Clinical trials: Autophagy
Colo-rectal Cancer
Association of Autophagy-related Genes ,LncRNA and SNPs With Colorectal Cancer in Egyptian Population
1. Determination of expression level of HOTTIP and EIF4EBP1(Eukaryotic translation initiation factor 4E-binding protein 1) . 2. Investigation of the SNP HOTTIP rs1859168 and it's association with CRC susceptibility. 3.
- Trial name
- NCT04729855
- Testing
- PBMCs and Tissue expression of HOTTIP ,EIF4EBP1 and serum SNP HOTTIP rs1859168
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Esraa Hassan,MD
Fasting, Autophagy
Time Course for Fasting-induced Autophagy in Humans
Autophagy, which involves the degradation of aged or damaged cellular components, has been shown to extend healthspan and lifespan in multiple organisms, including flies, worms, and mice.
- Conditions
- Fasting, Autophagy, Aging Well, Ketosis, Metabolic
- Trial name
- NCT04842864
- Testing
- Fasting
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Lung Cancer
Hydroxychloroquine, Carboplatin, Paclitaxel, and Bevacizumab in Recurrent Advanced Non-Small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy, such as hydroxychloroquine, carboplatin, and paclitaxel and work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00728845
- Testing
- bevacizumab, carboplatin, hydroxychloroquine
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Metastatic NRAS Melanoma
MEK and Autophagy Inhibition in Metastatic/Locally Advanced, Unresectable Neuroblastoma RAS (NRAS) Melanoma
Patients with metastatic Neuroblastoma RAS (NRAS) melanoma are currently treated with first line immune checkpoint inhibitors (nivolumab, pembrolizumab).
- Trial name
- CHLOROTRAMMEL (NCT03979651)
- Testing
- Trametinib plus hydroxychloroquine in patients with NRAS Melanoma (Dose 1), Trametinib plus hydroxychloroquine in patients with NRAS Melanoma (Dose 2), Trametinib plus hydroxychloroquine in patients with NRAS Melanoma (Dose 3)
- Where
- 5 sites in France
- Volunteers
- 29 people
- Sponsor
- Hospices Civils de Lyon
Acute Coronary Syndrome
Inflammation Reduction by TREhalose AdminisTration
Arterial wall inflammation has been consistently suggested to serve a causal role in promoting atherosclerosis and predisposing to hard cardiovascular outcomes.
- Trial name
- IR-TREAT (NCT03700424)
- Testing
- Trehalose, Normal saline
- Where
- Iran
- Volunteers
- 15 people
- Sponsor
- Mashhad University of Medical Sciences
Dermatology and Oncology
Association of Hydroxychloroquine, BRAF and MEK Inhibitors in Metastatic Melanoma : a Retrospective Case-control Study.
Patients with a BRAF mutated melanoma are usually treated in France by a first line of immunotherapy followed by a second line that combines a BRAF inhibitor (dabrafenib, vemurafenib, encorafenib) and a MEK inhibitor (trametinib…
- Trial name
- CHLORO-DATRAM (NCT04760080)
- Testing
- pre-treatment data, during study treatment
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Hospices Civils de Lyon
Non-Medullary Thyroid Carcinoma
Digoxin for the Reinduction of Radioiodine Uptake in Metastatic or Locally Advanced Non-medullary Thyroid Carcinoma
Non-medullary thyroid carcinoma has a good prognosis in most patients. However, a small subset of patients nevertheless develop metastatic or locally advanced and unresectable disease which in some cases also becomes radioiodine…
- Trial name
- DIGUP-TC (NCT05507775)
- Testing
- Digoxin tablet
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Breast Carcinoma, Hematopoietic and Lymphoid Cell Neoplasm
Autophagy Activation for the Alleviation of Cardiomyopathy Symptoms After Anthracycline Treatment, ATACAR Trial
This phase II trial compares two drug therapy plans for the correction of heart function changes (reduced ejection function) in patients who have undergone anthracycline-based treatment for lymphoma, sarcoma, or breast cancer.
