Clinical trials: Autologous Transplantation
Hematological Malignancies
An Evaluation of the Effect of 'Open Window' on Psychological Well-being and Experience of Stem Cell Transplantation
The 'Open Window' Study is a prospective longitudinal study using a 4 group randomised control trial design to evaluate the psychological effect of 'Open Window' on the consequences of long term isolation on patients undergoing…
- Trial name
- NCT00348959
- Testing
- 'Open Window' Project
- Where
- Ireland
- Volunteers
- 198 people
- Sponsor
- St. James's Hospital, Ireland
Leukemia, Lymphocytic, Acute, B-Cell, Leukemia, Lymphocytic, Chronic, B-Cell
CART19 Cells Treatment of MRD of B Cell Malignancies and Then Auto-HSCT
The clinical study of CART19 Cells treatment for MRD of B Cell Malignancies and then auto-HSCT
- Conditions
- Leukemia, Lymphocytic, Acute, B-Cell, Leukemia, Lymphocytic, Chronic, B-Cell, Lymphoma, B-Cell
- Trial name
- NCT03685786
- Testing
- CART19 cell and auto-HSCT
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen Second People's Hospital
Lymphoma, B-Cell, Autologous Stem Cell Transplantation
Clinical Study of CAR-T Cell Therapy Following ASCT for R/R B-cell Non-Hodgkin's Lymphoma
The study is designed to evaluate the efficacy and safety of chimeric antigen receptor T-cell therapy following autologous stem cell transplantation for relapsed/refractory B-cell Non-Hodgkin's lymphoma.
- Trial name
- NCT06381830
- Testing
- Apheresis, Autologous Stem Cell Transplantation, CAR-T Cell Therapy
- Where
- China
- Volunteers
- 8 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Multiple Myeloma
Prospective Evaluation of Taste Function In Multiple Myeloma Patients Undergoing Autologous Hematopoietic Cell Transplantation
The purpose of this study is to study taste disturbances on patients with myeloma who received high dose melphalan.
- Trial name
- NCT03276481
- Testing
- Oral microbiota assessment, Comprehensive chemical gustometry, Measurement of salivary flow
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Multiple Myeloma
Multiple Myeloma Outcomes Based on Maintenance Therapy Post Autologous Stem Cell Transplant
The purpose of the study is to determine outcomes for Multiple Myeloma patients on maintenance single agent vs. doublet (IMiD + PI) combination chemotherapy post Autologous Stem Cell Transplant (ASCT).
- Trial name
- NCT05271630
- Testing
- Autologous Stem Cell Transplant, Immunomodulatory Agent, Proteasome Inhibitor
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Chronic Lymphocytic Leukemia
Reduced Intensity Stem Cell Transplantation for Chronic Lymphocytic Leukemia Followed by Vaccination
The purpose of this research study is to assess the safety and immune activity of a vaccine made from the participant's own cancer cells, when administered after a reduced intensity transplant.
- Trial name
- NCT00442130
- Testing
- GM-K562 vaccine, stem cell transplantation
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Dana-Farber Cancer Institute
Spinal Deformity, Spinal Instability
RCT of AttraX® Putty vs. Autograft in Instrumented Posterolateral Spinal Fusion
The purpose of this study is to demonstrate the non-inferiority of AttraX® Putty as a bone graft substitute for autograft in instrumented posterolateral fusion of the thoracolumbar spine, in terms of efficacy and safety.
- Conditions
- Spinal Deformity, Spinal Instability, Instrumented Spinal Fusion
- Trial name
- AxA (NCT01982045)
- Testing
- AttraX® Putty, Autologous bone graft
- Where
- 4 sites in Netherlands
- Volunteers
- 100 people
- Sponsor
- UMC Utrecht
Autografts, Blood Flow Restriction Therapy
Blood Flow Restriction Following ACLR w/Quad Autograft
This project is intended to acquire objective measurements of implementing BFR rehabilitation in ACL reconstructions to show any changes upon completion of the BFR protocol.
- Conditions
- Autografts, Blood Flow Restriction Therapy, Rehabilitation Outcome, Quadriceps Muscle Strength
- Trial name
- BFR Quad Delay (NCT06636045)
- Testing
- Not applicable- observational study
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
B-Cell Non-Hodgkin Lymphoma, Hematopoietic and Lymphoid Cell Neoplasm
Lenalidomide and Ipilimumab After Stem Cell Transplant in Treating Patients With Hematologic or Lymphoid Malignancies
This pilot clinical trial studies the side effects of lenalidomide and ipilimumab after stem cell transplant in treating patients with hematologic or lymphoid malignancies.
- Conditions
- B-Cell Non-Hodgkin Lymphoma, Hematopoietic and Lymphoid Cell Neoplasm, Leukemia, Lymphoma
- Trial name
- NCT01919619
- Testing
- Ipilimumab, Lenalidomide
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Myeloma, Amyloidosis
Vinorelbine and Gemcitabine in Myeloma
The purpose of this study is to determine whether the efficacy of gemcitabine is comparable with the efficacy of the standard chemotherapy with vinorelbine for mobilization of autologous stem cells in myeloma patients
- Trial name
- ViGeM (NCT02791373)
- Testing
- Vinorelbine, Gemcitabine
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Neutropenia, Fungal Disease
Micafungin Prevention Study for Invasive Fungal Disease in Pediatric & Adolescent Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation
This study is to evaluate safety and prophylaxis effect of micafungin after hematopoietic stem cell transplantation. Micafungin is administered until confirmation of neutrophil engraftment or treatment failure.
