Colorado, Denver
Multiple Sclerosis
Cerebrovascular Changes in Multiple Sclerosis Patients
Multiple sclerosis (MS) MS is a chronic disease containing the inflammatory, demyelinating, anddegenerative processes of the central nervous system.
- Trial name
- NCT03709290
- Testing
- mri
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rheumatoid Arthritis
A Study to Evaluate the Safety and Tolerability of Multiple Doses of Gerilimzumab in Rheumatoid Arthritis Patients
The primary objective of this study is to evaluate the safety, tolerability and pharmacokinetic (PK) profiles of multiple abdominal subcutaneous injection of GB224 in combination with oral methotrexate in Chinese patients with…
- Trial name
- NCT04179513
- Testing
- GB224 10mg, GB224 20mg
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Genor Biopharma Co., Ltd.
Multiple Sclerosis, Ataxia
Effect of Life Kinetik Training on Lower Limb Coordination in Ataxic Patients
Coordination is essential for the performance of most daily motor activities. Coordination problems are common in MS patients. One of the most commonly reported symptoms is dysmetria (limb ataxia).
- Trial name
- NCT06001424
- Testing
- physical therapy, life kinetic exercises
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Type 1 Diabetes Mellitus
Pilot Study Investigating the Feasibility of Determining the Endogenous Glucose Production During a Hypoglycaemia
Primary objective is to investigate the feasibility and stability of determining the endogenous glucose production during a hypoglycaemic clamp in type 1 diabetes mellitus subjects by a stable tracer to tracee ratio with an…
- Trial name
- PILOT_EGP (NCT02028078)
- Testing
- Insulin human
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Type 1 Diabetes (T1D)
GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes
Blood glucose management in type 1 diabetes (T1D) remains a challenge, with only ~30% of adults within the recommended consensus guidelines.
- Trial name
- AID-JUNCT (NCT06630585)
- Testing
- Tirzepatide
- Where
- 3 sites in Switzerland
- Volunteers
- 42 people
- Sponsor
- University of Bern
Thyroid Eye Disease, Chronic (Inactive) Thyroid Eye Disease
A Study Evaluating TEPEZZA® Treatment in Patients With Chronic (Inactive) Thyroid Eye Disease
The overall objective is to investigate the efficacy, safety and tolerability of TEPEZZA® in participants with chronic (inactive) TED (thyroid eye disease). Approximately 57 participants will be enrolled.
- Trial name
- NCT04583735
- Testing
- TEPEZZA
- Where
- 12 sites in United States
- Volunteers
- 62 people
- Sponsor
- Amgen
Rheumatoid Arthritis, Gout
Effect of a New BI-specifiC Antibody Towards Dendritic Cells on Inflammation in Rheumatoid Arthritis
First, this study will evaluate, in vitro, the cellular composition of the synovial fluid from patient with rheumatoid arthritis, gout or osteoarthritis.
- Conditions
- Rheumatoid Arthritis, Gout, Osteoarthritis
- Trial name
- BIC_RA (NCT03416543)
- Testing
- Puncture
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Tours
Sjögren's Disease
A Phase 2a/b Study to Assess the Efficacy, Safety and Tolerability of DDY391 in Participants With Sjögren's Disease
To evaluate efficacy, safety, and tolerability of DDY391 up to 52 weeks in participants with Sjögren's disease (SjD) and to determine the dose response relationship of DDY391 in participants with SjD, to support dose selection…
- Trial name
- NCT07737743
- Testing
- DDY391
- Where
- 25 sites in United States, Australia and 4 more
- Volunteers
- 344 people
- Sponsor
- Novartis Pharmaceuticals
Type I Diabetes
Evaluating the Impact of Introducing Basaglar, a Long-acting Analog Insulin, on Clinical and Quality of Life Outcomes in Youth with Diabetes in Bangladesh
This study aimed to determine the effect of introducing Basaglar and insulin pen injection devices on clinical and quality of life (QOL) parameters in children and young adults with type 1 diabetes in Bangladesh
- Trial name
- NCT06674135
- Testing
- biosimilar insulin glargine
- Where
- Bangladesh
- Volunteers
- 202 people
- Sponsor
- Life for a Child Program, Diabetes Australia
Rheumatoid Arthritis
Mobile Medically Supervised Patient Management in Rheumatoid Arthritis
The purpose of this study is to evaluate the use, usability and feasibility of an Application (App) for patients with rheumatoid arthritis with diary functionalities, in patient-physician interaction.
- Trial name
- MiDEAR (NCT02565225)
- Testing
- RheumaLive App use
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
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