Clinical trials: Autologous Stem Cell Transplant
Non-Hodgkin's Lymphoma
Transplantation With Ybritumomab Tiuxetan (Zevalin) Plus BEAM Regimen in Patients With Refractory Large B-cell Difusse Lymphom
To evaluate the efficacy (complete response rate) of Ybritumomab Tiuxetan (Zevalin) administration in the conditioning treatment of patients with refractory large B-cell diffuse lymphoma submitted to autologous transplantation of…
- Trial name
- Z-BEAM LDGGB (NCT00646750)
- Testing
- Ybritumomab Tiuxetan (Zevalin); Rituximab; BEAM (BCNU, ARAC, VP16 and Melphalan)
- Where
- 18 sites in Spain
- Volunteers
- 31 people
- Sponsor
- Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
Myelofibrosis, MF
Ruxolitinib in Combination With Autotransplant
To determine the safety of the approach of giving RUXOLITINIB before and after an autologous stem cell transplant, as measured by graft failure or death.
- Trial name
- NCT02469974
- Testing
- RUXOLITINIB / INC 424, Filgrastim, Busulfan
- Sponsor
- Marina Kremyanskaya
Ischemia Reperfusion Injury
Protecting Autologous Free Flaps From Ischemia/Reperfusion Damage With Cold Storage.
Reconstructive microsurgery allows autologous transplantation of flaps. The procedure causes temporary ischemia. The absence of perfusion and the post-anastomosis reperfusion causes ischemia/reperfusion (I/R) damage and an…
- Trial name
- PAFFIRD (NCT06523920)
- Testing
- University of Wisconsin solution + cold storage, Unperfused free flap under warm ischemia
- Volunteers
- 90 people
- Sponsor
- University of Cagliari
Mucositis, Multiple Myeloma
Comparative Trial of Cryotherapy Versus Caphosol Versus Saline Solution Mouth Washes for the Prevention of Oral Mucositis in Patients With Multiple Myeloma Undergoing Hematopoietic Stem Cell Transplantation
Chemotherapy-induced oral mucositis is the inflammation of the oral mucous membranes, which are tissues that line the mouth. Oral mucositis is caused when chemotherapy attacks and kills the rapidly-dividing cells in the oral…
- Trial name
- NCT01066624
- Testing
- 0.9% Sodium Chloride irrigation solution, Cryotherapy (ice chips), Calcium phosphate (Caphosol) Ca2+/PO43- mouth rinse
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Crohn Disease, Anal Fistula
Study on the Treatment of Anal Fistulas Using Alofisel Versus Fat Autologous Stem Cells
One of the newest and most innovative medicinal approaches is cell therapy. Several clinical trials and experimental investigations have looked into the feasibility of treating CD-related fistulas with stem cells.
- Trial name
- CHAZAM (NCT05974280)
- Testing
- Alofisel, Fat stem cell
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Relapsed/Refractory Central Nervous System Lymphoma, Relapsed/Refractory Primary Central Nervous System Lymphoma
Autologous CD19-CD20-NKG2D-nsBicephali CAR-T for Relapsed/Refractory Central Nervous System Lymphoma
Central nervous system lymphoma (CNSL) includes primary CNS lymphoma (PCNSL) and secondary CNS lymphoma (SCNSL), with diffuse large B-cell lymphoma as the predominant pathological type.
- Conditions
- Relapsed/Refractory Central Nervous System Lymphoma, Relapsed/Refractory Primary Central Nervous System Lymphoma, Relapsed/Refractory Secondary Central Nervous System Lymphoma
- Trial name
- NCT07555561
- Testing
- Autologous CD19-CD20-NKG2D-nsBicephali CAR-T Cell Injection
- Where
- China
- Sponsor
- Beijing Boren Hospital
Middle Cerebral Artery Infarction, Anterior Cerebral Artery Infarction
Stem Cell Therapy For Acute Ischemic Stroke Patients
The purpose of this study is to determine whether patients with subacute ischemic stroke will benefit from infusion of patient's own bone marrow derived stem cells.
- Trial name
- InVeST (NCT02425670)
- Testing
- BMSCs
- Where
- 5 sites in India
- Volunteers
- 120 people
- Sponsor
- All India Institute of Medical Sciences
Multiple Sclerosis
Autologous Bone Marrow Derived Stem Cells for the Treatment of Multiple Sclerosis.
Until now, there is no effective approach to stop the progression of multiple sclerosis and stimulate re-myelination. Autologous stem cell transplantation shows hope and is quickly developing as an alternative therapy.
- Trial name
- NCT03069170
- Testing
- Stem Cell Transplantation
- Where
- Jordan
- Volunteers
- 50 people
- Sponsor
- Stem Cells Arabia
Unilateral Limbic Insufficiency
Regenerative Medicine in Ocular Surface: Application of Cell Therapy for Ocular Surface Repair Using Progenitor Cells of Sclerocorneal Limbus Amplified ex Vivo
Progenitor limbo sclerocorneal cells have properties of proliferation and differentiation to corneal and conjunctival epithelium.