- Conditions
- Breast Carcinoma, Hematopoietic and Lymphoid Cell Neoplasm, Lymphoma, Sarcoma
- Trial name
- NCT04190433
- Testing
- Carvedilol, Lisinopril, Pravastatin
- Sponsor
- Mayo Clinic
Melanoma
Dabrafenib/Trametinib/Hydroxychloroquine for Advanced Pretreated BRAF V600 Mutant Melanoma
This phase 1/2 trial addresses the efficacy and safety of the combination of dabrafenib, trametinib and the oral autophagy inhibitor hydroxychloroquine in patients with unresectable AJCC (American Joint Committee on Cancer) stage…
- Trial name
- COMBI-R2 (NCT03754179)
- Testing
- Dabrafenib, Trametinib, Hydroxychloroquine
- Where
- Belgium
- Volunteers
- 63 people
- Sponsor
- Universitair Ziekenhuis Brussel
Autophagy
Correlation Between Autophagy-related Proteins and Inflammatory Markers in Hemodialysis Patients
One recent study demonstrated impaired autophagy in patients receiving hemodialysis (HD). To clarify whether this alteration is related to the inflammatory state in HD patients, we focused on basal autophagy in peripheral blood…
- Trial name
- NCT03925753
- Where
- Taiwan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Breast Cancer
Autophagy Inhibition Using Hydrochloroquine in Breast Cancer Patients
Hydroxychloroquine is a drug that has been used to treat malaria and rheumatism. It is recently discovered that Hydroxychloroquine increases 'autophagy'.
- Trial name
- NCT01292408
- Testing
- Hydrochloroquine
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Type 2 Diabetes, Healthy Aging
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: Does presence of Type 2 Diabetes reduce autophagy and impair…
- Trial name
- NCT05593549
- Testing
- Trehalose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
HIV Seropositivity
Effects of Cannabidiol (CBD) on the Activation of Autophagy and Inflammation Genes, Functional Consequences in Virologically Controlled HIV-infected Patients
Autophagy and apoptosis are natural cellular mechanisms which consist for the first in a recycling and elimination process of potentially toxic cellular waste, and for the second in a process of cellular suicide when it becomes…
- Trial name
- GALIG-CBD (NCT05306249)
- Testing
- CBD LGP 50
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Oxidative Stress, Cardiovascular Diseases
Effects of Trehalose and Polyphenols in Vasculopathic Patients
Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis and is characterized by obstruction of the arteries of the lower extremities.
- Trial name
- NCT04061070
- Testing
- Supplementation with mix of threalose plus polyphenols, No Supplementation with mix of threalose plus polyphenols
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- University of Roma La Sapienza
Liver Cancer, Hepatobiliary Tract Adenomas and Carcinomas
Observational Study of Biomarker During Liver Surgery
The investigators would like to study whether Sirtuin 1 (SIRT1) plays a cytoprotective role in liver ischemia/reperfusion, and ultimately to develop therapeutic strategies to improve hepatic function of patients with liver…
- Trial name
- NCT02102971
- Testing
- Hepatocellular carcinoma
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Florida
Multiple Myeloma
Autophagy Induction After Bortezomib for Myeloma
The purpose of this study is to better understand the effects of the chemotherapy medication bortezomib on cancer cells. The investigators are therefore taking blood and bone marrow samples from patients with myeloma who are…
- Trial name
- NCT01594242
- Testing
- Bortezomib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Alcoholic Liver Disease
Ethanol Induces Skeletal Muscle Autophagy
In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.
- Trial name
- NCT03209791
- Testing
- Biopsies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Prostate Cancer Recurrent, Solid Tumor, Adult
COAST Therapy in Advanced Solid Tumors and Prostate Cancer
The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers.
- Trial name
- COAST (NCT05036226)
- Testing
- Hydroxychloroquine, Metformin, Sirolimus, Hydroxychloroquine, Metformin, Sirolimus, Dasatanib, Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Medical University of South Carolina
Acute Myeloid Leukemia
Hydrochloroquinine & Decitabine With Venetoclax in AML
Phase I: Primary Objective: Determine the maximum tolerated dose (MTD) and recommended Phase II dose (RP2D) of the o-Dec, ven, and HCQ Secondary Objectives: Characterize the safety profile of the triplet Estimate the efficacy of…
- Trial name
- NCT07814339
- Testing
- Hydroxychloroquine, Venetoclax, Oral Decitabine/cedazuridine
- Volunteers
- 18 people
- Sponsor
- Rutgers, The State University of New Jersey
Prostate Cancer
Docetaxel and Hydroxychloroquine in Treating Patients With Metastatic Prostate Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00786682
- Testing
- docetaxel, hydroxychloroquine
- Where
- 7 sites in United States
- Volunteers
- 11 people
- Sponsor
- University of Medicine and Dentistry of New Jersey