Clinical trials: Autonomic Nervous System Disorders
Cluster Headache
Psilocybin for the Treatment of Cluster Headache
The purpose of this study is to investigate the effects of an oral psilocybin pulse regimen in cluster headache. Subjects will be randomized to receive oral placebo, low dose psilocybin, or high dose psilocybin in three…
- Trial name
- NCT02981173
- Testing
- 0.143 mg/kg Psilocybin or 10 mg Psilocybin, 0.0143 mg/kg Psilocybin or 1 mg Psilocybin
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Postural Orthostatic Tachycardia Syndrome (POTS)
Beta-3 Enhanced Autonomic Therapy for POTS
The study will test the hypothesis that mirabegron is more effective than a placebo in alleviating postural orthostatic tachycardia (POTS) symptoms.
- Trial name
- BEAT-POTS (NCT07585513)
- Testing
- Mirabegron
- Volunteers
- 36 people
- Sponsor
- Cedars-Sinai Medical Center
Intraventricular Hemorrhage, Autoregulation
Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage
Annually, almost 5,000 extremely low birth weight (9 ounces to about 2 lbs) infants born in the US survive with severe bleeding in the brain (intraventricular hemorrhage); this devastating complication of prematurity is…
- Trial name
- PhysDis (NCT00665769)
- Testing
- Hypercapnia, Normocapnia
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- Baylor College of Medicine
Transcranial Magnetic Stimulation, Complex Regional Pain Syndrome of Upper Limb (Disorder)
CRPS - Diagnostics, Pathophysiological Mechanisms, and Response to Treatment With Noninvasive Brain Stimulation
This is a sham controlled, randomized, double-blind, navigated repetitive Transcranial Magnetic Stimulation (nrTMS) study for the treatment of complex regional pain syndrome (CRPS types 1 and 2).
- Trial name
- NCT04439669
- Testing
- Active nrTMS and open phase
- Where
- 2 sites in Finland
- Volunteers
- 62 people
- Sponsor
- Helsinki University Central Hospital
Bradycardia During Pulling of Eyeball
Autonomic Nervous System Activity and Oculocardiac Reflex.
Pulling the eyeball during ophthalmic surgery provokes decrease in heart rate. This phenomenon is called oculocardiac reflex. In some patients asystole may occur.
- Trial name
- NCT01714362
- Where
- Poland
- Volunteers
- 52 people
- Sponsor
- Medical University of Gdansk
Obstructive Sleep Apnea
Autonomic Function in Obstructive Sleep Apnea
The purpose of this study is to determine if obstructive sleep apnea (OSA) causes autonomic dysfunction independent of its effects on hyperglycemia.
- Trial name
- NCT00681161
- Testing
- continuous positive airway pressure (CPAP)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Vanderbilt University
Parkinson Disease, Multiple System Atrophy
Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial
This research is studying a supplement called tributyrin in people with Progressive Supranuclear Palsy (PSP) to learn about its safety and tolerability as a potential treatment.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy(PSP)
- Trial name
- BUTTER2 (NCT07863180)
- Testing
- Tributyrin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Prabesh Kanel
Acquired Brain Injury, Traumatic Brain Injury
Pilot Trial for Adults With Acquired Brain Injury
This pilot study will compare a yoga program to a non-yoga exercise program in adults with brain injuries. The investigators will measure possible improvements in balance and heartrate.
- Conditions
- Acquired Brain Injury, Traumatic Brain Injury, Stroke
- Trial name
- RCT (NCT05793827)
- Testing
- Adapted Hatha Yoga, Low-Impact Exercise
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Colorado State University
Orthostatic Hypotension, Autonomic Failure
Automated Abdominal Binder for Orthostatic Hypotension
The automated inflatable abdominal binder is an investigational device for the treatment of orthostatic hypotension (low blood pressure on standing) in patients with autonomic failure.
- Conditions
- Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT03482297
- Testing
- automated abdominal binder, Midodrine
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson's Disease, Multiple System Atrophy, Parkinson Variant
Pre-Gene Therapy Study in Parkinson's Disease and Multiple System Atrophy
The objective of this study is to describe disease progression in study participants diagnosed with early Parkinson's Disease or Multiple System Atrophy - Parkinsonian Type up to 18 months as delineated by clinical and…
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Parkinson Variant, Multiple System Atrophy
- Trial name
- NCT05699460
- Testing
- This is an observational study.
- Where
- 11 sites in United States, Poland
- Volunteers
- 73 people
- Sponsor
- AskBio Inc
Systemic Arterial Hypertension, Menopause
Effects of Probiotic Supplementation in Hypertensive Women on Menopause
In postmenopausal women, cardiovascular risk is increased and the mechanisms involving imbalance of the Autonomic Nervous System should be extensively investigated.
