Clinical trials: Autonomic Nervous System Disorders
Cluster Headache
Prophylactic Effects of Psilocybin on Chronic Cluster Headache
The purpose of this study is to investigate the prophylactic effects of psilocybin in chronic cluster headache. Subjects will receive a low dose of psilocybin during 3 sessions spaced by one week.
- Trial name
- EPOCH (NCT04280055)
- Testing
- Psilocybin
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Gitte Moos Knudsen
OBESITY, HYPERTENSION
The Autonomic Nervous System and Obesity
In its simplest terms, obesity is the results of a positive balance between food intake and energy expenditure (EE). I.e., we take in more energy, in the form of food, than we expend, e.g., by exercise.
- Conditions
- OBESITY, HYPERTENSION, PURE AUTONOMIC FAILURE, SHY-DRAGER SYNDROME
- Trial name
- NCT00179023
- Testing
- Trimethaphan, Pseudoephedrine
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Occupational Stress, Sleep Quality
Curcumin Nano Patch and Autonomic Function in Shift-Working Healthcare Professionals
This randomized, open-label, placebo-controlled crossover study compares a curcumin-containing patch with a cooling placebo patch without curcumin in healthcare professionals who work rotating shifts.
- Trial name
- NCT07910279
- Testing
- Curcumin Nano Patch
- Where
- Taiwan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Orthostatic Hypotension
Evaluation of the Contribution of Lower Limb and/or Abdominal Compression on Orthostatic Hypotension
Orthostatic hypotension (OH) is associated with an increased risk of myocardial infarction, stroke, heart failure and neurocognitive disorders. In the elderly, OH is an independent predictor of falls and mortality.
- Trial name
- HYPOFLEX (NCT06694688)
- Testing
- the supine/standing postural change test
- Where
- France
- Volunteers
- 43 people
- Sponsor
- Gérond'if
Healthy, Vasodilation
Impact of Intranasal Insulin on Sympathetic Activity and Cerebral Vasodilation
The purpose of this project is to examine the impact of increases in brain insulin on sympathetic nervous system activity, as well as peripheral and cerebral blood flow in humans.
- Conditions
- Healthy, Vasodilation, Insulin Resistance, Autonomic Dysfunction
- Trial name
- NCT05153395
- Testing
- Carbon dioxide breathing, Neurovascular Coupling, Human insulin
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Traumatic Brain Injury, Dysautonomia
Controlling Hyperadrenergic Activity in Neurologic Injury
Traumatic brain injury (TBI) is frequently associated with a hyperadrenergic state accompanied by elevated levels of plasma catecholamines.
- Trial name
- CHAIN (NCT01343329)
- Testing
- Esmolol, Propranolol
- Where
- United States
- Sponsor
- Johns Hopkins University
Insufficiency;Cardiac, Cancer
Effect of Physical Training in Patients With Heart Failure Caused by Chemotherapy for Cancer Treatment
New therapies for cancer increased patient survival, but led to the recognition of adverse effects associated with cancer treatment, such as the use of chemotherapy.
- Conditions
- Insufficiency;Cardiac, Cancer, Cardiotoxicity, Heart Failure
- Trial name
- NCT04047901
- Testing
- exercise training
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo General Hospital
Heart Failure, Chagas Disease
Effect of Ganglionar Electrical Stimulation on Central Arterial Pressure
This study will evaluate the applications of ganglionar electrical stimulation in patients with Chagas Disease and Ischemic Heart Failure patients.
- Trial name
- NCT01874795
- Testing
- TENS
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Brasilia
Solid Tumors, Breast Cancer
A Phase I/II Study of BGT226 in Adult Patients With Advanced Solid Malignancies Including Patients With Advanced Breast Cancer
This is a phase I/II clinical research study with BGT226, an inhibitor of phosphatidylinositol 3'-kinase (PI3K). The study consists of a Phase I dose escalation part followed by a safety expansion part and a Phase II expansion…
- Conditions
- Solid Tumors, Breast Cancer, Cowden Syndrome
- Trial name
- NCT00600275
- Testing
- BGT226
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 57 people
- Sponsor
- Novartis Pharmaceuticals
Complex Regional Pain Syndrome Type 1
Intravenous Immunoglobulins in Complex-regional Pain Syndrome
The purpose of this study is to determine whether intravenous immunoglobulins are effective in the treatment of complex-regional pain syndrome.
