Clinical trials: Autonomic Nerve Block
Migraine Disorders
Botox Injection in Treatment of Chronic Migraine
Chronic migraine is in many cases a most disabling condition. Chronic migraine is defined as headaches for at least 15 days per month, of which 8 days have typical migraine features.
- Trial name
- NCT02259075
- Testing
- Botulinum Toxin Type A
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Norwegian University of Science and Technology
Horner's Syndrome
Horner's SD After Thoracic Epidural Block
This study prospectively evaluates the incidence of Horner's syndrome after thoracic epidural anesthesia following continuous thoracic epidural analgesia for mastectomy.
- Trial name
- NCT02130739
- Testing
- thoracic epidural anesthesia, mastectomy, Ropivacaine
- Where
- South Korea
- Volunteers
- 450 people
- Sponsor
- Soonchunhyang University Hospital
Complex Regional Pain Syndrome
Evaluation of the Physiodoloris Pain Monitor in Patients With Complex Regional Pain Syndrome
A French University team (M. Jeanne, MD, and M. LOGIER, Ph D) have developed a pain assessment tool based on the analysis of the variability heart rate which evaluates the Analgesia Nociception Index (ANI).
- Trial name
- ANI-ALGO (NCT02663284)
- Testing
- Ropivacaine 0.5%
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hopital Foch
Visceral Pain, Analgesia
Intraoperative Autonomic Blockade for Laparoscopic Cholecystectomy
This study proposes infiltrating the hepatoduodenal ligament and the serosal reflection of the gallbladder cystic plate with a combination of Bupivacaine (a long-acting local anesthetic) and Dexamethasone (a corticosteroid).
- Conditions
- Visceral Pain, Analgesia, Opioid Use, Postoperative Nausea
- Trial name
- ANB (NCT06753500)
- Testing
- Autonomic neural blockade
- Where
- 2 sites in Colombia
- Volunteers
- 60 people
- Sponsor
- Universidad Simón Bolívar
Cluster Headache
Cluster Headache Cortivazol Injection (CHCI)
the aim of tis study is to demonstrate the efficacy of cortivazol injections at the level of the greater occipital nerve to diminish the frequency of cluster headache (episodic or chronic) attacks during an active period.
- Trial name
- CHCI (NCT00804895)
- Testing
- ALTIM, cortivazol injections, PROAMP, subcutaneous serum physiological saline, Verapamil
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Laparoscopic Sleeve Gastrectomy (LSG)
Combining Dexmedetomidine Infusion and Paragastric Autonomic Neural Block to Enhance Postoperative Recovery in Patients Undergoing Laparoscopic Sleeve Gastrectomy
The goal of this clinical trial is to learn if combining Dexmedetomidine infusion and paragastric autonomic neural block will enhance the postoperative recovery of patients undergoing laparoscopic sleeve gastrectomy.
- Trial name
- NCT06970678
- Testing
- Dexmedetomidine infusion, paragastric autonomic neural block
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Alexandria University
Colorectal Cancer, Colorectal Surgery
Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP)
Effective postoperative pain management is essential for enhanced recovery after laparoscopic colorectal surgery. This randomized, controlled, double-blind trial will compare conventional postoperative analgesia (intravenous…
- Conditions
- Colorectal Cancer, Colorectal Surgery, Anesthesia, Autonomic Nerve Block
- Trial name
- BAPTAP (NCT07388953)
- Testing
- Minimally Invasive Left-Sided Colorectal Resection, BAPTAP (Peripheral Autonomic Blockade + TAP Block), Trocar/Incision Infiltration
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Faculdade de Ciências Médicas de Minas Gerais
Spinal Cord Injuries
Early BOTOX After Spinal Cord Injury
The investigators would like to improve our understanding of how early intervention with the use of bladder chemodenervation can preserve bladder function in those with a new SCI.
- Trial name
- NCT06793683
- Testing
- Bladder chemodenervation (Botox)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Washington
Shoulder Hand Syndrome, Complex Regional Pain Syndromes
Tolerability of Suprascapular and Median Nerve Blocks for the Treatment of Shoulder-hand Syndrome
Shoulder-hand syndrome (SHS) in stroke patients is painful and lowers quality of life. Unfortunately, the cause of SHS is not known, diagnosing SHS can be difficult, and treating it can be hard.
