Clinical trials: Autotransplantation
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Tendon-Bone Versus All-Soft-Tissue for ACL Reconstruction: A Patient-Blinded Randomized Clinical Trial
In primary pediatric Anterior cruciate ligament (ACL) reconstruction, the quadriceps tendon with either tendon and patellar bone or an all-tendon graft is commonly employed.
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04039971
- Testing
- ACL Reconstruction
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Colorado, Denver
Anterior Cruciate Ligament Rupture
Arthroscopic ACL Reconstruction: Quadriceps Tendon vs Hamstring Tendon Autograft - A Prospective RCT
A prospective randomized controlled trial comparing functional outcomes of arthroscopic anterior cruciate ligament reconstruction using quadriceps tendon autograft versus hamstring tendon autograft at SMS Medical College, Jaipur.
- Trial name
- NCT07470944
- Testing
- Arthroscopic ACL Reconstruction
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Sawai Mansingh Medical College
Stenosis, Spondylolisthesis
Evaluation of Radiographic and Patient Outcomes Following Lumbar Spine Fusion Using Demineralized Bone Matrix (DBM) Mixed With Autograft
The purpose of this study is to compare Optecure™ as an autograft extender (treatment) to autograft alone (control) in patients undergoing 1 or 2 level fusion of the lumbar spine(one level is defined as two adjacent vertebrae)…
- Conditions
- Stenosis, Spondylolisthesis, Degenerative Disc Disease
- Trial name
- NCT00254852
- Testing
- Posterior Lateral Fusion (PLF), Anterior Lumbar Interbody Fusion (ALIF), Transforaminal lumbar interbody fusion (TLIF)
- Where
- 6 sites in United States
- Volunteers
- 94 people
- Sponsor
- Exactech
Knee Injuries
Efficacy and Safety of OMS103HP in Patients Undergoing Autograft Anterior Cruciate Ligament (ACL) Reconstruction
The anterior cruciate ligament (ACL) is an important stabilizer of the knee. Orthopedic surgeons replace the torn ligament during ACL reconstruction surgery.
- Trial name
- NCT00226772
- Testing
- OMS103HP, Vehicle
- Where
- 18 sites in United States, Canada
- Volunteers
- 326 people
- Sponsor
- Omeros Corporation
Multiple Myeloma
Exploration of Immune Response to Early PCV13 Vaccination in Conjunction With Autologous Transplant
There is no study hypothesis. The purpose of this study is to see if the Pneumococcal conjugate vaccine (PCV13), when administered before and early after an autologous peripheral stem cell transplant will induce an immune…
- Trial name
- PCV13 (NCT01852591)
- Testing
- PCV 13
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Spinal Fusion Acquired, Fusion of Spine (Disease)
Efficacy and Safety of SurgiFill™ on Spinal Fusion
This study was designed to investigate the safety and efficacy of SurgiFill™, a bone grafting material, in patients with spinal fusion.
- Trial name
- NCT02466048
- Testing
- Spinal Fusion, SurgiFill™
- Where
- 2 sites in South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Multiple Myeloma
Stem Cell Translpantation in Multiple Myeloma
The purpose of this study is to determine whether autologous transplantation (using the patient's own stem cells from the blood), followed by non-myeloablative (i.e.
- Trial name
- NCT05082675
- Testing
- HLA Matched allogeneic transplant
- Where
- 24 sites in Austria, Canada and 9 more
- Volunteers
- 357 people
- Sponsor
- European Society for Blood and Marrow Transplantation
Myeloma
Long-Term Follow Up Study for AMD3100 Patients
Objectives: The objective of this long-term observational study is to assess progression-free survival and overall survival for a period of five years following the first dose of study treatment (placebo or plerixafor [AMD3100])…
- Trial name
- NCT00476294
- Testing
- Telephone Questionnaire
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- M.D. Anderson Cancer Center
Full Thickness Thermal Burn
StrataGraft Overlay of Meshed Autograft in Full-thickness Thermal Burns
Autografting is a surgical procedure to transplant healthy skin (donor skin) from another part of the participant's own body (donor site) to the burned part. Autografting is the usual treatment for full-thickness (FT) burns.
- Trial name
- StrataSOMA (NCT04765202)
- Testing
- AG Tx, SOMA Tx
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Osteosarcoma
Adjuvant High-Dose Thiotepa and Stem Cell Rescue Associated With Conventional Chemotherapy in Relapsed Osteosarcoma
Approximately 150 new cases of osteosarcoma are reported each year in France, of which 15 to 20% are metastatic. Further to the initial standard care, about 45% of the patients relapse within a median duration of 20 months.
