Clinical trials: BRONCHIAL ASTHMA
Asthma, COPD
Comparison of 3 Methods to Assess Inhalation Technique
A significant percentage of patients with asthma and COPD do not use their inhalers properly. Experts recommend that in patients with obstructive lung diseases, inhalation technique and patient adherence should be evaluated at…
- Trial name
- CINTECH (NCT04349735)
- Testing
- Assessment of inhalation technique
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Warsaw
Asthma (Diagnosis)
Comparison of Box Breathing and Rhythmic Breathing Techniques in Patients With Asthma
Asthma is a chronic respiratory disease that can cause breathing difficulties, reduced lung function, and poor sleep quality. Breathing exercises are increasingly used as non-pharmacological interventions to improve respiratory…
- Trial name
- BRAS (NCT07717476)
- Testing
- Box Breathing, Rhythmic Breathing
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Asthma
Evaluation of Tiotropium 2.5 and 5 mcg Once Daily Delivered Via the Respimat® Inhaler Compared to Placebo and Salmeterol HydroFluoroAlkane (HFA) Metered Dose Inhaler (MDI) (50 mcg Twice Daily) in Patient With Moderate Persistent Asthma II
The aim of this trial is to evaluate the efficacy and safety of 2.5 and 5 mcg tiotropium over a 24-week treatment period as compared to placebo and salmeterol (50 mcg twice daily).
- Trial name
- NCT01172821
- Testing
- tiotropium Respimat® low dose, tiotropium Respimat® high dose, 50 mcg salmeterol HFA MDI
- Where
- 125 sites in United States, Brazil and 9 more
- Volunteers
- 1,032 people
- Sponsor
- Boehringer Ingelheim
Asthma
Treatment Of Symptomatic Asthma In Children
This study is being conducted to investigate whether in childhood salmeterol/ fluticasone propionate 50/100 bd delivered via the Diskus® inhaler and fluticasone propionate 200 mcg bd delivered via the Diskus® inhaler are non…
- Trial name
- NCT00197106
- Testing
- Salmeterol/ fluticasone propionate Diskus® inhaler 50/100 mcg, fluticasone propionate 2 x 100 mcg
- Where
- 18 sites in Netherlands
- Volunteers
- 176 people
- Sponsor
- GlaxoSmithKline
Asthma
Replication of the P04334 Asthma Trial in Healthcare Claims Data
Investigators are building an empirical evidence base for real world data through large-scale replication of randomized controlled trials.
- Trial name
- NCT04892758
- Testing
- Formoterol fumarate 10 mcg, Mometasone furoate/formoterol fumarate combination MDI 200/10 mcg BID
- Where
- United States
- Volunteers
- 10,288 people
- Sponsor
- Brigham and Women's Hospital
Asthma
Assessment and Evaluation of Pharmacokinetic Profile of E004 in Healthy Adults
This study examines the pharmacokinetic profile of Armstrong's proposed Epinephrine Inhalation Aerosol USP, an HFA-MDI (E004), using a stable isotope deuterium-labeled epinephrine (epinephrine-d3) to differentiate the…
- Trial name
- NCT01737892
- Testing
- Arm T Epinephrine Inhalation Aerosol HFA, 125 mcg, 1 inhalation, Arm C-Epinephrine Inhalation Aerosol CFC
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Asthma
Online Asthma Self-Management for Children Aged 5-10 and Their Parents
The potential benefits of this research to public health include improved understanding of cultural factors in pediatric asthma self-management, improved self-management skills for children, and better asthma management skills…
- Trial name
- ChildAsthma (NCT02602392)
- Testing
- Lungtropolis, Asthma educational booklet
- Where
- United States
- Volunteers
- 622 people, healthy volunteers welcome
- Sponsor
- Oregon Center for Applied Science, Inc.
Asthma
mRNA Expression as a Biomarker of Omalizumab Response
Objectives: 1. Determine if mRNA expression could be use as a biomarker to predict and monitor the response to omalizumab in patients with difficult control asthma 2.
- Trial name
- NCT01584687
- Testing
- Omalizumab
- Volunteers
- 6 people
- Sponsor
- Instituto de Investigação em Imunologia
Pediatric Respiratory Diseases
Structured Light Plethysmography in Obstructive Airways Disease
Obstructive airways disease is the most common group of acute illnesses leading to hospital treatment in children. This group consists of different age-related diagnoses, such as bronchiolitis in infants or wheezing and asthma in…
- Trial name
- NCT03499938
- Testing
- Structured Light Plethysmography
- Where
- United Kingdom
- Volunteers
- 57 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Asthma, Aspirin-Induced, Chronic Rhinosinusitis With Nasal Polyps
Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)
Primary objective: to investigate the efficacy of Mepolizumab 100 milligram (mg) every month compared to placebo in reducing validated Sinonasal Outcome Test -22 score and on reducing endoscopic Nasal Polyp Score.
