Clinical trials: Autonomic Nervous System Disorders
Pancreatic Adenocarcinoma
9-ING-41 Combined With Retifanlimab, Plus Modified FOLFIRINOX for Patients With Advanced Pancreatic Adenocarcinoma (RiLEY)
This is a study of the combination of 9 ING-41 (elraglusib) and retifanlimab plus mFOLFIRINOX in patients with pancreatic cancer without prior systemic therapy for advanced disease.
- Trial name
- RiLEY (NCT06896188)
- Testing
- Retifanlimab, Chemotherapy, 9-ING-41
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Anwaar Saeed
Cerebral Palsy
Conscious Sedation With Nitrous Oxide in Control of Stress During Dental Care for Individuals With Cerebral Palsy
Cerebral Palsy induces oral alterations that impact on oral health, requiring dental treatment. The objective of this study was to evaluate the use of conscious sedation with nitrous oxide (N2O) in the control of stress during…
- Trial name
- NCT02322983
- Testing
- Control of Stress
- Where
- Brazil
- Volunteers
- 77 people
- Sponsor
- Universidade Cruzeiro do Sul
Hypotension, Orthostatic
A Study for Patients With Neurogenic Orthostatic Hypotension
We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright…
- Trial name
- NCT00046475
- Testing
- Midodrine Hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 140 people
- Sponsor
- Shire
Breast Neoplasms, Autonomic Nervous System Diseases
Effect of Exercise Training in Autonomic Modulation in Breast Cancer Patients
The aim of this study is to evaluate the effect of exercise training in the autonomic nervous system activity in breast cancer patients, who underwent doxorubicin medication.
- Trial name
- NCT02584712
- Testing
- Combined Exercise Training
- Volunteers
- 18 people
- Sponsor
- Federal University of Maranhao
Type 2 Diabetes Mellitus, Hypertension
Effect of Beetroot Juice on Cardiovascular and Autonomic Responses to Exercise in Adults With Type 2 Diabetes
This study will investigate whether a single dose of beetroot juice can improve cardiovascular responses and recovery after exercise in adults with Type 2 Diabetes.
- Conditions
- Type 2 Diabetes Mellitus, Hypertension, Autonomic Nervous System Diseases
- Trial name
- DiaBEET (NCT07560800)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Oxford Brookes University
Type 2 Diabetes, Diabetes With Diabetic Autonomic Neuropathy (Diagnosis)
The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy
Diabetic cardiac autonomic neuropathy (DCAN) is a common chronic complication that reduces survival in patients with diabetes. Epidemiological surveys have shown that the prevalence of DCAN is 25-75% in people with type 2…
- Trial name
- NCT06461377
- Testing
- Glucagon-like peptide-1 receptor agonist：Semaglutide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Healthy
Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects
Impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.
- Trial name
- POLLAIR (NCT01042834)
- Testing
- Air pollution study on healthy volunteers.
- Where
- 2 sites in France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Benign Paroxysmal Positional Vertigo, Vertigo
The Cardiac Autonomic Control System Response to Vestibular Stimulation in Subjects With and Without BPPV
The vestibular system in the inner year is an important system in the body which is responsible for balance. In addition, there is evidence that the vestibular system plays a role in maintaining blood pressure while changing body…
- Conditions
- Benign Paroxysmal Positional Vertigo, Vertigo, Autonomic Nervous System
- Trial name
- NCT03867019
- Testing
- Heart rate variability parameters monitoring
- Where
- Israel
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Clalit Health Services
Coronary Artery Disease
Effect of PADMA 28 on Endothelial Function, Autonomic Nervous System and Biomarkers in Patients With Coronary Artery Disease
This randomized, placebo-controlled, double-blinded trial investigates the effect of a 6 week intake of PADMA 28 on the endothelial function, biomarkers and the autonomic nervous systems in patients with coronary artery disease.
- Trial name
- PADMA 28 (NCT01581034)
- Testing
- PADMA 28
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Chronic Pain, Low Back Pain
Research Protocol for Karuna Labs Inc.: Safety and Efficacy of Virtual Reality Graded Motor Imagery for Chronic Pain
The purpose of this study is to investigate, in two phases: (1) the feasibility and safety of Virtual Embodiment Therapy in treating chronic pain of lower back and upper limbs and (2) the efficacy of Virtual Embodiment Therapy on…
- Conditions
- Chronic Pain, Low Back Pain, Fibromyalgia, Upper Extremity Dysfunction
- Trial name
- NCT04060875
- Testing
- Karuna Labs Virtual Reality Software
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Karuna Labs Inc.
