Clinical trials: Autonomic Nervous System Disorders
Complex Regional Pain Syndromes
Ketamine and Midazolam Infusions for CRPS: Feasibility Study
This study will assess the feasibility of administering ketamine plus midazolam or midazolam alone, when infused over 5 days in an outpatient setting, to adults with complex regional pain syndrome (CRPS).
- Trial name
- NCT05945147
- Testing
- Ketamine, Midazolam, Normal Saline
- Where
- United States
- Sponsor
- Stanford University
Complex Regional Pain Syndromes
Sympatholytic Effects of High Thoracic Erector Spinae Plane Block: Changes in Optic Nerve Sheath Diameter
The thoracic erector spinae plane (ESP) block is suggested to potentially affect the stellate ganglion, a key component of the sympathetic nervous system, thereby influencing autonomic functions.
- Trial name
- NCT06468384
- Testing
- thoracic erector spinae plane (ESP) block
- Volunteers
- 15 people
- Sponsor
- Pamukkale University
Parkinson's Disease, Parkinsonian Syndrome
Transcranial Duplex Scanning and Single Photon Emission Computer Tomography (SPECT) in Parkinsonian Syndromes
The purpose of the study is to determine the sensitivity and specificity of transcranial duplex scanning (TCD) and single photon emission computer tomography (SPECT) in patients suspected of having Idiopathic Parkinson Disease…
- Conditions
- Parkinson's Disease, Parkinsonian Syndrome, Multiple System Atrophy, Supranuclear Palsy, Progressive
- Trial name
- NCT00368199
- Where
- Netherlands
- Volunteers
- 196 people
- Sponsor
- Maastricht University Medical Center
Pain, Autonomic Dysreflexia
Treatment of Pain and Autonomic Dysreflexia in Spinal Cord Injury With Deep Brain Stimulation
The purpose of this research study is to determine if DBS is a feasible, safe and effective therapy for pain and autonomic dysreflexia after spinal cord injury.
- Trial name
- NCT02006433
- Testing
- Deep Brain Stimulation
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Jonathan Jagid
POTS - Postural Orthostatic Tachycardia Syndrome
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT05554107)
- Testing
- Training program
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Hemiplegic Shoulder Pain
Fu's Subcutaneous Needling Treatment for Hemiplegic Shoulder Pain
The post-stroke survivors suffered from shoulder pain are very common. The investigators performed Fu's subcutaneous needling (FSN).
- Trial name
- NCT05085236
- Testing
- Fu's subcutaneous needling (FSN), Rehabilitation
- Where
- Taiwan
- Volunteers
- 48 people
- Sponsor
- China Medical University Hospital
Vasovagal Syncope, Smoke Inhalation
Relation Between Vasovagal Tendency and Smoking Among University Students
Almost everyone is aware these days is aware about the risk of smoking. Still many people start this habit specially in early life and during college year.
- Trial name
- NCT02949804
- Testing
- Comparison between two groups
- Where
- Jordan
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Jordan Collaborating Cardiology Group
Stroke
MTPr With Shockwave on Pain & Function of SHS in Stroke
Background: shoulder-hand syndrome is considered a significant reason for the reduction of upper limb functions after stroke. Purpose: To investigate the influence of Myofascial Trigger Points (MTrPs) release and shockwave…
- Trial name
- NCT04627636
- Testing
- Myofascial trigger points pressure (MTrP) release, Shockwave therapy application, conventional therapy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- October 6 University
Fibromyalgia Syndrome
Palpitations and Tachycardia in Fibromyalgia Syndrome
Clinically Characterized by the presence of chronic widespread pan and tenderness, Fibromyalgia (FM) is one of the most common "functional" syndromes. FM is currently conceived of as representing a prototype of central pain, i.e.
- Trial name
- NCT01147263
- Testing
- Evaluation of autonomic parameters
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Posttraumatic Stress Disorder, Pseudopheochromocytoma
Clinical Autonomic Disorders: A Training Protocol
Background: The autonomic nervous system helps control things that happen automatically in the body, like blood pressure, heart rate, and digestion. When it doesn t work properly, it s called dysautonomia.