- Trial name
- OSII-TTP (NCT00978471)
- Testing
- Thiotepa
- Where
- 23 sites in France
- Volunteers
- 44 people
- Sponsor
- Centre Leon Berard
Follicular Lymphoma
Immunochemotherapy, in Vivo Purging, PBSC Mobilization and Autotransplant in Relapsed or Refractory Follicular Lymphoma
The purpose of this study is to determine the rate and duration of complete remission and molecular response in patients with relapsed/refractory follicular lymphoma, using a combined treatment with rituximab plus chemotherapy…
- Trial name
- NCT00366275
- Testing
- Immunochemotherapy, in vivo purging and autrotransplant
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Pterygium of Both Eyes, Conjunctival Autograft
Sutureless Suerior vs Inferior Conjunctival Autograft for Pterygium
Superior bulbar conjunctival autograft is the standard procedure to reduce recurrence after pterygium excision. However, harvesting superior conjunctiva causes tissue scarring, which may compromise the site for potential future…
- Trial name
- SICAG (NCT07894848)
- Testing
- Sutureless Superior Conjunctival Autograft (CAG), Sutureless Inferior Conjunctival Autograft (CAG)
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Fayoum University
Myeloma, Lymphoma
Feasibility of an Adapted Physical Activity Program for Patients Treated With an Autograft (APA²)
Therapeutic intensification followed by an autograft of hematopoietic stem cells is a standard of care for young patients with myeloma from the first line and for lymphoma from the second or third line of treatment.
- Conditions
- Myeloma, Lymphoma, Autologous Transplant
- Trial name
- APA² (NCT04320420)
- Testing
- Adapted Physical Activity
- Where
- 2 sites in France
- Volunteers
- 57 people
- Sponsor
- Weprom
Pterygium
A Comparison Between Surgical Techniques for Securing Conjunctival Autografting in Primary Pterygium Surgery
Pterygium is a fibrovascular wing shaped encroachment of conjunctival fold on to the cornea with elastotic degeneration of a subconjunctival tissue, The standard treatment for pterygium is surgical excision, but the recurrence…
- Trial name
- NCT03301974
- Testing
- conjunctival autograft with fibrin glue, sutured conjunctival autograft, sutureless and glue-free conjunctival autograft
- Volunteers
- 60 people
- Sponsor
- Assiut University
Lumbar Degenerative Disc Disease, Lower Back Pain
Human Autograft Mesenchymal Stem Cell Mediated Stabilization of The Degenerative Lumbar Spine
Investigate the potential of tissue grafting that includes human mesenchymal stem cells in the repair and potential stabilization of the degenerative Lumbar disk and facet joint denovo and at the time of surgical reconstruction.
- Conditions
- Lumbar Degenerative Disc Disease, Lower Back Pain, Chronic Lower Back Pain
- Trial name
- NCT02529566
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Foundation for Spinal Research, Education and Humanitarian Care, Inc.
Epidermolysis Bullosa With Mitten Hands
Autologous Transplantation of Cultured Fibroblast on Amniotic Membrane in Patients With Epidermolysis Bullosa
Epidermolysis Bullosa (EB) is a blistering disease that is caused by defective anchoring fibrils and hemidesmosome in basement membrane of the skin layer. EB is inherited either autosomal or recessive and has 3 types.
- Trial name
- NCT01908088
- Testing
- Cell transplantation
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
Burns
Early Versus Late Upper Extremity Mobilization After Meshed / Sheet Split Thickness Skin Autograft on Wound Healing in Adult Burn Patients
STSGs are used to close wounds and minimize infections. After receiving a meshed or sheet split-thickness skin graft (STSG) to the upper extremity or hand for a thermal burn injury, burn surgeons use different methods to improve…
- Trial name
- EXTREMA (NCT06143683)
- Testing
- Early Mobilization, Late Mobilization
- Volunteers
- 100 people
- Sponsor
- Hamilton Health Sciences Corporation
Anterior Cruciate Ligament Rupture
Anterior Cruciate Ligament Reconstruction With a Periosteal - Patellar Tendon - Bone Autograft - The Kocabey Press-Fit Technique
This study aims to evaluate the clinical and radiological outcomes of patients undergoing anatomical single-bundle anterior cruciate ligament reconstruction with periosteal-patellar tendon-bone autograft and press-fit tibial…
- Trial name
- NCT06190223
- Testing
- Anterior cruciate ligament (ACL) reconstruction with a periost-patellar-tendon-bone (PPTB) autograft and a tibial press-fit technique
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Ankara City Hospital Bilkent
Asherman's Syndrome, Endometrium; Atrophy, Cervix
Bone Marrow Stem Cell Treatment for Asherman's Syndrome and Endometrial Atrophy
The purpose of this study is to determine whether Bone Marrow Stem Cell transplantation may improve Assisted Reproduction Techniques (ART) outcomes in refractive Asherman's Syndrome or Atrophic Endometrium.
- Trial name
- BMSCT (NCT02144987)
- Testing
- Bone Marrow CD133+ Stem Cell Transplantation
- Where
- 2 sites in Spain
- Volunteers
- 16 people
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Pterygium
Assessment of Low-temperature Plasma Surgery System in Pterygium With Fibrin Glue and Conjunctival Autografts
Pterygium is a wing-shaped fibrovascular tissue that has proliferated onto the cornea. Ultraviolet radiation and hot, dusty, windy, dry, smoky environments are regarded as risk factors for pterygium .
- Trial name
- NCT03204084
- Testing
- Low-temperature Plasma Surgery System
- Volunteers
- 56 people
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University