Clinical trials: BRONCHIAL ASTHMA
Asthma, Cardiovascular Diseases
Relationship Between Cardiovascular Disease in Asthma and Eosinophil Subtypes and Biomarkers of Bronchial Remodeling.
To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.
- Trial name
- NCT05589779
- Testing
- Asthma and cardiovascular disease
- Volunteers
- 40 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Asthma in Children
Forced Oscillations Technique During a Metacholine Test in Children
Asthma is the most common chronic lung disease in children. It affects more than 1 in 10 children in France. The methacholine bronchial challenge test (MBT) is indicated to assess the probability of asthma suggested by clinical…
- Trial name
- TPM AOS (NCT05734261)
- Testing
- Airway Oscillation System
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
Asthma
Chronic Bronchiolitis or Resistant Asthma?
Chronic Bronchiolitis or Resistant Asthma? Testing a way to diagnosis and treatment
- Trial name
- NCT00368342
- Testing
- Erythromycin, Azithromycin , Clarithromycin
- Sponsor
- Baqiyatallah Medical Sciences University
ASTHMA
Breathing Training for Asthma
For the proposed randomized controlled treatment study, the investigators plan to compare the effects of this hypoventilation-based breathing training with a control intervention that will focus on breathing regularity and…
- Trial name
- NCT00975273
- Testing
- Capnometry Assisted Respiration Training, Breathing Awareness
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Southern Methodist University
COPD Asthma
Home Spirometry in Primary Care: an Implementation Study
Rationale: Spirometry is essential in the diagnosis of airway disease and can be useful in monitoring patients. Despite the essential role, spirometry remains largely underused in primary care.
- Trial name
- Spiro@Home (NCT05162157)
- Testing
- NuvoAir platform
- Where
- 2 sites in Netherlands, Sweden
- Volunteers
- 144 people
- Sponsor
- General Practitioners Research Institute
Asthma
The Study of Omalizumab (CMAB007 and Xolair) in Healthy Subjects to Compare the PK, PD and Safety
A phase 1, randomized, double-blind, parallel group, single-dose study to compare the pharmacokinetics, pharmacodynamics and safety of two formulations of Omalizumab (CMAB007 and Xolair) in healthy subjects.
- Trial name
- NCT04778137
- Testing
- Omalizumab
- Where
- China
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Taizhou Mabtech Pharmaceutical Co.,Ltd
Asthma
Effects of Green Tea Extract (GTE) on Systemic Oxidative and Antioxidative Status in Chinese Patients With Stable Asthma
Asthma is a disease characterized by chronic inflammation in the airways. Recent research has demonstrated that one of the reasons for the chronic inflammatory state is an imbalance between oxidative stress and antioxidative…
- Trial name
- NCT01187147
- Testing
- green tea extract
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Allergic Asthma
Cobra (Severe Asthma)Medical-economic
The severe asthma is a major source of expenses in term of public health, while it concerns no more than 5 % of the asthmatics. The expenses is direct (medicines, hospitalizations, care) but especially indirect (absenteeisms…
- Trial name
- Cobra (NCT01669681)
- Where
- France
- Volunteers
- 81 people
- Sponsor
- University Hospital, Montpellier
Rhinitis, Allergic, Asthma
Study on the Correlation Between Intestinal Microecology and Allergic Diseases in Children
Allergic diseases, including allergic reactions of respiratory tract and skin, are often triggered by mast cell degranulation mediated by allergen-specific IgE and chronic inflammation of target organs, which are involved in a…
- Conditions
- Rhinitis, Allergic, Asthma, Dermatitis, Atopic, Urticaria
- Trial name
- NCT04938700
- Testing
- probiotics, conventional medical treatment
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Healthy Participants
A Phase 1 Trial of AMG 691 in Healthy Chinese and Japanese Volunteers
The trial is designed to evaluate the pharmacokinetics, safety, tolerability, and immunogenicity of AMG 691 in healthy Chinese and Japanese participants
- Trial name
- NCT07745907
- Testing
- AMG 691
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Amgen
Asthma, Cystic Fibrosis
Standardisation of Measurements in Exhaled Breath and Exhaled Breath Condensate.
Background: in various pediatric pulmonary diseases such as asthma, cystic fibrosis or bronchopulmonary dysplasia an increased inflammation is present.
