Clinical trials: Autotransplantation
Meniscal Injuries, Meniscal Tear
Semitendinosus Autograft vs Meniscal Allograft in Post-Meniscectomy Syndrome
This multicenter, stratified, partially randomized clinical trial aims to compare autologous semitendinosus tendon graft and meniscal allograft transplantation (MAT) in young adults with post-meniscectomy syndrome.
- Conditions
- Meniscal Injuries, Meniscal Tear, Meniscus Lesion
- Trial name
- MAT (NCT07204587)
- Testing
- Autologous Semitendinosus Tendon Graft, Meniscal Allograft Transplantation (MAT)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Non Hodgkin Lymphoma, Follicular Lymphoma
1630GCC: Zydelig Maintenance in B-Cell Non-Hodgkin's Lymphoma After Autologous Stem Cell Transplantation
This is a pilot study to learn how safe and how effective the study drug Zydelig works, after autologous stem cell transplant as a maintenance therapy in patients with indolent or transformed indolent B-cell non-Hodgkins lymphoma…
- Conditions
- Non Hodgkin Lymphoma, Follicular Lymphoma, Indolent Lymphoma, B-cell Lymphoma
- Trial name
- NCT03133221
- Testing
- Zydelig
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of Maryland, Baltimore
ACL Injury, Graft Failure
Differences in Outcomes and Failure Rates Between Allografts and Autografts in Revision Anterior Cruciate Ligament Reconstruction
Anterior cruciate ligament (ACL) rupture is one of the most common knee injuries, particularly in young and physically active individuals.
- Trial name
- ACLREV_GRAFT (NCT07671235)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Stefano Zaffagnini
Lymphoma
Peripheral Stem Cell Transplantation With Specially Treated Stem Cells in Treating Patients With Non-Hodgkin's Lymphoma or Hodgkin's Disease
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells.
- Trial name
- NCT00005998
- Testing
- carmustine, cyclophosphamide, cytarabine
- Sponsor
- Masonic Cancer Center, University of Minnesota
Multiple Myeloma
Study of MAGE-A3 and NY-ESO-1 Immunotherapy in Combo With DTPACE Chemo and Auto Transplantation in Multiple Myeloma
The hope is that the peptide vaccines will stimulate the immune system to attack and kill the myeloma cells. The purpose is to generate anti-myeloma T-cells which will kill myeloma cells and nothing else.
- Trial name
- NCT00090493
- Testing
- MAGE-A3, MAGE-A3 AND NY-ESO-1 IMMUNOTHERAPY
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Arkansas
Chronic Granulomatous Disease
Gene Therapy for Chronic Granulomatous Disease
X-linked Chronic Granulomatous Disease (CGD) is an inherited disorder caused by an abnormal gene that fails to make the protein known as gp91 phox.
- Trial name
- NCT00394316
- Testing
- Phagocyte Oxidase Subunit Transduced CD34 Hematopoietic Stem Cells
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Myeloma
Prevention of Delayed CINV After Autologous Transplant: Olanzapine-Containing Regimen vs. Dexamethasone-Containing Regimen
This study employs a prospective, multicenter, randomized, two-arm design aimed at evaluating the efficacy and safety of the FTO regimen in preventing delayed chemotherapy-induced nausea and vomiting (CINV) following high-dose…
- Trial name
- NCT07413809
- Testing
- Fosaprepitant, Tropisetron, Olanzapine
- Where
- China
- Volunteers
- 92 people
- Sponsor
- The Affiliated People's Hospital of Ningbo University
Dental Implant Failed
Digital Assessment at Peri-implant Tissues After Immediate Implants With Customized Healing Abutments and Connective Tissue Grafts
After a single-tooth extraction, physiological remodeling processes are unavoidable which leads to a total loss of the periodontal ligament and resorption of the bundle bone.
- Trial name
- NCT05060055
- Testing
- Immediate dental implant placement
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universidade Católica Portuguesa
Asherman's Syndrome, Endometrium; Atrophy, Cervix
Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy
The purpose of this study is to determine whether Bone Marrow Stem Cell transplantation may improve Assisted Reproduction Techniques (ART) outcomes in refractive Asherman's Syndrome or Atrophic Endometrium.
- Trial name
- BMSCT (NCT02144987)
- Testing
- Bone Marrow CD133+ Stem Cell Transplantation
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Multiple Myeloma
Personalized Autologous Transplant for Multiple Myeloma
This phase I trial studies the best dose and side effects of mephalan in treating patients with multiple myeloma who are undergoing stem cell transplant.