- Conditions
- Systemic Arterial Hypertension, Menopause, Dysbiosis, Autonomic Nervous System Imbalance
- Trial name
- NCT03955159
- Testing
- Probiotic supplementation
- Where
- Brazil
- Volunteers
- 86 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Complex Regional Pain Syndromes
Infrared Imaging in Complex Regional Pain Syndrome
This research proposal aims to investigate the potential use of Infrared (FLIR) imaging to monitor the successful achievement of the sympathetic blockade in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT05693337
- Testing
- Forward Looking Infrared Radar (FLIR) thermal imaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hospital for Special Surgery, New York
Spinal Cord Injuries, Autonomic Imbalance
Deciphering Preserved Autonomic Function After Spinal Cord Injury
This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder…
- Conditions
- Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic Hypotension
- Trial name
- NCT04493372
- Testing
- Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Osteoarthritis, Arthritis
Long-Term Analgesic Efficacy And Safety Of Tanezumab Alone Or In Combination With Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Versus NSAIDs Alone In Patients With Osteoarthritis Of The Knee Or Hip
The purpose of this study is to investigate the long-term analgesic efficacy and safety of tanezumab for patients with osteoarthritis (OA) of the knee or hip currently experiencing partial benefit from, and are tolerating…
- Trial name
- NCT00809354
- Testing
- NSAID, tanezumab
- Where
- 333 sites in United States, Canada and 10 more
- Volunteers
- 2,720 people
- Sponsor
- Pfizer
Optic Pathway Glioma
Safety and Efficacy of the PAINLESS Nerve Growth Factor CHF6467 in Optic Pathway Glioma (OPG)
Infantile optic pathway glioma (OPG) is generally benign and slow-growing, but due to infiltration and compression of sensitive neuronal structures in the optical pathways, progressive visual loss is a frequent and highly…
- Trial name
- NGF-OPG (NCT05733572)
- Testing
- CHF6467
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Benedetto Falsini
Parkinson's Disease, Multiple System Atrophy
Magnetic Resonance Imaging in the Diagnosis of Parkinsonian Syndromes
Parkinsonian syndrome is clinically characterized by the presence of resting tremor, rigidity, bradykinesia and postural instability.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Vascular Parkinsonism
- Trial name
- PARKIMAGE (NCT02445469)
- Testing
- MRI exam of the brain
- Where
- France
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Chronic Pain, Trigeminal Neuralgia
Regional-anaesthesiological Infiltration Techniques for the Management of Chronic Pain: a Retrospective Study
There is a significant debate whether local infiltration techniques may be a method to treat complicated chronic pain syndromes, e.g. refractory headache.
- Conditions
- Chronic Pain, Trigeminal Neuralgia, Cluster Headache, Post-Zoster Neuralgia
- Trial name
- RetroBlock (NCT03066037)
- Testing
- regional-anaesthesiological infiltration
- Where
- Germany
- Volunteers
- 83 people
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer, Colon Cancer
Stress-Reducing Intervention in Patients With Colorectal and Breast Cancer
The goal of this interventional study is to test the heart-rate variability biofeedback intervention (HRV BI) in 2 cohorts of patients.
- Trial name
- SRI-BrCa_CRC (NCT06281145)
- Testing
- Heart-rate variability biofeedback intervention
- Where
- Slovakia
- Volunteers
- 100 people
- Sponsor
- Comenius University
Multiple System Atrophy, MSA
AZD3241 PET MSA Trial, Phase 2, Randomized,12 Week Safety and Tolerability Trial With PET in MSA Patients
AZD3241 myeloperoxidase (MPO) inhibitor trial is assessing safety and tolerability, randomized trial, in patients with Multiple System Atrophy.
- Trial name
- NCT02388295
- Testing
- AZD3241
- Where
- 17 sites in United States, Austria and 5 more
- Volunteers
- 59 people
- Sponsor
- AstraZeneca
Autonomic Nervous System Imbalance, Psychological Distress
Stochastic Modulated Vibrations on Autonomic Nervous System of Breast Cancer Patients During Radiotherapy
The aim of this research is to study the influence of stochastic modulated vibrations on the autonomic nervous system of breast cancer patients during radiation therapy
- Conditions
- Autonomic Nervous System Imbalance, Psychological Distress, Cancer-related Pain, Breast Cancer Lymphedema
- Trial name
- NCT04125953
- Testing
- Andullation
- Where
- Belgium
- Volunteers
- 130 people
- Sponsor
- Universitair Ziekenhuis Brussel
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