Clinical trials: Autopsy, open to volunteers
Multiple Sclerosis
Pathological Basis of MRI Signal Changes in Multiple Sclerosis
Background: Multiple sclerosis (MS) is a disease that damages the central nervous system (brain and spinal cord). This leads to increased physical disability over time. The disease is lifelong once it begins.
- Trial name
- NCT02659956
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Breastfeeding, Infant Death
Support Via Online Social Networks to Promote Safe Infant Care Practices
This study aims to improve adherence to American Academy of Pediatrics safe sleep (SS) recommendations and improve rates of initiation and duration of partial and exclusive breastfeeding (BF); and reduce Black/White disparities…
- Conditions
- Breastfeeding, Infant Death, Sudden Infant Death Syndrome Without Mention of Autopsy
- Trial name
- SUPERSONIC (NCT05767658)
- Testing
- Safe Sleep, Breastfeeding, Early Brain Development and Parent-Child Relationships
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- University of Virginia
Sudden Unexplained Death
Molecular Autopsy Study
This study seeks to incorporate genetic testing into the postmortem examination of cases of sudden unexplained death.
- Trial name
- NCT02168088
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Scripps Translational Science Institute
Postmortem Care
The Effect of Simulation-Based Postmortem Care on Nursing Students' Knowledge, Skills, and Self-Efficacy Levels
PURPOSE AND TYPE OF THE RESEARCH This study is designed as a randomized controlled experimental study to investigate the impact of simulation-based learning experiences in the teaching of postmortem care on the knowledge, skills…
- Trial name
- NCT07125456
- Testing
- Postmortem Care Teaching Simulation
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Tachycardia
Molecular Autopsy in Young Individuals With Sudden Cardiac Death
The goal of this observational study is to create and test a pilot workflow for molecular autopsy (genetic testing after death) in children and adults aged 1 to 50 years who died suddenly from an unexplained cause and were…
- Trial name
- NCT07849738
- Testing
- Molecular autopsy by whole exome sequencing, Cascade genetic screening by targeted Sanger sequencing
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Alzheimer's Disease
Evaluate the Concordance Between PET Imaging of [18F]-APN-1607 Injection and Postmortem Brain Tissue Tau Pathology in Individuals With HV and MCI or AD.
1. To evaluate the diagnostic performance of [18F]-APN-1607 injection PET imaging in detecting uptake patterns consistent with AD neuropathological changes as defined by the National Institute on Aging-Alzheimer's Association…
- Trial name
- NCT07752784
- Testing
- [18F]-APN-1607
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- JYAMS PET Research & Development Limited
Central Venous Catheter Thrombosis
Autopsy and Photon Counting Computed Tomography to Evaluate Thromboses Related to Central Venous Catheters
Central venous (CVC) is essential in modern healthcare but unfortunately associated with complications, including thrombosis. In a recently published study, it was showed that 12 out of 12 deceased patients had subclinical…
- Trial name
- PHOTO CAT (NCT06417541)
- Testing
- Diseased patients with an indwelling central venous catheter who is referred to autopsy, Living patients with an indwelling central venous catheter referred to a CT scan without iv contrast
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Thomas Kander
Sudden Cardiac Arrest, Sudden Cardiac Death
Sudden Cardiac Arrest Related to Sport in Young and Value of the Genetic Assessment: a French Prospective Register
The increased risk of sudden cardiac arrest (SCA) or sudden cardiac death (SCD) related to vigorous physical activity is well-documented.
- Trial name
- RESOUDRE (NCT06642168)
- Testing
- Whole exome sequencing to detect myocardial genetic mutations (SCA group only)
- Where
- 26 sites in France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant
Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.
Clinical Study A. Retrospective Neuropathological Study of Synapse dysfunction. This is a cross-sectional study of patients retrospectively collected from existing postmortem collections and from existing collections of…
- Conditions
- Schizophrenia Disorder, Frontotemporal Dementia, Behavioral Variant, Major Depressive Disorder (MDD), Bipolar Disorder (BD)
- Trial name
- NCT07234851
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Small Cell Lung Cancer
Rapid Autopsy Protocol for Patients With Small Cell Lung Cancer
This is pilot study to establish a rapid autopsy program in Small Cell Lung Cancer (SCLC) at the Indiana University Simon Comprehensive Cancer Center and outline the components necessary for tumor tissue collection.
- Trial name
- NCT05889546
- Testing
- Biospecimen Collection
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Indiana University