Clinical trials: BCC - Basal Cell Carcinoma
Cancer
Thalidomide and Docetaxel in Treating Patients With Advanced Cancer
RATIONALE: Thalidomide may stop the growth of cancer by stopping blood flow to the tumor. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00049296
- Testing
- docetaxel, thalidomide
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Case Comprehensive Cancer Center
Actinic Keratosis, Basal Cell Carcinoma of the Skin
T4N5 Liposomal Lotion in Preventing The Recurrence of Nonmelanoma Skin Cancer in Patients Who Have Undergone a Kidney Transplant
This randomized phase II trial is studying how well T4N5 liposomal lotion works in preventing the recurrence of nonmelanoma skin cancer in patients who have undergone a kidney transplant.
- Conditions
- Actinic Keratosis, Basal Cell Carcinoma of the Skin, Recurrent Skin Cancer, Squamous Cell Carcinoma of the Skin
- Trial name
- NCT00089180
- Testing
- liposomal T4N5 lotion, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)
Basal Cell Carcinoma
Topical Itraconazole in the Treatment of Basal Cell Carcinoma
This research is being done to study the molecular effects of topically applied itraconazole ointment on the growth of basal cell carcinomas.
- Trial name
- NCT02120677
- Testing
- Itraconazole
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
BCC - Basal Cell Carcinoma, Immune Response
Laser Immunotherapy With and Without Topical Anti-PD1 in Basal Cell Carcinomas
The study aim is to assess the immunological and clinical response in basal cell carcinoma (BCC) treated with ablative fractionated laser (AFL) as monotherapy and compare with BCC treated with combination-therapy of AFL and the…
- Conditions
- BCC - Basal Cell Carcinoma, Immune Response, Immunotherapy, Ablative Fractionated Laser
- Trial name
- NCT04570683
- Testing
- Nivolumab 10 MG/ML, Ablative fractionated laser
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Bispebjerg Hospital
Basal Cell Carcinoma
Reflectance Confocal Microscopy to Diagnose BCC
It is proposed to undertake a study to determine the diagnostic utility of using RCM for the diagnosis of Basal Cell Carcinoma (BCC) in a tertiary referral centre as outlined by the recent NICE report (Nov 2015).
- Trial name
- NCT03509415
- Testing
- In-vivo imaging
- Where
- United Kingdom
- Volunteers
- 324 people
- Sponsor
- Skin Care Network Ltd.
Head and Neck Cancer
PET Scans in Patients With Head And Neck Cancer Who Are Undergoing 3-Dimensional Conformal Radiation Therapy And Intensity-Modulated Radiation Therapy
RATIONALE: Imaging procedures, such as PET scans, may determine the extent of cancer and help doctors plan radiation therapy. Radiation therapy uses high-energy x-rays to kill tumor cells.
- Trial name
- TEPORL (NCT00809016)
- Testing
- 3-dimensional conformal radiation therapy, fludeoxyglucose F 18, intensity-modulated radiation therapy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Oscar Lambret
Advanced Solid Tumor, Unresectable Solid Tumor
A Beta-only IL-2 ImmunoTherapY Study
This is a Phase 1/2, multi-center, open-label, dose-escalation and expansion study to evaluate safety and tolerability, PK, pharmacodynamic, and early signal of anti-tumor activity of MDNA11 alone or in combination with a…
- Conditions
- Advanced Solid Tumor, Unresectable Solid Tumor, Clear Cell Renal Cell Carcinoma, Triple Negative Breast Cancer
- Trial name
- ABILITY-1 (NCT05086692)
- Testing
- MDNA11, Pembrolizumab (KEYTRUDA®)
- Where
- 25 sites in United States, Australia and 6 more
- Volunteers
- 160 people
- Sponsor
- Medicenna Therapeutics, Inc.
Carcinoma, Basal Cell
Topical Green Tea Ointment in Treatment of Superficial Skin Cancer
Basal cell carcinoma (BCC) is the most frequently occurring nonmelanoma skin cancer in Caucasians, representing approximately 80% of cases.
- Trial name
- NCT02029352
- Testing
- Sinecatechins 10%
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Maastricht University Medical Center
Basal Cell Carcinoma
Neoadjuvant Nivolumab + Relatlimab (Opdualag) Versus Nivolumab for Resectable High-Risk Basal Cell Carcinoma
This is a Phase 2 clinical trial with a 2:1 randomization comparing neoadjuvant Nivolumab + Relatlimab (Opdualag) vs neoadjuvant Nivolumab in patients with resectable high risk basal cell carcinoma (HR BCC)
- Trial name
- NEON (NCT06624475)
- Testing
- Nivolumab, Relatlimab plus Nivolumab
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Carcinoma, Basal Cell
PD-1 in Patients With Advanced Basal Cell Carcinoma Who Experienced Progression of Disease on Hedgehog Pathway Inhibitor Therapy, or Were Intolerant of Prior Hedgehog Pathway Inhibitor Therapy
The primary objective is to estimate the objective response rate (ORR) for metastatic Basal Cell Carcinoma (BCC) (group 1) and for unresectable locally advanced BCC (group 2) when treated with cemiplimab as a monotherapy
- Trial name
- NCT03132636
- Testing
- cemiplimab
- Where
- 71 sites in United States, Austria and 8 more
- Volunteers
- 138 people
- Sponsor
- Regeneron Pharmaceuticals
Basal Cell Carcinoma
Open Label, Dose Escalation Study for the Safety and Efficacy of STP705 in Adult Patients With Basal Cell Carcinoma
This phase 2, open label, dose escalation study is designed to evaluate the safety, tolerability and efficacy of various doses of STP705 administered as localized injection in patients with Basal Cell Carcinoma (BCC).
