Clinical trials: Autoregulation
Diabetes Mellitus
Aldosterone and Glucose Homeostasis
Determine the effect of aldosterone on how the body handles glucose (sugar).
- Trial name
- NCT00732160
- Testing
- Aldosterone infusion (A), Vehicle Infusion (V), High Sodium Diet (HS)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Vanderbilt University
Intensive Care Unit Syndrome
Cerebral Perfusion Variation During Blood Pressure Changes in ICU
The risk associated with arterial hypotension during anesthesia for intensive care sedation has been demonstrated, but the threshold at which consequences for perfusion of one or more organs appear varies according to the…
- Trial name
- DELTAPAMREA (NCT05804773)
- Testing
- Non-invasive Measurement of cerebral blood velocity in the middle cerebral artery by transcranial pulsed Doppler (TCD) (Mean velocity, Vm, cm/s)
- Where
- France
- Volunteers
- 92 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Photobiology
Placebo-controlled Assessment of the Effect of a Food Supplement on Skin Protection After Exposure to UV Radiation
A probiotic bacterial strain was tested in a randomized, double blind , placebo controlled clinical trial with 54 healthy male volunteers.
- Trial name
- NCT00351689
- Testing
- dietary supplement
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- L'Oreal
Diabetes Mellitus, Type 2
Study to Assess the Effect on Glucose Homeostasis of Two Dose Levels of AZD9567, Compared to Prednisolone, in Adults With Type 2 Diabetes
The study is intended to assess the effect on glycaemic control of AZD9567, as measured by the glucose AUC(0-4) versus baseline following a standardised mixed meal tolerance test (MMTT), compared to prednisolone in adults with…
- Trial name
- NCT04556760
- Testing
- AZD9567, Prednisolone
- Where
- 3 sites in Germany
- Volunteers
- 46 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus, Pre-diabetes
Acute Effects of Cold-induced Shivering on 24-hour the Glucose Profile in Metabolically Compromised Populations
Type 2 Diabetes Mellitus (T2DM) and its associated comorbidities pose a major health concern worldwide. Although lifestyle strategies, such as exercise and diet-induced weight loss are effective interventions to counteract the…
- Trial name
- SHIVER (NCT05576025)
- Testing
- Lifestyle intervention (cold exposure)
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Maastricht University Medical Center
Steroid-refractory Diamond-Blackfan Anemia (DBA)
Study of the Selective GlyT1 Inhibitor Bitopertin for Steroid-Refractory Diamond-Blackfan Anemia
Background: Diamond-Blackfan anemia (DBA) is an inherited disease that affects the bone marrow. People with DBA have chronic anemia that can be severe. Many must have frequent transfusions of red blood cells.
- Trial name
- NCT05828108
- Testing
- Bitopertin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Diabetes Mellitus
Prevent/Delay Development of Type 2 Diabetes in Subjects With Impaired Glucose Homeostasis Treated With Acarbose in Primary Care
The purpose of the study is to determine if the administration of small doses of Acarbose can prevent or delay the appearance of Type 2 Diabetes Mellitus in a population of subjects with prediabetes.
- Trial name
- NCT01010100
- Testing
- Acarbose (Glucobay, BAYG5421)
- Where
- 23 sites in Spain
- Volunteers
- 204 people
- Sponsor
- Bayer
Obesity & Overweight, Insulin Resistance Syndrome
SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level
This single-center, randomized, single-blind, 2-period crossover interventional study will evaluate whether exposure to a pleasant food odor 10 minutes before a 75 g oral glucose tolerance test (OGTT) modifies glucose homeostasis…
- Trial name
- SENSILNS (NCT07638111)
- Testing
- Pleasant Food Odor Stimulation, Control Environmental Condition
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Insulin Resistance, Metabolic Syndrome
The Impact of Low-fat and Full-fat Dairy Consumption on Glucose Homeostasis (DAIRY Study)
This randomized controlled feeding trial aims to determine whether the consumption of different amounts and types of dairy products affects blood sugar regulation and cardiometabolic health in men and women with the metabolic…
- Conditions
- Insulin Resistance, Metabolic Syndrome, Obesity, Diabetes
- Trial name
- NCT02663544
- Testing
- Limited dairy diet, Low-fat dairy diet, Full-fat dairy diet
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Fred Hutchinson Cancer Center
Type 2 Diabetes, Cardiometabolic Syndrome
PDE3B in Metabolic Regulation
Phosphodiesterase 3B (PDE3B), an enzyme responsible for the degradation of cyclic AMP and GMP (two important second messengers used for intracellular signal transduction), has been associated with cardiometabolic outcomes.