- Trial name
- AirGOs-biol (NCT04823585)
- Testing
- Mepolizumab
- Where
- Finland
- Volunteers
- 95 people
- Sponsor
- Helsinki University Central Hospital
Asthma
AZISAST Study: AZIthromycin in Severe ASThma Study
The purpose of this study is to evaluate the efficacy, safety and cost-effectiveness of azithromycin as add-on therapy in adult subjects with severe persistent asthma, who remain inadequately controlled despite GINA (2006) step 4…
- Trial name
- AZISAST (NCT00760838)
- Testing
- Azithromycin 250 mg
- Where
- 7 sites in Belgium
- Volunteers
- 109 people
- Sponsor
- University Hospital, Ghent
Wheezy Bronchitis
Intravenous Magnesium in Wheezy Bronchitis
In infants and toddlers wheezy bronchitis is a common viral disease. To relieve wheezing symptoms bronchodilators or corticosteroids are commonly used but the efficacy is not always satisfactory.
- Trial name
- NCT01383655
- Testing
- Magnesium Sulfate
- Where
- Finland
- Volunteers
- 61 people
- Sponsor
- University of Oulu
Asthma
Non-Interventional Study to Describe the Clinical Management in Asthmatic Patients (NICMA)
Asthma is a heterogenic chronic disease that affects more than 300 million people worldwide, which it's characterized by acute symptomatic episodes of varying severity, including intermittently inflammation and narrowing of the…
- Trial name
- (NICMA) (NCT06811155)
- Where
- Spain
- Volunteers
- 288 people
- Sponsor
- Hospital Universitario Virgen de la Victoria
Acute Asthma
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms
The hypothesis to be tested is that acutely ill asthmatics who do not resolve their attacks following standard doses of albuterol and require admission to hospital have single nucleotide polymorphisms of their B2 adrenergic…
- Trial name
- NCT01016444
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- MetroHealth Medical Center
Asthma
Phase IV Study in Asthma Subjects for Dry Powder Inhaler (DPI) Versus (vs) Metered Dose Inhaler (MDI) Correct Use
The study is conducted to evaluate the potentially improved patient handling of the ELLIPTA Dry Powder Inhaler (DPI). Therefore, the study aims to evaluate errors encountered by subject with asthma during handling ELLIPTA DPI…
- Trial name
- NCT02794480
- Testing
- ELLIPTA DPI, GSK MDI, AZ MDI
- Where
- 20 sites in United States
- Volunteers
- 324 people
- Sponsor
- GlaxoSmithKline
Asthma
The Study is Enrolling Kids From 8 to 17 Years Old. The BreathSmart Device Attaches to the Inhaler to Measure Adherence.
Non-adherence to controller medication is a common problem in children with Asthma, resulting in overuse of reliever medication, increased asthma symptoms, more frequent Asthma attacks, and increased emergency room visits and…
- Trial name
- NCT03734861
- Testing
- BreatheSmart System, Standard of Care
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Connecticut Children's Medical Center
Asthma
Asthma Control, Quality of Life and Emotional Feelings in a Real Life Setting
This study aims to evaluate the asthma control status, asthma symptoms (severity, frequency, and limitations on activities, etc.), QOL, and use of drugs for asthma attack in adult asthma patients.
- Trial name
- ACQUIRE-2 (NCT02640742)
- Where
- 57 sites in Japan
- Volunteers
- 1,232 people
- Sponsor
- AstraZeneca
Sleep Apnea, Obstructive, Asthma, Exercise-Induced
Pulmonary Disorders During Exercise in Patients With Obstructive Sleep Apnea
Purposes: 1. To investigate whether patients with severe obstructive sleep apnea syndrome (OSAS) are at higher risk for exercised-induced bronchoconstriction (EIB) due to baseline airway inflammation compared with age, gender…
- Trial name
- NCT00916773
- Testing
- continuous positive airway pressure (CPAP)
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Asthma
Fluticasone-Vilanterol Once Daily Dose for the Treatment of Mild Asthma in Adults
Investigators will test the superiority of Superiority Trial of Fluticasone-Vilanterol as needed in mild asthma compared to standard of care
- Trial name
- NCT04265105
- Testing
- fluticasone-vilanterol, Standard Preparation
- Where
- Bahrain
- Volunteers
- 18 people
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Eosinophilic Asthma
A Multi-dose Study on the Safety and Efficacy of Self-administered Intranasal AD17002 Treatment for Eosinophilic Asthma
1. Eosinophilic asthma, a type 2 immune disorder, often involves the excessive production of type 2 cytokines. 2. Excessive Type 2 cytokines lead to chronic inflammation, airway hyperresponsiveness, and airflow obstruction. 3.
- Trial name
- NCT07250594
- Testing
- AD17002, Formulation buffer
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- Advagene Biopharma Co. Ltd.
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