- Conditions
- Asthma, Cystic Fibrosis, Chronic Lung Disease, Pneumonia
- Trial name
- NCT00983671
- Where
- Netherlands
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Asthma, Bronchial
The Cohort Study for Asthma in China
The study is to establish a standardized asthma cohort study, build an information network platform system and a biospecimen bank for asthma cohort, establish clear follow-up standards and norms, observe the asthma outcomes and…
- Trial name
- NCT05937334
- Testing
- Diagnostic Test: lung function test, chest CT, induced sputum, blood routine test, IgE test, FeNO test, six minutes walk test, questionnaires for asthma
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Beijing Chao Yang Hospital
Asthma
New Approaches for Empowering Studies of Asthma in Populations of African Descent
Background: Some groups of people have a high prevalence of asthma and allergic disease. Also, asthma and allergic disease are often found in several members of the same family.
- Trial name
- NCT03937804
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Asthma, Chronic Obstructive Pulmonary Disease (COPD)
Bioequivalence Study of Synflutide HFA Inhaler and Seretide Evohaler in Healthy Volunteers Without Charcoal Block
The objective of this pivotal study is to evaluate the relative bioavailability of Synflutide HFA 250/25 Inhaler and SeretideTM 250 EvohalerTM in healthy volunteers without charcoal block.
- Trial name
- NCT02466347
- Testing
- Fluticasone propionate, Salmeterol (as xinafoate)
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Intech Biopharm Ltd.
Asthma
Systemic Corticosteroids Avoidance Study in Severe Asthma Patients
The overall purpose of this study was to determine the efficacy of fevipiprant (150 mg and 450 mg once daily), compared with placebo, as add-on to standard-of-care asthma therapy, in terms of avoidance of corticosteroid use over…
- Trial name
- NCT03629249
- Testing
- QAW039 150 mg once daily, QAW039 450 mg once daily
- Where
- 120 sites in United States, Argentina and 19 more
- Volunteers
- 604 people
- Sponsor
- Novartis Pharmaceuticals
Wheezing, Asthma in Children
Respiratory Outcome of Infants With or Without Documented Wheezing During Bronchiolitis
Hospital admission for infant bronchiolitis is associated with an increased risk of recurrent wheezing and subsequent asthma in childhood.
- Trial name
- WheezOut (NCT04811248)
- Testing
- telephone call for parents of patients
- Where
- France
- Volunteers
- 281 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Asthma
Effects of Mometasone Furoate Dry Powder Inhaler, Fluticasone Propionate, and Montelukast on Bone Mineral Density in Asthmatics (Study P03418)
This is a randomized, multi-center, parallel-group, active-controlled, double-blind study evaluating the effects of mometasone furoate (MF) dry powder inhaler (DPI) on bone mineral density (BMD) in subjects with asthma.
- Trial name
- NCT00394355
- Testing
- mometasone furoate dry powder inhaler, fluticasone propionate hydrofluoroalkane (HFA), montelukast
- Volunteers
- 566 people
- Sponsor
- Organon and Co
Breastmilk Collection, Childhood Obesity
Breastmilk Composition and Microbial Profile in the Growth and Development of Healthy Term-born Infants
An increasing number of children are developing non-communicable diseases that carry immediate and long-term significant societal and economic impacts.
- Conditions
- Breastmilk Collection, Childhood Obesity, Childhood Asthma, Allergy
- Trial name
- NCT06970535
- Where
- 2 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Airway Inflammation, Asthma
An Exploratory Study to Characterise Changes in Airway Inflammation, Symptoms, Lung Function and Reliever Use in Adult Asthma Patients
This is a randomised, active-comparator, open-label, parallel-group, multicentre phase IV exploratory study to characterise changes in airway inflammation, symptoms, lung function, and reliever use in asthma patients using SABA…
- Trial name
- NCT03924635
- Testing
- SYMBICORT and salbutamol
- Where
- 6 sites in United Kingdom
- Volunteers
- 42 people
- Sponsor
- AstraZeneca
Asthma
Foster 100/6 mg NEXThaler Versus Foster 100/6mg Pressurized Metered-dose Inhaler (pMDI) in Patients With Controlled Asthma.
Primary Objective To demonstrate the non-inferiority of Foster® NEXThaler® 100/6 µg versus (vs.) Foster® pressurised metered dose inhaler (pMDI) 100/6 µg in terms of pulmonary function (change from baseline to the entire…
- Trial name
- FORTUNE (NCT03453112)
- Testing
- Foster 100/6µg NEXThaler, Foster 100/6µg pMDI
- Where
- 51 sites in China
- Volunteers
- 494 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
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