- Conditions
- Type 2 Diabetes, Cardiometabolic Syndrome, Cardiovascular Diseases
- Trial name
- NCT06533007
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Obesity, Morbid
Effect of Biliopancreatic Diversion on Glucose Homeostasis
Biliopancreatic diversion (BPD) surgery results in greater resolution of type 2 diabetes than all other bariatric surgical procedures, and it is hypothesized that this procedure has specific beneficial effects on glucose…
- Trial name
- BPD-Mingrone (NCT03111953)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Biliopancreatic Diversion Surgery
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Insulin Resistance
Effects of Intranasal Insulin Administration on Tissue Specific Insulin Sensitivity
Recent research has suggested that intranasally administered insulin can reach the brain quickly without passing through circulation and evoke increased insulin sensitivity and tissue glucose consumption during insulin…
- Trial name
- NASO-PET (NCT02933645)
- Testing
- Actrapid, [18F]-FDG PET-CT, Hyperinsulinemic euglycemic clamp
- Where
- Finland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Congenital Heart Disease in Children, Extracorporeal Circulation; Complications
Non-invasive Monitoring of Cerebral Autoregulation in Perioperative Neonatal Cardiac Surgery
Cardiac surgery under extracorporeal circulation (ECC) in newborns with congenital heart disease causes significant morbidity and mortality.
- Trial name
- NEMOCARD (NCT04295239)
- Testing
- MRI
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Healthy Controls
HA35 Acute Alcohol Study
Eligible subjects will be asked to take a placebo/treatment capsule for a total of 3 days and then participate in a study visit on the fourth day.
- Trial name
- NCT05025865
- Testing
- Sodium Hyaluronate
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Non-alcoholic Fatty Liver Disease
Rifaximin Modify the Pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD)
In this multicentric, double-blind, randomized,placebo-controlled study, the investigators hypothesized that rifaximin might act on Gram-negative bacteria and intestinal bacterial overgrowth(IBO) thereby inhibiting…
- Trial name
- NCT02884037
- Testing
- Rifaximin group 1
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Pre Diabetes, Prediabetic State
Study to Assess the Effects of Non Digestible Carbohydrates on Long-Term Glucose Homeostasis in Untreated Prediabetic Subjects
This clinical study aims to prove that the efficacy of non digestible carbohydrates supplementation (daily dose of 20 grams consumed twice a day for 12 weeks) on the regulation of glucose homeostasis is superior than placebo in…
- Conditions
- Pre Diabetes, Prediabetic State, Dysglycemia, PreDiabetes
- Trial name
- FOS_GLUCOSE (NCT04767672)
- Testing
- Non digestible carbohydrates
- Where
- 3 sites in France
- Volunteers
- 66 people
- Sponsor
- Tereos
Healthy
Healthy Combine Study
STUDY SUMMARY Title: EFFECTS OF NICOTINAMIDE AND LANTHANUM CARBONATE ON PHOSPHORUS HOMEOSTASIS Protocol Number:STU00090161 Phase: Phase 1, detailed physiologic study Methodology: double blind, randomized, placebo-controlled, 2x2…
- Trial name
- NCT03136705
- Testing
- Nicotinamide, Lanthanum Carbonate
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Delirium
Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium
Cardiac surgery is associated with multiple events and issues that increase risk for adverse postoperative neurological outcomes including postoperative cognitive dysfunction.
- Trial name
- NCT02084394
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Johns Hopkins University
Osteoporosis, Aging
Exercise Mode and Acute Bone Resorption
Endurance exercise is often recommended to improve cardiometabolic health and maintain bone health throughout life and to prevent osteoporotic fracture.
- Trial name
- NCT04815824
- Testing
- Exercise Mode
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Peri-Implantitis
Dental Hygiene and Peri-Implant Tissues Homeostasis Ancillary Study
Peri-implantitis is an inflammatory disease that leads to loss of jawbone around dental implants. Recent discoveries have identified increased release of Titanium (Ti) particles around implants as being associated to…
- Trial name
- NCT03917264
- Testing
- Peri-implantitis debridement, Dental hygiene procedures
- Where
- 2 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Washington