- Trial name
- MeRSO09 (NCT01470573)
- Testing
- biological replacement corneal surface
- Where
- 3 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Type 2 Diabetes Mellitus
Tissue Distribution of F18-FDG Labelled Autologous Bone Marrow Derived Stem Cells in Patients With Type 2 DM
Investigators purpose is to track stem cells in vivo in the type 2 diabetes mellitus patients after the same have been labelled with positron emission tomography tracer F18-FDG; as it is assumed that the therapeutic outcome will…
- Trial name
- NCT01694173
- Testing
- Stem cell therapy- SPD artery, Stem cell therapy- splenic artery, Stem cell therapy-intravenous
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Infertility, Asherman Syndrome
Treatment of Severe Asherman Syndrome by Collagen Scaffold Loaded With Autologous Bone Marrow Mononuclear Cells
This study evaluates the addition of collagen scaffold loaded with autologous bone marrow mononuclear cells(ABMNC) to Foley catheter balloon after hysteroscopic adhesiolysis in the treatment of severe asherman syndrome.
- Trial name
- NCT02680366
- Testing
- collagen/ABMNC scaffold, Foley catheter balloon
- Where
- China
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Guided Bone Regeneration
A Phase I Study of SB Cell for the Enhanced Osseointegration of Guided Bone Regeneration in Implant Surgery
This is a Phase 1 study to evaluate the safety profile of autologous-derived SB cells to enhance osseointegration of GBR in patients undergoing dental implant surgery.
- Trial name
- NCT04451486
- Testing
- SB cells
- Where
- Taiwan
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Leukemia, Acute Lymphoblastic Leukemia
Precursor B Cell Acute Lymphoblastic Leukemia (B-ALL) Treated With Autologous T Cells Genetically Targeted to the B Cell Specific Antigen CD19
This study is an investigational approach that uses immune cells, called "T cells", to kill leukemia. These T cells are removed from blood, modified in a laboratory, and then put back in the body.
- Trial name
- NCT01044069
- Testing
- gene-modified T cells targeted
- Where
- United States
- Volunteers
- 93 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer, Reconstructive Surgery
AFT: Introduction of a Full Breast Reconstructive Method
A multicentre prospective cohort study will monitor the efficacy and safety of Autologous Fat Transfer (AFT) with pre-expansion.
- Conditions
- Breast Cancer, Reconstructive Surgery, Breast Reconstruction
- Trial name
- BREAST-II (NCT04261829)
- Testing
- Autologous Fat Transfer
- Where
- 8 sites in Netherlands
- Volunteers
- 350 people
- Sponsor
- Maastricht University Medical Center
Bone Augmentation, Bone Loss, Alveolar
Evaluation of a Novel Horizontal Ridge Augmentation Technique in Dentistry
This case series aimed to assess the efficacy of a novel horizontal ridge augmentation modality using histomorphometry and Raman spectroscopy.
- Trial name
- NCT05612737
- Testing
- Horizontal bone augmentation
- Where
- Hungary
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Gaucher's Disease
Phase I Study of Retrovirally Mediated Transfer of the Human Glucocerebrosidase Gene Into Peripheral Blood Stem Cells for Autologous Transplantation in Patients With Type I Gaucher Disease
OBJECTIVES: I. Transfer the human glucocerebrosidase (GC) gene into peripheral blood stem cells (PBSC) obtained from patients with type I Gaucher disease using a retroviral vector. II.
- Trial name
- NCT00004294
- Testing
- human glucocerebrosidase gene into autologous peripheral blood stem cells
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Center for Research Resources (NCRR)
Type 1 Diabetes Mellitus
Autologous Hematopoietic Stem Cell Transplantation for Early Onset Type 1 Diabetes
This is a phase II trial in individuals who have been diagnosed with type 1 diabetes within the previous 6 months. The study is evaluating whether stem cell transplantation is safe when chemotherapy and immunotherapy are used in…
- Trial name
- NCT00807651
- Testing
- AHSCT, Insulin therapy
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Vitiligo
Study of Applications of Autologous Epidermal Cells in Liquid Phase in the Treatment of Vitiligo
Vitiligo is a depigmenting skin disease common. Vitiligo is caused by the disappearance of melanocytes in the epidermis. Vitiligo is the cause of disfigurement, psychological and social, that sounds a lot about the quality of…
- Trial name
- Viticell (NCT01511965)
- Testing
- autologous (cellular therapy)
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Relapsed or Refractory Diffuse Large B Cell Lymphoma (DLBCL)
Study Investigating the Safety and Efficacy of Blinatumomab in Combination With Pembrolizumab in Adults With Relapsed or Refractory Diffuse Large B Cell Lymphoma (DLBCL)
The primary objective of the study is to determine the maximum tolerated dose (MTD) of blinatumomab in combination with pembrolizumab in adults with relapsed or refractory (r/r) DLBCL.
- Trial name
- HARBOUR (NCT03340766)
- Testing
- Blinatumomab, Pembrolizumab
- Where
- 22 sites in United States, Australia and 4 more
- Volunteers
- 31 people
- Sponsor
- Amgen
Stroke, Ischemic
The STem Cell Application Researches and Trials In NeuroloGy-2 (STARTING-2) Study
The objectives of this study was to test hypothesis that ischemic stroke patients having moderate to severe persistent neurologic deficit will have better outcomes with intravenous transplantation of autologous mesenchymal stem…
- Trial name
- STARTING-2 (NCT01716481)
- Testing
- Mesenchymal stem cell
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Samsung Medical Center