Clinical trials: Autologous Transplantation
ACL Deficient Knee
ACLR: Isolated Autograft vs Allograft With Lateral Extra-articular Tenodesis
This study seeks to evaluate the utility of non-irradiated allograft tissue with lateral extra-articular tenodesis (LET) in the setting of anterior cruciate ligament reconstruction (ACLR).
- Trial name
- NCT06668155
- Testing
- Autograft Group, Allograft with LET Group
- Volunteers
- 60 people
- Sponsor
- University of Alabama at Birmingham
Peripheral T-cell Lymphoma (Not Otherwise Specified), Angioimmunoblastic T-cell Lymphoma
Study of Bortezomib and Panobinostat in Treating Patients With Relapsed/Refractory Peripheral T-cell Lymphoma or NK/T-cell Lymphoma
The purpose of this study is to determine whether intravenous Bortezomib combined with oral Panobinostat (LBH589) are effective in treating adult patients with relapsed/refractory peripheral T-cell lymphoma or NK/T-cell lymphoma…
- Conditions
- Peripheral T-cell Lymphoma (Not Otherwise Specified), Angioimmunoblastic T-cell Lymphoma, Extranodal NK/T-cell Lymphoma Nasal Type, Enteropathy- Type T-cell Lymphoma
- Trial name
- NCT00901147
- Testing
- panobinostat and bortezomib
- Where
- 5 sites in Malaysia, Singapore and 1 more
- Volunteers
- 25 people
- Sponsor
- Singapore General Hospital
Hematologic Diseases
A Study Evaluating the Safety and Efficacy of the BD211 Drug Product in β-Thalassemia Major Participants
This is a Phase 1,open label,safety,and efficacy study in subjects with non-β0/β0 TDT β-thalassemia Major by transplanting BD211 drug product which is for autologous use only,via a single IV administration.
- Trial name
- NCT05015920
- Testing
- BD211 Drug Product
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Shanghai BDgene Co., Ltd.
Ischemic Stroke
Autologous Bone Marrow Mesenchymal Stem Cells (BMSCs) Transplantation in the Treatment of Ischemic Stroke
This study is to evaluated the safety and efficacy of BMSCs transplantation in the treatment of ischemic stroke, so as to provide a basis for future clinical application of BMSCs transplantation in the treatment of ischemic…
- Trial name
- NCT05850208
- Testing
- Transplantation of self BMSCs
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Dilated Cardiomyopathy
Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy
Several studies have documented that transplantation of bone marrow-derived cells (BMC) following acute myocardial infarction is associated with a reduction in infarct scar size and improvements in left ventricular function and…
- Trial name
- NCT00629018
- Testing
- CD34+ autologous stem cell transplantation, Bone Marrow Stimulation, SC therapy
- Where
- Slovenia
- Volunteers
- 110 people
- Sponsor
- University Medical Centre Ljubljana
Multiple Myeloma, Plasma Cell Dyscrasia
Plerixafor Harvesting And No Chemotherapy for Transplantation of Autologous STem Cells In Cancer (PHANTASTIC)
To assess the efficacy and toxicity of plerixafor (AMD 3100) together with granulocyte-colony stimulating factor (G-CSF) for stem cell mobilisation, in patients with myeloma or lymphoma requiring high dose chemotherapy with stem…
- Conditions
- Multiple Myeloma, Plasma Cell Dyscrasia, Lymphoma, Lymphoproliferative Disorders
- Trial name
- PHANTASTIC (NCT01186224)
- Testing
- Plerixafor and G-CSF
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Liverpool
Malignant Lymphoma
TEAM (Thiotepa, Etoposide, Cytosar, Melphalan ) for AutoSCT in Lymphoma
Study is designed to explore whether the introduction of Thiotepa, to the pre autologous stem-cell transplantation (ASCT) conditioning will reduce toxicity and thus improve outcome following transplantation in up to 24 patients…
- Trial name
- TEAM (NCT03346096)
- Testing
- Thiotepa
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Sheba Medical Center
Acute Anterior Wall Myocardial Infarction
Autologous Stem Cell Transplantation in Acute Myocardial Infarction
Objectives Intracoronary transplantation of different cell populations have been used in acute myocardial infarction (AMI) with promising results.
- Trial name
- NCT00199823
- Testing
- Intracoronary aotologous stem cell transplantation
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Oslo University Hospital
Follicular Lymphoma
High-Dose Therapy Treatment in Patients With Follicular Lymphoma
Follicular lymphomas are a subgroup of B-cell non-Hodgkin lymphomas, accounting for 15% to 30% of newly diagnosed lymphomas.1-3 Median survival varies from 5 to 10 years depending on the prognostic factors at diagnosis and…
- Trial name
- NCT00696735
- Testing
- chemotherapy, high dose therapy and autologous stem cell transplantation
- Where
- 2 sites in France
- Volunteers
- 172 people
- Sponsor
- French Innovative Leukemia Organisation
Multiple Myeloma
COMbination Regimens in MM Post AHCT to elimiNate MRD Utilizing IbERdomide
Similar to the paradigm established in other hematologic malignancies that are considered curable, the achievement of MRD(-) status is necessary for long term disease control in MM.
