Clinical trials: BK Virus Infection
Kidney Transplant Infection, BK Virus Infection
BK With VST for Kidney Transplant Patients
This study measures the safety, feasibility, and efficacy of viral-specific T cells (VST) against BK Virus (BKV) in adult kidney transplant recipients. Participants are expected to be on study for 52 weeks.
- Trial name
- NCT05042076
- Testing
- BK-specific T cells from Donor Lymphocytes
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Kidney Transplantation, BK Virus
IVIg to Treat BK Viremia in Kidney Transplant Recipients
The overall goal of this study is to rapidly improve clearance of BK viremia with Immunoglobulin (Privigen®) thereby decreasing the potential for formation of alloantibodies in renal transplant recipients that have had…
- Conditions
- Kidney Transplantation, BK Virus, Isoantibodies
- Trial name
- NCT02659891
- Testing
- IVIg
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Massachusetts General Hospital
Adenovirus Infection, BK Virus Infection
Posoleucel (ALVR105, Formerly Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant
This is a Phase 2 study to evaluate posoleucel (ALVR105, formerly Viralym-M); an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets six viral pathogens: BK virus, cytomegalovirus, adenovirus, Epstein-Barr…
- Conditions
- Adenovirus Infection, BK Virus Infection, Cytomegalovirus Infections, Epstein-Barr Virus Infections
- Trial name
- Prevent (NCT04693637)
- Testing
- Posoleucel (ALVR105)
- Where
- 16 sites in United States
- Volunteers
- 26 people
- Sponsor
- AlloVir
BK Virus Nephropathy, BK Virus Infection
Study of Posoleucel (Formerly Known as ALVR105; Viralym-M) in Kidney Transplant Patients With BK Viremia
The purpose of this study is to compare Posoleucel (formerly known as ALVR105; Viralym-M) to placebo in kidney transplant recipients who have high or low levels of BK virus in their blood.
- Trial name
- NCT04605484
- Testing
- Posoleucel (formerly known as ALVR105) cells
- Where
- 33 sites in United States
- Volunteers
- 61 people
- Sponsor
- AlloVir
Viruria
CMX001 in Post-transplant Patients With BK Virus Viruria
This was a randomized, double-blind, multiple-dose placebo-controlled study of oral brincidofovir (BCV) in hematopoietic stem cell transplant and renal transplant recipients with BK virus viruria.
- Trial name
- NCT00793598
- Testing
- Brincidofovir
- Where
- 15 sites in United States
- Volunteers
- 29 people
- Sponsor
- Jazz Pharmaceuticals
Acquired Immunodeficiency Syndrome, BK Virus Infection
Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus
This phase II trial studies how well donor cytotoxic T lymphocytes work in treating patients with malignancies with BK and/or JC virus.
- Conditions
- Acquired Immunodeficiency Syndrome, BK Virus Infection, Human Immunodeficiency Virus, JC Virus Infection
- Trial name
- NCT02479698
- Testing
- Allogeneic BK-specific Cytotoxic T-lymphocytes, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- M.D. Anderson Cancer Center
BK Virus Infection
Safety and Efficacy Study of Everolimus to Treat BK Virus Infection in Kidney Transplant Recipients
This study is examining the safety and efficacy of converting anti-rejection therapy from mycophenolic acid (MPA) to Zortress (everolimus) in renal transplant recipients with BK virus infection.
- Trial name
- NCT01624948
- Testing
- Everolimus, Mycophenolic acid dose reduction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
BK Virus Infection, Nephropathy
Prediction of BKvirus Nephropathy Risk by the NEPHROVIR Method in Kidney Transplant Patients With BKvirus Viremia
BKvirus associated nephropathy (BKvAN) is a major complication in kidney transplantation. Due to BKvirus (BKv) intra-graft replication, BKvAN affects nearly 10% of patients and causes graft loss in more than 50% of cases.
- Conditions
- BK Virus Infection, Nephropathy, Kidney Transplantation
- Trial name
- BK-VIR (NCT05026021)
- Testing
- Blood sample
- Where
- 5 sites in France
- Volunteers
- 41 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
BK Virus (Nephropathy)
Cidofovir in Renal Transplant Recipients With BKVN
This study will look at the safety, tolerability and effectiveness of cidofovir in kidney transplant patients who have been diagnosed with BK virus nephropathy (BKVN), a viral condition that can cause patients to reject…
- Trial name
- NCT00138424
- Testing
- Cidofovir
- Where
- 12 sites in United States
- Volunteers
- 22 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
BK Virus Infection, BK Virus Nephropathy
BK Virus Post-Kidney Transplant: New Practice Versus Traditional Approach
The investigator's aim in this study is to evaluate the impact of a new standard of care protocol for the treatment of BK viremia and nephropathy (BKVAN), which includes switching from Tacrolimus to equivalent dose of…
- Trial name
- NCT02758288
- Testing
- New Protocol - BK viremia or BK virus nephropathy, Standard Protocol - BK viremia or BK virus nephropathy
- Where
- United States
- Sponsor
- Loma Linda University
Adenovirus Infection, BK Virus Infection
Study of Posoleucel (ALVR105,Viralym-M) for Multi-Virus Prevention in Patients Post-Allogeneic Hematopoietic Cell Transplant
This is a Phase 3 study to evaluate posoleucel (ALVR105, Viralym-M); an allogeneic, off-the-shelf multi-virus specific T cell therapy that targets six viral pathogens: BK virus, cytomegalovirus, adenovirus, Epstein-Barr virus…
- Conditions
- Adenovirus Infection, BK Virus Infection, Cytomegalovirus Infections, Epstein-Barr Virus Infections
- Trial name
- Prevent (NCT05305040)
- Testing
- Posoleucel (ALVR105)
- Where
- 88 sites in United States, Australia and 8 more
- Volunteers
- 451 people
- Sponsor
- AlloVir
Polyoma Virus Nephropathy
Haufen Diagnostic Biomarkers of BK Renal Disease
To prospectively test whether the detection of three-dimensional, cast-like polyomavirus aggregates, termed Haufen, in voided urine samples can serve as an accurate biomarker of intra-renal disease, i.e.
