Clinical trials: Autoinflammatory Disease
Behcet's Disease Uveitis
Efficacy and Safety Study of Gevokizumab to Treat Behcet's Disease Uveitis
The objective of this study is to assess the efficacy and safety of gevokizumab in treating Behcet's disease uveitis (BDU).
- Trial name
- EYEGUARD™-US (NCT02258867)
- Testing
- Gevokizumab
- Where
- 8 sites in United States
- Volunteers
- 4 people
- Sponsor
- XOMA (US) LLC
Rheumatoid Arthritis, Spondylitis, Ankylosing
Recombinant Herpes Zoster Vaccine in Patients With Autoimmune Rheumatic Diseases
Introduction: Patients with autoimmune rheumatic diseases (ARDs), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), psoriatic arthritis (PAs), ankylosing spondylitis (AS), systemic lupus erythematosus (SLE), primary…
- Conditions
- Rheumatoid Arthritis, Spondylitis, Ankylosing, Spondyloarthritis, Systemic Lupus Erythematosus
- Trial name
- RZVRheum (NCT05879419)
- Testing
- Recombinant Herpes Zoster Vaccine (RZV), MTX Discontinuation, MMF Discontinuation
- Where
- Brazil
- Volunteers
- 2,005 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Behçet Disease
IMPACT_BD (IMProving AdherenCe to Treatment in Behçet's Disease)
Behçet's disease (BD) is an autoimmune, rare, and severe multisystemic inflammatory disease characterized by recurrent oral aphthous ulcers, genital ulcers, skin lesions, and both anterior and posterior uveitis; articular…
- Trial name
- IMPACT_BD (NCT05128357)
- Testing
- the study is observational, no intervention foreseen
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Behçet
Neurofilament Light Chain as a Potential Marker in Behcet's Disease
To determine the role of neurofilament light chain in Behçet's disease with or without neurological affection and its relation to neurological manifestation (either peripheral or central ).
- Trial name
- NCT06060275
- Testing
- serum sample and nerve conduction study and cerebrospinal fluid study
- Volunteers
- 60 people
- Sponsor
- Assiut University
Schnitzler Syndrome, Urticarial Vasculitis With Monoclonal Immunoglobulin M Component, Schnitzler (Disorder)
Study of the Efficacy and Safety of RPH-104 in Adult Subjects With Schnitzler Syndrome
The primary goal of the study is to assess the efficacy and safety of RPH-104 in subjects with Schnitzler Syndrome using Schnitzler Disease Activity Score (SDAS), which includes the Physician's Global Assessment (PGA) and the…
- Trial name
- NCT04213274
- Testing
- 80 mg RPH-104
- Where
- 4 sites in United States
- Sponsor
- R-Pharm Overseas, Inc.
Behçet's Disease, Uveitis
Intravitreal Infliximab in Refractory Uveitis in Behcet's Disease: A Safety and Efficacy Clinical Study
Intravitreal injection of up to 2 mg of infliximab has proved to be safe in animal models (rabbits and primates). These studies have shown no evidence of intraocular inflammation or toxicity by clinical, electrophysiological, and…
- Trial name
- NCT02620618
- Testing
- Intravitreal Infliximab
- Volunteers
- 20 people
- Sponsor
- Cairo University
Behçet Disease, Behcet Syndrome
Erectile Dysfunction in Patients With Non Ocular Behçet's Disease
It was aimed to demonstrate whether erectile dysfunction is affected by BH pathogenesis and whether there is a relationship between erectile dysfunction and BD pathogenesis by assessing both sexual function and retinal…
- Conditions
- Behçet Disease, Behcet Syndrome, Erectile Dysfunction
- Trial name
- NCT04386824
- Testing
- Erectil dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Antalya Training and Research Hospital
Autoinflammatory Syndromes, HIDS
The Efficacy and Safety of ITF2357 in AIS
Autoinflammatory syndromes (AIS) are a group of disorders characterized by recurrent episodes of inflammation.Although for the hereditary autoinflammatory diseases the genetic mutations are known it remains largely unclear how…
- Conditions
- Autoinflammatory Syndromes, HIDS, TRAPS, Schnitzler's Syndrome
- Trial name
- NCT00442182
- Testing
- ITF2357
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Behcet's Syndrome, Intestinal Type
Pathogenesis of Intestinal Behcet's Syndrome
There is a direct interaction between food, intestinal flora and the intestinal barrier composed of intestinal epithelial cells and mucosal immunity, whose composition and functional alterations are theorized to be closely…
- Trial name
- NCT06026020
- Testing
- Biological samples collection
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Familial Mediterranean Fever, Heat Intolerance