- Trial name
- NCT01417169
- Testing
- micafungin
- Where
- South Korea
- Volunteers
- 112 people
- Sponsor
- Seoul National University Hospital
Liver Cirrhosis
Bone Mesenchymal Stem Cell (BMSC) Transplantation in Liver Cirrhosis Via Portal Vein
The objective of this study is to evaluate the therapeutic efficacy of autologous bone marrow mesenchymal stem cells (BMSCs) transplantation via portal vein in patients with early and middle stage of liver cirrhosis on the basis…
- Trial name
- NCT00993941
- Testing
- Autologous BMSCs transplantation, Conserved therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Refractory Multiple Myeloma, Stage I Multiple Myeloma
Melphalan and Stem Cell Transplant Before Total-Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Stage I-III Multiple Myeloma
In this study donor bone marrow transplantation is divided into a two step process to try to significantly reduce the side effects of the procedure yet still provide patients with multiple myeloma the benefits of this procedure
- Conditions
- Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT00003954
- Testing
- melphalan, autologous hematopoietic stem cell transplantation, autologous bone marrow transplantation
- Where
- 4 sites in United States, Italy
- Volunteers
- 40 people
- Sponsor
- Fred Hutchinson Cancer Center
Spinal Cord Injury
Evaluation of Autologous Mesenchymal Stem Cell Transplantation in Chronic Spinal Cord Injury: a Pilot Study
The purpose of this study is to analyze the safety and efficacy of mesenchymal stem cell transplantation through percutaneous injection in patients with chronic spinal cord injury.
- Trial name
- NCT02152657
- Testing
- Mesenchymal stem cell transplantation
- Where
- Brazil
- Volunteers
- 5 people
- Sponsor
- Hospital Sao Rafael
Autologous Hematopoietic Stem Cell Transplant Recipient, Loss of Chromosome 17p
Bortezomib, Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in Treating Patients Undergoing Donor Peripheral Blood Stem Cell Transplant For High-Risk Stage I or II Multiple Myeloma
RATIONALE: Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving chemotherapy drugs, such as fludarabine phosphate and melphalan, and total marrow irradiation before a donor…
- Conditions
- Autologous Hematopoietic Stem Cell Transplant Recipient, Loss of Chromosome 17p, Plasma Cell Leukemia, Recurrent Plasma Cell Myeloma
- Trial name
- NCT01163357
- Testing
- bortezomib, fludarabine phosphate, melphalan
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- City of Hope Medical Center
Extranodal NK/T-cell Lymphoma
BRIDGE-NK: Immunotherapy Versus Chemotherapy Induction Followed by Autologous HSCT in Advanced NKTCL
This is a randomized, open-label, prospective, multicenter phase III superiority study in patients with newly diagnosed stage IV extranodal NK/T-cell lymphoma.
- Trial name
- BRIDGE-NK (NCT07678229)
- Testing
- GELAD regimen, MEDA regimen, LEAP regimen
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Rong Tao
Acute Myelogenous Leukemia
A Risk-Oriented Therapeutic Strategy for Adult Acute Myelogenous Leukemia
The study was set up to assess: 1. A two-step, increasing-intensity remission induction phase. A conventional chemotherapy course (ICE, plus G-CSF) was followed, in unresponsive patients, by sequential high-dose cytarabine (plus…
- Trial name
- NCT00400673
- Testing
- Two-step remission induction and risk-oriented consolidation
- Where
- 12 sites in Italy
- Volunteers
- 581 people
- Sponsor
- Northern Italy Leukemia Group
Renal Transplant Rejection
Induction Therapy With Autologous Mesenchymal Stem Cells for Kidney Allografts
The goal of this study is to evaluate autologous MSCs as an alternative for antibody induction therapy in renal transplantation.
- Trial name
- NCT00658073
- Testing
- Kidney transplantation with MSCs infusion, kidney transplantation without MSC infusion
- Where
- China
- Volunteers
- 165 people
- Sponsor
- Fuzhou General Hospital
Multiple Myeloma
Study in Myeloma Patients Newly Diagnosed Treated as an Induction With Velcade-Dex or Velcade (Bortezomib) Thalidomide Dexamethasone (VTD)
Primary objective: Compare the complete remission (CR) rates (i.e., the true CR, with negative immunofixation) achieved with either four courses of VD or four courses of VTD.
- Trial name
- NCT00910897
- Testing
- Velcade-Dexamethasone, Velcade-Thalidomide-Dexamethasone
- Where
- 56 sites in Belgium, France
- Volunteers
- 205 people
- Sponsor
- Intergroupe Francophone du Myelome
Breast Cancer, Chronic Myeloproliferative Disorders
Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer
RATIONALE: Biological therapies use different ways to stimulate the immune system and stop cancer cells from growing. Combining chemotherapy and peripheral stem cell transplantation with biological therapy may kill more cancer…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Kidney Cancer
- Trial name
- NCT00003408
- Testing
- aldesleukin, recombinant interferon alfa, sargramostim
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Cancer Treatment Centers of America
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