Clinical trials: Autonomic Nervous System Disorders
Urinary Bladder, Neurogenic, Blood Pressure
Recovery of Bladder and Sexual Function After Human Spinal Cord Injury
This study will incorporate critical cross viscero-visceral intersystem interactions to investigate in a controlled laboratory setting the extent, severity, and frequency of occurrence of autonomic dysreflexia with respect to…
- Conditions
- Urinary Bladder, Neurogenic, Blood Pressure, Autonomic Dysreflexia, Bowel Incontinence
- Trial name
- NCT04193709
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Louisville
Hypertension, Blood Pressure
HIRREM for Stage 1 Primary Hypertension
The purpose of this study is to determine that effects of an intervention called High-resolution, relational, resonance-based, electroencephalic mirroring (HIRREM), on Stage 1 Primary Hypertension (systolic BP 130-139, and/or…
- Conditions
- Hypertension, Blood Pressure, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- HIRREM (NCT03479697)
- Testing
- HIRREM, Continued Current Care
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Wake Forest University Health Sciences
Acute Ischemic Stroke, Biofeedback
Effects of Biofeedback in Patients With Acute Cerebral Infarction
The major aim of this study is to investigate the effects of biofeedback assisted abdominal breathing training on improving the psychological and physiological distress in patients with ACI.
- Conditions
- Acute Ischemic Stroke, Biofeedback, Autonomic Dysfunction, Cognitive Function, Psychological Distress
- Trial name
- NCT03516227
- Testing
- heart rate variability biofeedback
- Volunteers
- 40 people
- Sponsor
- National Defense Medical Center, Taiwan
Advanced Stage Solid Tumors
ATRi Transition Rollover Study
The main purpose of the study was to monitor the safety of participant receiving long-term treatment of Berzosertib as monotherapy.
- Trial name
- NCT03309150
- Testing
- Berzosertib
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Diabetic Retinopathy, Macular Degeneration
Advancing Understanding of Transportation Options
This Stage II randomized, controlled, longitudinal trial seeks to assess the acceptability, feasibility, and effects of a driving decision aid use among geriatric patients and providers.
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Glaucoma, Retinitis Pigmentosa
- Trial name
- AUTO (NCT04141891)
- Testing
- Driving Decision Aid, Older Drivers Website
- Where
- 3 sites in United States
- Volunteers
- 529 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Health Personnel, Stress
Cereset Research In Healthcare Workers During COVID-19
The purpose of this study is to evaluate the use of Cereset Research to improve the symptoms of stress in healthcare workers in an open label, waitlist controlled pilot clinical trial, during the period of COVID-19.
- Conditions
- Health Personnel, Stress, Anxiety, Insomnia
- Trial name
- NCT04682197
- Testing
- Cereset Research
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Colon Cancer
Adjuvant Aspirin Treatment for Colon Cancer Patients
Following complete resection of their primary tumor, potentially eligible stage II or stage III colon cancer patients will undergo central PIK3CA testing.
- Trial name
- NCT02467582
- Testing
- Aspirin
- Where
- 60 sites in Belgium, Germany and 2 more
- Volunteers
- 1,040 people
- Sponsor
- Swiss Cancer Institute
Long COVID, Long Covid19
RECOVER-AUTONOMIC Platform Protocol
This study is a platform protocol designed to be flexible so that it is suitable for a wide range of settings within health care systems and in community settings where it can be integrated into COVID-19 programs and subsequent…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06305780
- Testing
- IVIG + Coordinated Care, Ivabradine + Coordinated Care, IVIG + Usual Care
- Where
- 50 sites in United States
- Volunteers
- 381 people
- Sponsor
- Kanecia Obie Zimmerman
Hypotension, Orthostatic
A Study for Patients With Neurogenic Orthostatic Hypotension
We are seeking male and female patients to voluntarily take part in a clinical research study. Patients must be aged 18 or older and diagnosed with symptomatic orthostatic hypotension (low blood pressure while in the upright…
- Trial name
- NCT00046475
- Testing
- Midodrine Hydrochloride
- Where
- 15 sites in United States
- Volunteers
- 140 people
- Sponsor
- Shire
Hypertension, Pure Autonomic Failure
Nitric Oxide and the Autonomic Nervous System
The amount of blood flowing to the different parts of the body is regulated by the autonomic (automatic) nerves and by local factors produced by the blood vessels.
