Clinical trials: BCC
Basal Cell Carcinoma (BCC)
Blue-Light Photodynamic Therapy and Sonidegib for Multiple Basal Cell Carcinomas
This research study is testing combination Blue-light photodynamic therapy and Sonidegib as a possible treatment for people with multiple basal cell carcinoma lesions.
- Trial name
- NCT06623201
- Testing
- aminolevulinic acid HCL (ALA), BLU-U device model 4170E
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Nathalie Zeitouni
Basal Cell Carcinoma
Vismodegib for Treatment of Basal Cell Carcinoma
The primary objectives of this study are to assess, using Mohs micrographic surgery (MMS) at the end of treatment, the efficacy (primary) and safety (secondary) of vismodegib compared to placebo in the oral adjunctive pre…
- Trial name
- Erivedge (NCT01543581)
- Testing
- Vismodegib
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Abel Torres, MD
Advanced Solid Tumor, Unresectable Solid Tumor
A Beta-only IL-2 ImmunoTherapY Study
This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a…
- Conditions
- Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
- Trial name
- ABILITY-1 (NCT05086692)
- Testing
- MDNA11, Pembrolizumab (KEYTRUDA®)
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 160 people
- Sponsor
- Medicenna Therapeutics, Inc.
Melanoma (Skin), Non-melanomatous Skin Cancer
Bioelectric Field Imaging in Diagnosing Melanoma and Other Skin Cancers in Patients With Skin Lesions
RATIONALE: New diagnostic procedures, such as bioelectric field imaging, may help find and diagnose melanoma and other skin cancers. It may also be a less invasive way to check for skin cancer.
- Trial name
- NCT00391300
- Testing
- bioelectric field imaging, biopsy, histopathologic examination
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eastern Virginia Medical School
Skin Cancer, Melanoma of Skin
How Consistent is the Output of DERM, When Used to Assess Images of Potentially Cancerous Skin Lesions.
DERM is a Medical Device that uses artificial intelligence to help doctors check if a skin lesion might be cancerous. It works by analysing close-up pictures of skin lesions taken with a smartphone.
- Conditions
- Skin Cancer, Melanoma of Skin, Squamous Cell Cancer, Basal Cell Cancer
- Trial name
- NCT06654999
- Testing
- Deep Ensemble for the Recognition of Malignancy (DERM)
- Where
- 3 sites in United Kingdom
- Volunteers
- 115 people
- Sponsor
- Skin Analytics Limited
Anorexia, Cachexia
Megestrol to Limit Weight Loss and Improve Quality of Life in Treating Patients With Head and Neck Cancer
RATIONALE: Megestrol helps improve appetite. It is not yet known if megestrol is effective in limiting weight loss caused by cancer.
- Conditions
- Anorexia, Cachexia, Head and Neck Cancer, Quality of Life
- Trial name
- NCT00006799
- Testing
- megestrol acetate, quality-of-life assessment
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Basal Cell Carcinoma
Periocular Basal Cell Carcinoma (BCC): Permanent vs. Frozen Section Pathological Control
This study is an equivalency study designed as a randomized clinical trial. Patients with a biopsy proven nodular periocular basal cell carcinoma (BCC) who have agreed to have surgical excision will be eligible.
- Trial name
- NCT00663650
- Testing
- Permanent Section Control, Frozen Section Control
- Where
- Canada
- Volunteers
- 290 people
- Sponsor
- Queen's University
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma
Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are: How well do two-photon fluorescence images of biopsies taken…
- Conditions
- Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma, Melanocytic Lesion, Adult
- Trial name
- NCT07773688
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- University of Rochester
Dermatological Tumors
Pathological Characteristics of Basal Cell Carcinoma
A hospital based cross-sectional study was conducted from 2017 to February 2021. Clinical history, examination and histopathological variants were collected from medical files and pathology reports.
- Trial name
- NCT05267691
- Testing
- Excision
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Al-Azhar University
Skin Cancer, Basal Cell Carcinoma
Raman Spectroscopy and Skin Cancer
The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors.
- Conditions
- Skin Cancer, Basal Cell Carcinoma, Squamous Cell Carcinoma
- Trial name
- NCT06384924
- Testing
- Raman Spectroscopy handheld probe (EmVision, FL, USA), Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tiezhi Zhang
Basal Cell Carcinoma, Cutaneous Squamous Cell Carcinoma
Outcome Research of a European Registry Platform on Real-world Treatment Data of Patients with Advanced NMSC
This current registry study will analyze real-world data to address questions about disease characteristics and treatment patterns in NMSC patients based on the European NMSC-Registry.
