Clinical trials: Autoregulation
Diabetes Mellitus, Type 1
Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study A
Glutathione is normally present at high (millimolar) levels in blood and plays an important role in the body's defense against oxidative stress, that is, against the damage caused to the body by reactive oxygen species produced…
- Trial name
- NCT00858897
- Testing
- Cysteine isotope infusion at normoglycemia vs hyperglycemia, Regular Insulin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Nemours Children's Clinic
Hematopoietic Stem Cell Transplant
Oral Supplementation of 2'-Fucosyllactose in Allogeneic Bone Marrow Transplant Recipients
High dose chemotherapy and radiation used as preparative regimens in patients undergoing an allogeneic hematopoietic stem cell transplant (HSCT) disrupts intestinal homeostasis by damaging the intestinal epithelium and altering…
- Trial name
- NCT04263597
- Testing
- 2'-fucosyllactose
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Glaucoma
Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
We have completed a study in which we examined the response of the retinal circulation to changes in posture from sitting to lying down in patients with primary open angle glaucoma (POAG).
- Trial name
- NCT00824824
- Testing
- Dorzolamide 2%-timolol 0.5%, Brimonidine 0.2%-0.5% timolol 0.5
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Glucose Intolerance, Type 2 Diabetes Mellitus
Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes
The purpose of the randomized trial is to quantify the effect of vitamin D and calcium supplementation on beta-cell function, insulin sensitivity, glucose tolerance and systemic inflammation and other cardiometabolic outcomes in…
- Conditions
- Glucose Intolerance, Type 2 Diabetes Mellitus, Metabolic Syndrome
- Trial name
- CaDDM (NCT00436475)
- Testing
- Vitamin D3 2,000 IU orally once daily, Calcium Carbonate 400 mg orally twice daily
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
Polycystic Ovary Syndrome, Disorder of Glucose Regulation
Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis
The objective of the present proposal is to compare the clinical, endocrine and metabolic effects of therapy with combination saxagliptin and metformin to saxagliptin and metformin monotherapy in women with PCOS and prediabetic…
- Trial name
- BMS-AZPCOS (NCT02022007)
- Testing
- Metformin XR, Saxagliptin, Saxagliptin-Metformin XR
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Woman's
Hepatitis C, Chronic, Insulin Resistance
Study of Response in Chronic Hepatitis C (CHC) Participants Genotype 1 With Insulin Resistance and Prolonged Treatment Duration in Late Responders (P04823/MK-4031-303)
This is a Phase 3b/4, prospective, open-label, randomized, multicenter study of peginterferon alfa-2b plus ribavirin in participants with chronic hepatitis C, genotype 1.
- Trial name
- NCT00493805
- Testing
- Combination of pegylated interferon alfa-2b and ribavirin
- Volunteers
- 59 people
- Sponsor
- Merck Sharp & Dohme LLC
Overweight and Obesity, Eating Behavior
Examination of Bromocriptine on Homeostatic and Hedonic Mechanisms of Food Intake in Individuals at High Risk for T2DM
The current project applies an integrative three-prong approach to investigate the potential of the dopamine D2 receptor (DRD2) agonist bromocriptine to: 1) increase homeostatic satiation signaling, 2) alter neural circuitry to…
- Trial name
- NCT05405244
- Testing
- Bromocriptine-QR
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Metabolic Syndrome, Pre-Diabetes
The Influence of Time-Restricted Eating in Patients With Metabolic Syndrome
In a randomized controlled trial, the investigators intend to measure the health impact of TRE in patients with metabolic syndrome (with three or more of the following criteria: increased waist circumference, abnormal cholesterol…
- Trial name
- TIMET (NCT04057339)
- Testing
- Time Restricted Eating + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, San Diego
GDM, Insulin Resistance
In Vitro Fertilization Impact on Metabolic Parameters
A quantitative prospective cohort study will be conducted, where blood samples will be collected at different timings during the IVF protocol, to assess the impact of fertility medications on metabolic parameters of patients…
- Conditions
- GDM, Insulin Resistance, Glucose Intolerance, PCOS
- Trial name
- IVF (NCT03426228)
- Testing
- HbA1C
- Where
- United Arab Emirates
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- University of Warwick
Obesity
Effect of Fibre Products on Appetite and Weight
This study explores the nutritional effects of fibre. Short chain fatty acid(SCFA), such as propionate, are produced through the fermentation of fibre in the bowel.