- Trial name
- PAINLESS (NCT00949065)
- Testing
- intravenous immunoglobulins
- Where
- Germany
- Sponsor
- University of Giessen
Obesity, Pre-hypertension
The Effects of Stretching Training on Arterial Function and Autonomic Control
Hypertension is a major risk factor for cardiovascular disease. Hypertension and abdominal obesity are associated with dysfunction of the main mechanisms of cardiovascular regulation, the autonomic nervous system and the vascular…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01741766
- Testing
- Stretching Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Subarachnoid Hemorrhage, Intracranial Hemorrhages
Time Frequency Analysis of Electrocardiogram and Blood Pressure in Intracranial Hemorrhage Patients
Dysregulation of autonomic nervous system is evident in patients with spontaneous intracranial hemorrhage. In this study, we utilize a non-invasive method (heart rate and blood pressure variability analysis to analyze the…
- Conditions
- Subarachnoid Hemorrhage, Intracranial Hemorrhages, Cerebral Hemorrhage
- Trial name
- NCT00713375
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Bruxism
Effectiveness of Visceral Manual Therapy in Bruxist Patients
Objective: check the effectiveness of visceral manual therapy on bruxist patients Design: Experimental, analytical, longitudinal, prospective, randomized, single-blind study with a blinded evaluator.
- Trial name
- NCT05751694
- Testing
- Visceral manual treatment, Respiratory listening
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- University of Seville
Neuropathic Pain, Complex Regional Pain Syndrome
IV Lidocaine Infusion for Neuropathic Pain
The investigators will conduct a retrospective cohort study of patients who have undergone i.v. lidocaine infusions in the previous 2 years for suspected neuropathic pain of heterogeneous origin.
- Conditions
- Neuropathic Pain, Complex Regional Pain Syndrome, Chronic Pain
- Trial name
- NCT05731739
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Multiple System Atrophy, Cerebellar Variant (Disorder)
tDCS for Multiple System Atrophy With Cerebellar Feature
The aim of study is to investigate most effective site for control the motor coordination using transcranial direct current stimulation in multiple system atrophy with cerebellar feature
- Trial name
- NCT04092556
- Testing
- transcranial direct current stimulation
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Samsung Medical Center
POTS - Postural Orthostatic Tachycardia Syndrome
Restoring Iron Deficiency in POTS
People with postural orthostatic tachycardia syndrome (POTS) often have low red blood cell volumes and low ferritin in their blood (a marker of iron storage in the body).
- Trial name
- NCT07197905
- Testing
- Intravenous iron
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University Medical Center
Spinal Muscular Atrophy
Spinal Muscular Atrophy and Cardiac Autonomic Function
Respiratory dysfunction is the major cause of morbidity and mortality in patients with spinal muscular atrophy (SMA). Air stacking is a clearance airway technique frequently used but its effects on cardiac autonomic function in…
- Trial name
- NCT01522079
- Testing
- Air stacking manuever
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Augusto Motta
Migraine, Heart Rate Variability (HRV)
App-based Breathing Program for Migraine Relief
Migraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation.
- Conditions
- Migraine, Heart Rate Variability (HRV), Autonomic Nervous System, Headache (Migraine)
- Trial name
- NCT07297901
- Testing
- Baseline Survey, Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arizona State University
Post-Traumatic Stress Disorder
Intra-Sessional Autonomic Arc Detection in Ketamine-Assisted Therapy for PTSD: A Signal Characterisation Pilot Study
This study examines whether a continuous wearable biosensor and a proprietary signal detection algorithm (JungleCODE, Open Medicine Studio) can detect and characterise the autonomic nervous system arc - a trajectory from a state…
- Trial name
- OMS-KAT (NCT07614581)
- Testing
- Continuous wearable physiological monitoring (EmbracePlus, Empatica), Ketamine-assisted therapy (independently arranged), Structured pre- and post-session interviews
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- Adriaan Dirk van der Wart
Attention Deficit Hyperactivity Disorder
Autonomic Correlates of Impulsivity for Preschool Children With Attention Deficit Hyperactivity Disorder (ADHD)
The goal of this pilot feasibility and utility study is to develop and validate a method that is reproducible over time for assessing biobehavioral and autonomic markers of impulsivity and their utility in assessing treatment…
- Trial name
- NCT00856063
- Volunteers
- 5 people
- Sponsor
- University of Arizona
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