Clinical trials: Autotransplantation
Bone Neoplasm
Comparison of Bioactive Glass and Beta-Tricalcium Phosphate as Bone Graft Substitute
This study is designed to perform a head-to-head comparison of two synthetic ceramic bone graft substitutes, bioactive glass (BAG) and beta-tricalcium phosphate (TCP), in filling of contained bone defects following surgical…
- Trial name
- BAGvsTCP (NCT00841152)
- Testing
- Bioactive glass, Beta-tricalcium phosphate (ChronOs), Autograft
- Where
- 5 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Turku University Hospital
Increase Success Rate of Tooth Transplantation
Use of CBCT-based Tooth Replica in Tooth Autotransplantation to Improve the Outcome of Tooth Replacement in Children
The aim of this study lies in comparing the outcome of the proposed technique in a large sample size group to the outcome of the conventional tooth autotransplantation method and to provide sufficient evidence for improving the…
- Trial name
- NCT02464202
- Testing
- stereolithography tooth replica
- Where
- Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Multiple Myeloma and Plasma Cell Neoplasm
Peripheral Stem Cell Transplantation Plus Combination Chemotherapy in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00003401
- Testing
- carmustine, cisplatin, cyclophosphamide
- Where
- United States
- Sponsor
- University of Maryland, Baltimore
Burn Degree Second, Burn Degree Third
The Use of Cultured (Dermal) Epithelial Autografts in Severely Burned Patients
The Swisskera project is a multicenter follow-up study at the three Swiss burn centers evaluating long-term outcomes after burn wound coverage with lab-grown epithelial grafts, specifically cultured epithelial autograft (CEA)…
- Conditions
- Burn Degree Second, Burn Degree Third, Skin Transplantation, Full Thickness Skin Defects
- Trial name
- Swisskera (NCT07415577)
- Testing
- Standard of Care (SOC)
- Where
- 3 sites in Switzerland
- Volunteers
- 236 people
- Sponsor
- University Children's Hospital, Zurich
Rotator Cuff Tears
Results of Arthroscopic Massive Rotator Cuff Tears Repair With or Without Using Long Head of Biceps Tendon
The Goal of this clinical trial is to asses the function of arthroscopic repair with or without superior capsular augmentation using biceps tendon .
- Trial name
- NCT05817071
- Testing
- Arthroscopic massive rotator cuff repair, Arthroscopic massive rotator cuff repair with superior capsular augmentation using the long head of biceps tendon
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Physical Activity
Clinical and Functional Outcomes at 2 Years of 4-strand Versus 5-strand Hamstring Autograft in Anterior Cruciate Ligament Reconstruction
This study aims to study differences in clinical and functional outcomes at 2 years based on hamstring graft size after single bundle anatomic ACL reconstruction using either 4-strand or 5-strand hamstring grafts.
- Trial name
- NCT03171532
- Testing
- Strands of Hamstring Autograft in ACL reconstruction
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University Hospital, Singapore
Anterior Cruciate Ligament Tear
A Comparison of ACL Repair With BEAR Device vs. Autograft Patellar Tendon ACL Reconstruction
This study is designed to evaluate bridge-enhanced ACL restoration (BEAR), a new surgical technique for repairing knees injured by a tear of the anterior cruciate ligament (ACL) that promotes reattachment and healing of the ACL…
- Trial name
- BEAR-MOON (NCT03776162)
- Testing
- ACL Reconstruction (Bone Patellar Tendon Bone Graft), Bridge Enhanced ACL Restoration (BEAR)
- Where
- 6 sites in United States
- Volunteers
- 150 people
- Sponsor
- The Cleveland Clinic
Anterior Cruciate Ligament Injuries
Anterior Cruciate Ligament Reconstruction Made With Hamstring Tendon And Quadriceps Tendon Autografts
Anterior cruciate ligament reconstruction (ACLR) is one of the most common procedure all around the world, however optimal graft source for ACLR still remains controversial.
- Trial name
- NCT04940169
- Testing
- anterior cruciate ligament recontruction
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- SB Istanbul Education and Research Hospital
Middle Ear Disease
Improved Otologic Implants on Demand Intraoperatively With 3D CAD/CAM Autografts
Prospectively analyze the use of 3D subtraction CAD/CAM in the operating room environment. Study participants, requiring middle ear surgery and ossicular reconstruction, will be implanted with one of two middle ear implants.
- Trial name
- NCT03297736
- Testing
- 3D CAD/CAM autograft prosthesis, Control device
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Nitinetics LLC
ADA-SCID
Autologous CD34+ Hematopoietic Stem Cells Transduced ex Vivo With Elongation Factor 1 Alpha Shortened (EFS) Lentiviral Vector Encoding for the Human ADA Gene
The aim of this study is to assess the safety and efficacy of autologous transplantation of hematopoietic stem cells (CD34+ cells) from the bone marrow (BM) of ADA-deficient SCID infants and children following human ADA cDNA…
- Trial name
- NCT01852071
- Testing
- Infusion of autologous EFS-ADA LV CD34+ (OTL-101), busulfan, PEG-ADA ERT
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of California, Los Angeles
Follicular Lymphoma
Immunochemotherapy, Zevalin, and Bone Marrow Transplant for Follicular Lymphoma
Follicular lymphoma has historically been considered an incurable lymphoma. By combining multiple effective treatments, the investigators believe that prolonged disease-free survival is achievable in this disease.