- Trial name
- NCT04669808
- Testing
- STP705
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Sirnaomics
Basal Cell Carcinoma of the Skin, Pain
Photodynamic Therapy Using Methyl-5-Aminolevulinate Hydrochloride Cream in Determining Pain Threshold in Patients With Skin Cancer
RATIONALE: Photodynamic therapy uses a drug that becomes active when it is exposed to a certain kind of light. When the drug is active, cancer cells are killed.
- Conditions
- Basal Cell Carcinoma of the Skin, Pain, Recurrent Skin Cancer
- Trial name
- NCT01292668
- Testing
- methyl-5-aminolevulinate hydrochloride cream, photodynamic therapy, laser therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Roswell Park Cancer Institute
Lymphoma, Lymphoma, Non-Hodgkin
Ultrasound Biomicroscopy - Apoptosis
A group of researchers at the Ontario Cancer Institute/Princess Margaret Hospital have discovered that a very specific form of cell death 'apoptosis' can be detected using high-frequency ultrasound imaging.
- Conditions
- Lymphoma, Lymphoma, Non-Hodgkin, Melanoma, Carcinoma, Basal Cell
- Trial name
- NCT00188370
- Testing
- high frequency ultrasound imaging
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Head and Neck Cancer, Mucositis Oral
GM-CSF Mouthwash for Preventing and Treating Mucositis in Patients Undergoing Radiation Therapy for Head and Neck Cancer
GM-CSF may protect normal cells from the side effects, such as mucositis, of radiation therapy and may help damaged tissue heal faster after radiation therapy.
- Conditions
- Head and Neck Cancer, Mucositis Oral, Radiation Toxicity, Tongue Cancer
- Trial name
- NCT00293462
- Testing
- sargramostim, oral salt and soda mouthwash
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Marilyn Dodd
Basal Cell Carcinoma
Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Nodular Basal Cell Carcinoma
The purpose of this study is to determine whether topical application of PEP005 is safe for the treatment of nodular basal cell carcinoma.
- Trial name
- NCT00108121
- Testing
- PEP005
- Where
- 10 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Peplin
Advanced Basal Cell Carcinoma (BCC), Inoperable Disease
Treatment of Basal Cell Carcinoma (BCC) of the Skin, of the Morpheiform, Infiltrative, and Noduloulcerative Types in Inoperable Patients and Not Suitable for Radiotherapy Using Formulated Methylene Blue
The goal of this clinical trial is to evaluate whether formulated methylene blue can safely and effectively treat advanced or inoperable basal cell carcinoma (BCC), a common type of skin cancer.
- Conditions
- Advanced Basal Cell Carcinoma (BCC), Inoperable Disease, Morpheaform Basal Cell Carcinoma, Noduloulcerative Basal Cell Carcinoma
- Trial name
- NCT07311070
- Testing
- Formulated Topical Methylene Blue (0.5 mg/mL), Wound Healing Gel
- Where
- Iran
- Volunteers
- 20 people
- Sponsor
- Daryoush Hamidi Alamdari, PhD
Basal Cell Carcinoma
Optical Coherence Tomography Guided C&D
The purpose of the study is to identify the presence of residual superficial and nodular basal cell carcinoma (BCC) status-post curettage and desiccation (C\&D) by using optical coherence tomography (OCT).
- Trial name
- NCT04510727
- Testing
- Optical Coherence Tomography (OCT), Curettage & Desiccation (C&D) Procedure
- Where
- United States
- Sponsor
- University of Miami
Basal Cell Cancer
AI in Histipathological Diagnosis of Bcc
The goal of this study is to evaluate the diagnostic performance of an Artificial Intelligence (AI) algorithm in the histopathological diagnosis of bcc compared to certified dermatopathologists
- Trial name
- AI\bcc (NCT07786376)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Basal Cell Carcinoma
Neoadjuvant Vismodegib in Patients With Large and/or Recurrent Resectable Basal Cell Carcinoma
In this study patients with resectable basal cell carcinoma (BCC) who usually undergo surgery without prior anticancer treatment will be treated with antitumor medication.
- Trial name
- NICCI (NCT03035188)
- Testing
- Vismodegib
- Where
- 12 sites in Germany
- Volunteers
- 40 people
- Sponsor
- SRH Wald-Klinikum Gera GmbH
Skin Cancer
Patient Reported Outcome Measures After Treatment of Skin Cancers on the Face
This study is to evaluate the psychological well-being in patients diagnosed with skin cancer (melanoma and Squamous Cell Carcinoma (SCC) in the face) at the time of diagnosis and after treatment.
- Trial name
- NCT04485442
- Testing
- data collection by questionnaires, data collection (photos of the patients' tumors)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University Hospital, Basel, Switzerland