Clinical trials: Autologous Transplantation
Anterior Cruciate Ligament Tear, Ankle Sprains
Effect of ACL Reconstruction in Biomechanical Properties of Ankle Joint Complex
BACKGROUND: Anterior cruciate ligament (ACL) is an important ligamentous structure in the knee joint which contributes in maintaining stability.
- Trial name
- NCT06631690
- Testing
- Isokinetic and functional balance tests
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Articular Cartilage Lesion of the Femoral Condyle
Autologous Mesenchymal Stem Cells vs. Chondrocytes for the Repair of Chondral Knee Defects
The objective of our study is to compare the safety and effectiveness of the use of autologous cultured adipose tissue-derived stem cells versus cultured autologous chondrocytes for the treatment of chondral knee lesions.
- Trial name
- ASCROD (NCT01399749)
- Testing
- Implantation of autologous cells
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario la Paz
Autologous Stem Cell Transplantation
NOX-A12 First-in-human (FIH) Study
This is the first time NOX-A12 will be administered to man. The principal aim of this study is to obtain safety and tolerability data when NOX-A12 is administered by single intravenous (IV) doses to healthy male and female…
- Trial name
- NCT00976378
- Testing
- NOX-A12
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- TME Pharma AG
Myeloma
Repeated HBO Therapy in Myeloma Patients Undergoing High-Dose Therapy and Auto-HCT
Subjects with multiple myeloma (MM) who are considered eligible for high-dose therapy and autologous stem cell transplantation by the transplant team at WCI will be enrolled in the study.
- Trial name
- NCT04862676
- Testing
- Hyperbaric oxygen
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Rochester
Ovarian Cancer
Combination Chemotherapy and Bone Marrow Transplant in Treating Patients With Refractory or Recurrent Ovarian Cancer
RATIONALE: Drugs used in chemotherapy, such as cyclophosphamide, carboplatin, and mitoxantrone, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00002474
- Testing
- carboplatin, cyclophosphamide, mitoxantrone hydrochloride
- Where
- United States
- Sponsor
- Loyola University
Non Segmental Vitiligo
Transplantation of Autologous Non-Cultured Extracted Hair Follicle Outer Root Sheath Cell Suspension and Mini Punch Graft for Stable Non-Segmental Vitiligo Lesions
Vitiligo is an acquired pigmentation disorder due to loss of melanocytes characterized by depigmentation macules or patches. One type of this disease is nonsegmental vitiligo (NSV).
- Trial name
- NCT06619184
- Testing
- NCEHFORSCS transplantation, MPG procedure
- Where
- Indonesia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Universitas Padjadjaran
Kidney Transplant Rejection
Autologous Tolerogenic Dendritic Cells (ATDC) for Highly Sensitized Kidney Transplant Recipients
The ATDC-PICI study is a Phase Ib, single-arm, prospective, non-randomized, multicentric trial, to evaluate the safety of ATDC cell product as adjunctive therapy to standard of care (SOC) in highly sensitized kidney transplant…
- Trial name
- ATDC-PICI (NCT06852625)
- Testing
- Autologous Tolerogenic Dendritic Cells
- Where
- 7 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Multiple Myeloma
Anakinra: Safety and Efficacy in the Management of Fever During Neutropenia and Mucositis in ASCT
Oral and intestinal mucositis are major risk factors for the occurrence of fever during neutropenia and bloodstream infections after intensive chemo- and radiotherapy.
- Trial name
- AFFECT-1 (NCT03233776)
- Testing
- Anakinra
- Where
- Netherlands
- Volunteers
- 9 people
- Sponsor
- Radboud University Medical Center
Liver Cirrhosis
Bone Mesenchymal Stem Cell (BMSC) Transplantation in Liver Cirrhosis Via Portal Vein
The objective of this study is to evaluate the therapeutic efficacy of autologous bone marrow mesenchymal stem cells (BMSCs) transplantation via portal vein in patients with early and middle stage of liver cirrhosis on the basis…
- Trial name
- NCT00993941
- Testing
- Autologous BMSCs transplantation, Conserved therapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sun Yat-sen University
Leukemia, Lymphoma
Peripheral Stem Cell Transplantation Plus Combination Chemotherapy in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses…
- Trial name
- NCT00003402
- Testing
- carmustine, cisplatin, cyclophosphamide
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Maryland, Baltimore
Hodgkin Lymphoma
Pembrolizumab and Brentuximab Vedotin vs GDP and Stem Cell Transplant for Relapsed/Refractory Hodgkin Lymphoma
This study is being done to determine if two new drugs can shrink or eliminate classical Hodgkins lymphoma.