- Trial name
- NCT01094691
- Testing
- Renal Allograft Biopsy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of North Carolina, Chapel Hill
Graft Dysfunction
Role of Anti-BK Virus Neutralizing Antibodies (BKV) as a Prognostic Marker for the Development of Nephropathy BK
BKV nephropathy (BKV) is one of the most frequent complications of kidney transplantation. In the absence of specific anti-BKV treatment, pre-emptive reduction of immunosuppression is the main strategy that has proven effective…
- Trial name
- NCT02826811
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Strasbourg, France
Viral Infection
ARMS - Rapidly Generated Multivirus-Specific CTLs for Prophylaxis & Treatment of EBV, CMV, Adenovirus, HHV6 & BK Virus
The subjects eligible for this trial have a type of blood cell cancer, other blood disease or a genetic disease for which they will receive a stem cell transplant.
- Trial name
- ARMS (NCT01570283)
- Testing
- Multivirus-specific T cells Dose Level 1, Multivirus-specific T cells Dose Level 2, Multivirus-specific T cells Dose Level 3
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- AlloVir
BK Virus Nephropathy After Kidney Transplantation
Multicenter Randomized Two-arms Study Evaluating the BK Viral Clearance in Kidney Transplant Recipients With BK Viremia.
BK virus nephropathy (BKVN), a consequence of the strong immunosuppressive therapy given after kidney transplantation, represents a growing problem in the kidney transplant (KT) setting.
- Trial name
- BK EVER (NCT03216967)
- Testing
- everolimus
- Where
- 15 sites in France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Strasbourg, France
BK Virus Infection, Kidney Transplant; Complications
Immune Registry for BK in Kidney Transplant Recipients
Kidney transplantation (KT) is the best treatment modality available to date for patients with advanced kidney disease and the success of KT is dependent on maintaining a selective intricate balance between the risk of rejection…
- Trial name
- NCT06538961
- Testing
- Blood samples: Main Study group, Data Collection, Urine Sample- Main Study group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
BK Virus, Salivary Replication
Salivary Replication of BK Virus in Post-kidney Transplant
BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in…
- Conditions
- BK Virus, Salivary Replication, Kidney Transplantation, Nephropathy
- Trial name
- BKSAL (NCT07256470)
- Testing
- Salivary self-collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HIV, Salivary Gland Disease
BK Virus in Salivary Gland Disease: Treating the Potential Etiologic Agent
The purpose of this study is to analyze BK viral infection in salivary gland diseases; specifically, to determine a definitive relationship between BK Virus and HIV associated salivary gland disease (HIVSGD).
- Conditions
- HIV, Salivary Gland Disease, Benign Lymphoepithelial Lesion
- Trial name
- NCT02068846
- Testing
- Ciprofloxacin
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of North Carolina, Chapel Hill
Viruria, Viremia
An Open-Label, Study to Treat Patients With Renal Allograft and Polyoma BK Viruria
This study will evaluate the clinical efficacy and safety of a combination of leflunomide and orotic acid in kidney transplant patients with high levels of Polyoma BK viruria for the purpose of preventing Polyoma BK viremia and…
- Trial name
- NCT01620268
- Testing
- Leflunomide and orotic acid
- Where
- 9 sites in United States
- Volunteers
- 24 people
- Sponsor
- Changzheng-Cinkate
Renal Transplant Rejection, Pediatric Kidney Disease
VIRTUUS Children's Study
The objective of the VIRTUUS Children's Study is to adapt identified and validated adult noninvasive diagnostic and prognostic biomarkers for the characterization of allograft status in pediatric recipients of kidney allografts.
- Conditions
- Renal Transplant Rejection, Pediatric Kidney Disease, End Stage Renal Disease, Nephropathy
- Trial name
- VIRTUUS (NCT03719339)
- Where
- 13 sites in United States, Canada
- Volunteers
- 445 people
- Sponsor
- Children's Hospital of Philadelphia