Clinical trials: Autotransplantation
High-Risk Breast Cancer
Adjuvant Breast Cancer Study of the Netherlands Working Party for Autotransplantation in Solid Tumors
Objectives of the study: This randomized multicenter phase II study compares the tolerability, toxicity and quality of life between two high-dose chemotherapy regimens based on cyclophosphamide, thiotepa and carboplatin.
- Trial name
- NCT00851110
- Testing
- stem cell reinfusion, Chemotherapy
- Where
- 10 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Multiple Myeloma, Autologous Stem Cell Transplantation
Olanzapine 2.5 vs 5 mg in Quadruplet Nausea/Vomiting Prophylaxis Before High-Dose Melphalan
Patients who receive a chemotherapy called melphalan are at high risk of having nausea and vomiting. A medication called olanzapine has been shown to decrease nausea and vomiting after chemotherapy.
- Trial name
- FONDO-LOW (NCT06588413)
- Testing
- Olanzapine
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Augusta University
ACL, ACL Injury
Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft
The aim of this study is to investigate the differences in graft failure between patients that underwent ACL reconstruction using allograft tendons and patients that underwent ACL reconstruction using autograft tendons in…
- Trial name
- NCT06584838
- Testing
- ACL reconstruction
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università Vita-Salute San Raffaele
Follicular Lymphoma
Comparison of High-Dose Chemotherapy + Rituximab and CHOP + Rituximab in High-Risk Follicular Lymphoma
The purpose of this study is to determine whether an intensified treatment plus Rituximab followed by autologous transplantation is superior to a conventional chemotherapy regimen also supplemented with Rituximab.
- Trial name
- NCT00435955
- Testing
- High dose chemotherapy with autologous transplantation, Rituximab
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Rotator Cuff Tear, Graft Complication
Arthroscopic Superior Capsular Reconstruction - Study of Different Types of Grafts
Multicentric prospective clinical and radiological comparative study of consecutive patients with irreparable rotator cuff tears to test the hypothesis that there are significant differences in the improvement of the clinical and…
- Trial name
- NCT03739749
- Testing
- Arthroscopic superior capsular reconstruction
- Where
- Portugal
- Sponsor
- Hospital de Egas Moniz
Lymphoma
Filgrastim and Chemotherapy Followed by Peripheral Stem Cell Transplant in Treating Patients With Hodgkin's Lymphoma or Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of…
- Trial name
- NCT00005985
- Testing
- filgrastim, carmustine, cyclophosphamide
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Myeloma Multiple, Lymphoma
Efficacy of Generic Pegfilgrastim vs Brand Name Pegfilrastim for Neutrophil Recovery After Autotransplant
This is a phase 2 clinical trial comparing time to neutrophil recovery after autotrasplant using generic pegfilgrastim vs brand-name pegfilgrastim.
- Trial name
- NCT05338047
- Testing
- Pegfilgrastim
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Lymphoma
S0629, Observation or Combination Chemotherapy, Bortezomib, Thalidomide, and Rituximab Followed By Two Autologous Peripheral Blood Stem Cell Transplants in Treating Patients With Waldenstrom Macroglobulinemia
RATIONALE: Sometimes the cancer may not need treatment until it progresses. In this case, observation may be sufficient. Giving combination chemotherapy together with bortezomib, thalidomide, and rituximab before an autologous…
- Trial name
- NCT00723658
- Testing
- rituximab, bortezomib, carmustine
- Where
- 29 sites in United States
- Sponsor
- SWOG Cancer Research Network
Breast Cancer Surgery, Reconstruction Breast Surgery
Improvement in Breast Skin Sensibility After Breast Reconstruction: a Comparison of 3 Surgical Techniques
The goal of this clinical trial is to learn if nerve sutures in free flap breast reconstruction can optimize sensibility in the reconstructed breast in patients opting for DIEP flap breast reconstruction due to breast cancer or…
- Conditions
- Breast Cancer Surgery, Reconstruction Breast Surgery, Sensitization, DIEP Flap Breast Reconstruction
- Trial name
- S-DIEP (NCT06930378)
- Testing
- Nerve Suture
- Where
- Switzerland
- Volunteers
- 63 people
- Sponsor
- Patricia Esther Engels
Pterygium
Polyglactin Sutures Versus Nylon Sutures for Suturing of Conjunctival Autograft in Pterygium Surgery: a Randomised Controlled Trial
To compare the use of polyglactin sutures versus nylon sutures for conjunctival autograft suturing in pterygium surgery.
- Trial name
- NCT00391573
- Testing
- Polyglactin sutures for suturing of conjunctival autograft in pterygium surgery, Nylon sutures for suturing of conjunctival autograft in pterygium surgery
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Hospital Authority, Hong Kong
Peripheral Nerve Injuries
A Comparison of NeuroSpan Bridge, NeuraGen Nerve Guide, and Nerve Autograft for Peripheral Nerve Repair
This is a multicenter, prospective, randomized, subject and evaluator blinded clinical trial to asses the efficacy of Auxilium's NeuroSpan Bridge.