Sleep Apnea, Obstructive
Pediatric Obstructive Sleep Apnea Diagnosis by Respiratory Polygraphy
Respiratory polygraphy (RP) can be used to detect obstructive sleep apnea syndrome in children (OSA) , but it underestimates the obstructive apnea-hypopnea index (OAHI) because hypopneas associated with cortical arousals are not…
- Trial name
- NCT06754800
- Testing
- Polysomnography in routine care
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Central Hospital, Nancy, France
Parkinson's Disease
Duodenal Levodopa Infusion, Quality of Life and Autonomic Nervous System in Parkinson's Disease
The aim of the study is to assess the effect of continuous levodopa infusion on autonomic nervous system in patients with Parkinson's Disease (PD), blood pressure regulation and sweating.
- Trial name
- NCT00914134
- Testing
- Levodopa infusion
- Where
- Finland
- Volunteers
- 12 people
- Sponsor
- University of Helsinki
Refractory Chronic Cluster Headache
Ketamine + Magnesium for Chronic Cluster Headache (KETALGIA)
Chronic cluster headache (CCH) is a rare primary headache disorder, defined by episodic attacks that occur for more than one year with no remission period or with remission periods lasting < 3 months (ICHD-3 criteria).
- Trial name
- KETALGIA (NCT04814381)
- Testing
- Ketamine + Magnesium sulfate (drug combination)
- Where
- 14 sites in France
- Volunteers
- 93 people
- Sponsor
- University Hospital, Clermont-Ferrand
Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
Hemodynamic Response of Neuropathic And Non-Neuropathic POTS Patients To Adrenoreceptor Agonist And Antagonist
The purpose of this study is to test the hypothesis that patients with non-neuropathic POTS will have different responsiveness than patients with neuropathic POTS to direct alpha-1 adrenoreceptor agonist therapy (droxidopa) and…
- Trial name
- NCT03070730
- Testing
- Droxidopa, Atenolol
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Beth Israel Deaconess Medical Center
Concussion, Mild
Impact of a Paced Breathing Exercise Intervention on Autonomic Nervous System Function After Pediatric Concussion
The goal of this pilot clinical trial is to assess the feasibility of administering a paced breathing exercise intervention program to children and adolescents in the sub-acute period after concussion, and to document the…
- Trial name
- Breathe (NCT06559865)
- Testing
- Breathing exercises
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Headache Disorders, Tension-Type Headache
An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache Patients
Headache disorders are among the most prevalent medical conditions worldwide. The diagnosis of headache disorders is based on medical history taking.
- Conditions
- Headache Disorders, Tension-Type Headache, Migraine Disorders, Cluster Headache
- Trial name
- NLPH-OPEN (NCT05153876)
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 1,150 people
- Sponsor
- University Hospital, Ghent
Prostate Cancer, Erectile Dysfunction
Nerve Grafting Technique to Preserve Erectile Function in Patients Undergoing Robotic Assisted Radical Prostatectomy
The investigator proposing a single arm prospective pilot trial evaluating the safety and the 1-year erectile recovery outcomes of patients undergoing Nerve Restoring (NR) Robotically assisted laparoscopic radical prostatectomy…
- Trial name
- NR-RALP (NCT06521710)
- Testing
- Intraoperative Somatic-Autonomic Nerve Grafting
- Where
- 2 sites in Canada
- Volunteers
- 10 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Pancreas Cancer, Peutz-Jeghers Syndrome (PJS)
The Cancer of the Pancreas Screening-5 CAPS5)Study
Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.
- Conditions
- Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier
- Trial name
- CAPS5 (NCT02000089)
- Testing
- Secretin, MRI, Tumor marker gene test with CA19-9
- Where
- 9 sites in United States
- Volunteers
- 9,000 people
- Sponsor
- Johns Hopkins University
Renal Transplant
Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction
The purpose of this study is to evaluate whether conversion to everolimus (Zortress®), allowing the elimination or reduction of calcineurin inhibitors, will reduce nephrotoxicity (measured by increased creatinine clearance) and…
- Trial name
- NCT01935128
- Testing
- Arm 1 Everolimus/Reduced dose tacrolimus
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Toledo Health Science Campus
Complex Regional Pain Syndrome I (CRPS I)
Treatment of Complex Regional Pain Syndrome With Once Daily Gastric-Retentive Gabapentin (Gralise)
The purpose of this study is to see if an FDA-approved drug (Gralise) can help people with certain types of neuropathic pain without causing too many side effects.
- Trial name
- NCT01623271
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.