Clinical trials: Autonomic Dysfunction, open to volunteers
Multiple System Atrophy, Parkinsons Disease
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
This phase I double-blind study focuses on the safety and feasibility of implanting autologous peripheral nerve tissue (PNT) into the substantia nigra area of the brain in persons who have been diagnosed with either Parkinson's…
- Trial name
- LEAP (NCT06683365)
- Testing
- Sural Nerve Graft to the Substantia Nigra
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Craig van Horne, MD, PhD
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Type I Complex Regional Pain Syndrome
Non Invasive Neurostimulation Technology for the Treatment of Type I Complex Regional Pain Syndrome (CRPS I)
Complex Regional Pain Syndrome (CRPS) / Complex Regional Pain Syndrome (CRPS) is a chronic neurological disorder that affects the extremities and is characterized by disabling pain, swelling, vasomotor instability, sudomotor…
- Trial name
- NCT05052736
- Testing
- Non-invasive Neuromodulation
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Las Palmas de Gran Canaria
Complex Regional Pain Syndrome Type I
Evaluation of IV AMBTX-01 (Neridronate) for Treatment of CRPS Type 1 (CRPS-RISE)
Phase 3 Trial of AMBTX-01 (neridronate) for Complex Regional Pain Syndrome Type 1
- Trial name
- CRPS-RISE (NCT07210515)
- Testing
- Neridronate
- Where
- 33 sites in United States
- Volunteers
- 270 people
- Sponsor
- Ambros Therapeutics, Inc.
Insomnia, Insomnia Chronic
SHADES Mechanistic Trial
Cardiovascular disease (CVD) is common, deadly, and costly, and adults with insomnia represent a large group of people at elevated risk of developing CVD in the future.
- Conditions
- Insomnia, Insomnia Chronic, Insomnia, Primary, Sleep Disturbance
- Trial name
- SHADES (NCT06041581)
- Testing
- Sleep Healthy Using The Internet (SHUTi), Telephonic CBT-I, Face-to-Face CBT-I
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome
Auricular Vagal Nerve Stimulation for Hypermobile Ehlers-Danlos Syndrome
Hypermobile Ehlers-Danlos Syndrome (hEDS) is a connective tissue disorder characterized by hyperextensible skin, joint hypermobility and additional connective tissue manifestations.
- Conditions
- Functional Gastrointestinal Disorders, Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome, Autonomic Nervous System Disease
- Trial name
- NCT05212129
- Testing
- Percutaneous vagal nerve stimulation (pVNS) device, Acoustic vagal nerve stimulation (aVNS) treatment
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Medical College of Wisconsin
Complex Regional Pain Syndromes
Infrared Images for Spinal Cord Stimulation in Complex Regional Pain Syndrome Patients
The goal of this observational study is to compare thermal camera Forward Looking InfraRed (FLIR) images before and after spinal cord stimulation to evaluate the difference in sympathetic activity of the affected limb in patients…
- Trial name
- SCS-FLIR (NCT05777889)
- Testing
- Forward Looking InfraRed Camera
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hospital for Special Surgery, New York
Orthostatic Hypotension, Postprandial Hypotension
Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)
The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments.
- Trial name
- HOPE65 (NCT07485998)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Neuropathy, Muscle Disorders
Data Collection of Standard Care of Patients in the EMG Section
Background: Most people who are referred to the EMG (Electromyography) Section of the NIH are enrolled into specific active studies. This allows researchers to learn about a range of rare neuromuscular disorders.
- Conditions
- Neuropathy, Muscle Disorders, Dysautonomia
- Trial name
- NCT05041387
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy
The Use of the CUE1/CUE1+ in People With Parkinson's Disease and Related Disorders
People with Parkinson's disease (PD) commonly experience a range of both motor (e.g., bradykinesia, rigidity, tremor, and postural instability) and non-motor (e.g., fatigue, psychiatric and behavioural disturbances, autonomic…
- Conditions
- Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Different Types of Tremor Including Essential Tremor, Dystonia
- Trial name
- NCT06174948
- Testing
- CUE1 non-invasive device
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Queen Mary University of London
Psoriatic Arthritis
Transcutaneous Auricular Vagus Nerve Stimulation in Psoriatic Arthritis
This prospective single-center interventional study aims to investigate the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on disease activity, pain, quality of life, autonomic dysfunction symptoms, and…
- Trial name
- NCT07653009
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Marmara University
Parkinson Disease, Orthostatic Hypotension
Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension
Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.
