Clinical trials: Autonomic Nervous System Disorders
Parkinson's Disease (PD), Parkinsonism
Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)
This study is designed to determine if magnetic resonance imaging (MRI) measures can be used to diagnose and monitor the progression of Parkinson's disease (PD) while distinguishing between PD and parkinsonisms [conditions that…
- Conditions
- Parkinson's Disease (PD), Parkinsonism, Progressive Supranuclear Palsy (PSP), Multiple System Atrophy (MSA)
- Trial name
- NCT01888185
- Where
- United States
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Fullterm Birth, Neonate
Assessment of Autonomic Maturation in Neonatal Period and Early Neural Development From a Longitudinal Prospective Cohort
The heart rate variability assessment of the sympathetic-parasympathetic balance is a strong analytical tool in the autonomic nervous system (ANS) physiology, at each end of life.
- Conditions
- Fullterm Birth, Neonate, Prematurity
- Trial name
- AUBE (NCT00951860)
- Testing
- Autonomic Nervous System activity
- Where
- France
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Spinal Cord Injury
Orthostatic Tolerance During FES (Functional Electrical Stimulation)-Walking in Paraplegia
Objective: The objective of this research is to undertake a safety and viability study of FES-evoked stepping in individuals with paraplegia.
- Trial name
- NCT00108043
- Testing
- FES-evoked functional upright gait
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- University of Sydney
Postural Tachycardia Syndrome
Intravenous (IV) Saline and Exercise in Postural Tachycardia Syndrome (POTS)
The investigators will test whether an intravenous infusion of saline (salt water) will improve the exercise capacity in patients with postural tachycardia syndrome (POTS).
- Trial name
- NCT01000350
- Testing
- Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Blood Pressure
Fibromyalgia and Circadian Blood Pressure
Fibromyalgia syndrome (FMS) is a chronic and multicomponent illness with unknown etiology and is considered the most frequent cause of diffuse chronic musculoskeletal pain.
- Trial name
- NCT05113589
- Testing
- PBM TREATMENT
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- University of Malaga
Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome
Long COVID Immune Profiling
Parasympathetic nervous system (PNS) is part of the body's autonomic nervous system(PNS) protects body against inflammation. Study shows that reduced PNS function activity is associated with persistent inflammation.
- Conditions
- Long COVID, POTS - Postural Orthostatic Tachycardia Syndrome, Autonomic Dysfunction
- Trial name
- NCT06027255
- Testing
- IL-6, cytokines (IL-17, and IFN-ɣ), Compass 31
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Chronic Cluster Headache
Efficacy of Modified Atkins Ketogenic Diet in Chronic Cluster Headache: a Prospective Case Series
Atkins diet is a nutritional regimen characterized by ad libitum protein and fat intake, but carbohydrate restriction. It is followed by millions of people around the word as a life-style, but in the last years was proposed as a…
- Trial name
- CCHD (NCT03244735)
- Testing
- Atkins diet
- Where
- Italy
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Complex Regional Pain Syndrome I (CRPS I)
Feasibility of a Combination of Graded Pain Exposure and Graded Motor Imagery in People With Complex Regional Pain Syndrome Type 1
Background: There is low quality evidence supporting the use of rehabilitation in Complex Regional Pain Syndrome (CRPS), despite it is the first line approach in the Guidelines .
- Trial name
- ABILITIES-1 (NCT05998889)
- Testing
- Experimental group, Control group
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- University of Vic - Central University of Catalonia
Autonomic Dysregulation, Anxiety
Potential Benefits of Parent Child Interaction Therapy (PCIT)
The goal of this study is to explore possible benefits of Parent-Child Interaction Therapy (PCIT). The main goals of the study are: To investigate whether pre-survey measures of autonomic reactivity relate to the overall…
- Conditions
- Autonomic Dysregulation, Anxiety, Depression, Parent-Child Relations
- Trial name
- NCT06827951
- Testing
- Parent-Child Interaction Therapy (PCIT)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
Blood Pressure, Post-Exercise Hypotension
The Effects of Dietary Salt on Post-exercise Hypotension
The new American Heart Association (AHA) blood pressure guidelines are expected to raise the prevalence of high blood pressure to ~46% in the United States.
