Clinical trials: BCC - Basal Cell Carcinoma
Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma
Two-photon Fluorescence Microscopy of Dermatologic Biopsies
The goal of this study is to investigate the ability of two-photon fluorescence microscopy to evaluate dermatologic biopsies. The main questions it aims to answer are: How well do two-photon fluorescence images of biopsies taken…
- Conditions
- Basal Cell Carcinoma of Skin, Squamous Cell Carcinoma, Melanocytic Lesion, Adult
- Trial name
- NCT07773688
- Testing
- Two photon microscopy imaging
- Where
- United States
- Volunteers
- 644 people
- Sponsor
- University of Rochester
BCC - Basal Cell Carcinoma, BCC
The Diagnostic Accuracy of Advanced Imaging in Identifying Suspected Skin Cancer (Basal Cell Carcinoma) Around the Eyes
The purpose is to investigate the diagnostic value (sensitivity and specificity) of dermal-Optical Coherence Tomography (D-OCT, VivoSight Dx), in patients with clinically suspected BCC lesions inside the periocular region and…
- Conditions
- BCC - Basal Cell Carcinoma, BCC, Skin Diseases, Eyelid Tumor
- Trial name
- dOCT-pBCC (NCT06279143)
- Where
- Denmark
- Volunteers
- 210 people
- Sponsor
- Vejle Hospital
Skin Basal Cell Carcinoma
Pembrolizumab With or Without Vismodegib in Treating Metastatic or Unresectable Basal Cell Skin Cancer
This phase 1-2 trial studies how well pembrolizumab with or without vismodegib works in treating patients with skin basal cell cancer that has spread to other places in the body or cannot be removed by surgery.
- Trial name
- NCT02690948
- Testing
- Pembrolizumab, Vismodegib
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Anne Chang
Skin Neoplasms
Safety Study of a Fluorescent Marker to Visualize Cancer Cells
Many types of cancer are primarily treated with surgery and patient survival is directly related to the extent to which the tumor is able to be removed.
- Trial name
- NCT02097875
- Testing
- BLZ-100
- Where
- Australia
- Volunteers
- 21 people
- Sponsor
- Blaze Bioscience Australia Pty Ltd
Skin Cancer, Squamous Cell Carcinoma
Skin Tumor Biomarkers by Mass Spectrometry Imaging
The purpose of the study is to investigate the ability of mass spectrometry imaging to locate aggregates of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) ex-vivo, and to distinguish areas containing these…
- Conditions
- Skin Cancer, Squamous Cell Carcinoma, Basal Cell Carcinoma, Non-melanoma Skin Cancer
- Trial name
- NCT06227416
- Testing
- Biopsy
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Bispebjerg Hospital
Basal Cell Nevus Syndrome, Gorlin's Syndrome
Trial Comparing the Effects of Intermittent Vismodegib vs. PDT in Patients With Multiple Basal Cell Carcinomas
The purpose of this study is to evaluate and compare the safety and efficacy of intermittent vismodegib and of Photodynamic Therapy (PDT).
- Trial name
- Vismodegib (NCT01556009)
- Testing
- Vismodegib, Aminolevulinic acid %20 topical solution
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Carcinoma, Basal Cell
VISmodegib for ORbital and Periocular Basal Cell Carcinoma
Basal cell carcinoma (BCCA) is the most common human cancer, and frequently affects facial structures. While rarely fatal, facial BCCA can be disfiguring and expensive to treat.
- Trial name
- VISORB (NCT02436408)
- Testing
- Vismodegib
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan Rogel Cancer Center
Squamous Cell Carcinoma (SCC), Basal Cell Carcinoma (BCC)
Intraoperative Margin Assessment During Mohs Surgery
The research team will develop an intraoperative handheld device for assessing surgical margins during Mohs surgery. The device technology is based on multimodal optical spectroscopy (MMS), combining three optical spectroscopy…
- Trial name
- NCT02750033
- Testing
- Multimodal Spectroscopy (MMS)
- Sponsor
- Seton Healthcare Family
Breast Cancer, Head and Neck Cancer
S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors
RATIONALE: Vandetanib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Conditions
- Breast Cancer, Head and Neck Cancer, Lung Cancer, Prostate Cancer
- Trial name
- NCT00937417
- Testing
- docetaxel, vandetanib, proteomic profiling
- Sponsor
- SWOG Cancer Research Network
Non-melanomatous Skin Cancer
Photodynamic Therapy in Treating Patients With Basal Cell Skin Cancer
RATIONALE: Photodynamic therapy uses light and drugs that make cancer cells more sensitive to light to kill tumor cells. Photosensitizing drugs such as HPPH are absorbed by cancer cells and, when exposed to light, become active…
- Trial name
- NCT00017485
- Testing
- HPPH
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Roswell Park Cancer Institute
Non-Small Cell Lung Cancer (NSCLC), Basal Cell Carcinoma (BCC)