- Trial name
- MasterPlan (NCT01130194)
- Testing
- Combination of treatment modalities
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- St. Louis University
Bone Loss, Alveolar, Tooth Loss
Tooth Autotransplantation and Bone Dimension Changes
Tooth autotransplantation is a treatment option to replace tooth with imposible prognosis. In several cases the receipt site has a reduced bone dimension.
- Conditions
- Bone Loss, Alveolar, Tooth Loss, Bone Atrophy, Alveolar
- Trial name
- NCT03927937
- Testing
- AUTOTRANSPLANTATION TOOTH
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Hyperparathyroidism, Secondary
Subtotal Parathyroidectomy or Total Parathyroidectomy With Autograft in Chronic Kidney Disease Patients Under Dialysis
This study evaluates the metabolic and clinical results of two well recognized and accepted surgical techniques in the management of severe hyperparathyroidism in patients under regular dialysis treatment.
- Trial name
- NCT02464072
- Testing
- Subtotal Parathyroidectomy, Total Parathyroidectomy + 45 autografts, Total Parathyroidectomy + 90 autografts
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- University of Sao Paulo General Hospital
Renal Vascular Disease, Nutcracker Syndrome, Renal
Renal Autotransplantation; Case Series
Renal autotransplantation (RAT) is a method of removing a kidney from its place of origin in a patient, repairing it, and transplanting it in another location of the body, generally the iliac fossa of the same patient.RAT is a…
- Conditions
- Renal Vascular Disease, Nutcracker Syndrome, Renal, Pelvic Trauma, Loin Pain-Hematuria Syndrome
- Trial name
- NCT05115812
- Testing
- Pre-Operative Information, Intra-Operative Data, Post-Operative Data (up to discharge)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Methodist Health System
Multiple Myeloma, Olfactivo-gustatory Disorder
Impact of a Sensory Rehabilitation Program on Olfactory-gustatory Alterations in Patients Treated With Chemotherapy for Haematological Cancer
Proposition of a sensory rehabilitation program that could reduce the olfactory-gustatory alterations in patients who have been treated with chemotherapy for Haematological Cancer, and also improve their life quality…
- Conditions
- Multiple Myeloma, Olfactivo-gustatory Disorder, Lymphoma, Haematological Cancer
- Trial name
- RE-NEZ-SENS (NCT04716153)
- Testing
- Multifactorial sensory rehabilitation workshops, Usual care, Tests and Questionnaire
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Leukemia
Chemotherapy and Peripheral Stem Cell Transplantation Followed by Immunotherapy in Treating Patients With Chronic Myelogenous Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with a peripheral stem cell transplant and immunotherapy may allow the doctor to give…
- Trial name
- NCT00003727
- Testing
- filgrastim, recombinant interferon alfa, sargramostim
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Maryland, Baltimore
Ovarian Reserve
Bone Marrow Transplantation to Promote Follicle Recruitment in Poor Ovarian Reserve
Women delay maternity and, as a consequence, available oocyte number and their quality decrease (9-18% of all IVF patients). Different treatment protocols have been developed nevertheless none of them optimal: the number of…
- Trial name
- NCT02240342
- Testing
- Bone marrow transplant into ovarian artery
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Hospital Universitario La Fe
Autologous Stem Cell Transplantation
AMD3100 (Plerixafor) With G-CSF in Poor Mobilizing Adult Patients Who Previously Failed Hematopoietic Stem Cell (HSC) Collection/Attempts
This study evaluates the safety, efficacy, and pharmacokinetics (PK) of plerixafor given in addition to granulocyte-colony stimulating factor (G-CSF) for collection of peripheral blood stem cells (PBSCs) for autologous…
- Trial name
- NCT00396331
- Testing
- G-CSF plus plerixafor
- Where
- 8 sites in United States
- Volunteers
- 100 people
- Sponsor
- Genzyme, a Sanofi Company
Thyroid
Thyroid Autotransplantation in Quadriceps Femoris Muscle
providing an almost natural ectopic thyroid in patients undergoing total thyroidectomy, remains a challenging subject that can benefits patients with a non-pharmacological substitute for their normal gland.
- Trial name
- NCT04684953
- Testing
- Throid autotransplantation, Hormone
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Thrombocytopoietin, Hematopoietic Stem Cell Mobilization
Recombinant Human Thrombopoietin for Mobilization of Peripheral Blood Progenitor Cells for Autologous Transplantation
The purpose of this study is to determine whether recombinant human thrombopoietin are effective in peripheral blood progenitor cells mobilization for autologous transplantation.
- Conditions
- Thrombocytopoietin, Hematopoietic Stem Cell Mobilization, Hematopoietic Stem Cell Transplantation
- Trial name
- NCT03014102
- Testing
- Recombinant Human Thrombopoietin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Hongnan Mo