Clinical trials: Autonomic Nervous System Disorders
Complex Regional Pain Syndrome
The Effects and Mechanisms of a High CBD Cannabis Extract (BRC-002) for the Treatment of Pain and Health in Complex Regional Pain Syndrome
The aim of this trial is to determine the potential effects and mechanisms of cannabinoid-induced pain relief in complex regional pain syndrome (CRPS).
- Trial name
- NCT06393101
- Testing
- BRC-002
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- University of California, San Diego
Postural Tachycardia Syndrome, Postural Orthostatic Tachycardia Syndrome
Breathing Device in Postural Orthostatic Tachycardia Syndrome (POTS)
The investigators will test whether breathing through an inspiratory resistance device will improve the ability to be upright and decrease heart rate increases on standing in patients with postural tachycardia syndrome.
- Trial name
- NCT00962728
- Testing
- Inspiratory Threshold Device (Res-Q-Gard ITD)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alfredo Gamboa
Children With Cerebral Palsy
The Effect of Nervus Vagus Stimulation on Spasticity, Autonomic Function, Motor Function and Quality of Life in Children With Spastic Cerebral Palsy
Introduction: Cerebral palsy (CP) is a heterogeneous neurodevelopmental syndrome affecting muscle tone, motor skills, and movement due to brain injury during developmental stages.
- Trial name
- NCT07165665
- Testing
- Bobath (Neurodevelopmental Treatment) approach, Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Pamukkale University
NMO and MS
Autonomic Dysfunction in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis : A Comparative Study
To compare the frequency and patterns of autonomic dysfunction in patients with NMOSD and MS, and to investigate its correlations with clinical disability, radiological findings, fatigue, and quality of life parameters
- Trial name
- English Title (NCT07273292)
- Testing
- Bedside cardiovascular reflex tests
- Volunteers
- 100 people
- Sponsor
- Mohamed Moshref abd alsattar
Postural Tachycardia Syndrome, Orthostatic Intolerance
Sleep Actigraphy in Postural Tachycardia Syndrome (POTS)
We propose to use actigraphy (measured by activity watches) as a tool to quantify sleep disturbances in patients with orthostatic intolerance compared with healthy control subjects.
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Intolerance, Sleep Disorders
- Trial name
- NCT00692471
- Testing
- Actigraphy Watch (motion sensors) with light sensors - ActiWatch from Minimitter
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Multiple System Atrophy
Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial
A purpose of the present study is to investigate the capability of serum uric acid elevation, safety, and tolerability of inosine 5'-monophosphate in patients with multiple system atrophy with multicenter, randomized, placebo…
- Trial name
- NCT03403309
- Testing
- 1) Inosine 5'-monophosphate
- Where
- South Korea
- Volunteers
- 43 people
- Sponsor
- Yonsei University
Rare Diseases, Aortic Aneurysm, Thoracic
Investigation of the Neurovegetative Pattern in Patients With Thoracic Aortic Aneurysms (TAA)
The goal of this observational cross-sectional study is to learn about vagal features in patients with syndromic and non-syndromic TAA.
- Trial name
- IPaNeMA (NCT05703893)
- Testing
- Supine resting (REST) and active standing (STAND)
- Where
- Italy
- Volunteers
- 139 people
- Sponsor
- IRCCS Policlinico S. Donato
Migraine, Cluster Headache
Intranasal Cooling for Cluster Headache and Migraine
This study will be looking at the clinical efficacy of using a intranasal evaporative cooling device in providing relief of the symptoms of migraine and cluster headache.
- Trial name
- COOLHEAD (NCT01898455)
- Testing
- RhinoChill intranasal cooling
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Cumbria Partnership NHS Foundation Trust
Neurally Mediated Syncope
The Iliac Arterio-venous Fistula for Treatment of Neurally Mediated Syncope Study
The purpose of the study is to investigate the efficacy of the ROX coupler in treating patients with tilt test proven Neurally mediated syncope.
- Trial name
- SHAM-ROX NMS (NCT02388087)
- Testing
- ROX COUPLER, Right heart catheterisation and routine care
- Volunteers
- 20 people
- Sponsor
- East Sussex Healthcare NHS Trust
Myofascial Pain Syndrome
Neurophysiological Effects of Dry Needling in Patients With Neck Pain
The present study aims to evaluate the differences that may be experienced in pain and cervical disability, before, during and just after the intervention of the Deep Dry Needling in the upper trapezius muscle in active, passive…
- Trial name
- NCT03345238
- Testing
- Deep Dry Needling
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Universidad Rey Juan Carlos
Complex Regional Pain Syndromes
Ketamine HCl Prolonged Release Oral Tablets for CRPS
The purpose of this study is to evaluate the efficacy of Ketamine HCl Prolonged Release (PR) tablets in participants with pain due to complex regional pain syndrome (CRPS).
