Clinical trials: Autonomic Nervous System
Diabetic Peripheral Neuropathy, Diabetes
Diabetes, Falls, and Fractures
Comparing severity of diabetic peripheral neuropathy (small and large fibers including autonomic neuroapthy) to postural control and vestibular measurements
- Conditions
- Diabetic Peripheral Neuropathy, Diabetes, Balance; Distorted, Vestibular Neuropathy
- Trial name
- DIAFALL (NCT05389566)
- Testing
- Quantative Sensory Testing, NCStat-DPN-Check, Composite Autonomic Symptom Score 31
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Acute Coronary Syndrome, Arrhythmia
High-intensity Interval Training in Patients With Post-acute Coronary Syndrome
To date, no studies have evaluated the safety or efficiency (improvement of maximal oxygen uptake [VO2peak]) of a high-intensity interval training (HIIT) program in post-acute coronary syndrome (post-ACS) patients.
- Trial name
- EXIT-IV (NCT03414996)
- Testing
- Exercise training
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Montreal Heart Institute
Long Covid19, Autonomic Dysfunction
Autonomic Nervous System Affection Due to Post Covid Syndrome
Post-Covid syndrome is defined as symptoms that develop in addition to respiratory symptoms in individuals who have had Covid-19 infection for more than 12 weeks.
- Trial name
- NCT05502094
- Testing
- Heart Rate Variability Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Cardiovascular Autonomic Neuropathy
Genetic, Environment and Its Interaction Analysis for Cardiovascular Autonomic Neuropathy
A large-scale, community-based, cross-sectional study was conducted to explore the extent to which genetic, environment and its interactions associated with cardiovascular autonomic neuropathy (CAN) in general Chinese population.
- Trial name
- NCT02461342
- Testing
- not intervention
- Where
- 2 sites in China
- Volunteers
- 2,100 people, healthy volunteers welcome
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Iron-deficiency, Postural Orthostatic Tachycardia Syndrome
Iron Sucrose in Patients With Iron Deficiency and POTS
This study aims to investigate whether the treatment of non-anemic iron deficiency with intravenous iron sucrose will result in decreased symptom reporting and improved cardiovascular indices in patients with Postural Orthostatic…
- Trial name
- NCT04855266
- Testing
- Sucrose, Tilt Table Test
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Complex Regional Pain Syndrome I (CRPS I)
CRPS-Hand: Contrast + Compression vs Whirlpool
This randomized controlled trial aims to evaluate and compare the effectiveness of combined contrast therapy with intermittent compression and whirlpool therapy in patients with post-traumatic CRPS-I of the hand and wrist, using…
- Trial name
- NCT07744269
- Testing
- Combined Contrast Therapy with Intermittent Compression, Whirlpool Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ankara Etlik City Hospital
Reflex Syncope
Implantable Loop Recorder and Cardioneuroblation
The study aims to determine which method of vagal ganglia ablation is most effective in preventing recurrences of reflex asystole syncope.
- Trial name
- ILR-CNA (NCT07162740)
- Testing
- Right atrial ablation, Bi-atrial ablation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Auxologico Italiano
Chronic Obstructive Pulmonary Disease
Effects of Long Acting Bronchodilators on CARDiac Autonomic Control in Chronic Obstructive Pulmonary Disease (COPD)
The aim of this interventional, randomized, double-blind, monocentric, cross-over study is to quantify the possible deleterious effect on the cardiac autonomic nervous system control of two long-acting anticholinergic…
- Trial name
- LAB-Card (NCT02872090)
- Testing
- Indacaterol, Glycopyrronium, Tiotropium
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hypertension, Pure Autonomic Failure
Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension
Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension).
- Conditions
- Hypertension, Pure Autonomic Failure, Multiple System Atrophy, Autonomic Failure
- Trial name
- NCT03042988
- Testing
- Heating pad
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Vanderbilt University Medical Center
Blood Pressure, Orthostatic Hypotension
Effects of Blueberries in Older Adults
This randomized, parallel-design trial will evaluate specific clinical and physiological effects of whole blueberries in adults 70 years of age or older.
- Conditions
- Blood Pressure, Orthostatic Hypotension, Vascular Diseases
- Trial name
- BnD (NCT05358210)
- Testing
- Blueberry Consumption, Dried Date Consumption
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy
Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH)
The purpose of this study is to assess the durability of effect of Droxidopa in treating symptoms of neurogenic orthostatic hypotension in patients with Primary Autonomic Failure (Pure Autonomic Failure, Multiple System Atrophy…
- Conditions
- Neurogenic Orthostatic Hypotension, Non-Diabetic Autonomic Neuropathy, Multiple System Atrophy, Dopamine Beta Hydroxylase Deficiency
- Trial name
- NOH303 (NCT00738062)
- Testing
- Droxidopa
- Where
- 54 sites in United States, Australia and 2 more
- Volunteers
- 103 people
- Sponsor
- Chelsea Therapeutics
Type 2 Diabetes Mellitus
GLP-1 and Hypoglycemia
Low blood sugar can negatively affect how blood vessels function, and this can lead to an increase in the risk for heart attacks, strokes and other problems related to the stiffening and blockage of blood vessels.
- Trial name
- NCT01858896
- Testing
- Glucagon-Like Peptide- 1 (GLP-1) infusion
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Spinal Cord Injuries, Spinal Cord Diseases
Spinal Cord Transcutaneous Stimulation Effect on Blood Pressure in Acute Spinal Cord Injury (SCI)
The goal of this clinical trial is to evaluate the effect of transcutaneous spinal cord stimulation on blood pressure in individuals with an acute spinal cord injury (within 30 days of injury).
- Conditions
- Spinal Cord Injuries, Spinal Cord Diseases, Trauma, Nervous System, Nervous System Diseases
- Trial name
- SCI (NCT05731986)
- Testing
- Orthostatic challenge, Biostim-5 transcutaneous spinal stimulation - Mapping, Biostim-5 transcutaneous spinal stimulation - "Optimal" testing
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Kessler Foundation
Viral Bronchiolitis
Respiratory Physical Therapy on the Cardiac Autonomic Modulation Paediatric Patients
The present study investigated the influence of respiratory affections on the heart rate variability (HRV) of paediatric patients.
- Trial name
- NCT01354561
- Testing
- Respiratory physical therapy
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Postmenopausal Disorder, Autonomic Imbalance
Inspiratory Muscle Training X CardioBreath App Effects On Vagal Modulation And Pulse Wave Velocity
Existing data points to relevant beneficial effects of respiratory exercises on cardiovascular health, with special regards to decreases on arterial pressure and improves on autonomic and vascular profiles, though mechanistics of…
- Conditions
- Postmenopausal Disorder, Autonomic Imbalance, Vascular Stiffness
- Trial name
- CardioBreath (NCT03672760)
- Testing
- CardioBreathApp, IMT PowerBreath
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Osteopathic Manual Manipulation of Neurovascular Regulation
Study of Osteopathic Manipulative Medicine on the Autonomic Nervous System
The purpose this study is to determine which manual medicine technique or combination of techniques has the greatest effect on the natural changes in heart rate.
- Trial name
- NCT02193373
- Testing
- Osteopathic Manual Medicine
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- New York Institute of Technology
Chronic Pain, Complex Regional Pain Syndromes
The Success of Lumbar Sympathetic Ganglion Block Using Lower Extremity Perfusion Index
The patient, who is experiencing chronic pain in the lower extremities persisting for more than three months, is scheduled to undergo lumbar sympathetic ganglion block.
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Peripheral Neuropathy, Post Herpetic Neuralgia
- Trial name
- NCT06241820
- Testing
- Lumbar Sympathetic Ganglion Block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeongsoo Kim
CRPS (Complex Regional Pain Syndrome) Type I
Evaluation of the Relationship Between the Duration of the Evolution of the Complex Regional Pain Syndrome Type 1 (CRPS 1) and Effectiveness of the Continuous Peripheral Nerve Block (CPNB) Associated With an Intensive Rehabilitation Program
The study evaluates the relationship between the duration of evolution of SDRC1 and the efficacy of continuous peripheral nerve block (c-PNB) associated with an intensive rehabilitation program to improve the therapeutic strategy…
- Trial name
- BLOCALGO (NCT04767646)
- Testing
- Intensive rehabilitation program with CPNB
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Pôle Saint Hélier
Familial Dysautonomia (Riley-Day Syndrome), Hereditary Sensory and Autonomic Neuropathies
The Natural History of Familial Dysautonomia
The study will collect clinical information from patients with FD and allow them to give blood to help develop biological markers of the disease to aid diagnosis and treatment.
- Conditions
- Familial Dysautonomia (Riley-Day Syndrome), Hereditary Sensory and Autonomic Neuropathies, Hereditary Sensory and Autonomic Neuropathy 3
- Trial name
- NCT03920774
- Where
- 2 sites in United States, Israel
- Volunteers
- 400 people
- Sponsor
- NYU Langone Health
CRPS (Complex Regional Pain Syndromes)
Capsaicin-Evoked Pain in Patients With CRPS
To evaluate the effect of capsaicin in patients with Complex Regional Pain Syndrome.
- Trial name
- NCT00468390
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Danish Pain Research Center