- Trial name
- HYPOPARK (NCT07139756)
- Testing
- Lower body negative pressure
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiac Dysautonomia
Development and Validation of the Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ)
Main aim will be to compare in patients with cardiac dysautonomia, newly developed disease specific questionnaire to established generalized SF-36 and EQ-5d questionnaires, as there are no disease specific questionnaires for…
- Trial name
- NCT06672861
- Testing
- Kansas City Cardiac Dysautonomia Questionnaire (KCDysQ)
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Multiple System Atrophy
Medical Decision Making in Multiple System Atrophy
The goal of this clinical study is to evaluate the effects of a personalized symptomatic treatment plan integrated with monthly telemedicine and mobile palliative care interventions on a population of individuals diagnosed with…
- Trial name
- MeDeMSA (NCT06072105)
- Testing
- Telemedicine visits, Multidisciplinary, personalized symptomatic treatment
- Where
- Austria
- Volunteers
- 92 people
- Sponsor
- Medical University Innsbruck
Distal Radius Fracture, Complex Regional Pain Syndrome Type I
The Effects of Whirlpool and Contrast Bath in Patients with Complex Regional Pain Syndrome After Distal Radius Fracture
The aim of our study is to investigate the effects of whirlpool bath and contrast bath treatments on pain, disability, functionality and grip strength in patients with complex regional pain syndrome after distal radius fracture.
- Conditions
- Distal Radius Fracture, Complex Regional Pain Syndrome Type I, Complex Regional Pain Syndrome
- Trial name
- NCT06769373
- Testing
- Whirlpool Bath, Contrast Bath
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Afyonkarahisar Health Sciences University
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury).
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Trauma, Nervous System, Nervous System Diseases
- Trial name
- SCI (NCT05731986)
- Testing
- Orthostatic challenge, Biostim-5 transcutaneous spinal stimulation - Mapping, Biostim-5 transcutaneous spinal stimulation - "Optimal" testing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Spinal Cord Injuries, Autonomic Dysreflexia
Autonomic Dysreflexia in Spinal Cord Injuries: UDS Filling Speed Impact
In patients with spinal cord injury, the investigators want to understand and understand the differences in AD prevalence and characteristics according to bladder injection rate, and to determine which factors have a greater…
- Conditions
- Spinal Cord Injuries, Autonomic Dysreflexia, UDS Filling Speed
- Trial name
- NCT06211491
- Testing
- Urodynamic test
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Pusan National University Yangsan Hospital
Cardiac Pacemaker, Arrythmia
Aveir DR Real-World Evidence Post-Approval Study
The purpose of this post-approval study is to evaluate the long-term safety of the dual-chamber Aveir DR leadless pacemaker using real-world evidence methods.
- Conditions
- Cardiac Pacemaker, Arrythmia, Bradycardia
- Trial name
- NCT05935007
- Testing
- Aveir DR Leadless Pacemaker System
- Where
- United States
- Volunteers
- 1,805 people
- Sponsor
- Abbott Medical Devices
Syncope, Vasovagal, Bradycardia
National Registry of Cardioneuroablation in Recurrent Reflex Syncope
This registry aims to collect patient data on cardioneuroablation for vasovagal syncope from multiple centers in France. The aim is to evaluate success rates, compare techniques and help institutions set up their own…
- Conditions
- Syncope, Vasovagal, Bradycardia, Heart Arrest
- Trial name
- CANVAS-R (NCT06159764)
- Testing
- Cardioneuroablation
- Where
- 14 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Postural Tachycardia Syndrome
The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity
This study is being to see if participating in breathing exercise training and practicing this training will help with Postural tachycardia syndrome (POTS).
- Trial name
- NCT05618067
- Testing
- breathing exercise training
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Virginia Commonwealth University