- Trial name
- NCT00750438
- Testing
- Propionate ester, Inulin, Cellulose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity
The Acute Effect of Propionate on Energy Homeostasis
The research project aims to examine the effect of a dietary supplement called propionate on how the human body in healthy adults aged (18- 65 years) responds to during fasting, exercise and following a liquid mixed meal test and…
- Trial name
- PROEM (NCT04093453)
- Testing
- Exercise, Sodium Propionate
- Where
- United Kingdom
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Obesity, Weight Loss
Leptin in Human Energy and Neuroendocrine Homeostasis
Previous work in our laboratory, and many others, has shown that body weight is regulated. When anyone, fat or thin, tries to maintain a reduced body weight, many systems affecting energy balance (skeletal muscle, neuroendocrine…
- Trial name
- NCT00265980
- Testing
- Leptin
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Columbia University
Anemia, Diamond-Blackfan
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag
Background: Diamond-Blackfan anemia (DBA) is treated with steroids. But some people cannot take steroids, or steroids don t work.
- Trial name
- NCT04269889
- Testing
- Eltrombopag
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hypertriglyceridemia
Effects of Prescription Omega-3 Acids on Glucose and Lipoprotein Lipids in Subjects With Hypertriglyceridemia
The objectives of this study are to assess the effects of 4 g/d prescription omega-3 acid ethyl esters (POM3), compared with a placebo, on indices of insulin sensitivity and secretion, as well as aspects of the fasting and…
- Trial name
- NCT01034540
- Testing
- POM3
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Provident Clinical Research
Docosohexaenoic Acid Supplementation of Mothers to
DHA Supplementation for Lactating Mothers
The purpose of this research study is to find out whether preterm infants are receiving enough of the essential and long chain fatty acids important for brain development and immune function.
- Trial name
- DHA-1 (NCT01732874)
- Testing
- Expecta 200 mg, Expecta 1 gram
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Quality of Life, Postoperative Complications
Low Pressure Pneumoperitoneum and Deep Neuromuscular Block vs. Standard During RARP to Improve Quality of Recovery; a Randomized Controlled Study.
Intra-abdominal pressure (IAP) needed to create sufficient workspace during laparoscopic surgery affects the surrounding organs with ischemia-reperfusion injury and a systemic immune response.
- Conditions
- Quality of Life, Postoperative Complications, Acute Pain, Immune System Tolerance
- Trial name
- RECOVER-2 (NCT04250883)
- Testing
- Low intra-abdominal pressure, Deep neuromuscular blockade (NMB), Standard intra-abdominal pressure
- Where
- Netherlands
- Volunteers
- 97 people
- Sponsor
- Radboud University Medical Center
Tinnitus
Regulating Homeostatic Plasticity and the Physiological Response to rTMS
This device-study includes a pilot, physiological investigation of normal human subjects. The aim is to determine how existing non-invasive neuromodulation devices affect brain circuitry as measured by EEG recording.
- Trial name
- NCT03309696
- Testing
- active tDCS and active rTMS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Nonalcoholic Fatty Liver Disease (NAFLD)
Impact of Fructose on Metabolism, Energy Homeostasis and Magnetic Resonance Biomarkers in Nonalcoholic Fatty Liver Disease
This study will advance several goals of the NIH Action Plan: 1) establish a multidisciplinary team to develop quantitative methodologies and imaging protocols for liver, 2) validate diagnostic criteria and methodologies for…
- Trial name
- NCT01930123
- Testing
- intravenous fructose challenge, Blood Draw
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Manal F Abdelmalek
Intraventricular Hemorrhage of Prematurity, Complications of Prematurity
Cerebral Oxygenation and Autoregulation in Preterm Infants
Premature infants are at high risk for variations in blood pressure and oxygenation during the first few days of life. The immaturity of the premature brain may further predispose these infants to death or the development of…
- Trial name
- Early NIRS (NCT02147769)
- Testing
- NIRS monitoring
- Where
- 7 sites in United States
- Volunteers
- 111 people
- Sponsor
- Stanford University