- Conditions
- Posttraumatic Stress Disorder, Pseudopheochromocytoma, Healthy Volunteers, Neurocardiogenic Syncope
- Trial name
- NCT02154009
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple System Atrophy
Comprehensive Swallowing Rehabilitation in Patients With MSA
The purpose of this study is to investigate the effect of comprehensive swallowing rehabilitation in patients with multiple system atrophy.
- Trial name
- NCT04782284
- Testing
- Comprehensive swallowing rehabilitation, Swallowing education
- Where
- South Korea
- Volunteers
- 24 people
- Sponsor
- Seoul National University Hospital
Orthostatic Hypotension, Nondipping Hypertension
Is Orthostatic Hypotension Associated With Nondipping Hypertension
The aim of the study is to evaluate whether orthostatic hypotension is associated with nondipping hypertension. Methods and patients: 400 subjects who are referred for 24hABPM will be filled questioner regarding their medical…
- Trial name
- NCT00491231
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Spinal Cord Injury
Mechanisms of Arterial Hypotension in Chronic Spinal Cord Injury
This clinical study is designed to investigate the mechanisms of blood pressure regulation and respiratory motor function affected by spinal cord injury (SCI).
- Trial name
- NCT02154412
- Testing
- Respiratory Training
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Orthostatic Hypotension
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Orthostatic hypotension (OH) has a high incidence rate of 30%-50% in the elderly and populations with neurodegenerative diseases.
- Trial name
- NCT07309666
- Testing
- Intelligent diagnostic system for orthostatic hypotension
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Multiple Sclerosis, Spinal Cord Injury
PURO - PUlmonary Rehabilitation With O-RAGT Platform
The goal of this interventional study is to assess differences in the metabolic consumption, the cardiorespiratory effort, the cardiac autonomic adaptation, and fatigability during ADL, such as standing from a chair and walking…
- Conditions
- Multiple Sclerosis, Spinal Cord Injury, Stroke, Traumatic Brain Damage
- Trial name
- PURO (NCT05757830)
- Testing
- UANGO suite exoskeleton
- Where
- 4 sites in Italy, Lithuania and 2 more
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Orthostatic Hypotension, Hemodynamic Instability
Trial Comparing Low Dose and High Dose Steroids in Patients Undergoing Colorectal Surgery
The purpose of this study is to evaluate the effect of low dose versus high dose steroids vital signs of patients currently on steroids or recently treated with steroids undergoing major colorectal surgery.
- Conditions
- Orthostatic Hypotension, Hemodynamic Instability, Fever, Hypothermia
- Trial name
- NCT01559675
- Testing
- Hydrocortisone High Dose, Hydrocortisone Low Dose
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Cedars-Sinai Medical Center
Insulin Sensitivity
The Importance of Insulin Action in the Brain for the Immune System During Physical Activity
The goal of this clinical trial is to clarify the interaction of central insulin action and physical activity with the immune system. Therefore, participants will undergo bicycle spiroergometer tests.
- Trial name
- NCT06552130
- Testing
- Spiroergometer test with intranasal insulin spray
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulm
REM Sleep Behavior Disorder, Parkinson Disease
North American Prodromal Synucleinopathy Consortium Stage 2
This study will enroll participants with idiopathic REM sleep behavior disorder (RBD) and healthy controls for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
- Conditions
- REM Sleep Behavior Disorder, Parkinson Disease, Lewy Body Dementia, Dementia With Lewy Bodies
- Trial name
- NAPS2 (NCT05826457)
- Where
- 9 sites in United States, Canada
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Parkinson Disease, Autonomic Dysfunction
Parkinson's Autonomic Responses to Treadmill Walking
This study will compare examine autonomic and cardiovascular responses to peak exercise testing in Parkinson's disease patients in varying stages of the disease, and healthy, age-matched participants.
- Trial name
- NCT03156400
- Testing
- Exercise Stress Test
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Miami
Metabolic Syndrome
The Effects of Chiropractic in Adults With Metabolic Syndrome
The purpose of this study is to assess the feasibility of our study procedures/protocols and to look at the potential effects of chiropractic care on people with metabolic syndrome.
- Trial name
- MET (NCT05884437)
- Testing
- Chiropractic adjustment
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Life University
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