Clinical trials: Axial Spondyloarthritis
Arthritis, Rheumatoid (RA), Axial Spondyloarthritis (axSpA)
A Real-world Study of Imraldi® Use
The primary objective of this study is to evaluate candidate predictors of persistence on adalimumab (Imraldi®) participants diagnosed with immune-mediated inflammatory disease in Europe (EU).
- Conditions
- Arthritis, Rheumatoid (RA), Axial Spondyloarthritis (axSpA), Arthritis, Psoriatic (PsA), Crohn's Disease (CD)
- Trial name
- PROPER (NCT04089514)
- Testing
- Adalimumab
- Where
- 54 sites in Belgium, Germany and 4 more
- Volunteers
- 1,000 people
- Sponsor
- Biogen
Axial Spondyloarthritis
Study of the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of BCD-180 in Patients With Axial Spondyloarthritis
The aim of the study is to evaluate the efficacy, safety, immunogenicity, pharmacokinetics and pharmacodynamics of two doses of study drug (BCD-180) in comparison with placebo in patients with active radiographic axial…
- Trial name
- ELEFTA (NCT05445076)
- Testing
- anti-TRBV9 monoclonal antibody, low dose, anti-TRBV9 monoclonal antibody, high dose
- Where
- 2 sites in Russia
- Volunteers
- 250 people
- Sponsor
- Biocad
Axial Spondyloarthritis
to Evaluate the Preliminary Efficacy and Safety of GR1501 Injection in Patients With Active Axial Spondyloarthritis
Dosage: 100mg or 200mg or 300mg Administration frequency: Q2W administration in the first 4 weeks (W0, W2, W4), and subsequent Q4W administration (W8, W12) Administration: subcutaneous injection Specifications: 100mg/ 1mL/bottle…
- Trial name
- NCT05162937
- Testing
- IL-17A antibody
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Axial Spondyloarthritis
High-intensity Training in Patients With Spondyloarthritis: a Randomized Controlled Trial
Project summary Background: For people diagnosed with a spondyloarthritis (SpA) e.g. ankylosing spondylitis or undifferentiated spondyloarthritis, physical activity and exercise are important components in the self-management.
- Trial name
- NCT05781763
- Testing
- High intensity interval training (HIIT), Control group
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Halmstad University
Axial Spondyloarthritis, Inflammatory Disease
Exercise Therapy in Patients With Axial Spondyloarthritis
Regular exercise, such as brisk walking, has been shown to lower levels of indicators of inflammation in the blood in people with long term conditions. This includes people with heart disease, kidney disease and diabetes.
- Conditions
- Axial Spondyloarthritis, Inflammatory Disease, Arthritis
- Trial name
- ExTASI (NCT04368494)
- Testing
- 12-week home based exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- Loughborough University
Axial Spondyloarthritis, Inflammatory Back Pain
Reliability of IBP Criteria & Activity Scores in Patients With AxSpA
The current ASAS classification of AxSpA relies either on sacroiliitis on imaging plus one SpA feature (imaging arm) or HLA-B27 antigen plus two SpA features (clinical arm), in a patient with chronic back pain and age at onset of…
- Trial name
- IBP/AxSpA (NCT05327140)
- Where
- Egypt
- Volunteers
- 206 people
- Sponsor
- Zagazig University
Axial Spondyloarthritis, Psoriatic Arthritis
Secukinumab (Cosentyx®) Effectiveness in Axial Spondyloarthritis and Psoriatic Arthritis Patients Using Artificial Intelligence (SpAINET): Spanish Multicenter, Retrospective, Real World Evidence Study
This was a multicenter, retrospective, and non-interventional study using secondary data captured in the Electronic Health Records (EHRs).
- Trial name
- NCT05677542
- Testing
- secukinumab
- Where
- 3 sites in Spain
- Volunteers
- 758 people
- Sponsor
- Novartis Pharmaceuticals
Axial Spondyloarthritis
Unmet Needs of Axial Spondyloarthrits in Egyptian Patients
During the past decade, the well-known disease called Ankylosing Spondylitis has come to be considered as a subset of the broader entity referred as axial spondyloarthritis (axSpA), which also includes non-radiographic axSpA.
- Trial name
- NCT05517031
- Testing
- ASDAS score , VAS score, BASFI score , Katz ADL index
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Axial Spondyloarthritis, Ankylosing Spondylitis
French Validation of Axial Spondyloarthritis Questionnaires (Val-SpA)
The aim is to do a French linguistic validation of three questionnaires used in axial Spondyloarthritis (BASFI, BAS-G, Dougados Functional Index).
- Trial name
- Val-SpA (NCT04212806)
- Where
- 2 sites in France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Grenoble
Axial Spondyloarthritis
Health Technology to Improve Exercise in axSpA
Despite the known benefits of physical activity, the majority of Canadians fail to meet recommended guidelines. Patients with axial spondyloarthritis (axSpA) also fail to meet recommended guidelines.
