Clinical trials: Autologous Stem Cell Transplant
Craniofacial Injuries
Use of Concentrated Endogenous Autologous Adipose Stromal Cells in Fat Grafts for Craniofacial Trauma
Traumatic facial injuries, especially those sustained in military combat, are characterized by destruction of bone and soft tissue.
- Trial name
- ARM5 (NCT01633892)
- Testing
- Fat Grafting
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoarthritis (OA)
Adipose-derived SVF for the Treatment of Knee OA
This is a pivotal study. The study will examine the safety and efficacy of autologous adipose-derived stromal vascular fraction (SVF) cells processed with the GID SVF-2 device for pain, function and stiffness in the knees of…
- Trial name
- NCT02726945
- Testing
- GID SVF-2
- Where
- 3 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- GID BIO, Inc.
Urinary Incontinence
Comparison of Surgical Procedures to Reduce Urinary Stress Incontinence
The primary aim of this clinical trial is to compare the treatment success for two surgical procedures that are frequently used and have similar cure rates, yet have not been compared directly to each other in a large, rigorously…
- Trial name
- SISTEr (NCT00064662)
- Testing
- Burch Modified Tanagho, Autologous Fascia Sling
- Where
- 9 sites in United States
- Volunteers
- 655 people, healthy volunteers welcome
- Sponsor
- Carelon Research
Tennis Elbow, Epicondylitis, Lateral Humeral
A Randomized Control Trial to Evaluate the Efficacy of Autologous Blood Injection Versus Local Corticosteroid Injection for Treatment of Lateral Epicondylitis
Lateral epicondylitis, is a common problem encountered in the orthopaedic practice. Histopathological reports have shown that lateral epicondylitis is not an inflammatory process but a degenerative condition termed 'tendinosis'.
- Trial name
- NCT00947765
- Testing
- Autologous blood injection, Local corticosteroid injection
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dojode, Chetan M., MBBS, MS
Solid Tumor Malignancies
ALI Post Radiation Therapy in Patients With Lung and Esophageal Canter
The goal of this clinical research study is to learn if giving autologous lymphocyte infusions to patients who are receiving chemotherapy and radiation for non-small cell lung cancer or esophageal cancer is safe and effective.
- Trial name
- NCT04668833
- Testing
- Autologous lymphocyte infusion (ALI)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Infectious Disease of Digestive Tract
Autologous Fecal Therapy
Ten healthy volunteers will be recruited to receive either an autologous stool transplant or a saline enema to determine if autologous fecal microbiota therapy will be able to rapidly, and safely, restore a patient's fecal…
- Trial name
- NCT02046525
- Testing
- Autologous fecal microbiota therapy
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Anterior Cruciate Ligament Tear
Bridge-Enhanced ACL Repair vs ACL Reconstruction
The goal of this trial is to compare the efficacy of the Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR™) technique with the current method of treatment for anterior cruciate ligament (ACL) injuries, ACL reconstruction.
- Trial name
- NCT02664545
- Testing
- BEAR Scaffold, Tendon Graft
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Miach Orthopaedics
Healthy
In Vivo Study to Assess the Recovery and Survival of Radiolabeled Autologous INTERCEPT Apheresis Platelet Components Suspended in 100% Plasma Stored for up to 7 Days
The principle objective of this study is to evaluate the hypothesis that INTERCEPT Platelets in 100% plasma stored for 5 or more days (up to 7 days) after apheresis collection retain sufficient viability for therapeutic…
- Trial name
- NCT04022889
- Testing
- INTERCEPT Treated Platelets
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Cerus Corporation
Hypertrophic Scar
Use of Autologous Platelet-Rich Plasma to Treat Hypertrophic Burn Scars
Hypertrophic burn scars are experienced by more than 70% of burn victims. They are a major source of decreased quality of life in burn patients due to pain, decreased range of motion, and poor cosmetic appearance.