Heat Intolerance in the Group of FMF Patients
There now causation between Heat Intolerance and FMF that were showed in studies till now. We suggest that the prevalence of Heat Intolerance in the group of the FMF patients will be significantly higher than in the group of…
- Conditions
- Familial Mediterranean Fever, Heat Intolerance, Heat Tolerance Test
- Trial name
- NCT01059279
- Where
- Israel
- Volunteers
- 7 people
- Sponsor
- Sheba Medical Center
Behcet's Syndrome
Ivarmacitinib for Refractory Behcet's Syndrome
Behcet's syndrome (BS) is a multisystem autoimmune vasculitis. Current clinical treatment primarily includes glucocorticoids, immunosuppressants, and molecularly targeted drugs such as TNF-α and IL-6 inhibitors; however, some…
- Trial name
- NCT07634848
- Testing
- Ivarmacitinib
- Where
- China
- Sponsor
- Liu Tian
AA Amyloidosis, Autoinflammatory Disease
Unclassified GENotypes of Autoinflammatory Diseases and AA Amyloidosis
Patients with autoinflammatory diseases (AID) have recurrent episodes of systemic inflammation accompanied by nonspecific elevation of blood inflammation markers typically absent between attacks.
- Trial name
- IPHYGENI MAI (NCT06354322)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Auto Inflammatory Diseases
National Cohort of Patients With SITRAME Syndrome
SITRAME syndrome is a recently described disease. In the absence of epidemiological data on SITRAME syndrome in France, the National Reference Center for Autoinflammatory Diseases proposes coordinating a database to collect both…
- Trial name
- CO-SITRAME (NCT07168746)
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Familial Mediterranean Fever (FMF), Autoinflammation
Familial Mediterranean Fever and Related Disorders: Genetics and Disease Characteristics
This study is designed to explore the genetics and pathophysiology of diseases presenting with intermittent fever, including familial Mediterranean fever, TRAPS, hyper-IgD syndrome, and related diseases.
- Conditions
- Familial Mediterranean Fever (FMF), Autoinflammation, Periodic Fever, Fever
- Trial name
- NCT00001373
- Where
- 5 sites in United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Observational
Progression of Renal Amyloidosis of FMF and Relation to Serum SAA Level
Purpose of this study is to determine whether keeping SAA on normal or near normal level will delay progression of renal failure in patients with amyloidosis secondary to FMF.
- Trial name
- NCT01168570
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease
Natural History of Trisomy 8-Associated Autoinflammatory Disease (TRIAD) and Related Disorders
Background: Trisomy 8 mosaicism is a genetic disorder that can increase inflammation in the body. Symptoms include fevers; sores or ulcers in the mouth, digestive tract, or genital area; skin rashes; problems in organs or…
- Conditions
- Trisomy 8 Mosaicism, Trisomy 8 Associated Autoinflammatory Disease, Mucosal Ulcerations
- Trial name
- NCT07683104
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Autoinflammatory Diseases
Epidemiology of SAIDs.
Systemic autoinflammatory diseases (SAIDs) are inflammatory conditions caused by a defect of the innate immune system. Most are hereditary, but little is known on recent entities.
- Trial name
- EPIMAI (NCT03643809)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Juvenile Idiopathic Arthritis, Familial Mediterranean Fever
Assessment of Cardiorespiratory Fitness Using the PACER in Patients With Juvenile Idiopathic Arthritis and Familial Mediterranean Fever
Juvenile Idiopathic Arthritis (JIA) and Familial Mediterranean Fever (FMF) are the most common autoimmune and autoinflammatory rheumatic diseases in childhood.
- Conditions
- Juvenile Idiopathic Arthritis, Familial Mediterranean Fever, Healty Controls
- Trial name
- NCT06697028
- Testing
- Usability and Comparison
- Where
- Turkey (Türkiye)
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Familial Mediterranean Fever, MEFV Gene Mutation
Characterization of a Functional Test for Mediterranean Family Fever Screening - 2
Familial Mediterranean fever (FMF) is the most common auto-inflammatory disease (prevalence: 1-5 / 10,000 inhabitants). It is caused by mutations in the MEFV gene, which encodes variants of the Pyrine inflammasome.
- Trial name
- DEPIST-FMF 2 (NCT04478409)
- Testing
- one additional blood sample during a planned blood test
- Where
- 8 sites in France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon