Clinical trials: Autonomic Nervous System Activity
Endotoxemia, Sepsis
Anti-inflammatory Effects of GTS-21 After LPS
Rationale: The vagus nerve exerts an anti-inflammatory effect in in vitro and animal experiments. This 'vagal anti-inflammatory pathway' is mediated by the nicotinergic α7nACh receptor that can be selectively stimulated by…
- Conditions
- Endotoxemia, Sepsis, Vagal Activity
- Trial name
- NCT00783068
- Testing
- GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Lipopolysaccharide E. Coli 113:H 10:K negative
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Chronic Migraine, Headache
Comprehensive Approach to Lifestyle Modification in Chronic Migraine
Migraine is a highly prevalent neurological disorder and one of the leading causes of disability worldwide, substantially affecting quality of life and individuals during their most productive years.
- Trial name
- CALM-Migraine (NCT07802860)
- Testing
- Comprehensive Lifestyle Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Hacettepe University
Autonomic Dysfunction
PD2i Analysis of Heart Rate Variability in Competitive Sports
This is a double blind observational analysis of changes in heart rate variability using PD2i analyser in competitive athletes during strenuous exercise and competition.
- Trial name
- PACA (NCT01249248)
- Testing
- PD2i Analyzer
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Mississippi Medical Center
To Evaluate the Effect of Supplementation of Citrus Aurantium in Active Individuals
Effects Of Acute Supplementation Of Citrus Aurantium L. On The Recovery Of Autonomic And Cardiovascular Activity After A Sub-Maximum Aerobic Exercise Session In Healthy Individuals
INTRODUCTION: Non-pharmacological interventions for the treatment of cardiovascular and metabolic disorders have been investigated.
- Trial name
- NCT04875143
- Testing
- Citrus aurantium L.
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Nicotine Dependence
E-Cigarettes and SNA
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
- Trial name
- NCT02724241
- Testing
- one time exposure to e-cig with nicotine, One time exposure to e-cigarette without nicotine, one time exposure to empty e-cigarette
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Heart Failure, Death, Sudden, Cardiac
Sympathetic Nerve Activity and an Implantable Cardioverter Defibrillator in Heart Failure Patients
The aim of this study is to analyze whether the sympathetic tone, measured indirectly and directly by muscle sympathetic nerve activity recording, is elevated in patients with heart failure receiving an appropriate shock from…
- Trial name
- NCT00439790
- Testing
- Microneurography
- Where
- France
- Volunteers
- 109 people
- Sponsor
- University Hospital, Toulouse
Hypoxia, Sleep
Autonomic Activity During Nap Under Hypoxia
Sleeping under hypoxic conditions can impair cognition and autonomic nervous activity. A short daytime nap can modify these changes.
- Conditions
- Hypoxia, Sleep, Healthy
- Trial name
- NAPOXIA (NCT04146857)
- Testing
- Normoxia, Hypoxia 1, Hypoxia 2
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Hypoglycemia
Hypoglycemia and Autonomic Nervous System Function
The goals of this proposal are to determine the effects of hypoglycemia on the autonomic nervous system.
- Trial name
- HypoANS (NCT01816893)
- Testing
- Hypoglycemic hyperinsulinemic clamp, Euglycemic hyperinsulinemic clamp
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Proctitis, Proctosigmoiditis
The Safety and Tolerability of Budesonide Foam in Participants With Active Ulcerative Proctitis or Proctosigmoiditis
The purpose of this study is to evaluate safety and tolerability of cyclically-dosed rectal budesonide foam in participants with active ulcerative proctitis (UP) or ulcerative proctosigmoiditis (UPS).
- Trial name
- NCT01349673
- Testing
- Budesonide Foam
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Bausch Health Americas, Inc.
Heart Rate Variability (HRV), Intracranial Pressure Change
Correlation Between the R-R Interval of the Electrocardiogram and the Intracranial Pulse Wave Interval Assessed by a Noninvasive Method in Healthy People
Heart rate variability (HRV) is a well-established cardiovascular and autonomic health metric in the medical literature. However, its applicability is limited by the difficulty of analysis and interpretation in clinical practice.
- Conditions
- Heart Rate Variability (HRV), Intracranial Pressure Change, Pulse Rate, Autonomic Nervous System Activity
- Trial name
- NCT07616674
- Testing
- Evaluate the correlation between R-R interval and R-R equivalent on the noninvasive intracranial compliance monitor (BRV) and evaluate their correspondence considering the Time domain (HR, NN, NN50, R
- Where
- Brazil
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Premenstrual Syndrome, Dysmenorrhea
The Efficacy of Different Doses of Acupuncture in Dysmenorrhea
Subjects in this study included premenstrual syndrome and dysmenorrhea. Premenstrual syndrome (PMS) is the sum of a group of symptoms (including physical and psychological symptoms) that occurs during the luteal phase of the…
- Trial name
- NCT03881319
- Testing
- Conventional gynecologic treatment, Low dose acupuncture, High dose acupuncture
- Where
- Taiwan
- Volunteers
- 105 people
- Sponsor
- Taipei City Hospital
Dysmenorrhea
The Efficacy of Two Types of Acupuncture on Autonomic Nervous Activity and Quality of Life in Women With Dysmenorrhea.
Integrative medicine raises public's attention due to either mainstream or traditional medicine has its limitation. The topic "dysmenorrhea", with prevalence up to 50%, troubled many females with symptom as depression, reduced…
- Trial name
- NCT04178226
- Testing
- Manual Acupuncture, Laser Acupuncture
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei City Hospital
Parkinson Disease, Orthostatic Hypotension
Cardiovascular Effects of Exercise in Patients With Parkinson's Disease
Abnormalities in the regulation of cardiovascular system due to autonomic nervous system (ANS) dysfunction may lead to a sudden decline in blood pressure (BP) upon standing, sitting or performing activities/exercises in patients…
- Trial name
- NCT03343574
- Testing
- Abdominal Strengthening Exercise
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- Faizan Ahmed
Nerve Growth Factor, Exercise
Cortical Neuroplasticity by Muscle Pain of Pain-induced Plasticity
The purpose of this study is to investigate the sensory-motor cortical excitability response to delayed onset muscle soreness (DOMS) on Extensor Carpi Radialis (ECR) muscle during muscle hyperalgesia provoked by nerve growth…
- Conditions
- Nerve Growth Factor, Exercise, Motor Activity, Abnormality of SSEPs
- Trial name
- NCT03354624
- Testing
- Sterile solutions of recombinant human nerve growth factor (NGF)
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Aging, Inflammation
The Role of the "Inflammatory/ Pathogen Burden" for Cardiac Ageing
In the elderly a chronic basal systemic inflammation prevails - which is evident by enhanced CRP or IL-6 plasma concentrations - and by compromised defense mechanisms against invading microbes.
- Trial name
- AntiCardAgeing (NCT01045512)
- Testing
- fluvastatin
- Where
- Germany
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Sleep Apnea
New Approach in the Study of the Autonomic Nervous System Through Cardiac Variability in Sleep Apnea Syndrome.
The main objective of this study is to compare the different variations of the cardiac variability index measured thanks to the technique developed by the CIC-IT between subjects with severe SAS and healthy subjects with sleep…
- Trial name
- HRVSAS (NCT06808464)
- Where
- France
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Post-Concussion Syndrome
Post-concussion Syndrome and Chiropractic
This proof-of-concept trial will explore the effects of manual chiropractic adjustments on nervous system function in individuals with post-concussion syndrome.
- Trial name
- PCS (NCT06151184)
- Testing
- Chiropractic adjustment
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Life University
Low Back Pain
A Study of Tanezumab in Adults With Chronic Low Back Pain
The purpose of this study is to evaluate the efficacy and safety of multiple doses of tanezumab administered every 8 weeks in treating chronic low back pain.
- Trial name
- NCT00876187
- Testing
- Tanezumab 20 mg IV, Tanezumab 10 mg IV, Tanezumab 5 mg IV
- Where
- 135 sites in United States
- Volunteers
- 1,359 people
- Sponsor
- Pfizer
Schizophrenia, Schizoaffective Disorder
Add-on HD Hf-tRNS Over Bilateral DLPFC for Treating Patients With Schizophrenia
The study aimed to investigate the effects of high-definition transcranial random noise stimulation over bilateral prefrontal cortex on psychopathological symptoms, other clinical outcomes, autonomic functioning ,and brain…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Psychotic Symptoms, Neurocognitive Dysfunction
- Trial name
- NCT04038788
- Testing
- HD hf-tRNS
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Tri-Service General Hospital (TSGH)
Insulin Sensitivity
The Importance of Insulin Action in the Brain for the Immune System During Physical Activity-Overweight
The goal of this clinical trial is to clarify the interaction of central insulin action and physical activity with the immune system. Therefore, participants will undergo bicycle spiroergometer tests.
- Trial name
- NCT07466173
- Testing
- Spiroergometer test with intranasal insulin spray
- Where
- Germany
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Ulm