Expanded Access Use of Cemiplimab in Patients With Solid Tumors
Provide expanded access of cemiplimab in patients with solid tumors
- Conditions
- Non-Small Cell Lung Cancer (NSCLC), Basal Cell Carcinoma (BCC), Cutaneous Squamous Cell Carcinoma (CSCC)
- Trial name
- NCT06132191
- Testing
- Cemiplimab
- Sponsor
- Regeneron Pharmaceuticals
Basal Cell Carcinoma, Keratosis Palmaris et Plantaris
The Evaluation of Oral Acitretin in the Treatment of Psoriasis, Cutaneous Disorders of Keratinization, Multiple Basal Cell Carcinomas and Other Retinoid Responsive Diseases
This is a continuing study which evaluates the long-term safety and efficacy of oral acitretin in an open manner in the treatment of psoriasis, cutaneous disorders of keratinization, multiple basal cell carcinomas and other…
- Conditions
- Basal Cell Carcinoma, Keratosis Palmaris et Plantaris, Psoriasis
- Trial name
- NCT00005660
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Cancer Institute (NCI)
Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma
At-Home Cancer Directed Therapy Versus in Clinic for the Treatment of Patients With Advanced Cancer
This clinical trial studies the effect of cancer directed therapy given at-home versus in the clinic for patients with cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the…
- Conditions
- Advanced Anal Carcinoma, Advanced Biliary Tract Carcinoma, Advanced Bladder Carcinoma, Advanced Breast Carcinoma
- Trial name
- NCT05969860
- Testing
- Clinical Encounter, Home Health Encounter, Quality-of-Life Assessment
- Where
- 2 sites in United States
- Volunteers
- 220 people
- Sponsor
- Mayo Clinic
Basal Cell Carcinoma
Photodynamic Therapy (PDT) With Metvix Cream 160 mg/g Versus PDT With Placebo Cream in Participants With Primary Nodular Basal Cell Carcinoma
Photodynamic therapy (PDT) was the selective destruction of abnormal cells through light activation of a photosensitiser in the presence of oxygen. These cells accumulated more photosensitiser than normal cells.
- Trial name
- NCT00472108
- Testing
- Photodynamic Therapy (PDT), Metvix cream
- Where
- 9 sites in United States
- Volunteers
- 65 people
- Sponsor
- Galderma R&D
Carcinoma, Basal Cell, Malignant
Identification of Psychosocial Factors Associated With Diagnostic Delay in Advanced Basal Cell Carcinoma
The aim of this study was to identify psycho-social factors associated with diagnostic delay in advanced basal cell carcinomas. Thus, the objective is to develop recommendations to better identify CBCa populations at risk…
- Trial name
- PSYCHO-CBC (NCT04124796)
- Testing
- Semi-structured interviews
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Basal Cell Carcinoma
Intron-A/Aldara Combination Therapy for Basal Cell Carcinoma (BCC)
A trial to see if BCC excluding the scalp and face can be treated successfully with a combination therapy of Intron-A and Aldara.
- Trial name
- NCT00581425
- Testing
- Imiquimod and Interferon alpha
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- The University of Texas Health Science Center, Houston
Basal Cell Carcinoma
Inter-Operator Variability in the Clinical Staging and Therapeutic Management of Basal Cell Carcinoma
Basal cell carcinoma (BCC) is the most frequent skin cancer in humans, primarily located in sun-exposed areas. The incidence of BCC increases with cumulative exposure to ultraviolet (UV) radiation and is particularly high in the…
- Trial name
- BASIX (NCT07571031)
- Testing
- Dermatological evaluation
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stage IV Melanoma, Advanced Lung Cancer
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer.
- Conditions
- Stage IV Melanoma, Advanced Lung Cancer, Stage IV Non-Small Cell Lung Cancer, Unresectable Non-Small Cell Lung Carcinoma
- Trial name
- UPLIFT (NCT04670445)
- Testing
- Educational Video and QPL List, Usual Care
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Non-Melanoma Skin Cancers
A Trial to Study the Safety and Efficacy of SM-020 Gel 1.0% in Subjects With Seborrheic Keratoses and Non-Melanoma Skin Cancers
Open-Label study evaluating safety and efficacy of SM-020 Gel 1.0% in subjects with Seborrheic Keratoses and Non-Melanoma Skin Cancers (i.e. Basal Cell Carcinoma and Squamous Cell Carcinoma In Situ).
- Trial name
- NCT06409195
- Testing
- SM-020 1% Gel
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- DermBiont, Inc.
Basal Cell Carcinoma of Skin
AI-enhanced OCT Imaging for Pre-surgical Margin Detection of Basal Cell Carcinoma
Basal cell carcinomas (BCCs) are the most common human malignancy, affecting about 2 million Americans each year. Mohs micrographic surgery (MMS) removes tissue by sequential excision.
- Trial name
- NCT07358637
- Testing
- AI-OCT
- Volunteers
- 30 people
- Sponsor
- Henry Ford Health System