Clinical trials: Autonomic Nervous System, open to volunteers
Autonomic Failure, Pure Autonomic Failure
[18F]F-DOPA Imaging in Patients With Autonomic Failure
Alpha-synucleinopathies refer to age-related neurodegenerative and dementing disorders, characterized by the accumulation of alpha-synuclein in neurons and/or glia.
- Conditions
- Autonomic Failure, Pure Autonomic Failure, Parkinson Disease, Multiple System Atrophy
- Trial name
- NCT04246437
- Testing
- [18F]FDOPA, Carbidopa 200mg oral dose, Entacapone 400mg oral dose
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Daniel Claassen
Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D)
Cardiac Morphology and Function in Individuals With Autonomic Dysreflexia
This case-control study aims to investigate left ventricular remodeling in individuals with chronic spinal cord injury or disease (SCI/D) (≥10 years) and autonomic dysreflexia (AD) who have no prior cardiovascular history.
- Conditions
- Autonomic Dysreflexia, Spinal Cord Injuries and Disorders (SCI/D), Cardiac Remodeling
- Trial name
- HEART_REMOD_AD (NCT07456722)
- Where
- Switzerland
- Volunteers
- 48 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Aquired Brain Injury
Retrospective Evaluation of Autonomic Activity Through Electrodermal Activity Measurement During Rehabilitation
Severe acquired brain injury (sABI) is a clinical condition characterised by brain damage severe enough to result in coma, with a worst Glasgow Coma Scale (GCS) score of ≤ 8 during the acute phase and a duration of more than 24…
- Trial name
- EDA-sABI (NCT07835659)
- Testing
- EmbracePlus EDA device
- Volunteers
- 72 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Complex Regional Pain Syndrome, Pain
CSS-SR Validation Study
Complex Regional Pain Syndrome (CRPS) is an orphan condition with no interventions proven effective in large-scale clinical trials.
- Trial name
- NCT06798493
- Testing
- Complex Regional Pain Syndrome (CRPS) Severity Score - Self Report
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Menkes Disease
NORTHERA (DROXIDOPA) for Dysautonomia in Pediatric Survivors of Menkes Disease
This clinical trial will evaluate the safety, tolerability, dosing, and efficacy of Northera (Droxidopa) in children with Menkes disease aged 7 to 17 years who survived the major neurodegenerative and neurocognitive effects of…
- Trial name
- NCT07398508
- Testing
- Droxidopa Oral Product
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stephen G. Kaler
Obstructive Sleep Apnea Syndromes
Fascial Mobilization Along the Vagus Nerve and Its Effects on Acute Physiological Parameters in Obstructive Sleep Apnea
This randomized controlled trial was designed to investigate the effects of fascial mobilization along the course of the vagus nerve on acute physiological parameters in individuals with obstructive sleep apnea syndrome (OSAS).
- Trial name
- NCT07169058
- Testing
- Vagus Nerve Fascial Mobilization
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Mardin Artuklu University
Trigeminal Autonomic Cephalalgias, Cluster Headache
Italian Trigeminal Autonomic Cephalalgias Assessment Study
ITACA is a prospective, multicenter, observational longitudinal cohort study conducted in routine clinical practice at six Italian headache centers.
- Conditions
- Trigeminal Autonomic Cephalalgias, Cluster Headache, Paroxysmal Hemicrania, SUNCT
- Trial name
- ITACA (NCT07812740)
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Autonomic Nervous System Disease, Concussive Injury
Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms
Many combat veterans (c-Vs), service members (SMs) and civilians with mild traumatic brain injury (mTBI, also termed concussion) suffer from persistent post-concussion symptoms (PPCS) that degrade physical and cognitive…
- Conditions
- Autonomic Nervous System Disease, Concussive Injury, Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
- Trial name
- NCT07071350
- Testing
- HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI)
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Virginia Commonwealth University
Healthy Volunteers, fMRI Research
Frequency Effects of Transcutaneous Trigeminal Nerve Stimulation (eTNS) on Brain and Autonomic Function
This study aims to investigate how different frequencies of transcutaneous Trigeminal Nerve Stimulation (eTNS) affect brain activity and the autonomic nervous system in healthy individuals.
- Trial name
- NCT07662291
- Testing
- 2Hz Transcutaneous Trigeminal Nerve Stimulation, 120Hz Transcutaneous Trigeminal Nerve Stimulation
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Xidian University
Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV)
taVNS During Multi-site HRV Measurement: Reliability & Agreement Study
This study examines the reliability and agreement of autonomic nervous system measurements obtained from different anatomical sites during transcutaneous auricular vagus nerve stimulation (taVNS).
- Conditions
- Autonomic Nervous System (ANS) Functioning and Mood State, Heart Rate Variability (HRV), Blood Pressure Monitoring, Transcutaneous Electric Nerve Stimulation
- Trial name
- taVNS-HRV (NCT07548723)
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- SEFA HAKTAN HATIK