- Trial name
- NeuroSpan-1 (NCT06529835)
- Testing
- NeuroSpan Bridge, NeuroGen Nerve Guide, Nerve Autograft
- Where
- 8 sites in United States
- Volunteers
- 80 people
- Sponsor
- Auxilium Biotechnologies
Osteoarthritis of the Knee
Autograft Versus Calcium Phosphate Macroporous Bioceramics as Bone Substitute for Tibial Valgus Osteotomy
The aim of the study is to compare radiological behavior of blocks of macroporous phosphocalcium as bone substitute in comparison with iliac crest autograft in tibial valgus osteotomy.
- Trial name
- NCT00200603
- Testing
- calcium phosphate macroporous bioceramics
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Nantes University Hospital
ACL Injury, Anterior Cruciate Ligament Rupture
Prospective Clinical Results of 3 Different Femoral Fixation in ACL Reconstruction
Anterior cruciate ligament (ACL) tears are one of the most common injuries of the knee. In today's world, due to developing sports industry , the increase in sports traumas of both genders and ages ACL injuries and treatments are…
- Trial name
- NCT04677218
- Testing
- Arthroscopic ACL reconstruction with retensioned hamstring autograft, Arthroscopic ACL reconstruction with retensioned and knotted hamstring autograft
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Emre Kocazeybek
Ligament; Laxity, Knee, Anterior Cruciate Ligament Injury
Treatment of Anterior Ligament Rupture With Internal Brace Repair - A Prospective Randomised Controlled Study.
The purpose of this study is to determine whether anterior cruciate ligament injury in patients wishing to return to sports activities may be treated with repair supplemented with internal brace compared with a standard operation…
- Trial name
- NCT03800225
- Testing
- Repair
- Where
- Denmark
- Volunteers
- 4 people
- Sponsor
- Aarhus University Hospital
Pterygium
Efficacy of Autologous Fibrin Glue in Pterygium
Pterygium is wing-shaped, vascular, fleshy growth that originates on the conjuntiva and that can spread to the corneal limbus and beyond The surgical exeresis with autologous conjunctival autograft technique is the treatment of…
- Trial name
- NCT04151017
- Testing
- Autologous fibrin glue, Suture
- Where
- Brazil
- Volunteers
- 64 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Iliac Crest Harvesting Procedure-Bone Void Filler
Study Performance of The Plexur P™ Bone Void Filler Device in Patients Undergoing Iliac Crest Harvesting Procedures
The purpose of this study is to determine if Plexur P grows bone in the iliac crest (where bone was removed or "harvested") for the back surgery. The study will be focusing on patients who require back surgery.
- Trial name
- NCT00837473
- Testing
- Plexur-P used as a Bone Void Filler in Iliac Crest Harvesting Procedures
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Osteotech, Inc
Rhizarthrosis
Biological Characterization Study of an Autograft Nanofat (Nanocarabio)
Rhizarthrosis (trapeziometacarpal osteoarthritis) is the most common primary osteoarthritis of the hand, and a source of major functional impact, as it affects the thumb.
- Trial name
- Nanocarabio (NCT05915962)
- Testing
- collecting a Nanofat-type microfat autograft
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
B-cell Lymphoma, Non-Hodgkin's Lymphoma
Safety and Efficacy of Bexxar Therapy in the Treatment of Relapsed/Residual B-Cell Lymphoma After Autologous Transplant
Patients with B-cell lymphoma who relapse after autologous transplant tend to have a poor prognosis. Currently, there is no standard treatment for such patients.
- Trial name
- NCT00434629
- Testing
- Bexxar
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pennsylvania
ACL Reconstruction (ACLR) With a Bone-patellar Tendon-bone (BPTB) Autograft
Cryoneurolysis in Anterior Cruciate Ligament Reconstruction (ACLR)
The purpose of this research study is to assess whether cryoneurolysis will help control pain after ACLR surgery and decrease the need of opioid medications.
- Trial name
- NCT07731178
- Testing
- Pacira Iovera Cryoneurolysis device
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- NYU Langone Health
Multiple Myeloma
IFM 2005-01: Velcade/Dexamethasone Versus Vincristine/Adriamycin (Doxorubicin)/Dexamethasone (VAD) for the Treatment of Patients With Multiple Myeloma
This is an open-label, multi-centre, randomised Phase III study, looking at a series of 480 patients up to the age of 65 with newly diagnosed multiple myeloma (MM) not previously treated.
- Trial name
- NCT00200681
- Testing
- Velcade
- Where
- France
- Volunteers
- 493 people
- Sponsor
- Nantes University Hospital