- Trial name
- NCT03935594
- Testing
- PRP Injection, Saline Injection
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hematopoietic Cell Transplantation Recipient, Recurrent Diffuse Large B-Cell Lymphoma
Venetoclax, Carmustine, Etoposide, Cytarabine, and Melphalan Before Stem Cell Transplant in Treating Participants With Relapsed or Refractory Non-Hodgkin Lymphoma
This phase I/II trial studies the side effects and best dose of venetoclax when given together with carmustine, etoposide, cytarabine, and melphalan before stem cell transplant in treating participants with non-Hodgkin lymphoma…
- Conditions
- Hematopoietic Cell Transplantation Recipient, Recurrent Diffuse Large B-Cell Lymphoma, Recurrent Grade 1 Follicular Lymphoma, Recurrent Grade 2 Follicular Lymphoma
- Trial name
- NCT03583424
- Testing
- Carmustine, Cytarabine, Etoposide
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Antibiotic Resistant Strain
Autologous Fecal Microbiota Transplantation to Prevent Antibiotic Resistant Bacteria Colonization
This study, a Randomized controlled trial of Autologous microbiome reconstitution to prevent Colonization by antibiotic rEsistant bacteria (RACE), seeks to investigate the safety, feasibility and the role of autologous fecal…
- Trial name
- RACE (NCT03061097)
- Testing
- Autologous fecal microbiota transplant (Auto-FMP Enema)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Microbiome Health Research Institute
Freeze Dried Plasma in Healthy Volunteers
Ascending Doses of Autologous FDP vs FFP
Assess the safety of single infusions with RePlas FDP product at increasing fixed doses
- Trial name
- FDP (NCT02930226)
- Testing
- Autologous Freeze Dried Plasma (FDP), Fresh Frozen Plasma (FFP)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Osteoarthritis
Autologous Conditioned Plasma (ACP) Intra-articular (IA) Injections for Knee Osteoarthritis (OA)
This study is primarily investigating the effectiveness of Autologous Conditioned Plasma (ACP) Intra-articular (IA) in patients with Osteoarthritis (OA) in the knee.
- Trial name
- NCT02713542
- Testing
- ACP
- Where
- 4 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Arthrex, Inc.
Complication of Transplant
Supportive Care Intervention In Patients Hospitalized For Hematopoietic Stem Cell Transplantation (Shield)
The main purpose of this study is to assess whether early integration of palliative and supportive care services in care of patients hospitalized for hematopoietic stem cell transplantation (HSCT) can improve patients' and family…
- Trial name
- SHIELD (NCT02207322)
- Testing
- transplant with early palliative care
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Healthy Subjects
A Study to Assess Recovery and Survival of Radiolabeled Apheresis Platelet Components Treated With the INTERCEPT Blood System for Platelets With LED Illuminator.
The objective of this study is to assess the post-infusion recovery and survival of platelets in 100% Plasma treated with INTERCEPT Blood System for Platelets with LED Illuminator and stored for 5 days after apheresis collection.
- Trial name
- NCT06697223
- Testing
- INTERCEPT Blood System for Platelets with LED Illuminator
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cerus Corporation
Corneal Epithelial Defect, Diabetic Retinopathy
Topical Autologous Serum Application for the Treatment of Corneal Epithelium Defect After Ocular Surgeries
Ophthalmology ,cornea Autologous serum has long been known to be effective to promote corneal epithelial wound healing in a variety of ocular surface disorders.
- Conditions
- Corneal Epithelial Defect, Diabetic Retinopathy, Penetrating Keratoplasty
- Trial name
- NCT01075347
- Testing
- autologous serum, Non-autologous serum
- Where
- Taiwan
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Erythrocyte Transfusion
Rejuvenated RBC and VO2 Max in Healthy Subjects
To compare the physiologic benefits of rejuvenated RBCs (rejRBCs) to standards RBCs (PRBCs), we will emulate critical conditions by safely maximizing stress on the cardiovascular system, in an elective, feasible volunteer study.
- Trial name
- NCT03089047
- Testing
- Transfusion of rejuvenated and washed autolgous RBCs, Transfusion of washed autolgous RBCs
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Duke University
Post Operative Pain
The Effect of Platelet Rich Plasma (PRP) on Post Operative Pain in Anterior Cruciate Ligament Reconstruction
The purpose of this research study is to investigate whether or not platelet rich plasma (PRP) may help to improve tendon healing and decrease post operative pain in patients undergoing anterior cruciate ligament (ACL)…
- Trial name
- NCT01765712
- Testing
- Anterior Cruciate ligament reconstruction bone patellar tendon bone autograft, Platelet Rich Plasma
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Brian Walters
Breast Fat Grafting Retention
AuraClens™ System in Processing of Lipoaspirate for Autologous Fat Grafting to the Breast
Prospective, multi-center, non-randomized, open-label, post-market clinical study evaluating adipose graft retention over time from lipoaspirate processed using the AuraGen 1-2-3™ with AuraClens™ Lipoaspirate Wash System.
- Trial name
- AuraGen (NCT05258305)
- Testing
- AuraGen 1-2-3 with AuraClens
- Where
- 14 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tiger Biosciences, LLC.
Laser Assisted Liposuction
Laser Assisted Liposuction and Facial Autologous Fat Grafting With the LipoLife System
Multi-center, prospective, open-label, single arm study. The study aims to evaluate the safety and efficacy of Laser Assisted Liposuction procedure performed with the LipoLife system.
- Trial name
- NCT03800563
- Testing
- LipoLife system
- Where
- 2 sites in United States, Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Alma Lasers