- Trial name
- NCT04483206
- Testing
- Autologous Hematopoietic Stem Cell Transplantation, Melphalan, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Emory University
Multiple Myeloma
Total Marrow Irradiation With High Dose Melphalan Prior to Autologous Transplant for Multiple Myeloma
In this phase I trial, patients with multiple myeloma will receive standard high dose melphalan with autologous stem cell rescue. In addition the pre-transplant conditioning will include targeted total marrow irradiation (TMI).
- Trial name
- BMT-02 (NCT02043860)
- Testing
- Total Marrow Irradiation, Autologous Transplant, Melphalan
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Illinois Chicago
Anterior Cruciate Ligament Reconstruction
Transtibial Versus Anteromedial Femoral Tunnel Technique in ACL Reconstruction
The anteromedial (AM) portal technique was introduced to position the femoral tunnel in anterior cruciate ligament (ACL) reconstruction to more closely replicate the original footprint compared to the transtibial (TT)…
- Trial name
- NCT02633410
- Testing
- Femoral tunnel creation
- Volunteers
- 96 people
- Sponsor
- Panam Clinic
Non-Hodgkin's Lymphoma
Busulfan, Melphalan and Etoposide as Conditioning for Autologous Transplantation for Non-Hodgkin's Lymphoma (NHL)
The investigators developed a protocol utilizing once-daily intravenous busulfan/melphalan/etoposide regimen as a conditioning for high-dose therapy (HDT) in the patients with high risk or relapsed Non-Hodgkin's Lymphoma (NHL).
- Trial name
- BME (NCT03792815)
- Testing
- Busulfan, Melphalan, Etoposide
- Where
- South Korea
- Volunteers
- 51 people
- Sponsor
- Soonchunhyang University Hospital
Hematopoietic Stem Cell Mobilization
Clinical Study of rhTPO in Hematopoietic Stem Cell Mobilization for Autologous Transplantation in Acute Leukemia
Evaluation of the efficacy and safety of recombinant human thrombopoietin (rhTPO) at 300 U/kg/day for hematopoietic stem cell mobilization in autologous transplantation among acute leukemia patients
- Trial name
- NCT06955858
- Testing
- Recombinant Human Thrombopoietin（rhTPO）
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Anterior Cruciate Ligament Reconstruction
Reducing Hemarthrosis in ACL Reconstruction With BTB Autograft by the Administration of Intravenous TXA
The purpose of the proposed study is to evaluate the effects of administering intravenous tranexamic acid (TXA) to patients undergoing anterior cruciate ligament (ACL) reconstruction with bone-patellar tendon-bone autograft to…
- Trial name
- NCT03631355
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- NYU Langone Health
Pterygium
A Novel Technique for the Removal of Pterygiums
The aim of this study is to introduce a new surgical technique for the removal of pterygiums that entails the use of bipolar electrocautery to secure the graft, rather than sutures.
- Trial name
- NCT02321150
- Testing
- Cautery, Sutures
- Where
- Barbados
- Volunteers
- 50 people
- Sponsor
- The University of The West Indies
Breast Cancer
CD34 Selection of the Peripheral Blood Stem Cell Graft for Autologous Transplant
Evaluate the feasibility and safety of autologous transplantation of CD34+Thy-1+ hematopoietic stem cells afer high dose marrow ablative chemotherapy in patients with breast cancer.
- Trial name
- NCT00186680
- Testing
- high dose chemo then auto hematopoietic cell transplant
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Stanford University
Germ Cell Tumor, Leukemia
CpG 7909 in Treating Patients Who Have Undergone Autologous Stem Cell Transplant
RATIONALE: Giving CpG 7909 after an autologous stem cell transplant may make a stronger immune response and prevent or delay the recurrence of cancer.
- Conditions
- Germ Cell Tumor, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00369291
- Testing
- keyhole limpet hemocyanin, tetanus toxoid
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pterygium of Conjunctiva and Cornea
Recurrence Rate of Mini-SLET vs. Limbal-Conjunctival Autograft in Primary Pterygium Excision
To study the efficacy and safety of amniotic membrane transplantation as an adjunctive therapy after surgical excision of primary pterygium and compare the clinical outcomes with conjunctival autograft
- Trial name
- NCT03363282
- Testing
- Pterygium Excision
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Instituto de Oftalmología Fundación Conde de Valenciana
Evidence of Liver Transplantation
Autologous Transplantation of Mesenchymal Stem Cells for Treatment of Patients With Onset of Type 1 Diabetes
Type 1 diabetes mellitus (T1DM)is characterized by the autoimmune destruction of the pancreatic β cells; as a result, patients with T1DM are dependent on exogenous insulin to control their blood glucose continuously.
- Trial name
- NCT01157403
- Testing
- Autologous transplantation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Lu Debin