- Trial name
- NCT05180097
- Testing
- Gemcitabine, Dexamethasone, Cisplatin
- Where
- 18 sites in Australia, Canada
- Volunteers
- 84 people
- Sponsor
- Canadian Cancer Trials Group
B-ALL
The Use of Blinatumomab in Patients With NGS-MRD Relapsed B-ALL After Autologous/Allogeneic Transplantation
To explore the efficacy and safety ofblinatumomab± TKI in B-ALL patients aged ≥ 14 years with NGS-MRD relapse (sensitivity: 10-6) after auto/allo HSCT, and to observe the disease-free survival (DFS), recurrence rate and toxicity…
- Trial name
- NCT06504186
- Testing
- Blinatumomab
- Volunteers
- 20 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Type1diabetes
Infusion of Autologous T Regulatory Cells (T Reg) at the Time of Transplantation of Allogenic Islets of Langerhans
Open single armed study to investigate safety and feasibility of administrating autologous T regulatory cells at the time of allogenic islet transplantation.
- Trial name
- NCT04820270
- Testing
- Autologous T regulatory cells
- Where
- 2 sites in Sweden
- Volunteers
- 8 people
- Sponsor
- The Nordic Network For Clinical Islet Transplantation
Myasthenia Gravis
Hematopoietic Stem Cell Therapy for Patients With Refractory Myasthenia Gravis
MG may be neonatal, congenital, or autoimmune. Neonatal MG arises from transplacental transfer of ACh receptor antibodies from a mother with autoimmune MG to the fetus.
- Trial name
- NCT00424489
- Testing
- Hematopoietic Stem Cell Transplantation, Cyclophosphamide, ATG (rabbit)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwestern University
Allogeneic Hematopoietic Stem Cell
Autologous Fecal Microbiota Transplantation (Auto-FMT) for Prophylaxis of Clostridium Difficile Infection in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation
The purpose of this study is to see if fecal microbiota transplantation (FMT) will prevent the future development of CDI. This is also known as fecal bacteriotherapy or stool transplant.
- Trial name
- NCT02269150
- Testing
- fecal microbiota transplantation (FMT), No fecal microbiota transplantation (FMT), routine management
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Ovarian Cancer
Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Persistent or Platinum Refractory Stage III or IV Ovarian Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003080
- Testing
- endocrine-modulating drug therapy, melphalan, mitoxantrone hydrochloride
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Leukemia, Lymphoma
Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and busulfan, before a donor bone marrow or peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma, Plasma Cell Neoplasm
- Trial name
- NCT00053196
- Testing
- anti-thymocyte globulin, G-CSF, busulfan
- Where
- 12 sites in United States
- Volunteers
- 82 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Multiple Myeloma, Non-eligible for Autologous Stem Cell Transplantation (ASCT)
Evaluation of Maintenance With Bortezomib Plus Daratumumab (V-Dara) After Induction With Bortezomib, Melphalan, Prednisone Plus Daratumumab (VMP-Dara) in Newly Diagnosed Multiple Myeloma (MM) Patients Non-eligible for autoSCT
This is a prospective, observational, single group and multicenter study to describe the effectiveness and safety of maintenance with V-Dara after induction with the VMP-Dara regimen in newly diagnosed MM patients who are not…
- Trial name
- NCT05218603
- Testing
- Bortezomib, Daratumumab
- Where
- 32 sites in Spain
- Volunteers
- 100 people
- Sponsor
- PETHEMA Foundation
Vitiligo
Efficacy of Autologous Outer-Root-Sheath Melanocytes Transplantation in the Treatment of Vitiligo
The purpose of this study is to evaluate the hypothesis that, in patients with stable vitiligo unresponsive to conventional treatments including traditional phototherapy and/or topical steroids, the application of a non-cultured…
- Trial name
- NCT01923142
- Testing
- Outer-Root-Sheath Melanocytes Suspension
- Where
- 2 sites in Italy
- Volunteers
- 4 people
- Sponsor
- Centro Studi Gised
Dystrophy
Intramuscular Transplantation of Muscle Derived Stem Cell and Adipose Derived Mesenchymal Stem Cells in Patients With Facioscapulohumeral Dystrophy (FSHD)
Facioscapulohumeral Dystrophy is a Autosomal dominant inherited dystrophy with the prevalence of 1:20,000 and it is the third most common dystrophy after the dystrophinopathies and myotonic dystrophy.
- Trial name
- NCT02208713
- Testing
- Intramuscular injection
- Where
- Iran
- Volunteers
- 21 people
- Sponsor
- Royan Institute
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