- Trial name
- NCT03291197
- Testing
- Suprascapular and median nerve blocks
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Ottawa Hospital Research Institute
Cluster Headache
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Cluster Headache
Cluster headache is a primary headache condition characterized by clusters of one-sided, high-intensity pain attacks. The headache may be episodic or chronic. Treatment options are limited and their effects unsatisfactory.
- Trial name
- BASIC (NCT03944876)
- Testing
- Botulinum toxin type A
- Where
- 5 sites in Germany, Italy and 3 more
- Volunteers
- 112 people
- Sponsor
- Norwegian University of Science and Technology
Melanoma
Effects of Anti-PD1 Adjuvant Checkpoint Blockade Immunotherapy on Atypical/Dysplastic Nevi
This study will examine the impact of anti-programmed cell death 1 (PD1) therapy given in the approved adjuvant therapeutic regimens upon the morphologic, histopathologic, molecular and immunologic as well as genomic features of…
- Trial name
- NCT06599619
- Testing
- Single agent, adjuvant anti-PD1 therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- John Kirkwood
Cluster Headache
Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues
Cluster headache (CH) is the most common of the trigeminal autonomic cephalalgias and one of the most severe pains known to man, having a large impact on the sufferer's quality of life.
- Trial name
- NCT03066635
- Testing
- Botulinum Toxin Type A 25 IU, Botulinum Toxin Type A 12.5 IU
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Norwegian University of Science and Technology
Autonomic Nervous System, Nerve Block
Heart Rate Variability and Electroencephalography Analysis in Laparoscopic Surgery With or Without Transversus Abdominis Plane Block
Heart rate variability(HRV) and electroencephalography(EEG) has been used widely in anesthetic practice nowadays. One of the most dominant applications is the nociception-analgesia balance.
- Conditions
- Autonomic Nervous System, Nerve Block, Laparoscopy, Anesthesia and Analgesia
- Trial name
- NCT04539080
- Testing
- transversus abdominis plane block
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Autonomic Nerve Block
Sternotomy PIFB Block in Open Heart Surgery
The purpose of this study is to evaluate if the use of a bilateral nerve block with a local anesthetic (ropivacaine), as part of a standard of care pain control regimen (called multimodal analgesia [MMA]), has a favorable effect…
- Trial name
- NCT06233318
- Testing
- Pecto-intercostal Fascial Block with 20 ml of 0.35% ropivacaine, Pecto-intercostal Fascial Block with normal saline
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Ohio State University
Complex Regional Pain Syndrome, Chronic Pain
Spinal Cord Stimulation Versus Nerve Blocks and Physical Therapy
The primary objective of this study is to compare the efficacy of SCS using the Precision implantable neurostimulation device and conventional medical treatment (nerve blocks + physical therapy) in subjects with…
- Conditions
- Complex Regional Pain Syndrome, Chronic Pain, Pain
- Trial name
- NCT00414804
- Testing
- Precision SCS, Nerve Blocks and PT
- Sponsor
- Boston Scientific Corporation
Pain, Acute Post-Operative, Nausea and Vomiting, Postoperative
Catheter Redosing of Autonomic Neural Blockade After Sleeve Gastrectomy
Postoperative visceral pain and autonomic symptoms after laparoscopic sleeve gastrectomy may reappear earlier in selected high-risk patients despite standard intraoperative autonomic neural blockade (ANB).
- Trial name
- NCT07655908
- Testing
- Bupivacaine 0.5% and Dexamethasone via Temporary Catheter
- Volunteers
- 30 people
- Sponsor
- Universidad Simón Bolívar
Complex Regional Pain Syndromes
Feasibility Study of Combined Peripheral Nerve Block and Physiotherapy for CRPS
Chronic pain is a debilitating condition affecting 1 in 5 Canadians with a yearly economic cost of over $40 billion in healthcare spending and loss of productivity.
- Trial name
- NCT05589259
- Testing
- Axillary Brachial Plexus Block plus Physiotherapy, Physiotherapy alone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tracy Cupido
Migraine Disorders
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine
This is a clinical trial to assess the efficacy of botox treatment of the sphenopalatine ganglion as an add-on treatment in drug resistant migraine.
- Trial name
- MiBlock (NCT04069897)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Norway
- Volunteers
- 170 people
- Sponsor
- St. Olavs Hospital