- Trial name
- NCT00178919
- Testing
- L-NMMA, Trimethaphan
- Where
- United States
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Orthostatic Intolerance
Sex Hormones and Orthostatic Tolerance
This study is designed to determine the causes of "orthostatic intolerance" which occurs more commonly in women than in men. Orthostatic tolerance is the ability to remain standing up right for long periods of time, or to avoid…
- Trial name
- NCT01153581
- Testing
- Ganirelix acetate, 17β-Oestradiol, Progesterone
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Yale University
Nasal Congestion and Inflammations, Sinus Congestion Chronic
Effects of SinuSonic on Psychological and Physical Well-Being
The goal of this clinical trial is to evaluate the effects of using the SinuSonic on psychological and physical well-being in adults who have nasal/sinus congestion.
- Trial name
- NCT06268730
- Testing
- SinuSonic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of North Carolina, Chapel Hill
Renal Transplant
Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction
The purpose of this study is to evaluate whether conversion to everolimus (Zortress®), allowing the elimination or reduction of calcineurin inhibitors, will reduce nephrotoxicity (measured by increased creatinine clearance) and…
- Trial name
- NCT01935128
- Testing
- Arm 1 Everolimus/Reduced dose tacrolimus
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of Toledo Health Science Campus
Spinal Cord Injury
Transcutaneous Stimulation in Spinal Cord Injury
Cardiovascular disease has become the leading cause of death in the spinal cord injury population. Increased reliance on the renin-angiotensin-aldosterone system (RAAS) is believed to decrease falls in blood pressure when moving…
- Trial name
- SCI (NCT05180227)
- Testing
- DS8R
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Cluster Headache
A Randomized Multicentre Study for the Acute Relief of Episodic and Chronic Cluster Headache.
The study will look at a non-invasive treatment for people suffering with chronic and episodic headaches. Study subjects will be randomized to an active treatment or an in-active treatment for 2 weeks.
- Trial name
- NCT01958125
- Testing
- gammaCore
- Where
- 9 sites in Denmark, Germany and 2 more
- Volunteers
- 102 people
- Sponsor
- ElectroCore INC
Locally Advanced or Metastatic Solid Tumors, Genes, BRCA 1
Javelin BRCA/ATM: Avelumab Plus Talazoparib in Patients With BRCA or ATM Mutant Solid Tumors
Avelumab in combination with talazoparib will be investigated in patients with locally advanced or metastatic solid tumors with a BRCA or ATM defect.
- Trial name
- NCT03565991
- Testing
- Avelumab, Talazoparib
- Where
- 100 sites in United States, Belgium and 7 more
- Volunteers
- 202 people
- Sponsor
- Pfizer
Hypotension, Orthostatic
Orthostatic Hypotension in Rehabilitation Patients
The purpose of this study is to determine the prevalence and clinical course of orthostatic hypotension (OH) on a rehabilitation and nursing home unit during their inpatient stay and to initiate a standardized, interdisciplinary…
- Trial name
- NCT00117585
- Testing
- Treatment Phase 1, Treatment Phase 2, Treatment Phase 3
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes Mellitus, Diabetic Peripheral Neuropathy
Evaluation of Exenatide in Patients With Diabetic Neuropathy
This study will look at whether or not the medication exenatide improves signs and symptoms of diabetic peripheral neuropathy in people with type 2 diabetes and mild to moderate diabetic peripheral neuropathy.
- Trial name
- NCT00855439
- Testing
- Exenatide, Glargine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Vasovagal Syncope
Prevention of Syncope Trial 6 - Atomoxetine in Vasovagal Syncope
Objective: To determine if atomoxetine 40 mg bid (bis in die) in patients ≥18 years old with recurrent vasovagal syncope will better prevent syncope during tilt testing than placebo.
- Trial name
- POST6 (NCT02500732)
- Testing
- Atomoxetine
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- University of Calgary
Syncope, Syncope, Vasovagal
Head-up Tilt Test in Patients With Reflex Syncope and Asystolic Response Who Received a Dual-chamber Pacemaker With the Closed Loop Stimulation (CLS) and Participated in the BIOSync Trial
The purpose of this study is to explore changes in patients' hemodynamic parameters during the Head-Up Tilt Test ("HUTT") and their timing with respect to onset of the Closed Loop Stimulation (CLS) pacing.
- Trial name
- BIO|Sync-HUTT (NCT06038708)
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Biotronik SE & Co. KG