- Trial name
- NCT05504616
- Testing
- Health technology-based intervention strategy
- Where
- Canada
- Volunteers
- 106 people
- Sponsor
- University Health Network, Toronto
Non-radiographic Axial Spondyloarthritis
A Study to Evaluate the Efficacy and Safety of SHR0302 in Patients With Non-Radiographic Axial Spondyloarthritis
This study is to evaluate the efficacy and safety of SHR0302 in subjects with active non-radiographic axial spondyloarthritis.
- Trial name
- NCT05324631
- Testing
- SHR0302
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Axial Spondyloarthritis, Nonradiographic Axial Spondyloarthritis
Multicenter Study Evaluating Certolizumab Pegol Compared to Placebo in Subjects With axSpA Without X-ray Evidence of AS
Patients with active Axial Spondyloarthritis without x-ray evidence of Ankylosing Spondylitis and with signs of inflammation will be randomly assigned to receive certolizumab pegol (CZP) 200 mg every two weeks or placebo.
- Conditions
- Axial Spondyloarthritis, Nonradiographic Axial Spondyloarthritis, Nr-axSpA
- Trial name
- C-AXSPAND (NCT02552212)
- Testing
- Certolizumab Pegol
- Where
- 105 sites in United States, Australia and 7 more
- Volunteers
- 317 people
- Sponsor
- UCB BIOSCIENCES GmbH
Axial Spondyloarthritis
Microbiome and Axial Spondyloarthritis
The purpose of this interventional study is to identify the root cause(s) of AxSpA (Axial Spondyloarthritis) relapses, which are likely due to the combination of nutrition, gut microbiome activities, leaky gut, and human genes…
- Trial name
- NCT04713995
- Testing
- Dietary recommendations
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Viome
Frailty, Axial Spondyloarthritis
Prevelance of Frailty and Its Associated Factors in Patients With Axial Spondyloarthritis
Axial Spondyloarthritis is an inflammatory arthritis disease and its main symptoms are chronic pain and stiffness, causing structural damage to the spinal vertebrae.
- Trial name
- NCT05010720
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acibadem University
Rheumatoid Arthritis, Ankylosing Spondylarthritis
Yuflyma® (Adalimumab), Patient Experience After Switching
Patient preference and experience can impact patients' adherence and persistence regarding a treatment, especially when switching.
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylarthritis, Axial Spondyloarthritis Without Radiographic Evidence of Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- YU-MATTER (NCT05427942)
- Testing
- Adalimumab
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Celltrion HealthCare France
Axial Spondyloarthritis
A Long Term Extension Study of Ixekizumab (LY2439821) in Participants With Axial Spondyloarthritis
The purpose of this study is to evaluate, in participants having achieved a state of sustained remission, if the ixekizumab treatment groups are superior to the placebo group in maintaining response during the randomized…
- Trial name
- NCT03129100
- Testing
- Ixekizumab
- Where
- 127 sites in United States, Argentina and 21 more
- Volunteers
- 773 people
- Sponsor
- Eli Lilly and Company
Axial Spondyloarthritis
Biomedicines and Bacterial Translocation in Spondyloarthritis
The aim of this project is to evaluate the effect of anti-TNF and anti-IL17 biotherapies on bacterial translocation in patients with NSAID-resistant axial spondyloarthritis.
- Trial name
- TEARE-BIO (NCT05244109)
- Testing
- Blood sample, anti-TNF antibody administration, anti-IL-17 antibody administration
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Non-radiographic Spondyloarthritis
Study of Efficacy and Safety of Secukinumab in Patients With Non-radiographic Axial Spondyloarthritis
The purpose of this study was to demonstrate the clinical efficacy, safety and tolerability of secukinumab compared to placebo in patients with nr-axSpA at Week 16 as well as Week 52 and long term efficacy and safety up to Week…
- Trial name
- PREVENT (NCT02696031)
- Testing
- Secukinumab
- Where
- 139 sites in United States, Australia and 22 more
- Volunteers
- 555 people
- Sponsor
- Novartis Pharmaceuticals
Axial Spondyloarthritis
Effects of Nonsteroidal Anti-Inflammatory Drugs in Recurrence of Spondyloarthritis Patients After Remission
The multicenter, randomized controlled trial is to investigate and evaluate the effect of NSAIDs therapy on recurrence in patients with axial spondyloarthritis;
- Trial name
- NCT03425812
- Testing
- To withdraw NSAIDs therapy, To continue NSAIDs therapy
- Where
- China
- Volunteers
- 140 people
- Sponsor
- The First Affiliated Hospital of Xiamen University
Axial Spondyloarthritis
Efficacy and Safety of Namilumab for Moderate-to-severe Axial Spondyloarthritis
The study will assess the effect of namilumab, a GM-CSF inhibitor, on the clinical response in subjects with axial spondyloarthritis. Subjects will receive treatment with either namilumab or placebo.
- Trial name
- NAMASTE (NCT03622658)
- Testing
- Namilumab
- Where
- 9 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- Izana Bioscience Ltd.