- Trial name
- COMMANDER (NCT05434689)
- Testing
- Iberdomide, Daratumumab, Dexamethasone
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Autoimmune Diseases
EBMT ADWP Prospective Non Interventional Study : AutoHSCT in SSc Patients
The purpose of this study is to assess the effectiveness of Autologous Hematopoietic Stem Cell transplantation (AHSCT) for early severe or rapidly progressive Systemic Sclerosis (SSc) as currently performed by different study…
- Trial name
- NISSC (NCT02516124)
- Testing
- Autologous HSCT
- Where
- France
- Volunteers
- 82 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Multiple Myeloma, Renal Failure
High Dose Therapy Followed by Autologous Transplantation for Myeloma Patients With Severe Renal Impairment
Multiple myeloma (MM) is a malignant plasma cell disorder, characterized by the presence of more than 10 % of clonal plasma cells in the bone marrow.
- Trial name
- IRMYG (NCT03234335)
- Testing
- Data collection
- Where
- 33 sites in Algeria, Belgium and 2 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Metatarsophalangeal Joint Arthritis
Synthetic Cartilage Implant vs Osteochondral Autograft Transfer for Advanced 1st Metatarsal Phalangeal Joint Arthritis
This is a prospective, randomized, controlled clinical trial comparing synthetic cartilage implantation versus osteochondral autograft transfer for treatment of first metatarsophalangeal (MTP) arthritis.
- Trial name
- NCT03489876
- Testing
- Synthetic Cartilage Implant, Osteochondral Autograft Transfer
- Sponsor
- University of Oklahoma
Pseudoarthrosis
Humeral Shaft Pseudoarthrosis Treated With Bone Autograft Versus Platelet Rich Plasma
Patients with humeral shaft pseudoarthrosis is going to be treated with a standard protocol with a locking compression plate and bone autograft, and other group of patients treated with platelet rich plasma.
- Trial name
- NCT02520089
- Testing
- bone autograft of iliac crest, Platelet Rich Plasma plus bone autograft
- Where
- Mexico
- Volunteers
- 23 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Metabolic Disease, Amyotrophy
Clinical Safety Evaluation and Preliminary Efficacy Study of Subcutaneous Myografts Transplantation
This study aims to apply autologous differentiated myocyte subcutaneous transplantation in patients with muscle atrophy to explore its safety, feasibility, and efficacy.
- Trial name
- NCT07426068
- Testing
- Autologous differentiated myocyte transplantation
- Where
- 2 sites in China
- Volunteers
- 6 people
- Sponsor
- National Clinical Research Center for Orthopedics, Sports Medicine and Rehabilitation, China
Central Nervous System Lymphoma
Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma
This is a multicenter open label randomized phase II trial. Enrolled Primary Central Nervous System Lymphoma (PCNSL) patients will be stratified according to the IELSG score and randomized to receive one of the follows as primary…
- Trial name
- NCT01011920
- Testing
- Methotrexate, Ara-C, Rituximab
- Where
- 54 sites in Denmark, Germany and 3 more
- Volunteers
- 227 people
- Sponsor
- International Extranodal Lymphoma Study Group (IELSG)
Hodgkin Lymphoma, Non Hodgkin Lymphoma
A Study of the Effects of AB-205 in Patients With Lymphoma Undergoing Autologous Hematopoietic Cell Transplantation
High-dose chemotherapy followed by blood stem cell transplantation is administered to lymphoma patients with an intention to cure.
- Trial name
- E-CELERATE (NCT05181540)
- Testing
- AB-205
- Where
- 28 sites in United States
- Volunteers
- 130 people
- Sponsor
- Angiocrine Bioscience
Diabetic Foot Ulcer
Cellular Reprogramming-Enhanced Skin Grafting for Diabetic Foot Ulcers
Diabetic foot ulcer is one of the refractory wounds and always poses many challenges in clinical practice. This study was conducted to have a prospective, randomised, controlled study compare the safety and efficacy of the…
- Trial name
- CREST-DFU (NCT02070835)
- Testing
- autologous skin cell, skin graft
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Hu Zhicheng
Liver Failure, Mesenchymal Stem Cells
Therapeutic Effects of Liver Failure Patients Caused by Chronic Hepatitis B After Autologous MSCs Transplantation
The study aimed to investigate the short-term efficacy and long-term prognosis of liver failure patients caused by hepatitis B after single transplantation with autologous marrow mesenchymal stem cells (MMSCs).
- Trial name
- NCT00956891
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Sun Yat-sen University
Lymphoma
Maintenance Lenalidomide in Lymphoma
This study is being conducted to evaluate the overall safety of lenalidomide (also known as Revlimid) in patients with lymphoma, and to determine whether it is effective in preventing this disease from returning after stem cell…
- Trial name
- NCT01575860
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.