- Trial name
- NCT05741073
- Where
- Belgium
- Volunteers
- 1,300 people
- Sponsor
- EuMelaReg gGmbH
Cutaneous Basal Cell Carcinoma
Cemiplimab Plus Imiquimod and Laser Therapy As Neoadjuvant Treatment In Cutaneous Basal Cell Carcinoma
Basal cutaneous cell carcinoma (BCC) is the most common skin cancer. Early-stage disease is managed with surgery or radiation that cure more than 95% of patients.
- Trial name
- CEMIQUID (NCT07251413)
- Testing
- cemiplimab, Topical imiquimod
- Where
- 4 sites in Spain
- Volunteers
- 18 people
- Sponsor
- Instituto Oncológico Dr Rosell
Basal Cell Carcinoma
The Role of Melanocyte in Basal Cell Carcinoma
Basal cell carcinoma (BCC) is the most frequent neoplasia worldwide. There are more than 30 histopathologic subtypes, however the nodular subtype is the most common.
- Trial name
- NCT02576769
- Testing
- No intervention
- Where
- Mexico
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma
Safety and Efficacy Evaluation of AIV001 in Nonmelanoma Skin Cancer of the Low Risk Basal Cell Carcinoma Subtype
To evaluate safety and efficacy of AIV001 treatment on low-risk Nonmelanoma Skin Caner of the basal cell carcinoma subtype.
- Conditions
- Superficial Basal Cell Carcinoma, Nodular Basal Cell Carcinoma, Nonmelanoma Skin Cancers
- Trial name
- NMSC (NCT04470726)
- Testing
- AIV001, AIV001 suspension
- Where
- 4 sites in United States
- Volunteers
- 26 people
- Sponsor
- AiViva BioPharma, Inc.
Basal Cell Carcinoma
Evaluating In Vivo OCT Imaging for Periocular Basal Cell Carcinoma
Optical coherence tomography (OCT) is an imaging technique which shows the internal structure of living tissue (in vivo). It is safe, quick and painless to perform, and does not damage the tissue in any way.
- Trial name
- NCT01603810
- Testing
- OCT
- Where
- United Kingdom
- Sponsor
- Maidstone & Tunbridge Wells NHS Trust
Basal Cell Carcinoma
Treatment of Primary Basal Cell Carcinomas of the Skin With Combination of Topical Imiquimod and Cryosurgery
The purpose of this study is to evaluate the efficacy of cryosurgery during continuing imiquimod application in the treatment of basal cell carcinoma of the skin.
- Trial name
- IMCX (NCT01212562)
- Testing
- Immunocryosurgery
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- University of Ioannina
Field Actinic Keratoses, Basal Cell Carcinoma
Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease
The aim of this study is to provide this investigational drug to patients who cannot be optimally treated with conventional therapies and to collect efficacy and safety data on the use of Metvix PDT in subjects with field actinic…
- Conditions
- Field Actinic Keratoses, Basal Cell Carcinoma, Bowen's Disease
- Trial name
- NCT00535080
- Testing
- Metvix (methyl aminolevulinate)
- Sponsor
- Galderma R&D
Basal Cell Carcinoma
AI-Based Risk Classification and Histopathological Subtype Prediction of Basal Cell Carcinoma Using Dermoscopic Images
This retrospective observational study aims to develop and evaluate a convolutional neural network (CNN)-based artificial intelligence model for risk classification and histopathological subtype prediction of basal cell carcinoma…
- Trial name
- BCC-AI (NCT07677124)
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people
- Sponsor
- Istanbul Training and Research Hospital
Melanoma (Skin), Nevus
Clinical vAlidation of a MobilE appLication ("ProRodinki") in the Assessment of the maLignant skIn neoplAsms
A Multicenter, Prospective, Low-interventional Clinical Study Evaluating on mobile application validation ("ProRodinki") in assessing the risk of skin malignant neoplasms
- Conditions
- Melanoma (Skin), Nevus, Nevus, Spitz, Nevus Halo
- Trial name
- CAMELLIA (NCT05402046)
- Testing
- Mobile phone application "ProRodinki"
- Where
- 2 sites in Russia
- Volunteers
- 605 people
- Sponsor
- MelanomaPRO, Russia
Head and Neck Cancer
Oxaliplatin and Capecitabine in Treating Patients With Relapsed or Metastatic Head and Neck Cancer
RATIONALE: Drugs used in chemotherapy, such as oxaliplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00448552
- Testing
- capecitabine, oxaliplatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Miami