- Trial name
- NCT03565653
- Testing
- High dietary salt
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Chronic Cluster Headache
Anodal Transcranial Direct Stimulation (tDCS) for the Treatment of Chronic Cluster Headache
Cluster headache is a primary headache that chiefly affects young men, and is less common than migraine. This disease can have devastating consequences due to the pain intensity (it is also called "suicide headache"), to the side…
- Trial name
- ANODECCH (NCT02462395)
- Testing
- tDCS
- Where
- Belgium
- Volunteers
- 32 people
- Sponsor
- University of Liege
Nasal Congestion and Inflammations, Sinus Congestion Chronic
Effects of SinuSonic on Psychological and Physical Well-Being
The goal of this clinical trial is to evaluate the effects of using the SinuSonic on psychological and physical well-being in adults who have nasal/sinus congestion.
- Trial name
- NCT06268730
- Testing
- SinuSonic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Multiple System Atrophy, Parkinsons Disease
Autologous suraL nervE Grafting to the Substantia nigrA in Patients With Synuclienopathies
This phase I double-blind study focuses on the safety and feasibility of implanting autologous peripheral nerve tissue (PNT) into the substantia nigra area of the brain in persons who have been diagnosed with either Parkinson's…
- Trial name
- LEAP (NCT06683365)
- Testing
- Sural Nerve Graft to the Substantia Nigra
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Craig van Horne, MD, PhD
Prostatic Neoplasms
Prevalence of HRR-related Genes Mutations and Prognosis in Metastatic Castration Resistant Prostate Cancer (mCRPC) Patients in Real World Setting
The purpose of this study is to investigate the prevalence of tissue homologous recombination repair (HRR)-related gene mutations (positive/negative/Variant of uncertain significance (VUS)), clinical outcome such as…
- Trial name
- ZENSHIN (NCT04425200)
- Where
- 26 sites in Japan
- Volunteers
- 205 people
- Sponsor
- AstraZeneca
Insulin Resistance, Healthy
Role of Sympathetic Vasoconstriction on Insulin-Mediated Microvascular Recruitment and Glucose Uptake in Obesity
The purpose of this study is to better understand the contribution of sympathetic vasoconstriction to impaired insulin-mediated vasodilation and subsequently insulin-mediated glucose uptake.
- Conditions
- Insulin Resistance, Healthy, Obesity
- Trial name
- NCT03318094
- Testing
- Phentolamine, Saline, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Endometrial Cancer
Inavolisib for PIK3CA Mutated Advanced Endometrial Cancer: MITO END-4
MITO END-4 is a prospective, single arm, multicentric phase II trial aiming to assess whether Inavolisib is effective in the treatment of advanced endometrial carcinoma with pathogenic PIK3CA mutation.
- Trial name
- MITO END-4 (NCT07522697)
- Testing
- Inavolisib
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute, Naples
Orthostatic Hypotension
A Novel Device for the Treatment of Postural Hypotension - a Signal of Effectiveness Study.
The goal of this clinical trial is to test a novel medical device (ISO-101) in patients diagnosied with orthostatic hypotension.
- Trial name
- NCT06039410
- Testing
- ISO-101
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Isotech Ltd
Vasovagal Syncope, Postural Tachycardia Syndrome
Hypnosis in Autonomic Function
This study will investigate the relationship between susceptibility to hypnosis and regulation of the autonomic nervous system (nerves that control involuntary body functions, such as heart rate and sweating).
- Conditions
- Vasovagal Syncope, Postural Tachycardia Syndrome, Hypnosis
- Trial name
- NCT00061009
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Autonomic Nervous System Diseases
Sympathetic-parasympathetic Ratio of Our Gaze
ABSTRACT BACKGROUND The existence of the retinohypothalamic pathway suggests that light may influence autonomic outflow activity.
- Trial name
- NCT03322904
- Testing
- iris photography
- Where
- Turkey (Türkiye)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Kecioren Education and Training Hospital
Primary Parkinsonism, Secondary Vascular Parkinson Disease
Application of Machine Learning Method in Validation of Screening Cognitive Test for Parkinsonisms
Based on a prospectively collected data analysis, a new tool, namely CoMDA (Cognition in Movement Disorders Assessment) is developed by merging each item of Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment…
- Conditions
- Primary Parkinsonism, Secondary Vascular Parkinson Disease, Multiple System Atrophy, Supranuclear Palsy, Progressive
- Trial name
- CoMDA-ML-P (NCT04858893)
- Testing
- CoMDA associated with Neural Net 91 classificator
- Where
- Italy
- Volunteers
- 562 people, healthy volunteers welcome
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
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