Clinical trials: BRONCHIAL ASTHMA
Asthma
Symbicort Onset of Action 1
The purpose of this study is to compare the early onset of effect of Symbicort compared to Advair Diskus and Ventolin in adults with asthma
- Trial name
- NCT00646620
- Testing
- budesonide/formoterol (Symbicort), fluticasone/salmeterol (Advair Diskus), albuterol (Ventolin)
- Volunteers
- 48 people
- Sponsor
- AstraZeneca
Asthma
The Association of Transgelin-2, Metallothionein-2 and Ezrin With Asthma
Asthma is one of the most common chronic respiratory diseases. Previous study found a series of differentially expressed genes and proteins (transgelin-2, metallothionein-2, ezrin) in asthmatic rat.
- Trial name
- NCT05496582
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Asthma
GSNOR Phenotyping/GSNO Challenge in Severe Asthma
Asthma is caused by or worsened by different things in different people. It is because of these differences that not all people with asthma respond the same to all treatments and medicines.
- Trial name
- NCT03926741
- Testing
- GSNO Challenge
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- James Reynolds
Bronchial Asthma
Additive Effects of Alternative Nostril Breathing with Pharmacological Management on Dyspnea and Control Pause in Patients with Bronchial Asthma
Bronchial asthma is a widespread chronic condition charactrized by inflammation and narrowing of airways, leading to repeateted episodes of breathlessness, wheezing and labored breathing.Breathing exercises help to manage…
- Trial name
- NCT06609941
- Testing
- Alternative nostril breathing, Pharmacological therapy
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Foundation University Islamabad
Asthma
Effect of Budesonide on Exhaled Nitric Oxide in Asthmatic Children
To study the improvement in airway inflammation in children with asthma non-invasively with exhaled breath NO, a marker of inflammation, after therapy with nebulized budesonide as 0.5mg daily.
- Trial name
- NCT00522782
- Testing
- Nebulized Budesonide, Nitric Oxide Analyzer
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- AAADRS Clinical Research Center
Chronic Obstructive Pulmonary Disease (COPD), Asthma
A Study to Evaluate the Disposition of Drug in Body and Safety After Administration of Single Inhaled Doses of Drugs Abediterol and AZD7594 Administered Alone, in Fixed Dose Combination and in Free Combination Using the Dry Powder Inhaler in Healthy Male Participants
AZD7594 is a non steroidal, potent and selective modulator of the glucocorticoid receptor (GR) under development for once daily inhaled treatment of chronic obstructive pulmonary disease (COPD) and asthma.
- Trial name
- NCT02967159
- Testing
- Abediterol, AZD7594, AZD7594/abediterol
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Allergic Asthma
Nasal Allergen Challenge - Reproducibility of Biomarkers and Effect of Topical Steroid Treatment
Subjects with allergic asthma developing the required nasal symptoms in response to nasal allergen titration during a screening period will be randomized 1:1 to one of 2 cohorts.
- Trial name
- NACHO (NCT03431961)
- Testing
- Triamcinolone Acetonide
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Gail Gauvreau
Mindfulness, Chronic Disease
Tailoring Mindfulness Interventions for Families Managing Chronic Health Conditions
This is not an intervention or treatment study. It is an observational qualitative data study about tailoring a mindfulness intervention to assist families managing chronic health conditions.
- Trial name
- PEP (NCT05271851)
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Persistent Asthma
Effect of Vitamin D Supplementation on the Control of Asthma in Children at a South African Academic Hospital
The aim of this randomized double-blind placebo controlled study is to assess whether vitamin D supplementation will improve control in South African children with persistent asthma at an academic hospital.
- Trial name
- NCT02053402
- Testing
- Vitamin D
- Where
- South Africa
- Volunteers
- 100 people
- Sponsor
- University of Limpopo
Asthma, COPD
An Evaluation of 9MW1911 Injection in Healthy Subjects
This study is a randomized, double-blind, dose-escalating phase I clinical study to evaluate the safety, tolerability and pharmacokinetics of 9MW1911 injection in healthy subjects.
- Conditions
- Asthma, COPD, Atopic Dermatitis
- Trial name
- NCT05803902
- Testing
- Experimental drug 9MW1911
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Asthma, Candidiasis, Oral
Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 mcg BID
This Pilot study is designed to explore the rate of local side effects of fluticasone as delivered by Advair and to determine the best outcome measure to assess these effects.
- Conditions
- Asthma, Candidiasis, Oral, Voice Disorders
- Trial name
- NCT00235053
- Testing
- fluticasone/salmeterol DISKUS 250/50
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Allergy & Asthma Medical Group & Research Center
Asthma
Improving Asthma Communication in Minority Families
The purpose of this study is to determine if teaching children with asthma how to talk to their doctor about controlling their asthma including symptom frequency in an asthma diary and medication use techniques, will result in…
- Trial name
- NCT00133666
- Testing
- Asthma Communication Education, Standard Asthma Education
- Where
- United States
- Volunteers
- 231 people
- Sponsor
- National Institute of Nursing Research (NINR)
Asthma, Bronchospasm
Single-Dose Cross-Over Study of the Effects of Albuterol-HFA in Exercise Induced Bronchoconstriction
This clinical study will evaluate and establish the protective effects of Amphastar's Albuterol Sulfate HFA Inhalation Aerosol (Albuterol-HFA), in preventing exercise-induced bronchoconstriction (EIB) in adolescent and adult…
- Trial name
- NCT00634829
- Testing
- albuterol (Armstrong Albuterol HFA), Albuterol Sulfate (Provenetil-HFA)
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Amphastar Pharmaceuticals, Inc.
Asthma, Allergic Rhinitis
Nasal Allergen Challenge in Rhinitic Subjects
Background: Nasal allergen challenge (NAC) is useful to study the pathophysiology of rhinitis, and multiple challenges may more adequately approximate natural exposure.
- Trial name
- NCT01286129
- Testing
- Nasal allergen challenge
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Laval University
Asthma
Qualitative Assessment of Patients Suffering From Difficult Asthma
Asthma is a chronic inflammatory disease, resulting from environmental, genetic and immunological factors. This is a triad specific to the diseases of the 21st century, linked to our environment, which the investigators thought…
- Trial name
- DIFFAsthme (NCT05185375)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma
Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
Aspirin Exacerbated Respiratory Disease (AERD) is a relatively homogeneous disease characterized by adult-onset severe asthma, development of non-cancerous growths in the nasal canal (i.e. nasal polyps) and aspirin allergy.
- Conditions
- Aspirin Exacerbated Respiratory Disease, Aspirin-Sensitive Asthma, Nasal Polyps
- Trial name
- AERD (NCT04261582)
- Where
- United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Asthma
Symbicort SMART (Symbicort Maintenance And Reliever Therapy)
The purpose of this study is to investigate the extent of Symbicort use in patients prescribed Symbicort as maintenance and reliever therapy.
- Trial name
- SMART (NCT00523679)
- Where
- 3 sites in South Korea
- Volunteers
- 2,000 people
- Sponsor
- AstraZeneca
Asthma
Efficacy and Safety of 3 Doses of Tiotropium Compared to Placebo in Adolescents (12 to 17 Yrs) With Moderate Asthma
The primary objective of this trial is to evaluate the efficacy and safety of tiotropium 1.25 mcg (2 actuations of 0.625 mcg), tiotropium 2.5 mcg (2 actuations of 1.25 mcg) and tiotropium 5 mcg (2 actuations of 2.5 mcg) once…
- Trial name
- NCT01122680
- Testing
- Tiotropium bromide
- Where
- 19 sites in United States, Germany and 3 more
- Volunteers
- 105 people
- Sponsor
- Boehringer Ingelheim
Asthma
Efficacy and Safety of Four Escalating Dose Regimens of TPI ASM8 in Patients With Allergic Asthma
During this proposed clinical trial, the investigators intend to evaluate the pharmacodynamic anti-inflammatory properties and safety of TPI ASM8, by investigating the effect on sputum eosinophils and the airway responses during…
- Trial name
- NCT00822861
- Testing
- TPI ASM8
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Syntara
Asthma
Study to Evaluate GSK2190915 in Subjects With Mild Asthma
This study will evaluate the safety and effect of repeat oral doses of GSK2190915 on lung function in mild asthmatics using a number of clinical and biological markers of efficacy.
- Trial name
- NCT00812773
- Testing
- GSK2190915
- Where
- 3 sites in United Kingdom
- Volunteers
- 17 people
- Sponsor
- GlaxoSmithKline
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