- Trial name
- NCT06419985
- Testing
- 80mg/day Ketamine HCl Prolonged Release, 160mg/day Ketamine HCl Prolonged Release
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Southern California
Non Small Cell Lung Cancer (NSCLC), Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Study of PX-866 and Docetaxel in Solid Tumors
Phase 1: To determine the maximally tolerated dose (MTD) or recommended dose (RD) and any potential efficacy of PX-866 in combination with docetaxel in patients with solid tumors.
- Trial name
- NCT01204099
- Testing
- Docetaxel, PX-866
- Where
- 33 sites in United States, Canada
- Volunteers
- 223 people
- Sponsor
- Cascadian Therapeutics Inc.
Trauma, Spinal Cord, SPINAL Fracture
A Study of Autonomic Dynamic Dysfunction to Predict Infections After Spinal Cord Injury.
The study is designed to investigate whether autonomic shifts (dysautonomia, sympatho-vagal instability) that develop after SCI have value in predicting SCI-associated infections (SCI-AI).
- Trial name
- NCT03253952
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Solid Tumor
Tuvusertib (M1774) Human Mass Balance and Absolute Bioavailability Study (DDRIVER Solid Tumors 303)
This is a single sequence 2-period open label study in participants with advanced solid tumors. The purpose of Period 1 of this study is to assess the mass balance to determine drug-related entities present in circulation and…
- Trial name
- NCT06308263
- Testing
- Tuvusertib [14C]Tuvusertib microtracer, Tuvusertib, Tuvusertib + [14C]Tuvusertib microdose bolus injection
- Where
- Hungary
- Volunteers
- 12 people
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Parkinson's Disease (PD), Parkinsonism
Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)
This study is designed to determine if magnetic resonance imaging (MRI) measures can be used to diagnose and monitor the progression of Parkinson's disease (PD) while distinguishing between PD and parkinsonisms [conditions that…
- Conditions
- Parkinson's Disease (PD), Parkinsonism, Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA)
- Trial name
- NCT01888185
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Prehypertension, Blood Pressure
HIRREM for Pre-Hypertension
This randomized, controlled clinical pilot trial will evaluate the effects associated with in-office use of closed-loop, acoustic stimulation neurotechnology (High-resolution, relational, resonance-based, electroencephalic…
- Conditions
- Prehypertension, Blood Pressure, Autonomic Nervous System Imbalance, Cardiovascular Risk Factor
- Trial name
- NCT03332043
- Testing
- HIRREM, Ambient Nature Sounds
- Sponsor
- Wake Forest University Health Sciences
Cardiac Pacemaker, Arrythmia
Aveir DR Real-World Evidence Post-Approval Study
The purpose of this post-approval study is to evaluate the long-term safety of the dual-chamber Aveir DR leadless pacemaker using real-world evidence methods.
- Conditions
- Cardiac Pacemaker, Arrythmia, Bradycardia
- Trial name
- NCT05935007
- Testing
- Aveir DR Leadless Pacemaker System
- Where
- United States
- Volunteers
- 1,805 people
- Sponsor
- Abbott Medical Devices
Late-Onset Neonatal Sepsis
Effect of Kangaroo Care on Heart Rate Variability in Late-onset Neonatal Sepsis
Background: Neonatal sepsis is the leading cause of mortality in preterm newborns. The autonomic nervous system modulates the response to sepsis through the cholinergic anti-inflammatory reflex.
- Trial name
- NCT05991648
- Testing
- Kangaroo Care (skin-to-skin contact)
- Where
- 3 sites in Colombia
- Volunteers
- 20 people
- Sponsor
- Universidad de la Sabana
Atrial Fibrillation (AF), Paroxysmal AF
Evaluation of the Impact of Pulsed Field Ablation on Autonomic Nervous System Modulation in Paroxysmal Atrial Fibrillation
The objective of this clinical trial is to evaluate the impact of pulse field (PF) energy, both alone and in combination with radiofrequency (RF) energy, on vagal modulation during point-by-point pulmonary vein isolation (PVI) in…
- Trial name
- GPfIRE (NCT06647485)
- Testing
- PF-only PVI, Hybrid PVI, RF-only PVI
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- VZW Cardiovascular Research Center Aalst
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