Clinical trials: Autopsy
Central Venous Catheter Thrombosis
Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central Venous Catheters
Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical…
- Trial name
- PHOTO CAT (NCT06417541)
- Testing
- Diseased patients with an indwelling central venous catheter who is referred to autopsy, Living patients with an indwelling central venous catheter referred to a CT scan without iv contrast
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Thomas Kander
Covid19
Spanish Study to Analyze the Histopathological, Ultrastructural and Microbiological Findings Obtained in Autopsies of Patients Who Died Due to COVID-19
The aim of this study is prospectively analyzing the histopathological, ultrastructural and microbiological findings from autopsies performed on patients with COVID-19.
- Trial name
- NCT04772833
- Testing
- Autopsy
- Where
- 10 sites in Spain
- Volunteers
- 50 people
- Sponsor
- Maimónides Biomedical Research Institute of Córdoba
Postmortem Care
The Effect of Simulation-Based Postmortem Care on Nursing Students' Knowledge, Skills, and Self-Efficacy Levels
PURPOSE AND TYPE OF THE RESEARCH This study is designed as a randomized controlled experimental study to investigate the impact of simulation-based learning experiences in the teaching of postmortem care on the knowledge, skills…
- Trial name
- NCT07125456
- Testing
- Postmortem Care Teaching Simulation
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Suicide, Fatal Suicide
Case Control Psychological Autopsy of Suicide
Suicide is a leading cause of death worldwide, and identifying risk factors has been considered as the key initiative of suicide prevention.
- Conditions
- Suicide, Fatal Suicide, Non Fatal Suicidal Behavior
- Trial name
- NCT05097690
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tamkeen Saleem
Stimulant Overdose, Overdose Accidental
Leveraging Psychological Autopsies to Accelerate Research Into Stimulant Overdose Mortality
In the LASSO study, the investigators will identify 100 stimulant overdose decedents (divided among stimulant-only, and stimulant with fentanyl), conduct informant interviews (including scales and qualitative data), and gather…
- Conditions
- Stimulant Overdose, Overdose Accidental, Overdose Cocaine, Overdose Methamphetamine
- Trial name
- LASSO (NCT06076564)
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- San Francisco Department of Public Health
Schizophrenia
Treatment Response in Schizophrenia: Bridging Imaging and Postmortem Studies
The overarching goal is to identify imaging markers that will predict treatment response, and to confirm or validate these biomarkers using anatomical studies of postmortem tissue.
- Trial name
- NCT00937716
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cause of Mortality, Cause of Neonatal Death
Defining Causes of Deaths in South and Southeast Asia
Brief Summary: Mortality data are important in low and middle-income countries to assess the population health status and trends.
- Conditions
- Cause of Mortality, Cause of Neonatal Death, Cause of Child Death, Cause of Maternal Death
- Trial name
- SEACTN-VA (NCT04595656)
- Testing
- verbal autopsy interview
- Where
- 5 sites in Bangladesh, Burma and 3 more
- Volunteers
- 3,413 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pulmonary Embolism
Pulmonary Embolism: an Autopsy Study
BACKGROUND: Pulmonary embolism (PE) is associated to high mortality rate worldwide. However, the diagnosis of PE often results inaccurate.
- Trial name
- NCT03887819
- Testing
- Hystological evaluation
- Volunteers
- 15 people
- Sponsor
- University of Campania Luigi Vanvitelli
Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant
Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.
Clinical Study A. Retrospective Neuropathological Study of Synapse dysfunction. This is a cross-sectional study of patients retrospectively collected from existing postmortem collections and from existing collections of…
- Conditions
- Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant, Major Depressive Disorder (MDD), Bipolar Disorder (BD)
- Trial name
- NCT07234851
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Stillbirth and Fetal Death, Termination of Pregnancy
A Feasibility Study of Virtopsy With Tissue Sampling in Besancon University Hospital
The aim of this project is to assess the feasibility of a new local post mortem procedure at Besançon University Hospital : Virtopsy+, magnetic resonance (MR) imaging with tissue sampling of the fetus and newborns.
- Conditions
- Stillbirth and Fetal Death, Termination of Pregnancy, Neonatal Death
- Trial name
- VIRTOPSY+ (NCT03877900)
- Where
- France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Death
Virtual Autopsy in Cardiology, Cardio- and Vascular-Surgery
Today complex vascular and cardiological interventions are performed in severely ill patients. Autopsy is the reference standard for quality control for almost two centuries, but autopsy rates for patients dying in hospitals are…
- Trial name
- NCT02502955
- Testing
- Comparison autopsy methods
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Covid19, Postmortem Changes
COVID-19 and Tissue Damage in Vital Organs
The study will be conducted in Dokuz Eylül University Hospital, COVID-19 (Coronavirus Disease 2019) intensive care unit. Three primary conditions will be sought for participants: 1.
- Trial name
- NCT04678687
- Testing
- Liver, lung, heart and kidney biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- Dokuz Eylul University
Alzheimer Disease
Phase III Study of Florbetaben (BAY94-9172) PET Imaging for Detection/Exclusion of Cerebral β-amyloid Compared to Histopathology
To determine the sensitivity and specificity of the visual assessment of tracer uptake in the Florbetaben PET images compared to histological verification of the presence or absence of cerebral β-amyloid in the respective…
- Trial name
- NCT01020838
- Testing
- Florbetaben (BAY94-9172)
- Where
- 19 sites in United States, Australia and 3 more
- Volunteers
- 218 people
- Sponsor
- Lantheus Biosciences Ltd.
Childhood Mortality
Mortality Reduction After Oral Azithromycin: Morbidity Study
The long-term goal of this study is to more precisely define the role of mass azithromycin treatments as an intervention for reducing childhood morbidity and increasing growth, and for the potential selection of antibiotic…
- Trial name
- MORDORMorb (NCT02048007)
- Testing
- Azithromycin
- Where
- 6 sites in United States, Malawi and 3 more
- Volunteers
- 72,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Perinatal Death, Neonatal Death
Verbal Autopsy of Maternal Deaths, Stillbirths, and Neonatal Deaths in BetterBirth
The purpose of this study is to conduct Verbal Autopsies of deaths ( stillbirths and neonatal deaths together) identified in the BetterBirth trial to identify their potential causes, timing, and social determinants.
- Conditions
- Perinatal Death, Neonatal Death, Stillbirth
- Trial name
- NCT03213509
- Testing
- Interview (Social and Verbal Autopsy)
- Where
- India
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Small Cell Lung Cancer
Rapid Autopsy Protocol for Patients With Small Cell Lung Cancer
This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection.
- Trial name
- NCT05889546
- Testing
- Biospecimen Collection
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Major Depression
Duke Conte Center for the Neuroscience of Depression in Late Life
The proposed Silvio O. Conte Center for Neuroscience of Depression will focus on understanding the neurobiological mechanism of depression. A total of 5 projects are proposed. The center is focused on a single hypothesis.
- Trial name
- NCT00576875
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Thromboembolism, Vascular Conditions
Evaluation of Contrast Medium Enhanced Post-mortem CT in Virtual Autopsy
The study aims to compare the value of contrast medium enhanced post mortem CT to classic autopsy.
- Trial name
- NCT01541995
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf